Basic Information | |||
Gene ID | 4306 ; Check Expression Profles ; Check TFs & Targets Binding | ||
Gene Name | NR3C2; MCR, MLR | ||
Full Name | Mineralocorticoid receptor | ||
Organism | Homo sapiens [9606] |
Cross Reference | |||
UniProt | P08235 | UniGene | Hs.163924 |
PDB | 3WFG | OMIM | 605115 |
KEGG | hsa:4306 | UCSC | uc003ilk.4 |
Protein Interactions | |
DIP | NULL |
IntAct | P08235 |
MINT | NULL |
STRING | 9606.ENSP00000350815 |
Ensembl/RefSeq | Transcript ID | Protein ID | Gene ID |
ENSEMBL | |||
ENSEMBL | |||
REFSEQ | |||
REFSEQ | |||
REFSEQ |
InterPro Annotation | |||||||
Protein | Program | Term | IPRS | Start | End | Score | Description |
ENSP00000341390 | Gene3D | G3DSA:1.10.565.10 | IPR008946 | 731 | 983 | 1.10e-69 | Nuclear hormone receptor, ligand-binding |
ENSP00000341390 | Gene3D | G3DSA:3.30.50.10 | IPR013088 | 601 | 676 | 1.00e-27 | Zinc finger, NHR/GATA-type |
ENSP00000341390 | Pfam | PF00104 | IPR000536 | 753 | 934 | 2.30e-28 | Nuclear hormone receptor, ligand-binding, core |
ENSP00000341390 | Pfam | PF00105 | IPR001628 | 602 | 669 | 2.40e-28 | Zinc finger, nuclear hormone receptor-type |
ENSP00000341390 | PRINTS | PR00047 | IPR001628 | 603 | 619 | 3.10e-14 | Zinc finger, nuclear hormone receptor-type |
ENSP00000341390 | PRINTS | PR00047 | IPR001628 | 619 | 634 | 3.10e-14 | Zinc finger, nuclear hormone receptor-type |
ENSP00000341390 | PRINTS | PR00047 | IPR001628 | 652 | 660 | 3.10e-14 | Zinc finger, nuclear hormone receptor-type |
ENSP00000341390 | PRINTS | PR00047 | IPR001628 | 660 | 668 | 3.10e-14 | Zinc finger, nuclear hormone receptor-type |
ENSP00000341390 | ProSitePatterns | PS00031 | IPR001628 | 603 | 629 | - | Zinc finger, nuclear hormone receptor-type |
ENSP00000341390 | ProSiteProfiles | PS51030 | IPR001628 | 600 | 675 | 0.00e-00 | Zinc finger, nuclear hormone receptor-type |
ENSP00000341390 | SMART | SM00399 | IPR001628 | 600 | 671 | 1.80e-37 | Zinc finger, nuclear hormone receptor-type |
ENSP00000341390 | SMART | SM00430 | IPR000536 | 771 | 935 | 2.70e-35 | Nuclear hormone receptor, ligand-binding, core |
ENSP00000341390 | SUPERFAMILY | SSF48508 | IPR008946 | 736 | 982 | 0.00e-00 | Nuclear hormone receptor, ligand-binding |
Pfam Annotation | ||||
Protein | Pfam ID | E.value | Name | Description |
ENSP00000341390 | PF00105 | 1.2e-28 | zf-C4 | Zinc finger, C4 type (two domains) |
ENSP00000341390 | PF00104 | 1.4e-28 | Hormone_recep | Ligand-binding domain of nuclear hormone receptor |
Gene Ontology Annotation | |||
Protein | Entry | Name Space | Description |
ENSP00000341390 | GO:0006351 | biological_process | transcription, DNA-templated |
ENSP00000341390 | GO:0006355 | biological_process | regulation of transcription, DNA-templated |
ENSP00000341390 | GO:0043401 | biological_process | steroid hormone mediated signaling pathway |
ENSP00000341390 | GO:0005634 | cellular_component | nucleus |
ENSP00000341390 | GO:0005737 | cellular_component | cytoplasm |
ENSP00000341390 | GO:0003677 | molecular_function | DNA binding |
ENSP00000341390 | GO:0003700 | molecular_function | sequence-specific DNA binding transcription factor activity |
ENSP00000341390 | GO:0003707 | molecular_function | steroid hormone receptor activity |
ENSP00000341390 | GO:0005496 | molecular_function | steroid binding |
ENSP00000341390 | GO:0008270 | molecular_function | zinc ion binding |
ENSP00000341390 | GO:0008289 | molecular_function | lipid binding |
ENSP00000341390 | GO:0043565 | molecular_function | sequence-specific DNA binding |
ENSP00000341390 | GO:0046872 | molecular_function | metal ion binding |
Orthologs | |||||
TAXID | Organism | Gene ID | TAXID | Organism | Gene ID |
8090 | Oryzias latipes | 100302443 | 9986 | Oryctolagus cuniculus | 100358449 |
10029 | Cricetulus griseus | 100750556 | 9597 | Pan paniscus | 100970550 |
9555 | Papio anubis | 101026548 | 39432 | Saimiri boliviensis | 101031058 |
9669 | Mustela putorius furo | 101687999 | 8083 | Xiphophorus maculatus | 102235678 |
59463 | Myotis lucifugus | 102439464 | 13735 | Pelodiscus sinensis | 102456908 |
10090 | Mus musculus | 110784 | 9598 | Pan troglodytes | 461533 |
28377 | Anolis carolinensis | ENSACAG00000003612 | 9646 | Ailuropoda melanoleuca | ENSAMEG00000002068 |
9615 | Canis familiaris | ENSCAFG00000007813 | 9358 | Choloepus hoffmanni | ENSCHOG00000003783 |
9483 | Callithrix jacchus | ENSCJAG00000002360 | 10141 | Cavia porcellus | ENSCPOG00000007770 |
10020 | Dipodomys ordii | ENSDORG00000016701 | 9365 | Erinaceus europaeus | ENSEEUG00000005639 |
9371 | Echinops telfairi | ENSETEG00000000678 | 9685 | Felis catus | ENSFCAG00000027453 |
69293 | Gasterosteus aculeatus | ENSGACG00000017193 | 9031 | Gallus gallus | ENSGALG00000010035 |
9595 | Gorilla gorilla | ENSGGOG00000001102 | 8049 | Gadus morhua | ENSGMOG00000001897 |
9785 | Loxodonta africana | ENSLAFG00000022550 | 9315 | Macropus eugenii | ENSMEUG00000006307 |
9103 | Meleagris gallopavo | ENSMGAG00000004038 | 30608 | Microcebus murinus | ENSMICG00000000592 |
9544 | Macaca mulatta | ENSMMUG00000014955 | 61853 | Nomascus leucogenys | ENSNLEG00000005677 |
9258 | Ornithorhynchus anatinus | ENSOANG00000005268 | 30611 | Otolemur garnettii | ENSOGAG00000014008 |
9978 | Ochotona princeps | ENSOPRG00000013315 | 9601 | Pongo abelii | ENSPPYG00000015113 |
132908 | Pteropus vampyrus | ENSPVAG00000010910 | 10116 | Rattus norvegicus | ENSRNOG00000034007 |
42254 | Sorex araneus | ENSSARG00000001143 | 9305 | Sarcophilus harrisii | ENSSHAG00000005709 |
9823 | Sus scrofa | ENSSSCG00000009026 | 43179 | Ictidomys tridecemlineatus | ENSSTOG00000004069 |
37347 | Tupaia belangeri | ENSTBEG00000012720 | 59729 | Taeniopygia guttata | ENSTGUG00000002577 |
99883 | Tetraodon nigroviridis | ENSTNIG00000017732 | 31033 | Takifugu rubripes | ENSTRUG00000014871 |
9478 | Tarsius syrichta | ENSTSYG00000005335 | 9739 | Tursiops truncatus | ENSTTRG00000014440 |
30538 | Vicugna pacos | ENSVPAG00000006935 | 8364 | Xenopus tropicalis | ENSXETG00000026061 |