Basic Information
Gene ID 3659 ; Check Expression Profles ; Check TFs & Targets Binding
Gene Name IRF1
Full Name Interferon regulatory factor 1
Organism Homo sapiens [9606]

Cross Reference
UniProt P10914 UniGene Hs.436061
PDB NULL OMIM 613659
KEGG hsa:3659 UCSC uc003kxa.2

Protein Interactions
DIP DIP-40988N
IntAct P10914
MINT MINT-123145
STRING 9606.ENSP00000245414

Ensembl/RefSeq
Transcript ID
Protein ID
Gene ID
ENSEMBL
ENSEMBL
REFSEQ

InterPro Annotation
Protein Program Term IPRS Start End Score Description
ENSP00000384406 Gene3D G3DSA:1.10.10.10 IPR011991 1 113 2.40e-54 Winged helix-turn-helix DNA-binding domain
ENSP00000384406 Pfam PF00605 IPR001346 5 113 3.10e-46 Interferon regulatory factor DNA-binding domain
ENSP00000384406 PIRSF PIRSF038196 IPR017431 1 315 9.70e-166 Interferon regulatory factor-1/2
ENSP00000384406 PRINTS PR00267 IPR001346 33 46 1.60e-28 Interferon regulatory factor DNA-binding domain
ENSP00000384406 PRINTS PR00267 IPR001346 51 68 1.60e-28 Interferon regulatory factor DNA-binding domain
ENSP00000384406 PRINTS PR00267 IPR001346 7 26 1.60e-28 Interferon regulatory factor DNA-binding domain
ENSP00000384406 PRINTS PR00267 IPR001346 74 96 1.60e-28 Interferon regulatory factor DNA-binding domain
ENSP00000384406 ProSitePatterns PS00601 IPR019817 26 59 - Interferon regulatory factor, conserved site
ENSP00000384406 ProSiteProfiles PS51507 IPR001346 5 113 0.00e-00 Interferon regulatory factor DNA-binding domain
ENSP00000384406 SMART SM00348 IPR001346 1 114 2.30e-64 Interferon regulatory factor DNA-binding domain

Pfam Annotation
Protein Pfam ID E.value Name Description
ENSP00000384406 PF00605 0 IRF Interferon regulatory factor transcription factor

Gene Ontology Annotation
Protein Entry Name Space Description
ENSP00000384406 GO:0006351 biological_process transcription, DNA-templated
ENSP00000384406 GO:0060333 biological_process interferon-gamma-mediated signaling pathway
ENSP00000384406 GO:0005634 cellular_component nucleus
ENSP00000384406 GO:0003700 molecular_function sequence-specific DNA binding transcription factor activity

Orthologs
TAXID Organism Gene ID TAXID Organism Gene ID
10029 Cricetulus griseus 100753270 9796 Equus caballus 100063253
9555 Papio anubis 100137219 6087 Hydra magnipapillata 100215166
10224 Saccoglossus kowalevskii 100368290 9646 Ailuropoda melanoleuca 100481969
400682 Amphimedon queenslandica 100631948 8128 Oreochromis niloticus 100704899
9305 Sarcophilus harrisii 100923018 30611 Otolemur garnettii 100956015
9597 Pan paniscus 100990921 39432 Saimiri boliviensis 101039413
9685 Felis catus 101095633 9595 Gorilla gorilla 101136839
8090 Oryzias latipes 101163430 9669 Mustela putorius furo 101687755
43179 Ictidomys tridecemlineatus 101974874 8083 Xiphophorus maculatus 102228257
13735 Pelodiscus sinensis 102447273 10090 Mus musculus 16362
9913 Bos taurus 337916 9031 Gallus gallus 396384
7668 Strongylocentrotus purpuratus 575472 9544 Macaca mulatta 707788
9598 Pan troglodytes 745042 9358 Choloepus hoffmanni ENSCHOG00000012067
10141 Cavia porcellus ENSCPOG00000004848 7955 Danio rerio ENSDARG00000032768
9365 Erinaceus europaeus ENSEEUG00000013362 9371 Echinops telfairi ENSETEG00000001016
69293 Gasterosteus aculeatus ENSGACG00000020876 8049 Gadus morhua ENSGMOG00000019456
9315 Macropus eugenii ENSMEUG00000011152 9103 Meleagris gallopavo ENSMGAG00000008932
30608 Microcebus murinus ENSMICG00000008190 59463 Myotis lucifugus ENSMLUG00000016545
13616 Monodelphis domestica ENSMODG00000013963 61853 Nomascus leucogenys ENSNLEG00000012720
9258 Ornithorhynchus anatinus ENSOANG00000010695 9986 Oryctolagus cuniculus ENSOCUG00000004165
9978 Ochotona princeps ENSOPRG00000011705 7757 Petromyzon marinus ENSPMAG00000005347
10116 Rattus norvegicus ENSRNOG00000008144 42254 Sorex araneus ENSSARG00000006226
59729 Taeniopygia guttata ENSTGUG00000001375 99883 Tetraodon nigroviridis ENSTNIG00000019636
9478 Tarsius syrichta ENSTSYG00000001107 9739 Tursiops truncatus ENSTTRG00000002597
30538 Vicugna pacos ENSVPAG00000003839 9823 Sus scrofa 396611
28377 Anolis carolinensis ENSACAG00000012699 9615 Canis familiaris ENSCAFG00000000851
10020 Dipodomys ordii ENSDORG00000003799 7897 Latimeria chalumnae ENSLACG00000001546
9785 Loxodonta africana ENSLAFG00000000088 9813 Procavia capensis ENSPCAG00000017088
9601 Pongo abelii ENSPPYG00000015235 132908 Pteropus vampyrus ENSPVAG00000000430
37347 Tupaia belangeri ENSTBEG00000006972 31033 Takifugu rubripes ENSTRUG00000004321
8364 Xenopus tropicalis ENSXETG00000016586