[Proteopedia] New kind of inter-chain bond involved in redox allostery

[Eric Martz]

Earlier this month, a new kind of covalent linkage between the 
sidechains of Lys and Cys was reported in Nature, a 
Nitrogen-Oxygen-Sulfur (NOS) bond. In the initial case of the 
transaldolases studied, it serves as an allosteric redox switch for 
enzymatic activity. NOS appears likely to occur in proteins in all 
domains of life including /Homo sapiens/, apparently overlooked in 
earlier interpretations of electron density maps.

Have a look at this new page:

https://proteopedia.org/w/Lysine-cysteine_NOS_bonds

-Eric

P.S. Thanks to crystallographer Fadel Samatey for pointing out the 
original report to me.

-------------- next part --------------
An HTML attachment was scrubbed...
URL: <http://www.bioinformatics.org/pipermail/proteopedialist-for-users/attachments/20210525/13279180/attachment.html>