Basic Information
Gene ID 6940 ; Check Expression Profles ; Check TFs & Targets Binding
Gene Name ZNF354A; EZNF, HKL1, TCF17
Full Name Zinc finger protein 354A
Organism Homo sapiens [9606]

Cross Reference
UniProt O60765 UniGene Hs.484324
PDB NULL OMIM 602444
KEGG hsa:6940 UCSC uc003mjj.3

Protein Interactions
DIP NULL
IntAct NULL
MINT NULL
STRING 9606.ENSP00000337122

Ensembl/RefSeq
Transcript ID
Protein ID
Gene ID
ENSEMBL
REFSEQ

InterPro Annotation
Protein Program Term IPRS Start End Score Description
ENSP00000337122 Gene3D G3DSA:3.30.160.60 IPR013087 212 243 6.80e-11 Zinc finger C2H2-type/integrase DNA-binding domain
ENSP00000337122 Gene3D G3DSA:3.30.160.60 IPR013087 244 271 1.90e-17 Zinc finger C2H2-type/integrase DNA-binding domain
ENSP00000337122 Gene3D G3DSA:3.30.160.60 IPR013087 272 294 4.40e-15 Zinc finger C2H2-type/integrase DNA-binding domain
ENSP00000337122 Gene3D G3DSA:3.30.160.60 IPR013087 295 323 2.60e-12 Zinc finger C2H2-type/integrase DNA-binding domain
ENSP00000337122 Gene3D G3DSA:3.30.160.60 IPR013087 352 383 1.80e-16 Zinc finger C2H2-type/integrase DNA-binding domain
ENSP00000337122 Gene3D G3DSA:3.30.160.60 IPR013087 384 411 2.80e-20 Zinc finger C2H2-type/integrase DNA-binding domain
ENSP00000337122 Gene3D G3DSA:3.30.160.60 IPR013087 412 439 1.30e-15 Zinc finger C2H2-type/integrase DNA-binding domain
ENSP00000337122 Gene3D G3DSA:3.30.160.60 IPR013087 440 467 1.10e-14 Zinc finger C2H2-type/integrase DNA-binding domain
ENSP00000337122 Gene3D G3DSA:3.30.160.60 IPR013087 468 495 5.10e-18 Zinc finger C2H2-type/integrase DNA-binding domain
ENSP00000337122 Gene3D G3DSA:3.30.160.60 IPR013087 496 523 4.30e-20 Zinc finger C2H2-type/integrase DNA-binding domain
ENSP00000337122 Gene3D G3DSA:3.30.160.60 IPR013087 524 550 7.20e-18 Zinc finger C2H2-type/integrase DNA-binding domain
ENSP00000337122 Gene3D G3DSA:3.30.160.60 IPR013087 551 569 1.40e-16 Zinc finger C2H2-type/integrase DNA-binding domain
ENSP00000337122 Gene3D G3DSA:3.30.160.60 IPR013087 570 603 5.90e-15 Zinc finger C2H2-type/integrase DNA-binding domain
ENSP00000337122 Pfam PF01352 IPR001909 14 54 1.60e-23 Krueppel-associated box
ENSP00000337122 ProSitePatterns PS00028 IPR007087 216 236 - Zinc finger, C2H2
ENSP00000337122 ProSitePatterns PS00028 IPR007087 244 264 - Zinc finger, C2H2
ENSP00000337122 ProSitePatterns PS00028 IPR007087 272 292 - Zinc finger, C2H2
ENSP00000337122 ProSitePatterns PS00028 IPR007087 300 320 - Zinc finger, C2H2
ENSP00000337122 ProSitePatterns PS00028 IPR007087 356 376 - Zinc finger, C2H2
ENSP00000337122 ProSitePatterns PS00028 IPR007087 384 404 - Zinc finger, C2H2
ENSP00000337122 ProSitePatterns PS00028 IPR007087 412 432 - Zinc finger, C2H2
ENSP00000337122 ProSitePatterns PS00028 IPR007087 440 460 - Zinc finger, C2H2
ENSP00000337122 ProSitePatterns PS00028 IPR007087 466 488 - Zinc finger, C2H2
ENSP00000337122 ProSitePatterns PS00028 IPR007087 496 516 - Zinc finger, C2H2
ENSP00000337122 ProSitePatterns PS00028 IPR007087 524 544 - Zinc finger, C2H2
ENSP00000337122 ProSitePatterns PS00028 IPR007087 552 572 - Zinc finger, C2H2
ENSP00000337122 ProSitePatterns PS00028 IPR007087 580 600 - Zinc finger, C2H2
ENSP00000337122 ProSiteProfiles PS50157 IPR007087 214 241 0.00e-00 Zinc finger, C2H2
ENSP00000337122 ProSiteProfiles PS50157 IPR007087 242 269 0.00e-00 Zinc finger, C2H2
ENSP00000337122 ProSiteProfiles PS50157 IPR007087 270 297 0.00e-00 Zinc finger, C2H2
ENSP00000337122 ProSiteProfiles PS50157 IPR007087 298 325 0.00e-00 Zinc finger, C2H2
ENSP00000337122 ProSiteProfiles PS50157 IPR007087 354 381 0.00e-00 Zinc finger, C2H2
ENSP00000337122 ProSiteProfiles PS50157 IPR007087 382 409 0.00e-00 Zinc finger, C2H2
ENSP00000337122 ProSiteProfiles PS50157 IPR007087 410 437 0.00e-00 Zinc finger, C2H2
ENSP00000337122 ProSiteProfiles PS50157 IPR007087 438 465 0.00e-00 Zinc finger, C2H2
ENSP00000337122 ProSiteProfiles PS50157 IPR007087 466 493 0.00e-00 Zinc finger, C2H2
ENSP00000337122 ProSiteProfiles PS50157 IPR007087 494 521 0.00e-00 Zinc finger, C2H2
ENSP00000337122 ProSiteProfiles PS50157 IPR007087 522 549 0.00e-00 Zinc finger, C2H2
ENSP00000337122 ProSiteProfiles PS50157 IPR007087 550 577 0.00e-00 Zinc finger, C2H2
ENSP00000337122 ProSiteProfiles PS50157 IPR007087 578 605 0.00e-00 Zinc finger, C2H2
ENSP00000337122 ProSiteProfiles PS50805 IPR001909 14 85 0.00e-00 Krueppel-associated box
ENSP00000337122 SMART SM00349 IPR001909 14 74 2.30e-40 Krueppel-associated box
ENSP00000337122 SMART SM00355 IPR015880 214 236 3.80e-06 Zinc finger, C2H2-like
ENSP00000337122 SMART SM00355 IPR015880 242 264 4.50e-06 Zinc finger, C2H2-like
ENSP00000337122 SMART SM00355 IPR015880 270 292 4.00e-06 Zinc finger, C2H2-like
ENSP00000337122 SMART SM00355 IPR015880 298 320 3.20e-07 Zinc finger, C2H2-like
ENSP00000337122 SMART SM00355 IPR015880 354 376 4.90e-06 Zinc finger, C2H2-like
ENSP00000337122 SMART SM00355 IPR015880 382 404 1.50e-06 Zinc finger, C2H2-like
ENSP00000337122 SMART SM00355 IPR015880 410 432 1.20e-06 Zinc finger, C2H2-like
ENSP00000337122 SMART SM00355 IPR015880 438 460 3.30e-05 Zinc finger, C2H2-like
ENSP00000337122 SMART SM00355 IPR015880 466 488 8.00e-06 Zinc finger, C2H2-like
ENSP00000337122 SMART SM00355 IPR015880 494 516 3.50e-06 Zinc finger, C2H2-like
ENSP00000337122 SMART SM00355 IPR015880 522 544 1.70e-06 Zinc finger, C2H2-like
ENSP00000337122 SMART SM00355 IPR015880 550 572 1.90e-05 Zinc finger, C2H2-like
ENSP00000337122 SMART SM00355 IPR015880 578 600 3.00e-06 Zinc finger, C2H2-like
ENSP00000337122 SUPERFAMILY SSF109640 IPR001909 9 70 0.00e-00 Krueppel-associated box

Pfam Annotation
Protein Pfam ID E.value Name Description
ENSP00000337122 PF00096 0 zf-C2H2 Zinc finger, C2H2 type
ENSP00000337122 PF13465 0 zf-H2C2_2 Zinc-finger double domain
ENSP00000337122 PF13894 1.19993e-41 zf-C2H2_4 C2H2-type zinc finger
ENSP00000337122 PF13912 5.2e-30 zf-C2H2_6 C2H2-type zinc finger
ENSP00000337122 PF01352 1e-23 KRAB KRAB box
ENSP00000337122 PF12171 5.4e-22 zf-C2H2_jaz Zinc-finger double-stranded RNA-binding
ENSP00000337122 PF09723 2e-09 Zn-ribbon_8 Zinc ribbon domain
ENSP00000337122 PF07975 1e-05 C1_4 TFIIH C1-like domain
ENSP00000337122 PF12874 1.3e-05 zf-met Zinc-finger of C2H2 type
ENSP00000337122 PF01722 0.00021 BolA BolA-like protein
ENSP00000337122 PF14446 0.00028 Prok-RING_1 Prokaryotic RING finger family 1

Gene Ontology Annotation
Protein Entry Name Space Description
ENSP00000337122 GO:0006351 biological_process transcription, DNA-templated
ENSP00000337122 GO:0006355 biological_process regulation of transcription, DNA-templated
ENSP00000337122 GO:0005634 cellular_component nucleus
ENSP00000337122 GO:0003677 molecular_function DNA binding
ENSP00000337122 GO:0003700 molecular_function sequence-specific DNA binding transcription factor activity
ENSP00000337122 GO:0046872 molecular_function metal ion binding

Orthologs
TAXID Organism Gene ID TAXID Organism Gene ID
9483 Callithrix jacchus 100395409 9601 Pongo abelii 100445555
9595 Gorilla gorilla 101139196 9598 Pan troglodytes 471765
9796 Equus caballus 100067884 10029 Cricetulus griseus 100759975
9597 Pan paniscus 100994298 9555 Papio anubis 101009870
39432 Saimiri boliviensis 101028862 9685 Felis catus 101086622
10116 Rattus norvegicus 102556119 10090 Mus musculus 21408
9615 Canis familiaris ENSCAFG00000031000 9358 Choloepus hoffmanni ENSCHOG00000008173
10020 Dipodomys ordii ENSDORG00000009396 9365 Erinaceus europaeus ENSEEUG00000008362
9371 Echinops telfairi ENSETEG00000020249 30608 Microcebus murinus ENSMICG00000006390
9544 Macaca mulatta ENSMMUG00000008975 30611 Otolemur garnettii ENSOGAG00000024624
9823 Sus scrofa ENSSSCG00000028295 43179 Ictidomys tridecemlineatus ENSSTOG00000008858
9739 Tursiops truncatus ENSTTRG00000010631 9646 Ailuropoda melanoleuca ENSAMEG00000009090
10141 Cavia porcellus ENSCPOG00000002227 9785 Loxodonta africana ENSLAFG00000002909
59463 Myotis lucifugus ENSMLUG00000013294 9669 Mustela putorius furo ENSMPUG00000000732
61853 Nomascus leucogenys ENSNLEG00000001410 9978 Ochotona princeps ENSOPRG00000017155
132908 Pteropus vampyrus ENSPVAG00000016750 9478 Tarsius syrichta ENSTSYG00000008405
30538 Vicugna pacos ENSVPAG00000011106