Basic Information | |||
Gene ID | 7014 ; Check Expression Profles ; Check TFs & Targets Binding | ||
Gene Name | TERF2; TRBF2, TRF2 | ||
Full Name | Telomeric repeat-binding factor 2 | ||
Organism | Homo sapiens [9606] |
Cross Reference | |||
UniProt | Q15554 | UniGene | Hs.63335 |
PDB | 4M7C | OMIM | 602027 |
KEGG | hsa:7014 | UCSC | uc002exe.4 |
Protein Interactions | |
DIP | DIP-34052N |
IntAct | Q15554 |
MINT | MINT-2831307 |
STRING | 9606.ENSP00000254942 |
Ensembl/RefSeq | Transcript ID | Protein ID | Gene ID |
ENSEMBL | |||
ENSEMBL | |||
REFSEQ |
InterPro Annotation | |||||||
Protein | Program | Term | IPRS | Start | End | Score | Description |
ENSP00000254942 | Gene3D | G3DSA:1.10.10.60 | IPR009057 | 488 | 538 | 4.80e-17 | Homeodomain-like |
ENSP00000254942 | Gene3D | G3DSA:1.25.40.210 | IPR013867 | 86 | 289 | 5.70e-94 | Telomere repeat-binding factor, dimerisation domain |
ENSP00000254942 | Pfam | PF00249 | IPR001005 | 489 | 536 | 6.50e-12 | SANT/Myb domain |
ENSP00000254942 | Pfam | PF08558 | IPR013867 | 95 | 290 | 1.60e-36 | Telomere repeat-binding factor, dimerisation domain |
ENSP00000254942 | PIRSF | PIRSF038016 | IPR017357 | 43 | 542 | 4.80e-12 | Telomeric repeat-binding factor 1/2 |
ENSP00000254942 | ProDom | PD014243 | IPR013867 | 94 | 280 | 0.00e-00 | Telomere repeat-binding factor, dimerisation domain |
ENSP00000254942 | ProSiteProfiles | PS51294 | IPR017930 | 484 | 541 | 0.00e-00 | Myb domain |
ENSP00000254942 | SMART | SM00717 | IPR001005 | 488 | 539 | 4.70e-17 | SANT/Myb domain |
ENSP00000254942 | SUPERFAMILY | SSF46689 | IPR009057 | 490 | 540 | 0.00e-00 | Homeodomain-like |
ENSP00000254942 | SUPERFAMILY | SSF63600 | IPR013867 | 87 | 286 | 0.00e-00 | Telomere repeat-binding factor, dimerisation domain |
Pfam Annotation | ||||
Protein | Pfam ID | E.value | Name | Description |
ENSP00000254942 | PF08558 | 1.1e-36 | TRF | Telomere repeat binding factor (TRF) |
ENSP00000254942 | PF00249 | 2.3e-12 | Myb_DNA-binding | Myb-like DNA-binding domain |
ENSP00000254942 | PF13921 | 5.3e-06 | Myb_DNA-bind_6 | Myb-like DNA-binding domain |
Gene Ontology Annotation | |||
Protein | Entry | Name Space | Description |
ENSP00000254942 | GO:0000723 | biological_process | telomere maintenance |
ENSP00000254942 | GO:0007049 | biological_process | cell cycle |
ENSP00000254942 | GO:0000781 | cellular_component | chromosome, telomeric region |
ENSP00000254942 | GO:0005634 | cellular_component | nucleus |
ENSP00000254942 | GO:0005654 | cellular_component | nucleoplasm |
ENSP00000254942 | GO:0005737 | cellular_component | cytoplasm |
ENSP00000254942 | GO:0003682 | molecular_function | chromatin binding |
ENSP00000254942 | GO:0003691 | molecular_function | double-stranded telomeric DNA binding |
ENSP00000254942 | GO:0042162 | molecular_function | telomeric DNA binding |
ENSP00000254942 | GO:0042803 | molecular_function | protein homodimerization activity |
Orthologs | |||||
TAXID | Organism | Gene ID | TAXID | Organism | Gene ID |
10141 | Cavia porcellus | 100723550 | 9555 | Papio anubis | 101013589 |
39432 | Saimiri boliviensis | 101048486 | 10090 | Mus musculus | 21750 |
9031 | Gallus gallus | 395598 | 9597 | Pan paniscus | 100979464 |
9646 | Ailuropoda melanoleuca | ENSAMEG00000007513 | 9361 | Dasypus novemcinctus | ENSDNOG00000014627 |
9796 | Equus caballus | ENSECAG00000024534 | 9371 | Echinops telfairi | ENSETEG00000013553 |
9685 | Felis catus | ENSFCAG00000013579 | 9544 | Macaca mulatta | ENSMMUG00000016633 |
9669 | Mustela putorius furo | ENSMPUG00000007352 | 61853 | Nomascus leucogenys | ENSNLEG00000005506 |
9986 | Oryctolagus cuniculus | ENSOCUG00000017662 | 30611 | Otolemur garnettii | ENSOGAG00000008071 |
9823 | Sus scrofa | ENSSSCG00000002762 | 37347 | Tupaia belangeri | ENSTBEG00000011528 |
9739 | Tursiops truncatus | ENSTTRG00000010015 | 30538 | Vicugna pacos | ENSVPAG00000003993 |
8083 | Xiphophorus maculatus | ENSXMAG00000017495 | 28377 | Anolis carolinensis | ENSACAG00000003497 |
9913 | Bos taurus | ENSBTAG00000007617 | 9615 | Canis familiaris | ENSCAFG00000020267 |
9358 | Choloepus hoffmanni | ENSCHOG00000010819 | 9483 | Callithrix jacchus | ENSCJAG00000015339 |
7955 | Danio rerio | ENSDARG00000039302 | 10020 | Dipodomys ordii | ENSDORG00000011208 |
69293 | Gasterosteus aculeatus | ENSGACG00000016307 | 9595 | Gorilla gorilla | ENSGGOG00000004372 |
7897 | Latimeria chalumnae | ENSLACG00000005641 | 9315 | Macropus eugenii | ENSMEUG00000003773 |
30608 | Microcebus murinus | ENSMICG00000009673 | 59463 | Myotis lucifugus | ENSMLUG00000006584 |
13616 | Monodelphis domestica | ENSMODG00000002766 | 9258 | Ornithorhynchus anatinus | ENSOANG00000002365 |
8128 | Oreochromis niloticus | ENSONIG00000017183 | 9978 | Ochotona princeps | ENSOPRG00000006995 |
8090 | Oryzias latipes | ENSORLG00000011747 | 9813 | Procavia capensis | ENSPCAG00000006534 |
9601 | Pongo abelii | ENSPPYG00000007505 | 13735 | Pelodiscus sinensis | ENSPSIG00000011530 |
9598 | Pan troglodytes | ENSPTRG00000008281 | 132908 | Pteropus vampyrus | ENSPVAG00000015982 |
42254 | Sorex araneus | ENSSARG00000000309 | 9305 | Sarcophilus harrisii | ENSSHAG00000013733 |
43179 | Ictidomys tridecemlineatus | ENSSTOG00000012882 | 59729 | Taeniopygia guttata | ENSTGUG00000008090 |
31033 | Takifugu rubripes | ENSTRUG00000000263 | 9478 | Tarsius syrichta | ENSTSYG00000008563 |
8364 | Xenopus tropicalis | ENSXETG00000031339 |