Basic Information
Gene ID 4306 ; Check Expression Profles ; Check TFs & Targets Binding
Gene Name NR3C2; MCR, MLR
Full Name Mineralocorticoid receptor
Organism Homo sapiens [9606]

Cross Reference
UniProt P08235 UniGene Hs.163924
PDB 3WFG OMIM 605115
KEGG hsa:4306 UCSC uc003ilk.4

Protein Interactions
DIP NULL
IntAct P08235
MINT NULL
STRING 9606.ENSP00000350815

Ensembl/RefSeq
Transcript ID
Protein ID
Gene ID
ENSEMBL
ENSEMBL
REFSEQ
REFSEQ
REFSEQ

InterPro Annotation
Protein Program Term IPRS Start End Score Description
ENSP00000341390 Gene3D G3DSA:1.10.565.10 IPR008946 731 983 1.10e-69 Nuclear hormone receptor, ligand-binding
ENSP00000341390 Gene3D G3DSA:3.30.50.10 IPR013088 601 676 1.00e-27 Zinc finger, NHR/GATA-type
ENSP00000341390 Pfam PF00104 IPR000536 753 934 2.30e-28 Nuclear hormone receptor, ligand-binding, core
ENSP00000341390 Pfam PF00105 IPR001628 602 669 2.40e-28 Zinc finger, nuclear hormone receptor-type
ENSP00000341390 PRINTS PR00047 IPR001628 603 619 3.10e-14 Zinc finger, nuclear hormone receptor-type
ENSP00000341390 PRINTS PR00047 IPR001628 619 634 3.10e-14 Zinc finger, nuclear hormone receptor-type
ENSP00000341390 PRINTS PR00047 IPR001628 652 660 3.10e-14 Zinc finger, nuclear hormone receptor-type
ENSP00000341390 PRINTS PR00047 IPR001628 660 668 3.10e-14 Zinc finger, nuclear hormone receptor-type
ENSP00000341390 ProSitePatterns PS00031 IPR001628 603 629 - Zinc finger, nuclear hormone receptor-type
ENSP00000341390 ProSiteProfiles PS51030 IPR001628 600 675 0.00e-00 Zinc finger, nuclear hormone receptor-type
ENSP00000341390 SMART SM00399 IPR001628 600 671 1.80e-37 Zinc finger, nuclear hormone receptor-type
ENSP00000341390 SMART SM00430 IPR000536 771 935 2.70e-35 Nuclear hormone receptor, ligand-binding, core
ENSP00000341390 SUPERFAMILY SSF48508 IPR008946 736 982 0.00e-00 Nuclear hormone receptor, ligand-binding

Pfam Annotation
Protein Pfam ID E.value Name Description
ENSP00000341390 PF00105 1.2e-28 zf-C4 Zinc finger, C4 type (two domains)
ENSP00000341390 PF00104 1.4e-28 Hormone_recep Ligand-binding domain of nuclear hormone receptor

Gene Ontology Annotation
Protein Entry Name Space Description
ENSP00000341390 GO:0006351 biological_process transcription, DNA-templated
ENSP00000341390 GO:0006355 biological_process regulation of transcription, DNA-templated
ENSP00000341390 GO:0043401 biological_process steroid hormone mediated signaling pathway
ENSP00000341390 GO:0005634 cellular_component nucleus
ENSP00000341390 GO:0005737 cellular_component cytoplasm
ENSP00000341390 GO:0003677 molecular_function DNA binding
ENSP00000341390 GO:0003700 molecular_function sequence-specific DNA binding transcription factor activity
ENSP00000341390 GO:0003707 molecular_function steroid hormone receptor activity
ENSP00000341390 GO:0005496 molecular_function steroid binding
ENSP00000341390 GO:0008270 molecular_function zinc ion binding
ENSP00000341390 GO:0008289 molecular_function lipid binding
ENSP00000341390 GO:0043565 molecular_function sequence-specific DNA binding
ENSP00000341390 GO:0046872 molecular_function metal ion binding

Orthologs
TAXID Organism Gene ID TAXID Organism Gene ID
8090 Oryzias latipes 100302443 9986 Oryctolagus cuniculus 100358449
10029 Cricetulus griseus 100750556 9597 Pan paniscus 100970550
9555 Papio anubis 101026548 39432 Saimiri boliviensis 101031058
9669 Mustela putorius furo 101687999 8083 Xiphophorus maculatus 102235678
59463 Myotis lucifugus 102439464 13735 Pelodiscus sinensis 102456908
10090 Mus musculus 110784 9598 Pan troglodytes 461533
28377 Anolis carolinensis ENSACAG00000003612 9646 Ailuropoda melanoleuca ENSAMEG00000002068
9615 Canis familiaris ENSCAFG00000007813 9358 Choloepus hoffmanni ENSCHOG00000003783
9483 Callithrix jacchus ENSCJAG00000002360 10141 Cavia porcellus ENSCPOG00000007770
10020 Dipodomys ordii ENSDORG00000016701 9365 Erinaceus europaeus ENSEEUG00000005639
9371 Echinops telfairi ENSETEG00000000678 9685 Felis catus ENSFCAG00000027453
69293 Gasterosteus aculeatus ENSGACG00000017193 9031 Gallus gallus ENSGALG00000010035
9595 Gorilla gorilla ENSGGOG00000001102 8049 Gadus morhua ENSGMOG00000001897
9785 Loxodonta africana ENSLAFG00000022550 9315 Macropus eugenii ENSMEUG00000006307
9103 Meleagris gallopavo ENSMGAG00000004038 30608 Microcebus murinus ENSMICG00000000592
9544 Macaca mulatta ENSMMUG00000014955 61853 Nomascus leucogenys ENSNLEG00000005677
9258 Ornithorhynchus anatinus ENSOANG00000005268 30611 Otolemur garnettii ENSOGAG00000014008
9978 Ochotona princeps ENSOPRG00000013315 9601 Pongo abelii ENSPPYG00000015113
132908 Pteropus vampyrus ENSPVAG00000010910 10116 Rattus norvegicus ENSRNOG00000034007
42254 Sorex araneus ENSSARG00000001143 9305 Sarcophilus harrisii ENSSHAG00000005709
9823 Sus scrofa ENSSSCG00000009026 43179 Ictidomys tridecemlineatus ENSSTOG00000004069
37347 Tupaia belangeri ENSTBEG00000012720 59729 Taeniopygia guttata ENSTGUG00000002577
99883 Tetraodon nigroviridis ENSTNIG00000017732 31033 Takifugu rubripes ENSTRUG00000014871
9478 Tarsius syrichta ENSTSYG00000005335 9739 Tursiops truncatus ENSTTRG00000014440
30538 Vicugna pacos ENSVPAG00000006935 8364 Xenopus tropicalis ENSXETG00000026061