Basic Information
Gene ID 493847
Gene Name TP53; TRP53
Full Name Cellular tumor antigen p53
Organism Felis catus [9685]

Cross Reference
UniProt P41685 UniGene NULL
PDB NULL OMIM NULL
KEGG fca:493847 UCSC NULL

Protein Interactions
DIP NULL
IntAct NULL
MINT NULL
STRING 9685.ENSFCAP00000008925

Ensembl/RefSeq
Transcript ID
Protein ID
Gene ID
ENSEMBL
REFSEQ

InterPro Annotation
Protein Program Term IPRS Start End Score Description
ENSFCAP00000008925 Gene3D G3DSA:2.60.40.720 IPR012346 87 288 3.60e-96 p53/RUNT-type transcription factor, DNA-binding domain
ENSFCAP00000008925 Gene3D G3DSA:4.10.170.10 IPR010991 312 352 4.40e-21 p53, tetramerisation domain
ENSFCAP00000008925 PANTHER PTHR11447 IPR002117 1 386 0.00e-00 p53 tumour suppressor family
ENSFCAP00000008925 Pfam PF00870 IPR011615 88 281 2.60e-108 p53, DNA-binding domain
ENSFCAP00000008925 Pfam PF07710 IPR010991 312 351 3.20e-19 p53, tetramerisation domain
ENSFCAP00000008925 Pfam PF08563 IPR013872 5 29 4.70e-11 p53 transactivation domain
ENSFCAP00000008925 PRINTS PR00386 IPR002117 108 134 2.30e-86 p53 tumour suppressor family
ENSFCAP00000008925 PRINTS PR00386 IPR002117 150 171 2.30e-86 p53 tumour suppressor family
ENSFCAP00000008925 PRINTS PR00386 IPR002117 206 227 2.30e-86 p53 tumour suppressor family
ENSFCAP00000008925 PRINTS PR00386 IPR002117 229 251 2.30e-86 p53 tumour suppressor family
ENSFCAP00000008925 PRINTS PR00386 IPR002117 257 279 2.30e-86 p53 tumour suppressor family
ENSFCAP00000008925 PRINTS PR00386 IPR002117 319 343 2.30e-86 p53 tumour suppressor family
ENSFCAP00000008925 ProSitePatterns PS00348 IPR002117 230 242 - p53 tumour suppressor family
ENSFCAP00000008925 SUPERFAMILY SSF47719 IPR010991 312 351 0.00e-00 p53, tetramerisation domain
ENSFCAP00000008925 SUPERFAMILY SSF49417 IPR008967 89 280 0.00e-00 p53-like transcription factor, DNA-binding

Pfam Annotation
Protein Pfam ID E.value Name Description
ENSFCAP00000008925 PF00870 0 P53 P53 DNA-binding domain
ENSFCAP00000008925 PF07710 1.5e-19 P53_tetramer P53 tetramerisation motif
ENSFCAP00000008925 PF08563 4.7e-11 P53_TAD P53 transactivation motif

Gene Ontology Annotation
Protein Entry Name Space Description
ENSFCAP00000008925 GO:0000122 biological_process negative regulation of transcription from RNA polymerase II promoter
ENSFCAP00000008925 GO:0000733 biological_process DNA strand renaturation
ENSFCAP00000008925 GO:0006289 biological_process nucleotide-excision repair
ENSFCAP00000008925 GO:0006351 biological_process transcription, DNA-templated
ENSFCAP00000008925 GO:0006355 biological_process regulation of transcription, DNA-templated
ENSFCAP00000008925 GO:0006915 biological_process apoptotic process
ENSFCAP00000008925 GO:0006978 biological_process DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
ENSFCAP00000008925 GO:0007049 biological_process cell cycle
ENSFCAP00000008925 GO:0007275 biological_process multicellular organismal development
ENSFCAP00000008925 GO:0007569 biological_process cell aging
ENSFCAP00000008925 GO:0010165 biological_process response to X-ray
ENSFCAP00000008925 GO:0010332 biological_process response to gamma radiation
ENSFCAP00000008925 GO:0012501 biological_process programmed cell death
ENSFCAP00000008925 GO:0030308 biological_process negative regulation of cell growth
ENSFCAP00000008925 GO:0031065 biological_process positive regulation of histone deacetylation
ENSFCAP00000008925 GO:0034644 biological_process cellular response to UV
ENSFCAP00000008925 GO:0042771 biological_process intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
ENSFCAP00000008925 GO:0043525 biological_process positive regulation of neuron apoptotic process
ENSFCAP00000008925 GO:0051262 biological_process protein tetramerization
ENSFCAP00000008925 GO:0090200 biological_process positive regulation of release of cytochrome c from mitochondria
ENSFCAP00000008925 GO:0097252 biological_process oligodendrocyte apoptotic process
ENSFCAP00000008925 GO:0005634 cellular_component nucleus
ENSFCAP00000008925 GO:0005657 cellular_component replication fork
ENSFCAP00000008925 GO:0005730 cellular_component nucleolus
ENSFCAP00000008925 GO:0005737 cellular_component cytoplasm
ENSFCAP00000008925 GO:0005739 cellular_component mitochondrion
ENSFCAP00000008925 GO:0005759 cellular_component mitochondrial matrix
ENSFCAP00000008925 GO:0005783 cellular_component endoplasmic reticulum
ENSFCAP00000008925 GO:0005829 cellular_component cytosol
ENSFCAP00000008925 GO:0003677 molecular_function DNA binding
ENSFCAP00000008925 GO:0003682 molecular_function chromatin binding
ENSFCAP00000008925 GO:0003700 molecular_function sequence-specific DNA binding transcription factor activity
ENSFCAP00000008925 GO:0005507 molecular_function copper ion binding
ENSFCAP00000008925 GO:0005524 molecular_function ATP binding
ENSFCAP00000008925 GO:0044212 molecular_function transcription regulatory region DNA binding
ENSFCAP00000008925 GO:0046872 molecular_function metal ion binding

Orthologs
TAXID Organism Gene ID TAXID Organism Gene ID
10141 Cavia porcellus 100379269 9483 Callithrix jacchus 100415710
10029 Cricetulus griseus 100682525 8128 Oreochromis niloticus 100702587
9305 Sarcophilus harrisii 100922473 9597 Pan paniscus 100973941
9555 Papio anubis 101006608 39432 Saimiri boliviensis 101043647
43179 Ictidomys tridecemlineatus 101957738 8083 Xiphophorus maculatus 102219062
13735 Pelodiscus sinensis 102448135 10116 Rattus norvegicus 24842
9598 Pan troglodytes 455214 9601 Pongo abelii 100435218
9595 Gorilla gorilla 101133524 9606 Homo sapiens 7157
9615 Canis familiaris ENSCAFG00000016714 9361 Dasypus novemcinctus ENSDNOG00000005252
9796 Equus caballus ENSECAG00000008126 9365 Erinaceus europaeus ENSEEUG00000014573
9371 Echinops telfairi ENSETEG00000008987 7897 Latimeria chalumnae ENSLACG00000014014
9785 Loxodonta africana ENSLAFG00000007483 9315 Macropus eugenii ENSMEUG00000013135
30608 Microcebus murinus ENSMICG00000014853 59463 Myotis lucifugus ENSMLUG00000006411
9669 Mustela putorius furo ENSMPUG00000009017 61853 Nomascus leucogenys ENSNLEG00000009730
9986 Oryctolagus cuniculus ENSOCUG00000001138 30611 Otolemur garnettii ENSOGAG00000016871
9978 Ochotona princeps ENSOPRG00000006441 9813 Procavia capensis ENSPCAG00000012725
132908 Pteropus vampyrus ENSPVAG00000016317 42254 Sorex araneus ENSSARG00000006206
37347 Tupaia belangeri ENSTBEG00000011771 99883 Tetraodon nigroviridis ENSTNIG00000010137
31033 Takifugu rubripes ENSTRUG00000012107 9739 Tursiops truncatus ENSTTRG00000010250
8364 Xenopus tropicalis ENSXETG00000025055