| Protein | Protein Name | Molecular Type | Hallmark | Feature | Evidence | Reference |
|---|---|---|---|---|---|---|
| PTEN | Phosphatase and tensin homolog | Lipid Phosphatase | Genome Instability, Mutation & Perturbation | Genome Instability | Inactivation of PTEN tumour suppressor through either homozygous deletion or deletion of one allele and mutation of the other, most crucially drives human prostate cancer and its progression to castration resistance. | Reference |