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URL: Chromhome: Comparative genomics and chromosome homology mapping
Submitted by Dr.Sridevi Nagarajan; posted on Wednesday, August 8, 2007
Chromhome is a database of comparative genomics showing maps of chromosome homologies across species. These homologies have been identified by cross-species chromosome painting with chromosome specific DNA probes prepared by chromosome sorting or microdissection. The chromosome products are amplified by random- primed PCR and labeled with various fluorochromes. The fluorescent probes are hybridized to be fixed and the air dried on microscopic slides and examined under fluorescence microscopy. For technical details refer Rens et al (2006) Nature Protocols 1, 783- 790.
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