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    Opportunity: Computational Biologist / Bioinformatics Engineer @ Massachusetts General Hospital -- Boston, MA (US)
    Submitted by Uma; posted on Wednesday, April 24, 2013


    The MGH Pathology Department and Cancer Center have led the field of clinical
    genetic profiling for personalized cancer diagnosis. Wed developed the MGH SNaPshot assay, one of the first multi-gene cancer genotyping tests to be used in routine clinical practice ([...]40568). The assay allows for molecular stratification of cancer patients, and in some cases placement of patients into trials of novel agents that target specific mutated gene products. We are now in the process of introducing next generation sequencing technologies to push patient care to the next level.

    We are building a state-of-the-art system to analyze and interpret next generation sequencing data from clinical cancer samples. We are looking to expand our bioinformatics team with a computational biologist who will help develop and maintain our clinical and research analysis pipelines. This system is central to MGH efforts in personalized diagnosis and treatment and provide a once-in-a-lifetime opportunity to impact clinical care of thousands of patients.


    • Implement and adapt NGS analysis tools (e.g. aligners, variant callers, annotation packages) for use in the MGH clinical and research cancer sequencing pipelines
    • Evaluate emerging tools for potential inclusion in analysis pipelines.
    • Develop testing and validation procedures for analysis pipelines
    • Data analysis to assist wet lab in protocol optimization


    • Strong programming skills (preferably R, Python, Perl and/or Java) in a Linux environment
    • Familiarity with major bioinformatics tools and databases
    • Experience with NGS data analysis
    • Experience in cancer genomics, molecular biology or a related field is a plus.
    • Experience in HPC environments is a plus


    Department: Pathology


    Hours: 40+ Hrs/week
    Status: Full-time


    Salary: Commensurate with level of experience


    Please feel free to send your recent resume to stqa8350[at]

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