Basic Information
Gene ID 6927 ; Check Expression Profles ; Check TFs & Targets Binding
Gene Name HNF1A; TCF1
Full Name Hepatocyte nuclear factor 1-alpha
Organism Homo sapiens [9606]

Cross Reference
UniProt P20823 UniGene Hs.654455
PDB 2GYP OMIM 612520
KEGG hsa:6927 UCSC uc001tzg.3

Protein Interactions
DIP DIP-33544N
IntAct P20823
MINT NULL
STRING 9606.ENSP00000257555

Ensembl/RefSeq
Transcript ID
Protein ID
Gene ID
ENSEMBL
ENSEMBL
ENSEMBL
ENSEMBL
REFSEQ
REFSEQ
REFSEQ

InterPro Annotation
Protein Program Term IPRS Start End Score Description
ENSP00000443112 Gene3D G3DSA:1.10.10.60 IPR009057 203 278 1.00e-37 Homeodomain-like
ENSP00000443112 Gene3D G3DSA:1.10.260.40 IPR010982 86 179 2.70e-44 Lambda repressor-like, DNA-binding domain
ENSP00000443112 Pfam PF00046 IPR001356 200 273 1.00e-05 Homeobox domain
ENSP00000443112 Pfam PF04812 IPR006897 282 541 5.30e-102 Hepatocyte nuclear factor 1, beta isoform, C-terminal
ENSP00000443112 Pfam PF04813 IPR006898 573 661 3.30e-33 Hepatocyte nuclear factor 1, alpha isoform C-terminal
ENSP00000443112 Pfam PF04814 IPR006899 1 176 4.80e-82 Hepatocyte nuclear factor 1, N-terminal
ENSP00000443112 ProSiteProfiles PS50071 IPR001356 197 278 0.00e-00 Homeobox domain
ENSP00000443112 SMART SM00389 IPR001356 199 282 7.30e-10 Homeobox domain
ENSP00000443112 SUPERFAMILY SSF100957 IPR023219 1 31 0.00e-00 Hepatocyte nuclear factor 1, dimerisation domain
ENSP00000443112 SUPERFAMILY SSF46689 IPR009057 192 287 0.00e-00 Homeodomain-like
ENSP00000443112 SUPERFAMILY SSF47413 IPR010982 88 179 0.00e-00 Lambda repressor-like, DNA-binding domain

Pfam Annotation
Protein Pfam ID E.value Name Description
ENSP00000443112 PF04812 0 HNF-1B_C Hepatocyte nuclear factor 1 (HNF-1), beta isoform C terminus
ENSP00000443112 PF04814 0 HNF-1_N Hepatocyte nuclear factor 1 (HNF-1), N terminus
ENSP00000443112 PF04813 7.7e-34 HNF-1A_C Hepatocyte nuclear factor 1 (HNF-1), alpha isoform C terminus
ENSP00000443112 PF00046 2.2e-06 Homeobox Homeobox domain

Gene Ontology Annotation
Protein Entry Name Space Description
ENSP00000443112 GO:0045893 biological_process positive regulation of transcription, DNA-templated
ENSP00000443112 GO:0005634 cellular_component nucleus
ENSP00000443112 GO:0003677 molecular_function DNA binding
ENSP00000443112 GO:0003700 molecular_function sequence-specific DNA binding transcription factor activity
ENSP00000443112 GO:0043565 molecular_function sequence-specific DNA binding

Orthologs
TAXID Organism Gene ID TAXID Organism Gene ID
400682 Amphimedon queenslandica 100633356 10029 Cricetulus griseus 100774677
9597 Pan paniscus 100991949 9555 Papio anubis 101016717
9685 Felis catus 101098407 9595 Gorilla gorilla 101144178
43179 Ictidomys tridecemlineatus 101974881 7668 Strongylocentrotus purpuratus 577214
9615 Canis familiaris 610402 8128 Oreochromis niloticus 100704340
10141 Cavia porcellus 100714798 39432 Saimiri boliviensis 101047808
10090 Mus musculus 21405 9913 Bos taurus 503578
9646 Ailuropoda melanoleuca ENSAMEG00000008387 9358 Choloepus hoffmanni ENSCHOG00000006010
9483 Callithrix jacchus ENSCJAG00000013594 51511 Ciona savignyi ENSCSAVG00000009827
7955 Danio rerio ENSDARG00000022295 10020 Dipodomys ordii ENSDORG00000007676
9796 Equus caballus ENSECAG00000019954 9371 Echinops telfairi ENSETEG00000019192
69293 Gasterosteus aculeatus ENSGACG00000012691 9315 Macropus eugenii ENSMEUG00000004163
9103 Meleagris gallopavo ENSMGAG00000008538 30608 Microcebus murinus ENSMICG00000001274
59463 Myotis lucifugus ENSMLUG00000009109 13616 Monodelphis domestica ENSMODG00000002966
9669 Mustela putorius furo ENSMPUG00000003290 9813 Procavia capensis ENSPCAG00000012898
7757 Petromyzon marinus ENSPMAG00000001209 13735 Pelodiscus sinensis ENSPSIG00000013055
9823 Sus scrofa ENSSSCG00000022417 37347 Tupaia belangeri ENSTBEG00000007107
99883 Tetraodon nigroviridis ENSTNIG00000011468 31033 Takifugu rubripes ENSTRUG00000016222
9739 Tursiops truncatus ENSTTRG00000015910 8364 Xenopus tropicalis ENSXETG00000012278
9544 Macaca mulatta 714540 28377 Anolis carolinensis ENSACAG00000006458
7719 Ciona intestinalis ENSCING00000007645 9361 Dasypus novemcinctus ENSDNOG00000000374
9365 Erinaceus europaeus ENSEEUG00000004998 9031 Gallus gallus ENSGALG00000005504
8049 Gadus morhua ENSGMOG00000016065 7897 Latimeria chalumnae ENSLACG00000017915
9785 Loxodonta africana ENSLAFG00000002573 61853 Nomascus leucogenys ENSNLEG00000015946
9258 Ornithorhynchus anatinus ENSOANG00000014646 30611 Otolemur garnettii ENSOGAG00000000869
9978 Ochotona princeps ENSOPRG00000001671 8090 Oryzias latipes ENSORLG00000004564
9601 Pongo abelii ENSPPYG00000005042 9598 Pan troglodytes ENSPTRG00000005551
132908 Pteropus vampyrus ENSPVAG00000008044 10116 Rattus norvegicus ENSRNOG00000002598
42254 Sorex araneus ENSSARG00000007152 9305 Sarcophilus harrisii ENSSHAG00000014771
59729 Taeniopygia guttata ENSTGUG00000009673 9478 Tarsius syrichta ENSTSYG00000010701
30538 Vicugna pacos ENSVPAG00000001980 8083 Xiphophorus maculatus ENSXMAG00000003472