Basic Information | |||
Gene ID | 79192 ; Check Expression Profles ; Check TFs & Targets Binding | ||
Gene Name | IRX1; IRXA1 | ||
Full Name | Iroquois-class homeodomain protein IRX-1 | ||
Organism | Homo sapiens [9606] |
Cross Reference | |||
UniProt | P78414 | UniGene | Hs.424156 |
PDB | NULL | OMIM | 606197 |
KEGG | hsa:79192 | UCSC | uc003jde.3 |
Protein Interactions | |
DIP | NULL |
IntAct | NULL |
MINT | NULL |
STRING | 9606.ENSP00000305244 |
Ensembl/RefSeq | Transcript ID | Protein ID | Gene ID |
ENSEMBL | |||
REFSEQ |
InterPro Annotation | |||||||
Protein | Program | Term | IPRS | Start | End | Score | Description |
ENSP00000305244 | Gene3D | G3DSA:1.10.10.60 | IPR009057 | 131 | 198 | 6.00e-25 | Homeodomain-like |
ENSP00000305244 | Pfam | PF05920 | IPR008422 | 145 | 184 | 3.10e-14 | Homeobox KN domain |
ENSP00000305244 | ProSitePatterns | PS00027 | IPR017970 | 163 | 186 | - | Homeobox, conserved site |
ENSP00000305244 | ProSiteProfiles | PS50071 | IPR001356 | 135 | 188 | 0.00e-00 | Homeobox domain |
ENSP00000305244 | SMART | SM00389 | IPR001356 | 128 | 192 | 2.80e-14 | Homeobox domain |
ENSP00000305244 | SMART | SM00548 | IPR003893 | 309 | 326 | 7.00e-08 | Iroquois-class homeodomain protein |
ENSP00000305244 | SUPERFAMILY | SSF46689 | IPR009057 | 132 | 193 | 0.00e-00 | Homeodomain-like |
Pfam Annotation | ||||
Protein | Pfam ID | E.value | Name | Description |
ENSP00000305244 | PF05920 | 1.8e-14 | Homeobox_KN | Homeobox KN domain |
ENSP00000305244 | PF00046 | 3.3e-07 | Homeobox | Homeobox domain |
Gene Ontology Annotation | |||
Protein | Entry | Name Space | Description |
ENSP00000305244 | GO:0000122 | biological_process | negative regulation of transcription from RNA polymerase II promoter |
ENSP00000305244 | GO:0006351 | biological_process | transcription, DNA-templated |
ENSP00000305244 | GO:0006355 | biological_process | regulation of transcription, DNA-templated |
ENSP00000305244 | GO:0007275 | biological_process | multicellular organismal development |
ENSP00000305244 | GO:0007399 | biological_process | nervous system development |
ENSP00000305244 | GO:0007420 | biological_process | brain development |
ENSP00000305244 | GO:0009953 | biological_process | dorsal/ventral pattern formation |
ENSP00000305244 | GO:0030154 | biological_process | cell differentiation |
ENSP00000305244 | GO:0045893 | biological_process | positive regulation of transcription, DNA-templated |
ENSP00000305244 | GO:0045944 | biological_process | positive regulation of transcription from RNA polymerase II promoter |
ENSP00000305244 | GO:0005634 | cellular_component | nucleus |
ENSP00000305244 | GO:0003677 | molecular_function | DNA binding |
ENSP00000305244 | GO:0003700 | molecular_function | sequence-specific DNA binding transcription factor activity |
ENSP00000305244 | GO:0043565 | molecular_function | sequence-specific DNA binding |
Orthologs | |||||
TAXID | Organism | Gene ID | TAXID | Organism | Gene ID |
10224 | Saccoglossus kowalevskii | 100302711 | 8128 | Oreochromis niloticus | 100707272 |
9555 | Papio anubis | 101000373 | 39432 | Saimiri boliviensis | 101030540 |
9601 | Pongo abelii | 100440802 | 132113 | Bombus impatiens | 100743820 |
10029 | Cricetulus griseus | 100750610 | 30611 | Otolemur garnettii | 100941204 |
9597 | Pan paniscus | 100988951 | 9595 | Gorilla gorilla | 101149388 |
8083 | Xiphophorus maculatus | 102231627 | 7897 | Latimeria chalumnae | 102353654 |
10090 | Mus musculus | 16371 | 7668 | Strongylocentrotus purpuratus | 590306 |
9544 | Macaca mulatta | 693825 | 28377 | Anolis carolinensis | ENSACAG00000023038 |
9646 | Ailuropoda melanoleuca | ENSAMEG00000001629 | 9483 | Callithrix jacchus | ENSCJAG00000008552 |
10141 | Cavia porcellus | ENSCPOG00000021147 | 7955 | Danio rerio | ENSDARG00000009510 |
9361 | Dasypus novemcinctus | ENSDNOG00000002056 | 10020 | Dipodomys ordii | ENSDORG00000003187 |
9796 | Equus caballus | ENSECAG00000015273 | 9365 | Erinaceus europaeus | ENSEEUG00000006088 |
9371 | Echinops telfairi | ENSETEG00000004419 | 9031 | Gallus gallus | ENSGALG00000013194 |
8049 | Gadus morhua | ENSGMOG00000006669 | 9315 | Macropus eugenii | ENSMEUG00000004557 |
61853 | Nomascus leucogenys | ENSNLEG00000011237 | 9258 | Ornithorhynchus anatinus | ENSOANG00000001749 |
9978 | Ochotona princeps | ENSOPRG00000003326 | 8090 | Oryzias latipes | ENSORLG00000005157 |
13735 | Pelodiscus sinensis | ENSPSIG00000016915 | 9598 | Pan troglodytes | ENSPTRG00000016709 |
42254 | Sorex araneus | ENSSARG00000009535 | 9823 | Sus scrofa | ENSSSCG00000002831 |
43179 | Ictidomys tridecemlineatus | ENSSTOG00000020840 | 37347 | Tupaia belangeri | ENSTBEG00000008254 |
31033 | Takifugu rubripes | ENSTRUG00000007467 | 9739 | Tursiops truncatus | ENSTTRG00000015625 |
9615 | Canis familiaris | ENSCAFG00000010422 | 9685 | Felis catus | ENSFCAG00000013031 |
69293 | Gasterosteus aculeatus | ENSGACG00000006572 | 9785 | Loxodonta africana | ENSLAFG00000012017 |
30608 | Microcebus murinus | ENSMICG00000011730 | 59463 | Myotis lucifugus | ENSMLUG00000004452 |
13616 | Monodelphis domestica | ENSMODG00000013210 | 9669 | Mustela putorius furo | ENSMPUG00000007638 |
9986 | Oryctolagus cuniculus | ENSOCUG00000024264 | 9813 | Procavia capensis | ENSPCAG00000003248 |
132908 | Pteropus vampyrus | ENSPVAG00000015986 | 9305 | Sarcophilus harrisii | ENSSHAG00000013463 |
59729 | Taeniopygia guttata | ENSTGUG00000008517 | 99883 | Tetraodon nigroviridis | ENSTNIG00000009262 |
9478 | Tarsius syrichta | ENSTSYG00000008216 | 8364 | Xenopus tropicalis | ENSXETG00000008892 |