[Proteopedia] New kind of inter-chain bond involved in redox allostery

[Kevin Karplus]

Cool!  Is anyone planning to write a program or query to scan all of PDB
looking for places where this structure may have been missed?  Or has that
already been done?

Kevin Karplus   karplus at soe.ucsc.edu    http://www.soe.ucsc.edu/~karplus
Undergraduate Director for Biomolecular Engineering and Bioinformatics
Professor of Biomolecular Engineering, University of California, Santa Cruz
Author of *Applied Analog Electronics
<https://leanpub.com/applied_analog_electronics>*

*Affiliations for identification only.*


On Tue, May 25, 2021 at 5:03 PM Eric Martz <emartz at microbio.umass.edu>
wrote:

> Earlier this month, a new kind of covalent linkage between the
> sidechains of Lys and Cys was reported in Nature, a
> Nitrogen-Oxygen-Sulfur (NOS) bond. In the initial case of the
> transaldolases studied, it serves as an allosteric redox switch for
> enzymatic activity. NOS appears likely to occur in proteins in all
> domains of life including /Homo sapiens/, apparently overlooked in
> earlier interpretations of electron density maps.
>
> Have a look at this new page:
>
> https://proteopedia.org/w/Lysine-cysteine_NOS_bonds
>
> -Eric
>
> P.S. Thanks to crystallographer Fadel Samatey for pointing out the
> original report to me.
>
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