Basic Information
Gene ID 6492 ; Check Expression Profles ; Check TFs & Targets Binding
Gene Name SIM1; BHLHE14
Full Name Single-minded homolog 1
Organism Homo sapiens [9606]

Cross Reference
UniProt P81133 UniGene Hs.520293
PDB NULL OMIM 603128
KEGG hsa:6492 UCSC uc003pqj.4

Protein Interactions
DIP NULL
IntAct NULL
MINT NULL
STRING 9606.ENSP00000262901

Ensembl/RefSeq
Transcript ID
Protein ID
Gene ID
ENSEMBL
ENSEMBL
REFSEQ
REFSEQ

InterPro Annotation
Protein Program Term IPRS Start End Score Description
ENSP00000262901 Gene3D G3DSA:4.10.280.10 IPR011598 3 51 5.70e-05 Myc-type, basic helix-loop-helix (bHLH) domain
ENSP00000262901 Pfam PF00010 IPR011598 8 51 3.80e-05 Myc-type, basic helix-loop-helix (bHLH) domain
ENSP00000262901 Pfam PF00989 IPR013767 81 142 5.80e-12 PAS fold
ENSP00000262901 Pfam PF06621 IPR010578 359 670 5.70e-130 Single-minded, C-terminal
ENSP00000262901 Pfam PF08447 IPR013655 243 329 1.70e-17 PAS fold-3
ENSP00000262901 ProSiteProfiles PS50112 IPR000014 233 270 0.00e-00 PAS domain
ENSP00000262901 ProSiteProfiles PS50112 IPR000014 77 140 0.00e-00 PAS domain
ENSP00000262901 ProSiteProfiles PS50888 IPR011598 1 53 0.00e-00 Myc-type, basic helix-loop-helix (bHLH) domain
ENSP00000262901 ProSiteProfiles PS51302 IPR010578 336 766 0.00e-00 Single-minded, C-terminal
ENSP00000262901 SMART SM00086 IPR001610 292 335 7.00e-09 PAC motif
ENSP00000262901 SMART SM00091 IPR000014 220 286 2.30e-07 PAS domain
ENSP00000262901 SMART SM00091 IPR000014 79 145 3.00e-16 PAS domain
ENSP00000262901 SMART SM00353 IPR011598 6 59 2.90e-08 Myc-type, basic helix-loop-helix (bHLH) domain
ENSP00000262901 SUPERFAMILY SSF47459 IPR011598 5 53 0.00e-00 Myc-type, basic helix-loop-helix (bHLH) domain
ENSP00000262901 SUPERFAMILY SSF55785 IPR000014 230 334 0.00e-00 PAS domain
ENSP00000262901 SUPERFAMILY SSF55785 IPR000014 88 194 0.00e-00 PAS domain

Pfam Annotation
Protein Pfam ID E.value Name Description
ENSP00000262901 PF06621 0 SIM_C Single-minded protein C-terminus
ENSP00000262901 PF08447 8.7e-24 PAS_3 PAS fold
ENSP00000262901 PF14598 4.5e-21 PAS_11 PAS domain
ENSP00000262901 PF00989 3.1e-18 PAS PAS fold
ENSP00000262901 PF00010 2.2e-06 HLH Helix-loop-helix DNA-binding domain
ENSP00000262901 PF13426 5.1e-05 PAS_9 PAS domain
ENSP00000262901 PF08448 0.00049 PAS_4 PAS fold

Gene Ontology Annotation
Protein Entry Name Space Description
ENSP00000262901 GO:0006351 biological_process transcription, DNA-templated
ENSP00000262901 GO:0005634 cellular_component nucleus
ENSP00000262901 GO:0003677 molecular_function DNA binding
ENSP00000262901 GO:0004871 molecular_function signal transducer activity

Orthologs
TAXID Organism Gene ID TAXID Organism Gene ID
13616 Monodelphis domestica 100020833 7425 Nasonia vitripennis 100117407
9823 Sus scrofa 100154026 10224 Saccoglossus kowalevskii 100303526
9601 Pongo abelii 100433526 61853 Nomascus leucogenys 100607894
30195 Bombus terrestris 100648501 132113 Bombus impatiens 100742767
10029 Cricetulus griseus 100770497 7463 Apis florea 100863085
143995 Megachile rotundata 100878780 34638 Metaseiulus occidentalis 100905945
9305 Sarcophilus harrisii 100929589 9597 Pan paniscus 100985708
9555 Papio anubis 101002336 39432 Saimiri boliviensis 101035840
9595 Gorilla gorilla 101132201 9669 Mustela putorius furo 101694087
8083 Xiphophorus maculatus 102227571 7460 Apis mellifera 410669
9598 Pan troglodytes 472084 7668 Strongylocentrotus purpuratus 577676
10116 Rattus norvegicus 309888 7070 Tribolium castaneum 656297
9544 Macaca mulatta 695324 9358 Choloepus hoffmanni ENSCHOG00000005099
51511 Ciona savignyi ENSCSAVG00000003790 7955 Danio rerio ENSDARG00000023316
9361 Dasypus novemcinctus ENSDNOG00000010261 10020 Dipodomys ordii ENSDORG00000008569
9365 Erinaceus europaeus ENSEEUG00000009806 9371 Echinops telfairi ENSETEG00000010692
9685 Felis catus ENSFCAG00000005942 69293 Gasterosteus aculeatus ENSGACG00000009479
8049 Gadus morhua ENSGMOG00000018211 7897 Latimeria chalumnae ENSLACG00000015924
9785 Loxodonta africana ENSLAFG00000006594 9315 Macropus eugenii ENSMEUG00000011682
9103 Meleagris gallopavo ENSMGAG00000013553 30608 Microcebus murinus ENSMICG00000008851
59463 Myotis lucifugus ENSMLUG00000002874 9978 Ochotona princeps ENSOPRG00000013168
8090 Oryzias latipes ENSORLG00000012840 9813 Procavia capensis ENSPCAG00000008763
13735 Pelodiscus sinensis ENSPSIG00000002579 132908 Pteropus vampyrus ENSPVAG00000012822
42254 Sorex araneus ENSSARG00000000736 43179 Ictidomys tridecemlineatus ENSSTOG00000015624
37347 Tupaia belangeri ENSTBEG00000005949 99883 Tetraodon nigroviridis ENSTNIG00000012304
31033 Takifugu rubripes ENSTRUG00000018267 9478 Tarsius syrichta ENSTSYG00000007116
9739 Tursiops truncatus ENSTTRG00000008248 30538 Vicugna pacos ENSVPAG00000001407
8364 Xenopus tropicalis ENSXETG00000002406 7227 Drosophila melanogaster FBgn0004666

Paralogs
6493