Basic Information
Gene ID 3663 ; Check Expression Profles ; Check TFs & Targets Binding
Gene Name IRF5
Full Name Interferon regulatory factor 5
Organism Homo sapiens [9606]

Cross Reference
UniProt Q13568 UniGene Hs.521181
PDB 3DSH OMIM 612251
KEGG hsa:3663 UCSC uc003voh.3

Protein Interactions
DIP DIP-46348N
IntAct Q13568
MINT NULL
STRING 9606.ENSP00000349770

Ensembl/RefSeq
Transcript ID
Protein ID
Gene ID
ENSEMBL
ENSEMBL
ENSEMBL
ENSEMBL
ENSEMBL
ENSEMBL
REFSEQ
REFSEQ
REFSEQ
REFSEQ
REFSEQ
REFSEQ
REFSEQ
REFSEQ
REFSEQ

InterPro Annotation
Protein Program Term IPRS Start End Score Description
ENSP00000349770 Gene3D G3DSA:1.10.10.10 IPR011991 11 121 3.20e-45 Winged helix-turn-helix DNA-binding domain
ENSP00000349770 Gene3D G3DSA:2.60.200.10 IPR017855 253 492 2.00e-98 SMAD domain-like
ENSP00000349770 Pfam PF00605 IPR001346 14 122 9.00e-47 Interferon regulatory factor DNA-binding domain
ENSP00000349770 Pfam PF10401 IPR019471 264 447 4.90e-68 Interferon regulatory factor-3
ENSP00000349770 PRINTS PR00267 IPR001346 16 35 7.80e-26 Interferon regulatory factor DNA-binding domain
ENSP00000349770 PRINTS PR00267 IPR001346 42 55 7.80e-26 Interferon regulatory factor DNA-binding domain
ENSP00000349770 PRINTS PR00267 IPR001346 60 77 7.80e-26 Interferon regulatory factor DNA-binding domain
ENSP00000349770 PRINTS PR00267 IPR001346 83 105 7.80e-26 Interferon regulatory factor DNA-binding domain
ENSP00000349770 ProSitePatterns PS00601 IPR019817 35 68 - Interferon regulatory factor, conserved site
ENSP00000349770 ProSiteProfiles PS51507 IPR001346 14 122 0.00e-00 Interferon regulatory factor DNA-binding domain
ENSP00000349770 SMART SM00348 IPR001346 10 123 1.20e-67 Interferon regulatory factor DNA-binding domain
ENSP00000349770 SUPERFAMILY SSF49879 IPR008984 262 479 0.00e-00 SMAD/FHA domain

Pfam Annotation
Protein Pfam ID E.value Name Description
ENSP00000349770 PF00605 0 IRF Interferon regulatory factor transcription factor
ENSP00000349770 PF10401 0 IRF-3 Interferon-regulatory factor 3

Gene Ontology Annotation
Protein Entry Name Space Description
ENSP00000349770 GO:0006351 biological_process transcription, DNA-templated
ENSP00000349770 GO:0005634 cellular_component nucleus
ENSP00000349770 GO:0005737 cellular_component cytoplasm
ENSP00000349770 GO:0000975 molecular_function regulatory region DNA binding
ENSP00000349770 GO:0003700 molecular_function sequence-specific DNA binding transcription factor activity

Orthologs
TAXID Organism Gene ID TAXID Organism Gene ID
9986 Oryctolagus cuniculus 100350244 9483 Callithrix jacchus 100396202
9601 Pongo abelii 100448322 9103 Meleagris gallopavo 100542404
61853 Nomascus leucogenys 100594750 9785 Loxodonta africana 100667576
8128 Oreochromis niloticus 100705073 9597 Pan paniscus 100990704
9555 Papio anubis 101025947 39432 Saimiri boliviensis 101044656
9595 Gorilla gorilla 101145333 43179 Ictidomys tridecemlineatus 101959638
8083 Xiphophorus maculatus 102228154 7897 Latimeria chalumnae 102347224
59463 Myotis lucifugus 102425960 13735 Pelodiscus sinensis 102460672
10090 Mus musculus 16364 10029 Cricetulus griseus 100761633
10116 Rattus norvegicus 364081 13616 Monodelphis domestica ENSMODG00000002539
9544 Macaca mulatta 712958 28377 Anolis carolinensis ENSACAG00000017711
9646 Ailuropoda melanoleuca ENSAMEG00000005109 9615 Canis familiaris ENSCAFG00000001611
9358 Choloepus hoffmanni ENSCHOG00000011538 7719 Ciona intestinalis ENSCING00000002820
10141 Cavia porcellus ENSCPOG00000000246 9361 Dasypus novemcinctus ENSDNOG00000013370
10020 Dipodomys ordii ENSDORG00000010627 9796 Equus caballus ENSECAG00000009902
9365 Erinaceus europaeus ENSEEUG00000014653 9371 Echinops telfairi ENSETEG00000002100
9685 Felis catus ENSFCAG00000000956 69293 Gasterosteus aculeatus ENSGACG00000000695
9031 Gallus gallus ENSGALG00000028368 8049 Gadus morhua ENSGMOG00000007988
9315 Macropus eugenii ENSMEUG00000002435 30608 Microcebus murinus ENSMICG00000000138
9669 Mustela putorius furo ENSMPUG00000006034 9258 Ornithorhynchus anatinus ENSOANG00000011449
30611 Otolemur garnettii ENSOGAG00000009608 9978 Ochotona princeps ENSOPRG00000006148
8090 Oryzias latipes ENSORLG00000000511 9813 Procavia capensis ENSPCAG00000000685
132908 Pteropus vampyrus ENSPVAG00000015756 42254 Sorex araneus ENSSARG00000013038
9305 Sarcophilus harrisii ENSSHAG00000006683 9823 Sus scrofa ENSSSCG00000016573
37347 Tupaia belangeri ENSTBEG00000017451 59729 Taeniopygia guttata ENSTGUG00000015958
99883 Tetraodon nigroviridis ENSTNIG00000003346 31033 Takifugu rubripes ENSTRUG00000006951
9478 Tarsius syrichta ENSTSYG00000010982 9739 Tursiops truncatus ENSTTRG00000001121
30538 Vicugna pacos ENSVPAG00000010247 8364 Xenopus tropicalis ENSXETG00000018661