Basic Information
Gene ID 4780 ; Check Expression Profles ; Check TFs & Targets Binding
Gene Name NFE2L2; NRF2
Full Name Nuclear factor erythroid 2-related factor 2
Organism Homo sapiens [9606]

Cross Reference
UniProt Q16236 UniGene Hs.744006
PDB 4IFL OMIM 600492
KEGG hsa:4780 UCSC uc002ulg.5

Protein Interactions
DIP DIP-29971N
IntAct Q16236
MINT MINT-2844437
STRING 9606.ENSP00000380252

Ensembl/RefSeq
Transcript ID
Protein ID
Gene ID
ENSEMBL
ENSEMBL
ENSEMBL
ENSEMBL
REFSEQ
REFSEQ
REFSEQ

InterPro Annotation
Protein Program Term IPRS Start End Score Description
ENSP00000380252 Gene3D G3DSA:1.10.880.10 IPR008917 440 513 4.80e-37 Transcription factor, Skn-1-like, DNA-binding domain
ENSP00000380252 Pfam PF03131 IPR004826 469 558 2.80e-16 Basic leucine zipper domain, Maf-type
ENSP00000380252 ProSitePatterns PS00036 IPR004827 502 517 - Basic-leucine zipper domain
ENSP00000380252 ProSiteProfiles PS50217 IPR004827 497 560 0.00e-00 Basic-leucine zipper domain
ENSP00000380252 SMART SM00338 IPR004827 495 559 9.00e-15 Basic-leucine zipper domain
ENSP00000380252 SUPERFAMILY SSF47454 IPR008917 454 521 0.00e-00 Transcription factor, Skn-1-like, DNA-binding domain

Pfam Annotation
Protein Pfam ID E.value Name Description
ENSP00000380252 PF03131 2.8e-16 bZIP_Maf bZIP Maf transcription factor
ENSP00000380252 PF00170 3.2e-08 bZIP_1 bZIP transcription factor
ENSP00000380252 PF07716 2.7e-06 bZIP_2 Basic region leucine zipper

Gene Ontology Annotation
Protein Entry Name Space Description
ENSP00000380252 GO:0006351 biological_process transcription, DNA-templated
ENSP00000380252 GO:0005634 cellular_component nucleus
ENSP00000380252 GO:0003700 molecular_function sequence-specific DNA binding transcription factor activity
ENSP00000380252 GO:0043565 molecular_function sequence-specific DNA binding

Orthologs
TAXID Organism Gene ID TAXID Organism Gene ID
10224 Saccoglossus kowalevskii 100369481 9483 Callithrix jacchus 100386539
9103 Meleagris gallopavo 100546407 28377 Anolis carolinensis 100560087
61853 Nomascus leucogenys 100580741 10029 Cricetulus griseus 100752102
9597 Pan paniscus 100985885 9555 Papio anubis 100999610
39432 Saimiri boliviensis 101029719 9685 Felis catus 101098812
9669 Mustela putorius furo 101690167 8083 Xiphophorus maculatus 102236765
7897 Latimeria chalumnae 102349207 10090 Mus musculus 18022
9615 Canis familiaris 478813 9361 Dasypus novemcinctus ENSDNOG00000019020
9796 Equus caballus ENSECAG00000005675 7757 Petromyzon marinus ENSPMAG00000004467
9305 Sarcophilus harrisii ENSSHAG00000018277 9739 Tursiops truncatus ENSTTRG00000014247
9544 Macaca mulatta 707606 9646 Ailuropoda melanoleuca ENSAMEG00000011937
9913 Bos taurus ENSBTAG00000019255 9358 Choloepus hoffmanni ENSCHOG00000005792
10141 Cavia porcellus ENSCPOG00000004256 7955 Danio rerio ENSDARG00000042824
10020 Dipodomys ordii ENSDORG00000016595 9365 Erinaceus europaeus ENSEEUG00000011243
9371 Echinops telfairi ENSETEG00000001387 69293 Gasterosteus aculeatus ENSGACG00000004470
9031 Gallus gallus ENSGALG00000009240 9595 Gorilla gorilla ENSGGOG00000001231
8049 Gadus morhua ENSGMOG00000004196 9785 Loxodonta africana ENSLAFG00000016263
9315 Macropus eugenii ENSMEUG00000009798 30608 Microcebus murinus ENSMICG00000009559
59463 Myotis lucifugus ENSMLUG00000003909 13616 Monodelphis domestica ENSMODG00000009624
9258 Ornithorhynchus anatinus ENSOANG00000008623 9986 Oryctolagus cuniculus ENSOCUG00000001009
30611 Otolemur garnettii ENSOGAG00000034393 8128 Oreochromis niloticus ENSONIG00000012253
9978 Ochotona princeps ENSOPRG00000013934 8090 Oryzias latipes ENSORLG00000017568
9813 Procavia capensis ENSPCAG00000013845 9601 Pongo abelii ENSPPYG00000012968
13735 Pelodiscus sinensis ENSPSIG00000003007 132908 Pteropus vampyrus ENSPVAG00000010382
10116 Rattus norvegicus ENSRNOG00000001548 42254 Sorex araneus ENSSARG00000010915
9823 Sus scrofa ENSSSCG00000015987 43179 Ictidomys tridecemlineatus ENSSTOG00000000313
37347 Tupaia belangeri ENSTBEG00000008704 59729 Taeniopygia guttata ENSTGUG00000009026
99883 Tetraodon nigroviridis ENSTNIG00000016959 31033 Takifugu rubripes ENSTRUG00000017486
9478 Tarsius syrichta ENSTSYG00000000155 30538 Vicugna pacos ENSVPAG00000005117