Basic Information
Gene ID 281814
Gene Name HIF1A
Full Name Hypoxia inducible factor 1, alpha subunit (Basic helix-loop-helix transcription factor)
Organism Bos taurus [9913]

Cross Reference
UniProt A0JND0 UniGene Bt.4184
PDB NULL OMIM NULL
KEGG bta:281814 UCSC NULL

Protein Interactions
DIP NULL
IntAct NULL
MINT NULL
STRING 9913.ENSBTAP00000027885

Ensembl/RefSeq
Transcript ID
Protein ID
Gene ID
ENSEMBL
REFSEQ

InterPro Annotation
Protein Program Term IPRS Start End Score Description
NP_776764 Pfam PF00989 IPR013767 94 150 1.80e-05 PAS fold
NP_776764 Pfam PF08778 IPR014887 784 823 1.50e-22 HIF-1 alpha, transactivation domain, C-terminal
NP_776764 Pfam PF11413 IPR021537 550 582 4.80e-16 Hypoxia-inducible factor, alpha subunit
NP_776764 PRINTS PR01080 IPR001321 201 224 3.40e-48 Hypoxia-inducible factor-1 alpha
NP_776764 PRINTS PR01080 IPR001321 360 378 3.40e-48 Hypoxia-inducible factor-1 alpha
NP_776764 PRINTS PR01080 IPR001321 417 435 3.40e-48 Hypoxia-inducible factor-1 alpha
NP_776764 PRINTS PR01080 IPR001321 457 477 3.40e-48 Hypoxia-inducible factor-1 alpha
NP_776764 ProSiteProfiles PS50112 IPR000014 247 298 0.00e-00 PAS domain
NP_776764 ProSiteProfiles PS50112 IPR000014 93 158 0.00e-00 PAS domain
NP_776764 ProSiteProfiles PS50888 IPR011598 17 70 0.00e-00 Myc-type, basic helix-loop-helix (bHLH) domain
NP_776764 SMART SM00086 IPR001610 302 345 3.40e-11 PAC motif
NP_776764 SMART SM00091 IPR000014 230 296 8.20e-11 PAS domain
NP_776764 SMART SM00091 IPR000014 87 153 1.50e-12 PAS domain
NP_776764 SMART SM00353 IPR011598 23 78 2.80e-11 Myc-type, basic helix-loop-helix (bHLH) domain
NP_776764 SUPERFAMILY SSF47459 IPR011598 15 71 0.00e-00 Myc-type, basic helix-loop-helix (bHLH) domain
NP_776764 SUPERFAMILY SSF55785 IPR000014 242 343 0.00e-00 PAS domain
NP_776764 SUPERFAMILY SSF55785 IPR000014 96 203 0.00e-00 PAS domain
NP_776764 TIGRFAM TIGR00229 IPR000014 100 153 6.70e-06 PAS domain
NP_776764 TIGRFAM TIGR00229 IPR000014 249 330 7.60e-08 PAS domain

Pfam Annotation
Protein Pfam ID E.value Name Description
NP_776764 PF08447 8.2e-26 PAS_3 PAS fold
NP_776764 PF14598 1.2e-25 PAS_11 PAS domain
NP_776764 PF08778 7.6e-23 HIF-1a_CTAD HIF-1 alpha C terminal transactivation domain
NP_776764 PF11413 2e-16 HIF-1 Hypoxia-inducible factor-1
NP_776764 PF00989 8.6e-16 PAS PAS fold
NP_776764 PF13426 3.1e-12 PAS_9 PAS domain
NP_776764 PF08448 2.3e-07 PAS_4 PAS fold

Gene Ontology Annotation
Protein Entry Name Space Description
NP_776764 GO:0001666 biological_process response to hypoxia
NP_776764 GO:0006351 biological_process transcription, DNA-templated
NP_776764 GO:0006355 biological_process regulation of transcription, DNA-templated
NP_776764 GO:0007165 biological_process signal transduction
NP_776764 GO:0045893 biological_process positive regulation of transcription, DNA-templated
NP_776764 GO:0005634 cellular_component nucleus
NP_776764 GO:0005737 cellular_component cytoplasm
NP_776764 GO:0003677 molecular_function DNA binding
NP_776764 GO:0003700 molecular_function sequence-specific DNA binding transcription factor activity
NP_776764 GO:0004871 molecular_function signal transducer activity
NP_776764 GO:0035035 molecular_function histone acetyltransferase binding
NP_776764 GO:0046983 molecular_function protein dimerization activity