Basic Information
Gene ID 1482 ; Check Expression Profles ; Check TFs & Targets Binding
Gene Name NKX2-5; CSX, NKX2.5, NKX2E
Full Name Homeobox protein Nkx-2.5
Organism Homo sapiens [9606]

Cross Reference
UniProt P52952 UniGene Hs.54473
PDB 3RKQ OMIM 614435
KEGG hsa:1482 UCSC uc011dfe.2

Protein Interactions
DIP NULL
IntAct P52952
MINT NULL
STRING 9606.ENSP00000327758

Ensembl/RefSeq
Transcript ID
Protein ID
Gene ID
ENSEMBL
ENSEMBL
ENSEMBL
REFSEQ
REFSEQ
REFSEQ

InterPro Annotation
Protein Program Term IPRS Start End Score Description
ENSP00000327758 Gene3D G3DSA:1.10.10.60 IPR009057 123 199 2.10e-25 Homeodomain-like
ENSP00000327758 Pfam PF00046 IPR001356 139 195 8.00e-21 Homeobox domain
ENSP00000327758 PRINTS PR00024 IPR020479 160 171 1.80e-06 Homeodomain, metazoa
ENSP00000327758 PRINTS PR00024 IPR020479 175 185 1.80e-06 Homeodomain, metazoa
ENSP00000327758 PRINTS PR00024 IPR020479 185 194 1.80e-06 Homeodomain, metazoa
ENSP00000327758 ProSitePatterns PS00027 IPR017970 171 194 - Homeobox, conserved site
ENSP00000327758 ProSiteProfiles PS50071 IPR001356 136 196 0.00e-00 Homeobox domain
ENSP00000327758 SMART SM00389 IPR001356 138 200 5.20e-26 Homeobox domain
ENSP00000327758 SUPERFAMILY SSF46689 IPR009057 132 197 0.00e-00 Homeodomain-like

Pfam Annotation
Protein Pfam ID E.value Name Description
ENSP00000327758 PF00046 4.2e-21 Homeobox Homeobox domain

Gene Ontology Annotation
Protein Entry Name Space Description
ENSP00000327758 GO:0005634 cellular_component nucleus
ENSP00000327758 GO:0003700 molecular_function sequence-specific DNA binding transcription factor activity
ENSP00000327758 GO:0043565 molecular_function sequence-specific DNA binding

Orthologs
TAXID Organism Gene ID TAXID Organism Gene ID
8364 Xenopus tropicalis 100038094 7029 Acyrthosiphon pisum 100159676
9823 Sus scrofa 100521411 30611 Otolemur garnettii 100943700
9597 Pan paniscus 100982957 9555 Papio anubis 101002465
39432 Saimiri boliviensis 101039504 9669 Mustela putorius furo 101690011
43179 Ictidomys tridecemlineatus 101976370 7897 Latimeria chalumnae 102366680
10116 Rattus norvegicus 114109 7425 Nasonia vitripennis 100116335
6087 Hydra magnipapillata 100214228 10224 Saccoglossus kowalevskii 100303529
30195 Bombus terrestris 100648043 8128 Oreochromis niloticus 100709334
132113 Bombus impatiens 100741068 10029 Cricetulus griseus 100772699
7463 Apis florea 100868936 143995 Megachile rotundata 100878295
34638 Metaseiulus occidentalis 100906762 9305 Sarcophilus harrisii 100925222
9685 Felis catus 101090739 9595 Gorilla gorilla 101124584
8083 Xiphophorus maculatus 102219020 6239 Caenorhabditis elegans 179877
7227 Drosophila melanogaster 3355151 9598 Pan troglodytes 462273
9913 Bos taurus 538870 9544 Macaca mulatta 703795
7460 Apis mellifera 724373 28377 Anolis carolinensis ENSACAG00000003684
9646 Ailuropoda melanoleuca ENSAMEG00000011319 9615 Canis familiaris ENSCAFG00000009469
10141 Cavia porcellus ENSCPOG00000026347 51511 Ciona savignyi ENSCSAVG00000006091
7955 Danio rerio ENSDARG00000018004 9361 Dasypus novemcinctus ENSDNOG00000015890
10020 Dipodomys ordii ENSDORG00000003645 9315 Macropus eugenii ENSMEUG00000011672
9103 Meleagris gallopavo ENSMGAG00000003616 30608 Microcebus murinus ENSMICG00000017468
61853 Nomascus leucogenys ENSNLEG00000010047 9258 Ornithorhynchus anatinus ENSOANG00000022656
9978 Ochotona princeps ENSOPRG00000002368 9601 Pongo abelii ENSPPYG00000016055
13735 Pelodiscus sinensis ENSPSIG00000014981 59729 Taeniopygia guttata ENSTGUG00000009415
31033 Takifugu rubripes ENSTRUG00000010802 10090 Mus musculus 18089
7070 Tribolium castaneum 656094 7719 Ciona intestinalis ENSCING00000006231
9483 Callithrix jacchus ENSCJAG00000017049 9796 Equus caballus ENSECAG00000023495
9365 Erinaceus europaeus ENSEEUG00000013947 9371 Echinops telfairi ENSETEG00000000957
69293 Gasterosteus aculeatus ENSGACG00000018433 9031 Gallus gallus ENSGALG00000002886
8049 Gadus morhua ENSGMOG00000015370 9785 Loxodonta africana ENSLAFG00000029311
59463 Myotis lucifugus ENSMLUG00000012413 13616 Monodelphis domestica ENSMODG00000016788
9986 Oryctolagus cuniculus ENSOCUG00000004296 8090 Oryzias latipes ENSORLG00000007346
9813 Procavia capensis ENSPCAG00000013736 7757 Petromyzon marinus ENSPMAG00000000997
132908 Pteropus vampyrus ENSPVAG00000003246 42254 Sorex araneus ENSSARG00000002300
37347 Tupaia belangeri ENSTBEG00000011031 99883 Tetraodon nigroviridis ENSTNIG00000017075
9739 Tursiops truncatus ENSTTRG00000004510