Basic Information
Gene ID 10736 ; Check Expression Profles ; Check TFs & Targets Binding
Gene Name SIX2
Full Name Homeobox protein SIX2
Organism Homo sapiens [9606]

Cross Reference
UniProt Q9NPC8 UniGene Hs.101937
PDB NULL OMIM 604994
KEGG hsa:10736 UCSC uc002ruo.3

Protein Interactions
DIP NULL
IntAct NULL
MINT NULL
STRING 9606.ENSP00000304502

Ensembl/RefSeq
Transcript ID
Protein ID
Gene ID
ENSEMBL
REFSEQ

InterPro Annotation
Protein Program Term IPRS Start End Score Description
ENSP00000304502 Gene3D G3DSA:1.10.10.60 IPR009057 125 196 1.10e-23 Homeodomain-like
ENSP00000304502 Pfam PF00046 IPR001356 130 180 2.40e-14 Homeobox domain
ENSP00000304502 ProSitePatterns PS00027 IPR017970 157 180 - Homeobox, conserved site
ENSP00000304502 ProSiteProfiles PS50071 IPR001356 122 182 0.00e-00 Homeobox domain
ENSP00000304502 SMART SM00389 IPR001356 125 186 3.60e-20 Homeobox domain
ENSP00000304502 SUPERFAMILY SSF46689 IPR009057 122 192 0.00e-00 Homeodomain-like

Pfam Annotation
Protein Pfam ID E.value Name Description
ENSP00000304502 PF00046 8.6e-15 Homeobox Homeobox domain
ENSP00000304502 PF05920 2.8e-12 Homeobox_KN Homeobox KN domain

Gene Ontology Annotation
Protein Entry Name Space Description
ENSP00000304502 GO:0005634 cellular_component nucleus
ENSP00000304502 GO:0003700 molecular_function sequence-specific DNA binding transcription factor activity
ENSP00000304502 GO:0043565 molecular_function sequence-specific DNA binding

Orthologs
TAXID Organism Gene ID TAXID Organism Gene ID
59729 Taeniopygia guttata 100218142 10029 Cricetulus griseus 100767057
143995 Megachile rotundata 100880596 9597 Pan paniscus 100973560
7425 Nasonia vitripennis 100115806 7029 Acyrthosiphon pisum 100160072
6087 Hydra magnipapillata 100192245 10224 Saccoglossus kowalevskii 100369568
9483 Callithrix jacchus 100397818 9646 Ailuropoda melanoleuca 100468465
61853 Nomascus leucogenys 100605305 400682 Amphimedon queenslandica 100639860
30195 Bombus terrestris 100649208 132113 Bombus impatiens 100746030
7463 Apis florea 100867252 34638 Metaseiulus occidentalis 100900652
9305 Sarcophilus harrisii 100921913 9555 Papio anubis 101018624
39432 Saimiri boliviensis 101054481 31033 Takifugu rubripes 101078813
9595 Gorilla gorilla 101131409 8090 Oryzias latipes 101161260
9669 Mustela putorius furo 101676499 43179 Ictidomys tridecemlineatus 101976995
7897 Latimeria chalumnae 102365580 13735 Pelodiscus sinensis 102452073
6239 Caenorhabditis elegans 191622 10090 Mus musculus 20472
7227 Drosophila melanogaster 35662 9598 Pan troglodytes 459197
9615 Canis familiaris 481357 7668 Strongylocentrotus purpuratus 576117
7070 Tribolium castaneum 660875 7955 Danio rerio 83415
28377 Anolis carolinensis ENSACAG00000023286 9913 Bos taurus ENSBTAG00000012139
9358 Choloepus hoffmanni ENSCHOG00000001094 7719 Ciona intestinalis ENSCING00000022188
51511 Ciona savignyi ENSCSAVG00000002607 9361 Dasypus novemcinctus ENSDNOG00000018725
10020 Dipodomys ordii ENSDORG00000005524 9796 Equus caballus ENSECAG00000017789
9365 Erinaceus europaeus ENSEEUG00000013612 9371 Echinops telfairi ENSETEG00000019169
9685 Felis catus ENSFCAG00000029823 69293 Gasterosteus aculeatus ENSGACG00000010790
9031 Gallus gallus ENSGALG00000023303 8049 Gadus morhua ENSGMOG00000015501
9785 Loxodonta africana ENSLAFG00000013981 9315 Macropus eugenii ENSMEUG00000010820
30608 Microcebus murinus ENSMICG00000004949 59463 Myotis lucifugus ENSMLUG00000002337
9544 Macaca mulatta ENSMMUG00000023752 13616 Monodelphis domestica ENSMODG00000008640
9986 Oryctolagus cuniculus ENSOCUG00000027205 30611 Otolemur garnettii ENSOGAG00000034436
9978 Ochotona princeps ENSOPRG00000003825 7757 Petromyzon marinus ENSPMAG00000009968
132908 Pteropus vampyrus ENSPVAG00000013457 10116 Rattus norvegicus ENSRNOG00000024511
42254 Sorex araneus ENSSARG00000013256 9823 Sus scrofa ENSSSCG00000008446
37347 Tupaia belangeri ENSTBEG00000007513 99883 Tetraodon nigroviridis ENSTNIG00000007465
9478 Tarsius syrichta ENSTSYG00000002547 9739 Tursiops truncatus ENSTTRG00000013829
8083 Xiphophorus maculatus ENSXMAG00000016855 9813 Procavia capensis ENSPCAG00000002941
8364 Xenopus tropicalis ENSXETG00000016943