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BACKGROUND

The MGH Pathology Department and Cancer Center have led the field of clinical
genetic profiling for personalized cancer diagnosis. Wed developed the MGH SNaPshot assay, one of the first multi-gene cancer genotyping tests to be used in routine clinical practice (http://abcnews.go.com/video/playerIndex?id=7740568). The assay allows for molecular stratification of cancer patients, and in some cases placement of patients into trials of novel agents that target specific mutated gene products. We are now in the process of introducing next generation sequencing technologies to push patient care to the next level.

We are building a state-of-the-art system to analyze and interpret next generation sequencing data from clinical cancer samples. We are looking to expand our bioinformatics team with a computational biologist who will help develop and maintain our clinical and research analysis pipelines. This system is central to MGH efforts in personalized diagnosis and treatment and provide a once-in-a-lifetime opportunity to impact clinical care of thousands of patients.

RESPONSIBILITIES

Implement and adapt NGS analysis tools (e.g. aligners, variant callers, annotation packages) for use in the MGH clinical and research cancer sequencing pipelines
Evaluate emerging tools for potential inclusion in analysis pipelines.
Develop testing and validation procedures for analysis pipelines
Data analysis to assist wet lab in protocol optimization

REQUIREMENTS

Strong programming skills (preferably R, Python, Perl and/or Java) in a Linux environment
Familiarity with major bioinformatics tools and databases
Experience with NGS data analysis
Experience in cancer genomics, molecular biology or a related field is a plus.
Experience in HPC environments is a plus

LOCALE

Department: Pathology

TERMS

Hours: 40+ Hrs/week
Status: Full-time

COMPENSATION

Salary: Commensurate with level of experience

HOW TO APPLY

Please feel free to send your recent resume to stqa8350[at]gmail.com.

Discussion forums: Opportunity: Computational Biologist / Bioinformatics Engineer @ Massachusetts General Hospital -- Boston, MA (US)

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