Basic Information
Gene ID 704678
Gene Name HIF1A
Full Name Hypoxia-inducible factor 1-alpha isoform 2
Organism Macaca mulatta [9544]

Cross Reference
UniProt F7HKJ4 UniGene Mmu.4843
PDB NULL OMIM NULL
KEGG mcc:704678 UCSC NULL

Protein Interactions
DIP NULL
IntAct NULL
MINT NULL
STRING NULL

Ensembl/RefSeq
Transcript ID
Protein ID
Gene ID
ENSEMBL
REFSEQ
REFSEQ

InterPro Annotation
Protein Program Term IPRS Start End Score Description
XP_001099149 Pfam PF00989 IPR013767 94 149 2.00e-05 PAS fold
XP_001099149 Pfam PF08778 IPR014887 787 826 1.50e-22 HIF-1 alpha, transactivation domain, C-terminal
XP_001099149 Pfam PF11413 IPR021537 550 582 4.80e-16 Hypoxia-inducible factor, alpha subunit
XP_001099149 PRINTS PR01080 IPR001321 201 224 3.10e-48 Hypoxia-inducible factor-1 alpha
XP_001099149 PRINTS PR01080 IPR001321 360 378 3.10e-48 Hypoxia-inducible factor-1 alpha
XP_001099149 PRINTS PR01080 IPR001321 417 435 3.10e-48 Hypoxia-inducible factor-1 alpha
XP_001099149 PRINTS PR01080 IPR001321 457 477 3.10e-48 Hypoxia-inducible factor-1 alpha
XP_001099149 ProSiteProfiles PS50112 IPR000014 247 298 0.00e-00 PAS domain
XP_001099149 ProSiteProfiles PS50112 IPR000014 93 148 0.00e-00 PAS domain
XP_001099149 ProSiteProfiles PS50888 IPR011598 17 70 0.00e-00 Myc-type, basic helix-loop-helix (bHLH) domain
XP_001099149 SMART SM00086 IPR001610 302 345 2.60e-11 PAC motif
XP_001099149 SMART SM00091 IPR000014 230 296 8.20e-11 PAS domain
XP_001099149 SMART SM00091 IPR000014 87 153 1.50e-12 PAS domain
XP_001099149 SMART SM00353 IPR011598 23 78 2.80e-11 Myc-type, basic helix-loop-helix (bHLH) domain
XP_001099149 SUPERFAMILY SSF47459 IPR011598 15 71 0.00e-00 Myc-type, basic helix-loop-helix (bHLH) domain
XP_001099149 SUPERFAMILY SSF55785 IPR000014 242 343 0.00e-00 PAS domain
XP_001099149 SUPERFAMILY SSF55785 IPR000014 96 207 0.00e-00 PAS domain
XP_001099149 TIGRFAM TIGR00229 IPR000014 100 153 5.10e-06 PAS domain
XP_001099149 TIGRFAM TIGR00229 IPR000014 249 330 2.20e-08 PAS domain

Pfam Annotation
Protein Pfam ID E.value Name Description
XP_001099149 PF14598 2.6e-26 PAS_11 PAS domain
XP_001099149 PF08447 9.1e-26 PAS_3 PAS fold
XP_001099149 PF08778 7.7e-23 HIF-1a_CTAD HIF-1 alpha C terminal transactivation domain
XP_001099149 PF11413 2e-16 HIF-1 Hypoxia-inducible factor-1
XP_001099149 PF00989 1.1e-15 PAS PAS fold
XP_001099149 PF13426 1.7e-12 PAS_9 PAS domain
XP_001099149 PF08448 1.6e-07 PAS_4 PAS fold

Gene Ontology Annotation
Protein Entry Name Space Description
XP_001099149 GO:0001666 biological_process response to hypoxia
XP_001099149 GO:0006351 biological_process transcription, DNA-templated
XP_001099149 GO:0006355 biological_process regulation of transcription, DNA-templated
XP_001099149 GO:0007165 biological_process signal transduction
XP_001099149 GO:0045893 biological_process positive regulation of transcription, DNA-templated
XP_001099149 GO:0045944 biological_process positive regulation of transcription from RNA polymerase II promoter
XP_001099149 GO:0071456 biological_process cellular response to hypoxia
XP_001099149 GO:0005634 cellular_component nucleus
XP_001099149 GO:0005737 cellular_component cytoplasm
XP_001099149 GO:0003677 molecular_function DNA binding
XP_001099149 GO:0003700 molecular_function sequence-specific DNA binding transcription factor activity
XP_001099149 GO:0004871 molecular_function signal transducer activity
XP_001099149 GO:0035035 molecular_function histone acetyltransferase binding
XP_001099149 GO:0046983 molecular_function protein dimerization activity