Basic Information
Gene ID 8648 ; Check Expression Profles ; Check TFs & Targets Binding
Gene Name NCOA1; BHLHE74, SRC1
Full Name Nuclear receptor coactivator 1
Organism Homo sapiens [9606]

Cross Reference
UniProt Q15788 UniGene Hs.596314
PDB 4J5X OMIM 602691
KEGG hsa:8648 UCSC uc002rfl.3

Protein Interactions
DIP DIP-30877N
IntAct Q15788
MINT MINT-153305
STRING NULL

Ensembl/RefSeq
Transcript ID
Protein ID
Gene ID
ENSEMBL
ENSEMBL
ENSEMBL
ENSEMBL
ENSEMBL
ENSEMBL
REFSEQ
REFSEQ
REFSEQ
REFSEQ
REFSEQ
REFSEQ
REFSEQ

InterPro Annotation
Protein Program Term IPRS Start End Score Description
ENSP00000320940 Gene3D G3DSA:4.10.280.10 IPR011598 30 96 6.60e-06 Myc-type, basic helix-loop-helix (bHLH) domain
ENSP00000320940 Gene3D G3DSA:4.10.630.10 IPR008955 623 639 2.90e-27 Nuclear receptor coactivator Src-1
ENSP00000320940 Gene3D G3DSA:4.10.630.10 IPR008955 684 710 2.90e-27 Nuclear receptor coactivator Src-1
ENSP00000320940 PANTHER PTHR10684 IPR017426 2 1441 0.00e-00 Nuclear receptor coactivator
ENSP00000320940 PANTHER PTHR10684:SF1 IPR028819 2 1441 0.00e-00 Nuclear receptor coactivator 1
ENSP00000320940 Pfam PF00989 IPR013767 115 172 3.30e-07 PAS fold
ENSP00000320940 Pfam PF07469 IPR010011 1149 1204 4.60e-16 Domain of unknown function DUF1518
ENSP00000320940 Pfam PF07469 IPR010011 1212 1268 4.50e-19 Domain of unknown function DUF1518
ENSP00000320940 Pfam PF08815 IPR014920 924 973 2.70e-22 Nuclear receptor coactivator, Ncoa-type, interlocking
ENSP00000320940 Pfam PF08832 IPR014935 630 708 3.00e-27 Steroid receptor coactivator
ENSP00000320940 PIRSF PIRSF038181 IPR017426 1 1388 0.00e-00 Nuclear receptor coactivator
ENSP00000320940 ProSiteProfiles PS50112 IPR000014 109 180 0.00e-00 PAS domain
ENSP00000320940 ProSiteProfiles PS50888 IPR011598 23 80 0.00e-00 Myc-type, basic helix-loop-helix (bHLH) domain
ENSP00000320940 SMART SM00091 IPR000014 111 178 5.30e-13 PAS domain
ENSP00000320940 SMART SM00353 IPR011598 29 86 5.70e-12 Myc-type, basic helix-loop-helix (bHLH) domain
ENSP00000320940 SUPERFAMILY SSF47459 IPR011598 14 87 0.00e-00 Myc-type, basic helix-loop-helix (bHLH) domain
ENSP00000320940 SUPERFAMILY SSF55785 IPR000014 120 184 0.00e-00 PAS domain
ENSP00000320940 SUPERFAMILY SSF55785 IPR000014 260 365 0.00e-00 PAS domain
ENSP00000320940 SUPERFAMILY SSF69125 IPR009110 920 966 0.00e-00 Nuclear receptor coactivator, interlocking

Pfam Annotation
Protein Pfam ID E.value Name Description
ENSP00000320940 PF14598 1.8e-39 PAS_11 PAS domain
ENSP00000320940 PF07469 1.6e-32 DUF1518 Domain of unknown function (DUF1518)
ENSP00000320940 PF08832 3e-27 SRC-1 Steroid receptor coactivator
ENSP00000320940 PF08815 2.7e-22 Nuc_rec_co-act Nuclear receptor coactivator
ENSP00000320940 PF00989 5.1e-08 PAS PAS fold
ENSP00000320940 PF13426 5.1e-07 PAS_9 PAS domain
ENSP00000320940 PF08447 8.9e-05 PAS_3 PAS fold
ENSP00000320940 PF00010 0.00013 HLH Helix-loop-helix DNA-binding domain

Gene Ontology Annotation
Protein Entry Name Space Description
ENSP00000320940 GO:0006351 biological_process transcription, DNA-templated
ENSP00000320940 GO:0005634 cellular_component nucleus
ENSP00000320940 GO:0003713 molecular_function transcription coactivator activity
ENSP00000320940 GO:0004402 molecular_function histone acetyltransferase activity
ENSP00000320940 GO:0004871 molecular_function signal transducer activity
ENSP00000320940 GO:0030374 molecular_function ligand-dependent nuclear receptor transcription coactivator activity
ENSP00000320940 GO:0035257 molecular_function nuclear hormone receptor binding
ENSP00000320940 GO:0046983 molecular_function protein dimerization activity

Orthologs
TAXID Organism Gene ID TAXID Organism Gene ID
61853 Nomascus leucogenys 100586410 39432 Saimiri boliviensis 101039086
9986 Oryctolagus cuniculus 100341249 143995 Megachile rotundata 100877371
9597 Pan paniscus 100995476 9555 Papio anubis 101007720
9595 Gorilla gorilla 101143172 9669 Mustela putorius furo 101694173
8083 Xiphophorus maculatus 102232836 59463 Myotis lucifugus 102443319
10116 Rattus norvegicus 313929 9615 Canis familiaris 475684
7070 Tribolium castaneum 656017 28377 Anolis carolinensis ENSACAG00000000619
10141 Cavia porcellus ENSCPOG00000001117 10020 Dipodomys ordii ENSDORG00000001089
9685 Felis catus ENSFCAG00000025791 9785 Loxodonta africana ENSLAFG00000014442
9315 Macropus eugenii ENSMEUG00000011144 9103 Meleagris gallopavo ENSMGAG00000014153
30608 Microcebus murinus ENSMICG00000013998 13616 Monodelphis domestica ENSMODG00000015907
30611 Otolemur garnettii ENSOGAG00000000754 9813 Procavia capensis ENSPCAG00000006518
13735 Pelodiscus sinensis ENSPSIG00000007514 9305 Sarcophilus harrisii ENSSHAG00000003234
37347 Tupaia belangeri ENSTBEG00000006393 31033 Takifugu rubripes ENSTRUG00000006619
9478 Tarsius syrichta ENSTSYG00000010360 9739 Tursiops truncatus ENSTTRG00000015113
8364 Xenopus tropicalis ENSXETG00000021173 9646 Ailuropoda melanoleuca ENSAMEG00000002653
9913 Bos taurus ENSBTAG00000015007 9358 Choloepus hoffmanni ENSCHOG00000004072
9361 Dasypus novemcinctus ENSDNOG00000009924 9365 Erinaceus europaeus ENSEEUG00000011176
9371 Echinops telfairi ENSETEG00000013375 7897 Latimeria chalumnae ENSLACG00000017956
9544 Macaca mulatta ENSMMUG00000020838 9258 Ornithorhynchus anatinus ENSOANG00000004546
9978 Ochotona princeps ENSOPRG00000008579 9601 Pongo abelii ENSPPYG00000012598
132908 Pteropus vampyrus ENSPVAG00000017511 42254 Sorex araneus ENSSARG00000014416
9823 Sus scrofa ENSSSCG00000008581 43179 Ictidomys tridecemlineatus ENSSTOG00000005990
99883 Tetraodon nigroviridis ENSTNIG00000019142 30538 Vicugna pacos ENSVPAG00000005553