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    RESPONSIBILITIES

    Job Summary/Basic Function:
    My laboratory is seeking a highly motivated, self-starter, Post-doctoral Fellow with the ability to work with optimal resources and little direct supervision to address important questions in the genetics and genomics of the autoimmune diseases Sjögren's syndrome, systemic lupus erythematosus, and multiple sclerosis. Successful candidates will be proficient in techniques such as transracial mapping, high-throughput sequencing of DNA, RNA, and methylation, flow cytometry, cell culture, electrophoretic mobility shift assays, chromosome conformation capture, ChIP-PCR, and genome CRISPR/Cas9 or similar approaches. Competitive individuals will also have some experience in the analysis of genetic data, high-throughput sequencing data and the use of bioinformatics software.

    REQUIREMENTS

    Minimum Qualifications:
    • Ph.D., M.D., or Ph.D./M.D.
    • Previous experience in basic human genetics and/or genomics is required. Must have at least one first author publication. Good written skills necessary. Ability to communicate and write summaries of results required.
    Minimum Degree Required:
    • Doctorate
    Preferred Qualifications:
    • Ideally would have at least two publications with one or more first author, peer-reviewed, English manuscripts in human genetics or genomics. Experience with molecular techniques and analytical methodologies described above would be ideal.

    TERMS

    Classification: Ongoing
    Status: Full-Time

    COMPENSATION

    We offer attractive salaries & comprehensive benefits package, view our benefits omrf.org/abou[...]fits/.

    HOW TO APPLY

    Interested candidates should apply online at apptrkr.com/1302624

    Posting Number: 0001165
    Department: Arthritis & Clinical Immunology – Lessard

    DESCRIPTION

    The University of Texas Southwestern Medical Center (UTSW) has launched a fully philanthropically funded Department of Bioinformatics with the mission of creating computational methods for integrative analysis and modeling of complex biomedical processes in high-dimensional and multi-modal data sets. The development of this research program is driven under the premise that bioinformatics is a pattern recognition problem whose solution builds on the combination of computational theory and algorithms that are sharable across all biomedical data types and research applications. Accordingly, the Department seeks continued growth of its faculty with individuals who will address fundamental questions in computer science while effectively translating the results into high-impact basic and clinical research.

    Openings can be filled at the rank of Assistant, Associate, or Full Professor. Generous startup packages and research space will be available through department resources and/or co-recruitment with other UTSW departments. Candidates applying for a position at the Assistant Professor level may qualify for nomination for the (www.utsouthwestern.edu/educ[...].html). Candidates at the Associate and Full Professor level are expected to have an established grant portfolio that will be transferred to UTSW (multiple R01 equivalents).

    LOCALE

    Lyda Hill Department of Bioinformatics
    The University of Texas Southwestern Medical Center
    Dallas, Texas

    COMPENSATION

    Negotiable

    HOW TO APPLY

    Candidates must have a Ph.D. and should submit before December 31, 2018 a 1-page letter of interest, a NIH-formatted biosketch including the sections Personal Statement and Contributions to Science, followed by a complete list of publications, a 3-page research statement, and three letters of reference. All materials must be submitted electronically to AcademicJobsOnline (academicjobsonline.org/ajo/jobs/12104).

    DEADLINE

    December 31, 2018

    POLICY

    UT Southwestern is an affirmative action/equal opportunity employer. Women and members of minority groups, protected veterans and individuals with disabilities, as well as others who would bring additional dimensions to the center's research, teaching, and clinical mission are encouraged to apply.

    BACKGROUND

    We are looking for a Bioinformatician in Epigenetics.

    The position will be available in the Jenuwein group at the Max Planck Institute of Immunobiology and Epigenetics in Freiburg, Germany (www.ie-freiburg.mpg.de/jenuwein). The Jenuwein group studies molecular mechanisms that establish and maintain heterochromatin in mammalian cells. There is a particular focus on the genome-wide regulation of repetitive element expression during mouse ES cell differentiation and in disease using a variety of experimental and next generation sequencing approaches. For these genomewide analyses, we seek an experienced bioinformatician, with a strong background in data analysis and with previous exposure to chromatin biology and epigenetic control mechanisms. This position is open immediately and initially funded for two years.

    Your Opportunities:
    As an embedded bioinformatician, you will have the opportunity to contribute directly to multiple research projects, from experimental design to data analysis and interpretation. This position also offers additional possibilities for participating in the Collaborative Research Center "Medical Epigenetics" (MEDEP). You will also interact with a strong, interdisciplinary bioinformatics and deep sequencing team that provides access to a large Sequencing Facility (HiSeq3000, HiSeq2500, NextSeq500), as well as a high-performance Data Center with Petabyte-scale storage solutions.

    RESPONSIBILITIES

    Your Tasks:
    Responsibilities include the bioinformatics analysis of genome-wide datasets, such as ChIP-seq and RNA-seq, as well as transcription factor motif analysis and analysis of other next-generation sequencing-based experiments. A strong understanding of epigenetic mechanisms of gene regulation will also be necessary, in order to process, analyze, and interpret a variety of datasets, focusing particularly on repetitive DNA elements and chromatin modifying factors.

    REQUIREMENTS

    Your Qualifications:
    We are looking for a dedicated and motivated team player with strong communication skills and good command of the English language, who has a MSc or PhD degree in bioinformatics or biology with a clear computational component. The successful applicant will have a proven record in the analysis of genome-wide datasets and computational skills (Python, R) in a Linux environment. Knowledge of alignment programs (such as STAR), RepeatMasker, and data analysis and visualization tools in R will be necessary.

    COMPENSATION

    We Offer:
    Based within a region that connects Germany, France and Switzerland, our institute hosts a vibrant community of international researchers, state-of-the-art facilities, and modern office spaces. A childcare facility is directly attached to the institute. At the heart of the Black Forest, Freiburg offers a family-friendly atmosphere and excellent recreational possibilities for cultural and outdoor activities. Salaries will be based on previous experience according to the German pay scale for civil service (TVöD) including health insurance and other social benefits.

    HOW TO APPLY

    Candidates should submit their full applications (including a 1 page motivation summary, CV, contact details of referees) to our home page: www.ie-freiburg.mpg.de/jobs.

    For informal inquiries please contact: jenuwein[at]ie-freiburg.mpg.de.

    DEADLINE

    Application deadline: 31.10.2018

    POLICY

    The Max Planck Society seeks to increase the number of women in areas where they are underrepresented and therefore explicitly encourages women to apply. Handicapped applicants with equal qualifications will be given preferential treatment.

    RESPONSIBILITIES

    The postdoctoral fellow positions in our R&D and Regeneron Genetics Center(RGC) are for early career scientist trainees to receive a rigorous scientific training at Regeneron under the auspices of a scientist mentor for a training period up to 4-years. Fellows will be expected to conduct creative exploratory research that results in publishable data within their fellowship period.

    Essential Functions required for the job. List both technical and managerial requirements if applicable.

    The program will consist of:
    • Four years of formal postdoctoral training in a program directed by an award-winning educator
    • Exposure to the biotechnology industry's most successful and innovative scientists
    • Opportunities to pursue cutting-edge, creative biomedical research in a prestigious, well-resourced, and highly driven industry environment
    • Weekly postdoctoral scientist meetings to foster scientific rigor, creative thinking, critical reasoning, and career advancement
    • Encouragement of scholarly productivity such as publications and conference presentations
    As part of your Postdoctoral Training Program, you will:
    • Conduct forward-looking, innovative, and creative research to address a novel scientific question of your choice under the auspices of a scientist mentor
    • Publish and disseminate data via external conferences and peer-reviewed publications
    • Assist with mentoring and teaching intern and other more junior trainees
    • Participate in postdoctoral program activities such as weekly meetings and the annual research conference
    • Present data internally, including at lab meetings, trainee meetings, and company wide seminars
    • Provide ongoing reports of research progress to supervisors and program staff

    REQUIREMENTS

    Experience and Required Skills:
    • Doctoral degree in a relevant discipline
    • Scientists looking for their first or second postdoctoral training
    • Superior scientific skills including critical and analytical thinking
    • Demonstrated publication success as evidenced by peer-reviewed publications
    • Good written and oral communication skills
    • Ability to interact dynamically and constructively with scientific peers
    • Note: occasional travel

    HOW TO APPLY

    Log in to www.regeneron.com, Select – Careers, and Enter – the Job # for the position(s) of interest.

    Job #'s:
    Postdoctoral Fellow, R&D – 14207BR
    Postdoctoral Fellow, RGC – 14212BR

    Application Details:
    Applications Accepted: October 1, 2018 - December 1, 2018
    Letter of recommendation are required. (Please find additional details in online application)

    Applications received after December 1, 2018 may not be considered.
    Following the close date, please allow 3-4 months for review and interviews.

    Targeted Start Date: July 2019
    If you have an issue submitting or any questions, please email:
    postdoctoral[at]regeneron.com.

    BACKGROUND

    Job Summary/Basic Function:
    The Functional and Chemical Genomics Program at the Oklahoma Medical Research Foundation (OMRF, omrf.org) is inviting applications for Staff Scientist positions. The selected candidates will help lead collaborative projects. OMRF is a non-profit private foundation dedicated to fundamental, interdisciplinary research and to the translation of knowledge to medicine. Research interests within FCG include fundamental questions emerging from ongoing high-throughput genetic and epigenetic studies of disease using the latest technologies in genomics, functional genomics, model system biology, and chemical biology. The Program occupies newly renovated space designed to foster highly collaborative and innovative research using genetic model systems including C. elegans, Drosophila, planaria, zebrafish, mice, and stem cells. Our strategy aims to embrace the post-genomic era in scaling the functional analysis of genetic and epigenetic alterations underlying human disease. OMRF researchers have access to state-of-the-art facilities and outstanding core technology laboratories including Imaging, Next-generation Sequencing, Clinical Genomics, and more.

    Three specific interdisciplinary project opportunities include:
    • Dr. Wan Hee Yoon and Dr. Gaurav Varshney are collaborating on a project to model human diseases carrying OGDH family genes. Fellows undertaking this project will emerge with expertise in Drosophila genetics and CRISPR/Cas-9 targeting in zebrafish.
    • Dr. David Jones, Dr. Jian Li, and Dr. Magdalena Bieniasz are collaborating on a project examining a novel role of HSF1 and its aberrant activation in cancer. Fellows will have the opportunity to develop expertise in utilization of patient-derived xenograft (PDX) tumor models, to determine programmatic transcriptional targets of HSF1 and its connection to known oncogenes and tumor suppressor genes.
    • Dr. David Forsthoefel, Dr. Wan Hee Yoon, and Dr. David Jones are collaborating on a project examining the roles of Xbp1 in stem cells, regeneration, innate immunity, and cancer. Fellows involved in this project will help define the mechanistic roles of Xbp1 and novel proteostasis regulators in planaria, Drosophila, and zebrafish.

    REQUIREMENTS

    Minimum Qualifications:
    • Ph.D. in a biological science, chemistry, physics or other relevant area, M.D., or equivalent.
    Minimum Degree Required:
    • Doctorate

    TERMS

    Classification: Ongoing
    Status: Full-Time

    COMPENSATION

    We offer attractive salaries & comprehensive benefits package, view our benefits here: omrf.org/abou[...]fits/

    HOW TO APPLY

    Interested candidates should apply online at apptrkr.com/1305739

    Posting Number: 0001185
    Department: Functional and Chemical Genomics
    Opportunity: Rare Disease Analyst @ Genomics England -- London, UK
    Submitted by Eugene Mc Daid; posted on Wednesday, October 03, 2018

    Submitter

    BACKGROUND

    Paramount are working in partnership with Genomics England to expand their team in order to deliver success with the 100,000 Genomes Project. This is a challenging and fast moving project with the aim to carry out whole genome sequencing on 100,000 participants.
    We are excited to advertise this position for a Senior Rare Disease Analyst as a 12-month fixed contract with the likelihood of extension.

    RESPONSIBILITIES

    This senior role is part of a talented and motivated Bioinformatics team and it will be responsible for applying computational and statistical methods to analyse large datasets using:
    • Whole exome/genome sequencing
    • Association testing
    • Rare variant association analysis
    • Burden testing
    • Benchmarking genome analysis pipelines

    REQUIREMENTS

    • Post doctorate with at least 2-3 years' experience of working in this field
    • Deep knowledge of association testing
    • Good knowledge of genomics and rare diseases
    • A demonstrable ability to cope under pressure and deliver to deadlines
    • Ability to communicate effectively within a multidisciplinary team
    • Flexible and co-operative approach to colleagues
    • Ability to work independently and to show initiative within a team
    • Ability to prioritise and balance competing demands
    • Excellent technical writing skills

    ABOUT US

    Genomics England works at the cutting edge of science, technology and healthcare. Our mission is to deliver the ground-breaking 100,000 Genomes Project – the biggest national genome sequencing project of its kind anywhere in the world. As it moves beyond the 100,000 Genomes Project, Genomics England will work with NHSE to launch the world's first Genomic Medicine Service within a national healthcare system. In partnership with government, the NHS, academia, industry and the public, Genomics England aims to realise the potential of genomic medicine: to embed state-of-the-art care in the NHS; bring health benefits to UK citizens; and consolidate the UK's position as the 'go to' destination for international genomic research and investment.

    COMPENSATION

    There are some great benefits on offer with this role including a competitive salary, pension, generous holidays and more.

    HOW TO APPLY

    Please do not hesitate to contact Harvey Uppal at huppal[at]pararecruit.com or call (+44) 121 616 3407 to discuss this opportunity further.

    Keywords: Rare, Disease, Analyst, WGS, WES, Genomics, Bioinformatics, Pipelines, Statistics, Testing, Writing, Variants, NGS, London, Fixed-Term.

    Submitter

    BACKGROUND

    A very interesting opportunity has just become available for a Principal Scientist within Computational Biology to join a world leading Pharma company in Germany. You will be joining the research department as a Principal Scientist, working with dedicated partners in specific Therapeutic Area (TA) departments. These include, CNS/Neuroscience, Cancer Immunology, Cardiometabolic Disease and Research Beyond Borders. An ideal candidate will have a strong background in biomarker discovery and strong connections/collaborations with various Pharma, Biotech or Academic Institutions within this field that they can utilise.

    RESPONSIBILITIES

    Your Tasks:
    • You work as an Expert in Bioinformatics and Data Science within the Computational Biology Group together with members of the Partner function and the Computational Biology Core function.
    • You will establish and develop new analysis strategies for RNA-Seq, single cell RNA-Seq and other NGS approaches and have strong experience with GWAS studies.
    • You oversee and contribute to the development of automated standard analysis pipelines, automation of interactions between infrastructure components, or requirements analyses for such systems. You will also contribute to the company's global computational biology infrastructure in collaborations with bioinformaticians and members of IT and external partners in international teams.
    • You are the key interface to the NGS lab within the Computational Biology group and play a driving role in the definition of experimental design strategies and coordinate the implementation and development of the LIMS. Together with the NGS lab you develop outsourcing strategies.
    • You carry out data analyses to generate and test hypotheses in the context of new therapeutic concepts in collaboration with other members of the Computational Biology group or scientists from BI's Therapeutic Areas for Drug Discovery (Cardiometabolic Research, Central Nervous System Research, Inflammation & Respiratory Research, Immune Modulation & Research Beyond Borders). You support others and drive projects as the responsible computational biologist.
    • You contribute to projects during all phases from experimental design to downstream analysis as the computational biology specialist in interdisciplinary teams.

    REQUIREMENTS

    Your Qualifications:
    • You hold a PhD degree or equivalent qualification in Computational Biology or related fields several years of post-PhD experience.
    • You will have strong experience in data science, Machine Learning and statistical approaches in order to analyse large multi-omics data sets.
    • You have excellent knowledge and a broad spectrum in bioinformatics and computational biology with a focus on topics related to RNA-Seq, single cell RNA-Seq and other NGS applications as well as GWAS experience. You have analyzed from initial QC to downstream a large number of different RNA-Seq projects, and you have hands-on experience with scRNA-Seq data from multiple platforms. In addition you have a good overview of recent developments in terms of NGS instruments and protocols. Ideally you have collaborated closely with genomics teams and dealt with LIMS as well.
    • Your solid background in statistics and experimental design allows you to define the way forward also for complex questions.
    • You have several years of experience in R/Bioconductor or Python and at least one additional programming language. You have robust coding skills, experience with version control systems (e.g. git) and constantly strive for well documented and reproducible analyses. In addition you are familiar with Linux, local and cloud-based HPC environments and have experience with queuing systems and modern pipelining systems (e.g. CWL, bpipe etc).
    • Experience with other type of omics data, network biology or machine learning is an additional asset.
    • You have previously demonstrated that you can apply your skills to turn large datasets into relevant insight in concrete biological and disease related topics in interdisciplinary collaborations.
    • Your fluency in English both in writing and in speaking will enable you to act in an international working environment.
    • You are characterized by a focused working style, flexibility as well as innovative thinking, and problem solving and analytical skills.
    • You are a reliable team player with excellent organization and communication skills, and with a high degree of motivation.

    COMPENSATION

    There are some great benefits on offer with this position including a competitive salary, bonus scheme, relocation package and more.

    HOW TO APPLY

    Please do not hesitate to contact Harvey Uppal on +44 121 616 3407 or huppal[at]pararecruit.com to discuss this opportunity further.

    Keywords: Principal, Scientist, Computational, Biology, Data Science, Biostatistics, Stats, Machine Learning, AI, Human, Genetics, GWAS, RNA, Python, Bioinformatics, Genomics, NGS, Drug Discovery, Biomarker, Germany, Europe

    BACKGROUND

    We are looking for two new senior systems administrators to join our new operations unit at the National Genome Center.

    If you are interested in a unique opportunity to be involved and put your mark on the development on the new infrastructure for personalized medicine in Denmark you should consider applying for this position.

    About us / National Genome Center:
    In December 2016, the Danish Government and Danish Regions launched the national strategy for Personalised Medicine. The strategy lays the foundation for a balanced development of Personalised Medicine in Denmark for the benefit of patients – now and in the future.

    The National Genome Center is established as part of the realisation of the national strategy for Personalised Medicine 2017-2020 and is intended to ensure governance and coordination of the strategy's initiatives at the national level. The center's primary task is to lay the foundation for the development of better diagnostics and more targeted treatments using whole genome sequencing.

    In order to achieve this goal, the National Genome Center's core mission is, in cooperation with the Danish Regions and universities, to establish and operate a national technological infrastructure with sufficient capacity to handle a significant increase in the use of whole genome sequencing in the Danish healthcare system and associated needs for data analysis, interpretation, storage, knowledge sharing, and research.

    The National Genome Center is located at Ørestads Boulevard 5, 2300 København S, together with Statens Serum Institute and the Danish Health Data Authority. The center is expected to become an organization with a core of approx. 40 employees including a separate organization in relation to IT infrastructure (HPC systems, etc.). Broad cooperation across the country with regions, universities, organizations, etc. is essential for Center's work.

    More information about the national strategy for Personalised Medicine and the National Genome Center is to be found at www.sum.dk under "Tema".

    RESPONSIBILITIES

    About the positions:
    The two HDPA System Administrators share responsibility for Linux high performance cluster and hardware and software systems including but not limited to: stand-alone servers and private cloud infrastructure, back-up systems and on demand high-performance computing environments.

    The computer installation comprises of a multi-processor high performance cluster, and a large number of Linux servers dedicated to specific services.

    The work will focus on assuring the stable operation of the center's scientific supercomputing facility. It will include maintenance of the hardware and software installation and monitoring of the system software backup, documentation and user support.

    REQUIREMENTS

    Education and experience:
    If you have a degree in Computer Science or a related field it is an advantage but not a requirement for this position. Relevant it work experience is required.

    Required qualifications include:
    • Experience with Linux server and network administration
    • Experience with server and network security
    • Experience with system and network log analysis
    • Extensive experience with network and security solutions
    • Experience with Linux virtualization
    • Experience with queuing systems
    • Experience with Open stack is a plus
    • Experience with Backup and Tiered storage
    • Experience with Linux modules and software installation
    • Experience with Linux, Mac OS end user support
    • Fluency in English, spoken and written

    TERMS

    The position is a full time position and is available from December 1st 2018.

    COMPENSATION

    We offer:
    We offer an interesting and challenging job in an international atmosphere with the focus on innovation, in an ambitious environment. We place emphasis on a high level of professionalism among our staff, so skills development is an integral part of our organization. We offer a great flexibility in the position.

    Salary and appointment terms:
    Depending on your educational background salary and appointment terms will be bases on either...

    1. The collective agreement between the Danish Ministry of Finance and the Danish Federation of Professional Associations (AC) (overenskomst for akademikere i staten) Depending on your academic qualifications and experience there is a possibility of being classified as a special or senior consultant according to appendix 4 (protocol concerning special- and senior consultants).

    or

    2. The organizational agreement between The Danish Finance Ministry and the Organisation for Salaried Employees HK/Stat (Organisationsaftale for kontorfunktionærer, laboranter og it-medarbejdere (HK)), according to chapter 5 in the agreement and the collective agreement between The Danish Finance Ministry and the Organisation of Public Employees (OAO-S-Fællesoverenskomsten).

    HOW TO APPLY

    Please visit candidate.hr-manager.net/Appl[...]aId=5

    Click "apply" to send your job application with curriculum vitae and diploma / exam certificates before October 14th 2018. The first round of interviews is expected to be held from October 15th till October 19th 2018 (week 42) and second round of interviews is expected to be held from October 22nd till October 26th 2018 (week 43).

    Further information:
    For further information about the job you are welcome to contact head of the infrastructure of the National Genome Center, Peter Løngreen, (phone 29 44 14 99).

    DEADLINE

    Application due: 14-10-2018
    Start date: 01-12-2018

    POLICY

    The Ministry of Health have non-smoking working hours.

    We encourage everyone who are interested to apply to the position – regardless of age, gender, religion, disabilities or ethnicity.

    BACKGROUND

    We are looking for a Database administrator with a strong focus on performance and scalability to join our new operations unit at the National Genome Center.

    If you are interested in a unique opportunity to be involved and put your mark on the development on the new infrastructure for personalized medicine in Denmark you should consider applying for this position.

    About us / National Genome Center:
    In December 2016, the Danish Government and Danish Regions launched the national strategy for Personalised Medicine. The strategy lays the foundation for a balanced development of Personalised Medicine in Denmark for the benefit of patients – now and in the future.

    The National Genome Center is established as part of the realisation of the national strategy for Personalised Medicine 2017-2020 and is intended to ensure governance and coordination of the strategy's initiatives at the national level. The center's primary task is to lay the foundation for the development of better diagnostics and more targeted treatments using whole genome sequencing.

    In order to achieve this goal, the National Genome Center's core mission is, in cooperation with the Danish Regions and universities, to establish and operate a national technological infrastructure with sufficient capacity to handle a significant increase in the use of whole genome sequencing in the Danish healthcare system and associated needs for data analysis, interpretation, storage, knowledge sharing, and research.

    The National Genome Center is located at Ørestads Boulevard 5, 2300 København S, together with Statens Serum Institute and the Danish Health Data Authority. The center is expected to become an organization with a core of approx. 40 employees including a separate organization in relation to IT infrastructure (HPC systems, etc.). Broad cooperation across the country with regions, universities, organizations, etc. is essential for Center's work.

    More information about the national strategy for Personalised Medicine and the National Genome Center is to be found at www.sum.dk under "Tema".

    RESPONSIBILITIES

    About the position:
    You will as our new Database Administrator be managing high performance databases at the national platform as well as participate in designing and implementing new databases.

    Our technology stack:
    • Mongo
    • HIVE
    • Oracle/MS-SQL
    • Open stack & Spark
    • PostgreSQL/MySQL, Elastic, Neo4j
    You will be managing systems for exploring, interacting with the data coming from various sources such as our internal systems and external providers. Your responsibilities will relate mostly to the backend systems.

    Your main tasks would include:
    • Developing new architectures and systems while maintaining clean and coherent infrastructure
    • Performance and maintaining systems
    • Optimising queries and fine-tuning
    • Collaborating with the project partners outside of the team if needed
    • Participate and manage design and deployment of the new systems
    • Maintaining user-facing documentation and description of the system
    • Ensuring compliance of the system and liaise in with the data protection team
    • Participating in regular meetings where the team members altogether discuss the progress and the next steps
    Your education and experience:
    • A degree in Computer Science, Bioinformatics, Data Science or a related field, or equivalent work experience.
    Required qualifications include:
    • Experience with using REST APIs
    • Proven track record
    • Relevant experience
    • Invest time in new upcoming technologies

    PREFERENCES

    It would be a plus to have experience with:
    • Open stack
    • Compliance
    • Managing Linux servers
    • Data lake architecture
    • Agile development (Scrum etc.)

    TERMS

    The position is a full time position and is available from December 1st 2018.

    COMPENSATION

    We offer:
    We offer an interesting and challenging job in an international atmosphere with the focus on innovation, in an ambitious environment. We place emphasis on a high level of professionalism among our staff, so skills development is an integral part of our organization. We offer a great flexibility in the position.

    Salary and appointment terms:
    Depending on your educational background salary and appointment terms will be bases on either...

    1. The collective agreement between the Danish Ministry of Finance and the Danish Federation of Professional Associations (AC) (overenskomst for akademikere i staten). Depending on your academic qualifications and experience there is a possibility of being classified as a special or senior consultant according to appendix 4 (protocol concerning special- and senior consultants).

    or

    2. The organizational agreement between The Danish Finance Ministry and the Organisation for Salaried Employees HK/Stat (Organisationsaftale for kontorfunktionærer, laboranter og it-medarbejdere (HK)), according to chapter 5 in the agreement and the collective agreement between The Danish Finance Ministry and the Organisation of Public Employees (OAO-S-Fællesoverenskomsten).

    HOW TO APPLY

    Please visit candidate.hr-manager.net/Appl[...]aId=5

    Click "apply" to send your job application with curriculum vitae and diploma / exam certificates before October 14th 2018. The first round of interviews is expected to be held from October 15th till October 19th 2018 (week 42) and second round of interviews is expected to be held from October 22nd till October 26th 2018 (week 43).

    Further information:
    For further information about the job you are welcome to contact head of the infrastructure of the National Genome Center, Peter Løngreen, (phone 29 44 14 99).

    DEADLINE

    Application due: 14-10-2018
    Start date: 01-12-2018

    POLICY

    The Ministry of Health have non-smoking working hours.

    We encourage everyone who are interested to apply to the position – regardless of age, gender, religion, disabilities or ethnicity.

    BACKGROUND

    We are looking for a Backend developer with experience in designing secure scalable systems to join our new operations unit at the National Genome Center.

    If you are interested in a unique opportunity to be involved and put your mark on the development on the new infrastructure for personalized medicine in Denmark you should consider applying for this position.

    About us / National Genome Center:
    In December 2016, the Danish Government and Danish Regions launched the national strategy for Personalised Medicine. The strategy lays the foundation for a balanced development of Personalised Medicine in Denmark for the benefit of patients – now and in the future.

    The National Genome Center is established as part of the realisation of the national strategy for Personalised Medicine 2017-2020 and is intended to ensure governance and coordination of the strategy's initiatives at the national level. The center's primary task is to lay the foundation for the development of better diagnostics and more targeted treatments using whole genome sequencing.

    In order to achieve this goal, the National Genome Center's core mission is, in cooperation with the Danish Regions and universities, to establish and operate a national technological infrastructure with sufficient capacity to handle a significant increase in the use of whole genome sequencing in the Danish healthcare system and associated needs for data analysis, interpretation, storage, knowledge sharing, and research.

    The National Genome Center is located at Ørestads Boulevard 5, 2300 København S, together with Statens Serum Institute and the Danish Health Data Authority. The center is expected to become an organization with a core of approx. 40 employees including a separate organization in relation to IT infrastructure (HPC systems, etc.). Broad cooperation across the country with regions, universities, organizations, etc. is essential for Center's work.

    More information about the national strategy for Personalised Medicine and the National Genome Center is to be found at www.sum.dk under "Tema".

    RESPONSIBILITIES

    About the position:
    You will be a member of a team that will designing and building maintainable system aimed at providing easy access to advanced functionalities in very complex backends.

    As a Backend developer/Software architect, you will play a key role in designing new high performing systems for our users and customers. Each new system has to take into consideration the individual domain of the users, while still being secure and scalable and easy to use. While your main responsibilities are within a backend domain, you might be required to take on overall tasks as well.

    Your main tasks would include:
    • Designing new secure scalable systems
    • Building these systems
    • Building a back catalogue of Customizable Software Components for the technology stack used at the center
    You will have the opportunity to influence the choice of languages, frameworks and tools.

    You will have a unique opportunity to involved and put your mark on the development on the new infrastructure for personalized medicine in Denmark.

    REQUIREMENTS

    Your education and experience:
    • A degree in Computer Science, Bioinformatics, Data Science or a related field, or equivalent work experience is required.
    Required qualifications include:
    • Solid Experience with building applications on the NGS data
    • Documented experience with Python & R
    • Experience with building and using REST APIs
    • Experience with Object Oriented and MVC approaches to programming
    • Experience with databases
    • Experience with CI/CD (continuous integration and continuous delivery)
    • Git version control
    • Experience with architectures using security by design

    PREFERENCES

    It would be a plus to have experience with:
    • Agile development (Scrum etc)
    • Designing domain specific solutions
    • Test drive design
    • Frontend framework such as Angular
    • NodeJS
    • Frameworks for rapid development
    • Provisioning and configuration management tools

    TERMS

    The position is a full time position and is available from December 1st 2018.

    COMPENSATION

    We offer:
    We offer an interesting and challenging job in an international atmosphere with the focus on innovation, in an ambitious environment. We place emphasis on a high level of professionalism among our staff, so skills development is an integral part of our organization. We offer a great flexibility in the position.

    Salary and appointment terms:
    Depending on your educational background salary and appointment terms will be bases on either...

    1. The collective agreement between the Danish Ministry of Finance and the Danish Federation of Professional Associations (AC) (overenskomst for akademikere i staten) Depending on your academic qualifications and experience there is a possibility of being classified as a special or senior consultant according to appendix 4 (protocol concerning special- and senior consultants).

    or

    2. The organizational agreement between The Danish Finance Ministry and the Organisation for Salaried Employees HK/Stat (Organisationsaftale for kontorfunktionærer, laboranter og it-medarbejdere (HK)), according to chapter 5 in the agreement and the collective agreement between The Danish Finance Ministry and the Organisation of Public Employees (OAO-S-Fællesoverenskomsten).

    HOW TO APPLY

    Please visit candidate.hr-manager.net/Appl[...]aId=5

    Click "apply" to send your job application with curriculum vitae and diploma / exam certificates before October 14th 2018. The first round of interviews is expected to be held from October 15th till October 19th 2018 (week 42) and second round of interviews is expected to be held from October 22nd till October 26th 2018 (week 43).

    Further information:
    For further information about the job you are welcome to contact head of the infrastructure of the National Genome Center, Peter Løngreen (phone 29 44 14 99).

    DEADLINE

    Application due: 14-10-2018
    Start date: 01-12-2018

    POLICY

    The Ministry of Health have non-smoking working hours.

    We encourage everyone who are interested to apply to the position – regardless of age, gender, religion, disabilities or ethnicity.

    BACKGROUND

    Computercraft is seeking a forward thinker to work on site at the National Center for Biotechnology Information (NCBI) to drive the advancement of existing and new sequence display and analysis tools. This individual will develop and actualize a user-focused vision for NCBI's displays and tools that are part of many well-known sequence resources (e.g., BLAST, RefSeq, Gene, Genome Data Viewer) relied upon daily for sequence alignment and analysis. This work will involve identifying and prioritizing customer needs, conceiving a vision for the advancement of these displays and tools, developing a plan to guide implementation, and working in a cross-functional capacity, communicating with both scientists and programmers as well as NCBI leadership.

    To see the "big picture," the right candidate will have training in molecular biology, bioinformatics, or related field and bench research to understand the science; familiarity with graphical displays (genome browsers), aligners, and sequence analysis tools to understand currently available resources; knowledge of how these tools are used by those engaged in basic research, clinical work, and educational efforts to understand the needs of NCBI's users; and experience in the area of software development to understand the process for transforming ideas into public-facing online products.

    RESPONSIBILITIES

    • Determine community needs with respect to different areas of sequence analysis through attendance at research conferences, analysis of the literature, and the establishment of relationships with biologists and bioinformaticians.
    • Evaluate competitor tools.
    • Identify existing and new research areas that would benefit from tools and displays offering access to NCBI sequence data.
    • Support program leadership in defining a product vision, a road map, and growth opportunities for sequence data analysis tools.
    • Provide direction to Agile development teams to transform NCBI's value-added sequence data into resources serving researchers, educators and clinicians world wide.
    • Define, evaluate, and apply key performance indicators in development of NCBI resources.

    REQUIREMENTS

    • Ph.D. in molecular biology, bioinformatics, or related field
    • Extensive experience with a wide range of locally developed, public and/or commercial tools for sequence analysis and visualization of biological data (e.g., graphical displays/genome browsers, BLAST, alignment tools)
    • Experience with software development, including writing scripts
    • Ability to develop a creative, user-focused vision and communicate vision to developers
    • Proficiency in problem solving, planning, and time management
    • Excellent verbal and written communication, consensus-building, and interpersonal skills
    • Ability to guide and motivate a product team and collaborate with cross-functional groups of scientists and software developers

    PREFERENCES

    • Demonstrated engagement with communities developing or using sequence analysis tools
    • Postdoctoral training
    • Familiarity with Agile development methods
    • Certified Scrum Product Owner (CSPO)

    LOCALE

    Computercraft, NIH Main Campus in Bethesda, MD

    COMPENSATION

    Computercraft offers a competitive salary, an excellent benefits package, the opportunity for a positive work-life balance with a standard 40-hour work week, and the chance to work alongside a team of highly accomplished professionals.

    HOW TO APPLY

    To apply for this position or learn about other Computercraft job opportunities, please visit the Careers section of our website: computercraft-usa.com.

    POLICY

    Computercraft is an equal opportunity employer.

    BACKGROUND

    General Dynamics Information Technology has an opportunity for a Bioinformatics Developer to work on our contract at the National Institutes of Health's Center for Information Technology (CIT).We are looking for a talented, mid-level Bioinformatics Developer who is nimble and able to adopt new skills quickly for CIT's Office of Intramural Research to work on a variety of bioinformatics problems, including collaboration for classification of cancer with the National Cancer Institute.

    RESPONSIBILITIES

    • Provide bioinformatics support, data quality assurance, and curation activities.
    • Solve complex problems in a broad range of research topics.
    • Computational analysis, integration, and modeling of diverse data sets.
    • Develop scientific software and computational infrastructure.
    • Write custom scripts and develop programs in shell, Perl, Python, PHP, R, Java, etc.

    REQUIREMENTS

    • BS and five years related experience or a MS and three years related experience or the equivalent experience and education
    • Minimum of three years research experience in bioinformatics, especially in the areas of NGS and MS proteomics data analysis
    • Sound knowledge of statistics and quantitative modeling
    • Solid computer programming skills with proficiency in R, S-Plus or MATLAB and at least one scripting language (Perl/Python/PHP)

    PREFERENCES

    • M.S. or PhD degree in bioinformatics, computer science, mathematics, engineering, or related fields
    • Experience with Web development in Linux environment
    • Experience with relational databases like Postgres, MySQL, etc.
    • Deep understanding of and experience in processing high throughput biomedical data: data cleaning, normalization, analysis, interpretation and visualization
    • Experience in data science, machine learning, and predictive analytics
    • Strong problem identification and analytical skills. An independent problem solver who enjoys collaborative research and development
    • Ability to multi-task across projects
    • Desire to learn new technologies
    • Excellent verbal and written communication skills
    • Ability to create and deliver clear reports and documentation
    • Embrace and embody GDITs values of Commitment, Impact, Integrity, Imagination, and Agility. Learn more.

    TERMS

    Full Time Employment with General Dynamics

    LOCALE

    Bethesda, MD

    HOW TO APPLY

    Please visit csra.wd5.myworkdayjobs.com/Exte[...]711-1

    BACKGROUND

    Job Summary/Basic Function:
    The Oklahoma Medical Research Foundation (OMRF) is an independent, not-for-profit, biomedical research institute adjacent to the campus of the University of Oklahoma Health Sciences Center (OUHSC) located in Oklahoma City. OMRF investigators have internationally recognized expertise in Autoimmunity, Immunology, Genetics, Aging, Cardiovascular Disease, and Cancer. Our Autoimmune Disease Institute houses Centers of Excellence and specialty research clinics for Rheumatic Diseases (focusing on Lupus, Rheumatoid Arthritis, UCTD, and Sjogren's) and for Multiple Sclerosis and related diseases. In addition to following over 4,000 patients with these conditions, teams of basic and clinical investigators conduct extensive clinical, translational and mechanistic research using samples obtained from these large clinical programs. Investigators at OMRF enjoy close scientific interactions with OUHSC faculty and participate in OUHSC graduate programs. Additional information about OMRF can be found at the Oklahoma Medical Research Foundation web site: www.omrf.org.

    Join our dynamic team in a well-funded research group in an autoimmune disease center of excellence. We are focused on studying immune mechanisms associated with autoimmunity and translational research questions. Dr. Joel Guthridge and Dr. Judith James are seeking a Post-Doctoral Fellow with a strong immunology and/or bioinformatics/data science background to be part of the team working to apply precision medicine and molecular phenotype classification approaches to clinical and translational autoimmune disease research to improve the lives to patients with autoimmune disease. Large datasets for analysis are already available and growing daily.

    The successful candidate will help lead efforts to apply computational and new statistical tools to molecular phenotype pipelines for patient characterization and stratification, assist with data analysis, modeling, visualization and interpretation of clinical and experimental data. We have access to an extensive curated electronic clinical research health record and experimental data warehouse already available to be leveraged for these projects. The team utilizes high throughput bimolecular assays, deep cellular phenotyping, and single cell genomic and proteomic methods through our Human Phenotyping Core. We also have access to high performance computational resources both in-house and through cloud-based resources.

    This is a mentored position for postdoctoral training. Incumbents at this level plan, design and conduct analysis plans for research projects; prepare reports and papers for publication, presentation and future research; contribute to grant writing and are encouraged to write applications for fellowships. Successful candidates will learn the complexities of data analytics/research lab management and participate in various lab management responsibilities.

    RESPONSIBILITIES

    Benchmark Expectations:
    • Conduct scientific research/data analysis.
    • Manage research projects.
    • Contribute to grant writing; prepare reports and papers for publication.
    • Present scientific/technical information both formally and informally.
    • Work collaboratively and collegially as part of the team while learning to become an independent investigator.

    REQUIREMENTS

    Knowledge, Skills, and Abilities:
    Knowledge of the principles and practices of scientific theory and research; demonstrates skill in formulating and testing hypotheses; demonstrates ability to conduct scientific research analysis and summarize data and results; writes technical, scientific papers; writes grants and communicates effectively both orally and in writing; mentor students; provides analytic support and input to other projects in the group and guides/directs the work of less senior scientists.

    Minimum Qualifications: Ph.D. in a biological science, chemistry, physics or other relevant area, M.D., or equivalent

    Minimum Degree Required: Doctorate

    Preferred Qualifications: Doctorate in Immunology, Clinical Science, Bioinformatics, Biostatistics, or related quantitative field.

    Demonstrated basic computer (UNIX, R or similar statistical package), statistical experience in multivariate and machine learning analysis. Strong oral and written communication skills. Must be efficient with time and project management, with a strong organizational ability with exquisite attention to detail. Must have the ability to multi-task and work both independently and as a member of an interdisciplinary team with complementary skill sets.

    Evidence of applied analysis experience of immune and genetic data is strongly desired. Programming skills, data visualization and ability to develop meaningful interfaces for end-users to access high-dimensional data in a meaningful way are also desired. Exposure to biomedical, genetic and/or clinical research preferred. Experience with univariate and multivariate analyses, machine learning, clustering, pathway, genetic and genomic data analyses and bioinformatics is helpful. Experience or training in database design, development, implementation and data structures are also helpful.

    Physical Demands: Regularly required to stand, use manual dexterity, talk or hear; Frequently required to walk and reach with hands and arms; occasionally sit; frequently lift and/or move up to 50 pounds; vision abilities include close vision, color vision, depth perception and ability to adjust focus.

    Potential exposure to fumes, airborne particles, or rodent dander. May work with toxic, caustic chemicals, radioactive materials, liquid nitrogen, human tissue or blood. Potential risk of electrical shock. Occasional exposure to cold 4C, and/or extreme cold -80C from freezers. Noise level is usually moderate.

    TERMS

    Position Type: SCIENTIFIC
    Classification: Ongoing
    Status: Full-Time

    HOW TO APPLY

    Application Type Accepted: General Application
    Required Applicant Documents: Resume/Curriculum Vitae
    Optional Applicant Documents: Cover Letter

    Quicklink for Posting:
    jobsearch.omrf.org/appl[...]51904

    Posting Number: 0001171
    Title: Post-doctoral Fellow
    Working Title: Post-doctoral Fellow / Bioinformatics Specialist
    Department: Arthritis & Clinical Immunology – Guthridge

    BACKGROUND

    Job Summary/Basic Function:
    Join our cutting edge computational and quantitative research group focused on the identification of genes predisposing to complex diseases. Dr. Montgomery is seeking a Post-doctoral Fellow, Assistant-/ Associate-/Staff Scientist, Biostatistician or Bioinformatics Scientist to assist with ongoing projects including the development of new statistical and computational tools. The successful candidate will design, conduct and lead or oversee a variety of analyses and will evaluate methods to obtain data to ensure their validity, accuracy, reliability and usability. Results of analyses will be conveyed to colleagues via presentations and manuscripts. We have access to a high throughput molecular laboratory and a strong array of analytical computing resources. For additional information please visit: omrf.org/rese[...]gray/.

    REQUIREMENTS

    Minimum Qualifications:
    Doctorate in Biostatistics, Bioinformatics, or related quantitative field. Applied analysis experience essential. Superb computer (UNIX OS and R or similar statistical package) and communication skills required. Must have very efficient project management skills and strong organizational ability. Must have the ability to multi-task and work independently as well as with a team. Must be detail oriented, dependable, flexible, and willing to assist with manuscript and grant preparations. Works independently and as a team player and performs other duties as assigned by supervisor.

    Minimum Degree Required:
    Doctorate

    Preferred Qualifications:
    Programming skills are highly valued but not required. Experience with and/or exposure to biomedical research and/or clinical research preferred. Some exposure to genetic analysis also preferred. Experience with case-control analysis, pathway analysis, bioinformatics, gene expression data analysis and/or simple program development helpful. Experience or training in data structure, database design, and database implementation a plus.

    TERMS

    Classification: Ongoing
    Status: Full-Time

    COMPENSATION

    We offer attractive salaries & comprehensive benefits package, view our benefits omrf.org/abou[...]fits/.

    HOW TO APPLY

    Interested candidates should apply online at apptrkr.com/1302512

    Posting Number: 0001069
    Department: Arthritis & Clinical Immunology – Montgomery

    BACKGROUND

    This postdoctoral position is a temporary position for up to one year, which may be renewed at Sandia's discretion up to five additional years. You qualify for application if you received your PhD within a five-year timeframe prior to employment.

    As a Sandian, in your postdoctoral position, you may bid on regular Sandia positions as an internal applicant. In some cases, a possibility could exist for you to be converted to regular career positions during your term if warranted by ongoing operational needs, continuing availability of funds, and satisfactory job performance.

    Sandia/California's Systems Biology Department is seeking a highly motivated biochemist / molecular biologist / immunologist postdoctoral appointee to join a multidisciplinary team using immunotherapy, computational biology/chemistry, high-throughput screening and gene editing to develop medical countermeasures for infectious disease. The successful postdoctoral candidate will help generate, screen, engineer, and optimize therapeutic antibodies using animal models, molecular biology, immunoassays, cell-based assays, and structure based computational design. The successful postdoctoral candidate will also be responsible for the effective communication of research results through publications and conference presentations.

    Are you ready for your next challenge? Join this diverse and passionate team of high performing individuals and achieve success while making a difference.

    RESPONSIBILITIES

    On any given day, you may be called on to:
    • Discover and characterize monoclonal antibodies in vitro and in vivo
    • Antibody engineering
    • Evaluate target antibodies using biochemical/immunological assays, cell-based viral growth assays, and in vivo models of infectious disease
    • Perform small to mid-scale protein production and protein purification
    • Improve and optimize protein expression and other desired properties of host cells through targeted genetic modifications and other molecular engineering approaches
    • Perform in silico docking of antibodies to antigen to identify antibody variants with improved binding affinity and guide antibody engineering
    • Data interpretation, manuscript preparation, publication and presentation

    REQUIREMENTS

    • PhD in Microbiology, Immunology, Cell and Molecular Biochemistry, Molecular Biology, Cell Biology, Biology or related discipline;
    • Hands on expertise performing protein production, protein engineering, protein chemistry and protein purifications (column based methods, gravity flow, FPLC, or HPLC)
    • Experience with molecular techniques including PCR, primer design, DNA/RNA sample preparation, molecular cloning, Northern blots, Western blots, and immunoassays (flow cytometry, ELISA, immunocytochemistry)
    • Demonstrated record of high technical achievement (e.g. as evidenced by publication in high-impact scientific journals) and the proven ability to conduct creative, independent research

    PREFERENCES

    • Ability to perform routine tasks involved in a virology laboratory, including knowledge of techniques and basic safety procedures in BSL2 (or higher) environment and proper storeage and handling of viruses
    • Proven role as a strong individual contributor within a multidisciplinary team, and within the framework of a research project which shows evidence of meeting deadlines
    • Familiarity with bioinformatics or cheminformatics software tools
    • Experience in computational chemistry, software development and programming (e.g., C/C++, Perl, Python)
    • Strong written and oral communication skills
    • Knowledge of general immunology, virology and immune evasion by viruses
    • Experience in assay development, high-throughput screening methods, and animal models
    • Experience in phage display, methods to characterize binding affinity and thermodynamic properties, and label-free technologies for measuring biomolecular interactions (SPR or BLI)
    • Protein optimization laboratory research experience, particularly in the production and engineering of antibodies and structural based protein design
    • Familiarity with in vivo methods to measure CNS uptake, including pharmacokinetic techniques (intravenous administration and tissue sampling), brain perfusions, micro dialysis, and imaging techniques

    ABOUT US

    Department Description:
    The Systems Biology Department performs biological and bioengineering research with applications in national security, healthcare, and alternative energy. The department consists of dynamic, engaged, and passionate team of staff, postdocs, technologists, and students with expertise in microbiology, virology, molecular biology, computational biology, and analytical chemistry. The basic research activities in the department are focused on the identification and characterization of clinical and environmental pathogens, developing a systems-level understanding of host-pathogen interactions, and microbiomes relevant to human health and the environment. Applied research activities are focused on enzyme and microbial engineering for biofuels development, biological detection, and medical diagnostics.

    About Sandia:
    Sandia National Laboratories is the nation's premier science and engineering lab for national security and technology innovation, with teams of specialists focused on cutting-edge work in a broad array of areas. Some of the main reasons we love our jobs:
    • Challenging work with amazing impact that contributes to security, peace, and freedom worldwide
    • Extraordinary co-workers
    • Some of the best tools, equipment, and research facilities in the world
    • Career advancement and enrichment opportunities
    • Flexible schedules, generous vacations, strong medical and other benefits, competitive 401k, learning opportunities, relocation assistance and amenities aimed at creating a solid work/life balance+++
    World-changing technologies. Life-changing careers. Learn more about Sandia at: www.sandia.gov

    +++These benefits vary by job classification.

    HOW TO APPLY

    Please visit cg.sandia.gov/psp/[...]Seq=1

    POLICY

    Security Clearance:
    This position does not currently require a Department of Energy (DOE)-granted security clearance.

    Sandia will conduct a pre-employment drug testing, and a pre-employment background review that includes personal reference checks, law enforcement record checks, and employment and education verifications. Further, employees in New Mexico must pass a U.S. Air Force background screen for access to the work site. Substance abuse or illegal drug use, falsification of information, criminal activity, serious misconduct or other indicators of untrustworthiness can cause access to be denied or terminated, rendering the inability to perform the duties assigned and resulting in termination of employment.

    If hired without a clearance, and one subsequently becomes required or you bid on positions that require a DOE-granted security clearance, a pre-processing background review that includes personal reference checks, law enforcement record and credit checks, and employment and education verifications may be conducted prior to a required federal background investigation. Applicants for DOE-granted security clearances must be U.S. citizens and be able to obtain and maintain the appropriate DOE security clearance as required for the position.

    EEO Statement:
    All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or veteran status.
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