Basic Information | |||
Gene ID | 4087 ; ![]() ![]() | ||
Gene Name | SMAD2; MADH2, MADR2 | ||
Full Name | Mothers against decapentaplegic homolog 2 | ||
Organism | Homo sapiens [9606] |
Cross Reference | |||
UniProt | Q15796 | UniGene | Hs.741342 |
PDB | 2LB3 | OMIM | 601366 |
KEGG | hsa:4087 | UCSC | uc010xdc.3 |
Protein Interactions | |
DIP | DIP-29716N |
IntAct | Q15796 |
MINT | MINT-5006109 |
STRING | 9606.ENSP00000262160 |
Ensembl/RefSeq | Transcript ID | Protein ID | Gene ID |
ENSEMBL | |||
ENSEMBL | |||
ENSEMBL | |||
ENSEMBL | |||
ENSEMBL | |||
REFSEQ | |||
REFSEQ | |||
REFSEQ | |||
REFSEQ | |||
REFSEQ |
InterPro Annotation | |||||||
Protein | Program | Term | IPRS | Start | End | Score | Description |
ENSP00000384449 | Gene3D | G3DSA:2.60.200.10 | IPR017855 | 266 | 467 | 7.90e-100 | SMAD domain-like |
ENSP00000384449 | Gene3D | G3DSA:3.90.520.10 | IPR013019 | 2 | 183 | 3.60e-59 | MAD homology, MH1 |
ENSP00000384449 | PANTHER | PTHR13703 | IPR013790 | 1 | 467 | 0.00e-00 | Dwarfin |
ENSP00000384449 | Pfam | PF03165 | IPR003619 | 41 | 171 | 5.80e-43 | MAD homology 1, Dwarfin-type |
ENSP00000384449 | Pfam | PF03166 | IPR001132 | 269 | 444 | 1.50e-77 | SMAD domain, Dwarfin-type |
ENSP00000384449 | ProSiteProfiles | PS51075 | IPR013019 | 10 | 176 | 0.00e-00 | MAD homology, MH1 |
ENSP00000384449 | ProSiteProfiles | PS51076 | IPR001132 | 274 | 467 | 0.00e-00 | SMAD domain, Dwarfin-type |
ENSP00000384449 | SMART | SM00523 | IPR003619 | 36 | 174 | 1.80e-67 | MAD homology 1, Dwarfin-type |
ENSP00000384449 | SMART | SM00524 | IPR001132 | 272 | 443 | 4.60e-111 | SMAD domain, Dwarfin-type |
ENSP00000384449 | SUPERFAMILY | SSF49879 | IPR008984 | 217 | 458 | 0.00e-00 | SMAD/FHA domain |
ENSP00000384449 | SUPERFAMILY | SSF56366 | IPR013019 | 111 | 171 | 0.00e-00 | MAD homology, MH1 |
ENSP00000384449 | SUPERFAMILY | SSF56366 | IPR013019 | 31 | 80 | 0.00e-00 | MAD homology, MH1 |
Pfam Annotation | ||||
Protein | Pfam ID | E.value | Name | Description |
ENSP00000384449 | PF03166 | 0 | MH2 | MH2 domain |
ENSP00000384449 | PF03165 | 3.19496e-43 | MH1 | MH1 domain |
ENSP00000384449 | PF10401 | 1.5e-06 | IRF-3 | Interferon-regulatory factor 3 |
Gene Ontology Annotation | |||
Protein | Entry | Name Space | Description |
ENSP00000384449 | GO:0006351 | biological_process | transcription, DNA-templated |
ENSP00000384449 | GO:0007179 | biological_process | transforming growth factor beta receptor signaling pathway |
ENSP00000384449 | GO:0005634 | cellular_component | nucleus |
ENSP00000384449 | GO:0005667 | cellular_component | transcription factor complex |
ENSP00000384449 | GO:0005737 | cellular_component | cytoplasm |
ENSP00000384449 | GO:0003700 | molecular_function | sequence-specific DNA binding transcription factor activity |
Orthologs | |||||
TAXID | Organism | Gene ID | TAXID | Organism | Gene ID |
9597 | Pan paniscus | 100980706 | 9669 | Mustela putorius furo | 101691860 |
8083 | Xiphophorus maculatus | 102216927 | 10116 | Rattus norvegicus | 25631 |
13616 | Monodelphis domestica | 100014493 | 10224 | Saccoglossus kowalevskii | 100313734 |
9483 | Callithrix jacchus | 100396826 | 9646 | Ailuropoda melanoleuca | 100467069 |
61853 | Nomascus leucogenys | 100589735 | 30195 | Bombus terrestris | 100646575 |
8128 | Oreochromis niloticus | 100710325 | 132113 | Bombus impatiens | 100740756 |
10029 | Cricetulus griseus | 100771578 | 7463 | Apis florea | 100864028 |
143995 | Megachile rotundata | 100882571 | 34638 | Metaseiulus occidentalis | 100906659 |
9555 | Papio anubis | 101004882 | 39432 | Saimiri boliviensis | 101040653 |
31033 | Takifugu rubripes | 101072871 | 9685 | Felis catus | 101087179 |
8090 | Oryzias latipes | 101159109 | 43179 | Ictidomys tridecemlineatus | 101973097 |
7897 | Latimeria chalumnae | 102360430 | 59463 | Myotis lucifugus | 102429768 |
13735 | Pelodiscus sinensis | 102457921 | 9031 | Gallus gallus | 395247 |
7460 | Apis mellifera | 412601 | 7668 | Strongylocentrotus purpuratus | 577345 |
9544 | Macaca mulatta | 697581 | 9598 | Pan troglodytes | 748161 |
7719 | Ciona intestinalis | 778756 | 28377 | Anolis carolinensis | ENSACAG00000009914 |
9913 | Bos taurus | ENSBTAG00000012599 | 9358 | Choloepus hoffmanni | ENSCHOG00000011289 |
10141 | Cavia porcellus | ENSCPOG00000013398 | 51511 | Ciona savignyi | ENSCSAVG00000004749 |
10020 | Dipodomys ordii | ENSDORG00000013015 | 9796 | Equus caballus | ENSECAG00000015132 |
9365 | Erinaceus europaeus | ENSEEUG00000007736 | 9371 | Echinops telfairi | ENSETEG00000003612 |
69293 | Gasterosteus aculeatus | ENSGACG00000013323 | 9595 | Gorilla gorilla | ENSGGOG00000004706 |
8049 | Gadus morhua | ENSGMOG00000007444 | 9785 | Loxodonta africana | ENSLAFG00000021903 |
30608 | Microcebus murinus | ENSMICG00000006119 | 9258 | Ornithorhynchus anatinus | ENSOANG00000013558 |
9978 | Ochotona princeps | ENSOPRG00000014996 | 9813 | Procavia capensis | ENSPCAG00000012688 |
7757 | Petromyzon marinus | ENSPMAG00000000489 | 9601 | Pongo abelii | ENSPPYG00000009144 |
42254 | Sorex araneus | ENSSARG00000003487 | 9823 | Sus scrofa | ENSSSCG00000004505 |
37347 | Tupaia belangeri | ENSTBEG00000016121 | 59729 | Taeniopygia guttata | ENSTGUG00000000016 |
99883 | Tetraodon nigroviridis | ENSTNIG00000011436 | 9478 | Tarsius syrichta | ENSTSYG00000005303 |
30538 | Vicugna pacos | ENSVPAG00000007781 | 8364 | Xenopus tropicalis | ENSXETG00000020292 |
9615 | Canis familiaris | 480144 | 7955 | Danio rerio | 58092 |
9315 | Macropus eugenii | ENSMEUG00000016668 | 9103 | Meleagris gallopavo | ENSMGAG00000009879 |
132908 | Pteropus vampyrus | ENSPVAG00000007760 | 9305 | Sarcophilus harrisii | ENSSHAG00000012543 |
9739 | Tursiops truncatus | ENSTTRG00000002628 |