| Protein | Protein Name | Molecular Type | Hallmark | Feature | Evidence | Reference |
|---|---|---|---|---|---|---|
| SHH | Sonic hedgehog | Ligand | Metastasis | Bone Metastasis | Sonic hedgehog (SHH), secreted by bone metastatic human prostate cancer cell induces osteoblast differentiation which in turn stimulates bone metastatic progression. | Reference |