Basic Information
Gene ID 161452 ; Check Expression Profles ; Check TFs & Targets Binding
Gene Name Lef1
Full Name Lymphoid enhancer-binding factor 1
Organism Rattus norvegicus [10116]

Cross Reference
UniProt Q9QXN1 UniGene Rn.228611
PDB NULL OMIM NULL
KEGG rno:161452 UCSC NULL

Protein Interactions
DIP NULL
IntAct Q9QXN1
MINT MINT-8388232
STRING NULL

Ensembl/RefSeq
Transcript ID
Protein ID
Gene ID
ENSEMBL
REFSEQ
REFSEQ
REFSEQ

InterPro Annotation
Protein Program Term IPRS Start End Score Description
ENSRNOP00000013694 Gene3D G3DSA:1.10.30.10 IPR009071 295 377 8.20e-29 High mobility group box domain
ENSRNOP00000013694 Gene3D G3DSA:4.10.900.10 IPR027397 1 67 2.30e-26 Catenin binding domain
ENSRNOP00000013694 PANTHER PTHR10373 IPR024940 1 397 0.00e-00 Transcription factor TCF/LEF
ENSRNOP00000013694 PANTHER PTHR10373:SF11 IPR028769 1 397 0.00e-00 Lymphoid enhancer-binding factor 1
ENSRNOP00000013694 Pfam PF00505 IPR009071 297 364 1.20e-21 High mobility group box domain
ENSRNOP00000013694 Pfam PF08347 IPR013558 1 211 1.90e-72 CTNNB1 binding, N-teminal
ENSRNOP00000013694 ProSiteProfiles PS50118 IPR009071 297 365 0.00e-00 High mobility group box domain
ENSRNOP00000013694 SMART SM00398 IPR009071 296 366 2.50e-25 High mobility group box domain
ENSRNOP00000013694 SUPERFAMILY SSF47095 IPR009071 296 377 0.00e-00 High mobility group box domain

Pfam Annotation
Protein Pfam ID E.value Name Description
ENSRNOP00000013694 PF08347 0 CTNNB1_binding N-terminal CTNNB1 binding
ENSRNOP00000013694 PF00505 1.2e-21 HMG_box HMG (high mobility group) box
ENSRNOP00000013694 PF09011 1.7e-08 HMG_box_2 HMG-box domain

Gene Ontology Annotation
Protein Entry Name Space Description
ENSRNOP00000013694 GO:0060070 biological_process canonical Wnt signaling pathway
ENSRNOP00000013694 GO:0005634 cellular_component nucleus
ENSRNOP00000013694 GO:0003700 molecular_function sequence-specific DNA binding transcription factor activity
ENSRNOP00000013694 GO:0008013 molecular_function beta-catenin binding

Orthologs
TAXID Organism Gene ID TAXID Organism Gene ID
13616 Monodelphis domestica 100011783 9785 Loxodonta africana 100658960
8128 Oreochromis niloticus 100704365 9597 Pan paniscus 100995847
9555 Papio anubis 101017352 39432 Saimiri boliviensis 101047688
9595 Gorilla gorilla 101140253 9669 Mustela putorius furo 101689480
9986 Oryctolagus cuniculus 100352691 9646 Ailuropoda melanoleuca 100465982
28377 Anolis carolinensis 100556215 8090 Oryzias latipes 101167344
13735 Pelodiscus sinensis 102456780 10020 Dipodomys ordii ENSDORG00000007694
9796 Equus caballus ENSECAG00000019975 9685 Felis catus ENSFCAG00000027039
9315 Macropus eugenii ENSMEUG00000006871 30608 Microcebus murinus ENSMICG00000012833
59463 Myotis lucifugus ENSMLUG00000008891 9258 Ornithorhynchus anatinus ENSOANG00000002638
132908 Pteropus vampyrus ENSPVAG00000016128 99883 Tetraodon nigroviridis ENSTNIG00000018022
9739 Tursiops truncatus ENSTTRG00000008109 7955 Danio rerio 30701
9598 Pan troglodytes 461425 9358 Choloepus hoffmanni ENSCHOG00000005968
10141 Cavia porcellus ENSCPOG00000013758 9361 Dasypus novemcinctus ENSDNOG00000019529
9371 Echinops telfairi ENSETEG00000018357 69293 Gasterosteus aculeatus ENSGACG00000017458
8049 Gadus morhua ENSGMOG00000017345 7897 Latimeria chalumnae ENSLACG00000004977
9103 Meleagris gallopavo ENSMGAG00000005753 61853 Nomascus leucogenys ENSNLEG00000012942
9978 Ochotona princeps ENSOPRG00000002250 9813 Procavia capensis ENSPCAG00000012331
42254 Sorex araneus ENSSARG00000012174 9305 Sarcophilus harrisii ENSSHAG00000003436
43179 Ictidomys tridecemlineatus ENSSTOG00000001371 37347 Tupaia belangeri ENSTBEG00000011345
59729 Taeniopygia guttata ENSTGUG00000004013 31033 Takifugu rubripes ENSTRUG00000008652
9478 Tarsius syrichta ENSTSYG00000003979 30538 Vicugna pacos ENSVPAG00000005950
8364 Xenopus tropicalis ENSXETG00000021102 8083 Xiphophorus maculatus ENSXMAG00000010205

Paralogs
ENSRNOG00000049232