[Molvis-list] pdb files of wild type/mutants

Gabriel Pons gpons at ub.edu
Fri May 6 12:19:46 EDT 2005

Frieda Reichsman wrote:

> Dear Colleagues,
> I am seeking pdb files to use as paired examples of the effects of a 
> single amino acid substitution on protein structure/function. Ideally 
> I would like to have some examples of substitutions that alter 
> function, and some that have little or no evident functional effect. 
> If both types of substitutions are available for the same protein, so 
> much the better.
> A good example is normal and sickle cell hemoglobin, but I would like 
> to have somewhere between four and ten different protein examples. I 
> need some that affect binding or enzymatic activity and are located in 
> the binding or active site.
> Thanks in advance for suggestions on this topic.
> Frieda
> Frieda Reichsman, PhD
> Molecules in Motion
> Interactive Molecular Structures
> www.moleculesinmotion.com
> MyDNA Project
> www.bio.umass.edu/biochem/mydna
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What about ras and ras mutated in cancer cells? A single aminoacid 
change provokes that ras get always activated and with GTP bound to the 
"active center"

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