Basic Information | |||
Gene ID | 281814 | ||
Gene Name | HIF1A | ||
Full Name | Hypoxia inducible factor 1, alpha subunit (Basic helix-loop-helix transcription factor) | ||
Organism | Bos taurus [9913] |
Cross Reference | |||
UniProt | A0JND0 | UniGene | Bt.4184 |
PDB | NULL | OMIM | NULL |
KEGG | bta:281814 | UCSC | NULL |
Protein Interactions | |
DIP | NULL |
IntAct | NULL |
MINT | NULL |
STRING | 9913.ENSBTAP00000027885 |
Ensembl/RefSeq | Transcript ID | Protein ID | Gene ID |
ENSEMBL | |||
REFSEQ |
InterPro Annotation | |||||||
Protein | Program | Term | IPRS | Start | End | Score | Description |
NP_776764 | Pfam | PF00989 | IPR013767 | 94 | 150 | 1.80e-05 | PAS fold |
NP_776764 | Pfam | PF08778 | IPR014887 | 784 | 823 | 1.50e-22 | HIF-1 alpha, transactivation domain, C-terminal |
NP_776764 | Pfam | PF11413 | IPR021537 | 550 | 582 | 4.80e-16 | Hypoxia-inducible factor, alpha subunit |
NP_776764 | PRINTS | PR01080 | IPR001321 | 201 | 224 | 3.40e-48 | Hypoxia-inducible factor-1 alpha |
NP_776764 | PRINTS | PR01080 | IPR001321 | 360 | 378 | 3.40e-48 | Hypoxia-inducible factor-1 alpha |
NP_776764 | PRINTS | PR01080 | IPR001321 | 417 | 435 | 3.40e-48 | Hypoxia-inducible factor-1 alpha |
NP_776764 | PRINTS | PR01080 | IPR001321 | 457 | 477 | 3.40e-48 | Hypoxia-inducible factor-1 alpha |
NP_776764 | ProSiteProfiles | PS50112 | IPR000014 | 247 | 298 | 0.00e-00 | PAS domain |
NP_776764 | ProSiteProfiles | PS50112 | IPR000014 | 93 | 158 | 0.00e-00 | PAS domain |
NP_776764 | ProSiteProfiles | PS50888 | IPR011598 | 17 | 70 | 0.00e-00 | Myc-type, basic helix-loop-helix (bHLH) domain |
NP_776764 | SMART | SM00086 | IPR001610 | 302 | 345 | 3.40e-11 | PAC motif |
NP_776764 | SMART | SM00091 | IPR000014 | 230 | 296 | 8.20e-11 | PAS domain |
NP_776764 | SMART | SM00091 | IPR000014 | 87 | 153 | 1.50e-12 | PAS domain |
NP_776764 | SMART | SM00353 | IPR011598 | 23 | 78 | 2.80e-11 | Myc-type, basic helix-loop-helix (bHLH) domain |
NP_776764 | SUPERFAMILY | SSF47459 | IPR011598 | 15 | 71 | 0.00e-00 | Myc-type, basic helix-loop-helix (bHLH) domain |
NP_776764 | SUPERFAMILY | SSF55785 | IPR000014 | 242 | 343 | 0.00e-00 | PAS domain |
NP_776764 | SUPERFAMILY | SSF55785 | IPR000014 | 96 | 203 | 0.00e-00 | PAS domain |
NP_776764 | TIGRFAM | TIGR00229 | IPR000014 | 100 | 153 | 6.70e-06 | PAS domain |
NP_776764 | TIGRFAM | TIGR00229 | IPR000014 | 249 | 330 | 7.60e-08 | PAS domain |
Pfam Annotation | ||||
Protein | Pfam ID | E.value | Name | Description |
NP_776764 | PF08447 | 8.2e-26 | PAS_3 | PAS fold |
NP_776764 | PF14598 | 1.2e-25 | PAS_11 | PAS domain |
NP_776764 | PF08778 | 7.6e-23 | HIF-1a_CTAD | HIF-1 alpha C terminal transactivation domain |
NP_776764 | PF11413 | 2e-16 | HIF-1 | Hypoxia-inducible factor-1 |
NP_776764 | PF00989 | 8.6e-16 | PAS | PAS fold |
NP_776764 | PF13426 | 3.1e-12 | PAS_9 | PAS domain |
NP_776764 | PF08448 | 2.3e-07 | PAS_4 | PAS fold |
Gene Ontology Annotation | |||
Protein | Entry | Name Space | Description |
NP_776764 | GO:0001666 | biological_process | response to hypoxia |
NP_776764 | GO:0006351 | biological_process | transcription, DNA-templated |
NP_776764 | GO:0006355 | biological_process | regulation of transcription, DNA-templated |
NP_776764 | GO:0007165 | biological_process | signal transduction |
NP_776764 | GO:0045893 | biological_process | positive regulation of transcription, DNA-templated |
NP_776764 | GO:0005634 | cellular_component | nucleus |
NP_776764 | GO:0005737 | cellular_component | cytoplasm |
NP_776764 | GO:0003677 | molecular_function | DNA binding |
NP_776764 | GO:0003700 | molecular_function | sequence-specific DNA binding transcription factor activity |
NP_776764 | GO:0004871 | molecular_function | signal transducer activity |
NP_776764 | GO:0035035 | molecular_function | histone acetyltransferase binding |
NP_776764 | GO:0046983 | molecular_function | protein dimerization activity |