Basic Information
Gene ID 3280 ; Check Expression Profles ; Check TFs & Targets Binding
Gene Name HES1; BHLHB39, HL, HRY
Full Name Transcription factor HES-1
Organism Homo sapiens [9606]

Cross Reference
UniProt Q14469 UniGene Hs.250666
PDB NULL OMIM 139605
KEGG hsa:3280 UCSC uc003ftq.2

Protein Interactions
DIP NULL
IntAct Q14469
MINT MINT-6774152
STRING 9606.ENSP00000232424

Ensembl/RefSeq
Transcript ID
Protein ID
Gene ID
ENSEMBL
REFSEQ

InterPro Annotation
Protein Program Term IPRS Start End Score Description
ENSP00000232424 Gene3D G3DSA:4.10.280.10 IPR011598 33 94 1.30e-14 Myc-type, basic helix-loop-helix (bHLH) domain
ENSP00000232424 Pfam PF00010 IPR011598 35 92 2.10e-14 Myc-type, basic helix-loop-helix (bHLH) domain
ENSP00000232424 Pfam PF07527 IPR003650 109 150 3.20e-20 Orange
ENSP00000232424 ProSiteProfiles PS50888 IPR011598 34 91 0.00e-00 Myc-type, basic helix-loop-helix (bHLH) domain
ENSP00000232424 ProSiteProfiles PS51054 IPR003650 110 143 0.00e-00 Orange
ENSP00000232424 SMART SM00353 IPR011598 40 97 2.10e-16 Myc-type, basic helix-loop-helix (bHLH) domain
ENSP00000232424 SMART SM00511 IPR018352 108 152 6.70e-21 Orange subgroup
ENSP00000232424 SUPERFAMILY SSF47459 IPR011598 25 94 0.00e-00 Myc-type, basic helix-loop-helix (bHLH) domain

Pfam Annotation
Protein Pfam ID E.value Name Description
ENSP00000232424 PF07527 1.8e-20 Hairy_orange Hairy Orange
ENSP00000232424 PF00010 1.2e-14 HLH Helix-loop-helix DNA-binding domain

Gene Ontology Annotation
Protein Entry Name Space Description
ENSP00000232424 GO:0000122 biological_process negative regulation of transcription from RNA polymerase II promoter
ENSP00000232424 GO:0006351 biological_process transcription, DNA-templated
ENSP00000232424 GO:0006355 biological_process regulation of transcription, DNA-templated
ENSP00000232424 GO:0007219 biological_process Notch signaling pathway
ENSP00000232424 GO:0007275 biological_process multicellular organismal development
ENSP00000232424 GO:0045892 biological_process negative regulation of transcription, DNA-templated
ENSP00000232424 GO:0005634 cellular_component nucleus
ENSP00000232424 GO:0003677 molecular_function DNA binding
ENSP00000232424 GO:0043565 molecular_function sequence-specific DNA binding
ENSP00000232424 GO:0046982 molecular_function protein heterodimerization activity
ENSP00000232424 GO:0046983 molecular_function protein dimerization activity

Orthologs
TAXID Organism Gene ID TAXID Organism Gene ID
9669 Mustela putorius furo 101691000 7897 Latimeria chalumnae 102355895
8364 Xenopus tropicalis 100038090 7425 Nasonia vitripennis 100117641
7029 Acyrthosiphon pisum 100163408 59729 Taeniopygia guttata 100225879
10224 Saccoglossus kowalevskii 100303558 28377 Anolis carolinensis 100558625
30195 Bombus terrestris 100643707 132113 Bombus impatiens 100742057
10029 Cricetulus griseus 100756407 7463 Apis florea 100865915
143995 Megachile rotundata 100876689 34638 Metaseiulus occidentalis 100897626
9597 Pan paniscus 100975593 9555 Papio anubis 101006374
39432 Saimiri boliviensis 101047984 9595 Gorilla gorilla 101137927
43179 Ictidomys tridecemlineatus 101960521 13735 Pelodiscus sinensis 102463824
7227 Drosophila melanogaster 35800 9031 Gallus gallus 395128
7668 Strongylocentrotus purpuratus 414294 9598 Pan troglodytes 460942
9913 Bos taurus 539547 7070 Tribolium castaneum 660626
7460 Apis mellifera 724914 9615 Canis familiaris ENSCAFG00000019577
9358 Choloepus hoffmanni ENSCHOG00000005633 7719 Ciona intestinalis ENSCING00000003929
9483 Callithrix jacchus ENSCJAG00000000166 51511 Ciona savignyi ENSCSAVG00000004162
10020 Dipodomys ordii ENSDORG00000014783 9796 Equus caballus ENSECAG00000026945
9365 Erinaceus europaeus ENSEEUG00000007286 9685 Felis catus ENSFCAG00000029144
8049 Gadus morhua ENSGMOG00000015708 9315 Macropus eugenii ENSMEUG00000013941
9103 Meleagris gallopavo ENSMGAG00000007566 30608 Microcebus murinus ENSMICG00000012430
59463 Myotis lucifugus ENSMLUG00000008549 13616 Monodelphis domestica ENSMODG00000019833
61853 Nomascus leucogenys ENSNLEG00000006836 9258 Ornithorhynchus anatinus ENSOANG00000015683
30611 Otolemur garnettii ENSOGAG00000024214 8128 Oreochromis niloticus ENSONIG00000002619
9978 Ochotona princeps ENSOPRG00000006690 8090 Oryzias latipes ENSORLG00000007556
9813 Procavia capensis ENSPCAG00000007135 7757 Petromyzon marinus ENSPMAG00000001409
9601 Pongo abelii ENSPPYG00000014419 132908 Pteropus vampyrus ENSPVAG00000015487
10116 Rattus norvegicus ENSRNOG00000001720 42254 Sorex araneus ENSSARG00000014246
9823 Sus scrofa ENSSSCG00000026362 37347 Tupaia belangeri ENSTBEG00000017537
99883 Tetraodon nigroviridis ENSTNIG00000015567 31033 Takifugu rubripes ENSTRUG00000017395
9739 Tursiops truncatus ENSTTRG00000001687 30538 Vicugna pacos ENSVPAG00000000708
8083 Xiphophorus maculatus ENSXMAG00000003794 9646 Ailuropoda melanoleuca ENSAMEG00000015855
10141 Cavia porcellus ENSCPOG00000021042 69293 Gasterosteus aculeatus ENSGACG00000009264