| Protein | Protein Name | Molecular Type | Hallmark | Feature | Evidence | Reference |
|---|---|---|---|---|---|---|
| SPOP | Speckle type POZ protein | Transcription Regulatory Protein | Genome Instability, Mutation & Perturbation | Mutation | SPOP gene mutation (one of the most common point mutation in prostate cancer which involves the SPOP substrate-binding cleft in 6-15% of tumors across multiple independent cohorts) mediates prostate cancer development in part through genomic instability via modulation of DNA double strand break (DSB) repair. | Reference |