Basic Information
Gene ID 3297 ; Check Expression Profles ; Check TFs & Targets Binding
Gene Name HSF1; HSTF1
Full Name Heat shock factor protein 1
Organism Homo sapiens [9606]

Cross Reference
UniProt Q00613 UniGene Hs.530227
PDB 2LDU OMIM 140580
KEGG hsa:3297 UCSC uc003zbt.4

Protein Interactions
DIP DIP-35670N
IntAct Q00613
MINT MINT-230849
STRING 9606.ENSP00000332698

Ensembl/RefSeq
Transcript ID
Protein ID
Gene ID
ENSEMBL
ENSEMBL
REFSEQ

InterPro Annotation
Protein Program Term IPRS Start End Score Description
ENSP00000431512 Gene3D G3DSA:1.10.10.10 IPR011991 14 118 2.90e-42 Winged helix-turn-helix DNA-binding domain
ENSP00000431512 PANTHER PTHR10015 IPR027725 1 529 0.00e-00 Heat shock transcription factor family
ENSP00000431512 PANTHER PTHR10015:SF42 IPR027072 1 529 0.00e-00 Heat shock factor protein 1
ENSP00000431512 Pfam PF00447 IPR000232 17 120 2.10e-35 Heat shock factor (HSF)-type, DNA-binding
ENSP00000431512 Pfam PF06546 IPR010542 246 529 2.50e-115 Vertebrate heat shock transcription factor, C-terminal domain
ENSP00000431512 PRINTS PR00056 IPR000232 18 41 1.90e-20 Heat shock factor (HSF)-type, DNA-binding
ENSP00000431512 PRINTS PR00056 IPR000232 56 68 1.90e-20 Heat shock factor (HSF)-type, DNA-binding
ENSP00000431512 PRINTS PR00056 IPR000232 69 81 1.90e-20 Heat shock factor (HSF)-type, DNA-binding
ENSP00000431512 ProSitePatterns PS00434 IPR000232 57 81 - Heat shock factor (HSF)-type, DNA-binding
ENSP00000431512 SMART SM00415 IPR000232 14 118 7.20e-69 Heat shock factor (HSF)-type, DNA-binding

Pfam Annotation
Protein Pfam ID E.value Name Description
ENSP00000431512 PF06546 0 Vert_HS_TF Vertebrate heat shock transcription factor
ENSP00000431512 PF00447 1.3e-35 HSF_DNA-bind HSF-type DNA-binding

Gene Ontology Annotation
Protein Entry Name Space Description
ENSP00000431512 GO:0006351 biological_process transcription, DNA-templated
ENSP00000431512 GO:0045944 biological_process positive regulation of transcription from RNA polymerase II promoter
ENSP00000431512 GO:0005634 cellular_component nucleus
ENSP00000431512 GO:0005737 cellular_component cytoplasm
ENSP00000431512 GO:0003700 molecular_function sequence-specific DNA binding transcription factor activity

Orthologs
TAXID Organism Gene ID TAXID Organism Gene ID
6087 Hydra magnipapillata 100209282 9601 Pongo abelii 100453225
30195 Bombus terrestris 100644212 132113 Bombus impatiens 100746442
10029 Cricetulus griseus 100762942 7463 Apis florea 100871205
143995 Megachile rotundata 100874674 34638 Metaseiulus occidentalis 100906511
9597 Pan paniscus 100994747 9555 Papio anubis 101020821
43179 Ictidomys tridecemlineatus 101977595 7425 Nasonia vitripennis 100116399
7029 Acyrthosiphon pisum 100573878 39432 Saimiri boliviensis 101042035
9615 Canis familiaris 475124 7668 Strongylocentrotus purpuratus 591088
9358 Choloepus hoffmanni ENSCHOG00000010951 9371 Echinops telfairi ENSETEG00000002048
9685 Felis catus ENSFCAG00000007722 8049 Gadus morhua ENSGMOG00000000596
9785 Loxodonta africana ENSLAFG00000021374 9315 Macropus eugenii ENSMEUG00000000470
9544 Macaca mulatta ENSMMUG00000014728 13616 Monodelphis domestica ENSMODG00000010663
8128 Oreochromis niloticus ENSONIG00000015330 9978 Ochotona princeps ENSOPRG00000004863
9813 Procavia capensis ENSPCAG00000006962 7757 Petromyzon marinus ENSPMAG00000004630
132908 Pteropus vampyrus ENSPVAG00000009267 42254 Sorex araneus ENSSARG00000011800
9823 Sus scrofa ENSSSCG00000004238 99883 Tetraodon nigroviridis ENSTNIG00000018157
9478 Tarsius syrichta ENSTSYG00000006467 30538 Vicugna pacos ENSVPAG00000009387
8364 Xenopus tropicalis ENSXETG00000005693 8083 Xiphophorus maculatus ENSXMAG00000001905
7227 Drosophila melanogaster 37068 7460 Apis mellifera 411854
10116 Rattus norvegicus 64441 28377 Anolis carolinensis ENSACAG00000012604
9646 Ailuropoda melanoleuca ENSAMEG00000005847 9913 Bos taurus ENSBTAG00000012946
9483 Callithrix jacchus ENSCJAG00000003956 10141 Cavia porcellus ENSCPOG00000007509
51511 Ciona savignyi ENSCSAVG00000009385 10020 Dipodomys ordii ENSDORG00000002333
9796 Equus caballus ENSECAG00000000621 69293 Gasterosteus aculeatus ENSGACG00000010434
9595 Gorilla gorilla ENSGGOG00000013602 7897 Latimeria chalumnae ENSLACG00000013265
30608 Microcebus murinus ENSMICG00000015688 59463 Myotis lucifugus ENSMLUG00000002310
9669 Mustela putorius furo ENSMPUG00000006704 61853 Nomascus leucogenys ENSNLEG00000010525
9258 Ornithorhynchus anatinus ENSOANG00000001941 9986 Oryctolagus cuniculus ENSOCUG00000012921
8090 Oryzias latipes ENSORLG00000001699 13735 Pelodiscus sinensis ENSPSIG00000014566
9598 Pan troglodytes ENSPTRG00000018561 9305 Sarcophilus harrisii ENSSHAG00000000079
37347 Tupaia belangeri ENSTBEG00000013569 31033 Takifugu rubripes ENSTRUG00000000233
9739 Tursiops truncatus ENSTTRG00000006426