Basic Information
Gene ID 4862 ; Check Expression Profles ; Check TFs & Targets Binding
Gene Name NPAS2; BHLHE9, MOP4, PASD4
Full Name Neuronal PAS domain-containing protein 2
Organism Homo sapiens [9606]

Cross Reference
UniProt Q99743 UniGene Hs.705895
PDB NULL OMIM 608516
KEGG hsa:4862 UCSC uc002tap.1

Protein Interactions
DIP NULL
IntAct Q99743
MINT NULL
STRING 9606.ENSP00000338283

Ensembl/RefSeq
Transcript ID
Protein ID
Gene ID
ENSEMBL
ENSEMBL
REFSEQ
REFSEQ

InterPro Annotation
Protein Program Term IPRS Start End Score Description
ENSP00000438428 Gene3D G3DSA:4.10.280.10 IPR011598 75 123 8.90e-11 Myc-type, basic helix-loop-helix (bHLH) domain
ENSP00000438428 Pfam PF00010 IPR011598 75 122 7.70e-08 Myc-type, basic helix-loop-helix (bHLH) domain
ENSP00000438428 Pfam PF00989 IPR013767 150 221 2.50e-11 PAS fold
ENSP00000438428 PRINTS PR00785 IPR001067 140 163 2.40e-13 Nuclear translocator
ENSP00000438428 PRINTS PR00785 IPR001067 315 332 2.40e-13 Nuclear translocator
ENSP00000438428 PRINTS PR00785 IPR001067 89 104 2.40e-13 Nuclear translocator
ENSP00000438428 ProSiteProfiles PS50112 IPR000014 147 210 0.00e-00 PAS domain
ENSP00000438428 ProSiteProfiles PS50112 IPR000014 325 372 0.00e-00 PAS domain
ENSP00000438428 ProSiteProfiles PS50888 IPR011598 74 124 0.00e-00 Myc-type, basic helix-loop-helix (bHLH) domain
ENSP00000438428 SMART SM00086 IPR001610 376 419 2.40e-09 PAC motif
ENSP00000438428 SMART SM00091 IPR000014 149 215 5.20e-12 PAS domain
ENSP00000438428 SMART SM00091 IPR000014 304 370 1.30e-08 PAS domain
ENSP00000438428 SMART SM00353 IPR011598 80 130 2.10e-12 Myc-type, basic helix-loop-helix (bHLH) domain
ENSP00000438428 SUPERFAMILY SSF47459 IPR011598 71 143 0.00e-00 Myc-type, basic helix-loop-helix (bHLH) domain
ENSP00000438428 SUPERFAMILY SSF55785 IPR000014 158 217 0.00e-00 PAS domain
ENSP00000438428 SUPERFAMILY SSF55785 IPR000014 313 416 0.00e-00 PAS domain
ENSP00000438428 TIGRFAM TIGR00229 IPR000014 147 212 1.60e-05 PAS domain

Pfam Annotation
Protein Pfam ID E.value Name Description
ENSP00000438428 PF14598 4.6e-26 PAS_11 PAS domain
ENSP00000438428 PF08447 9.3e-16 PAS_3 PAS fold
ENSP00000438428 PF00989 6.9e-15 PAS PAS fold
ENSP00000438428 PF00010 3.4e-08 HLH Helix-loop-helix DNA-binding domain

Gene Ontology Annotation
Protein Entry Name Space Description
ENSP00000438428 GO:0006351 biological_process transcription, DNA-templated
ENSP00000438428 GO:0006355 biological_process regulation of transcription, DNA-templated
ENSP00000438428 GO:0006974 biological_process cellular response to DNA damage stimulus
ENSP00000438428 GO:0007165 biological_process signal transduction
ENSP00000438428 GO:0032922 biological_process circadian regulation of gene expression
ENSP00000438428 GO:0048511 biological_process rhythmic process
ENSP00000438428 GO:0005634 cellular_component nucleus
ENSP00000438428 GO:0005667 cellular_component transcription factor complex
ENSP00000438428 GO:0005694 cellular_component chromosome
ENSP00000438428 GO:0005737 cellular_component cytoplasm
ENSP00000438428 GO:0001047 molecular_function core promoter binding
ENSP00000438428 GO:0003677 molecular_function DNA binding
ENSP00000438428 GO:0003700 molecular_function sequence-specific DNA binding transcription factor activity
ENSP00000438428 GO:0004402 molecular_function histone acetyltransferase activity
ENSP00000438428 GO:0004871 molecular_function signal transducer activity
ENSP00000438428 GO:0046983 molecular_function protein dimerization activity

Orthologs
TAXID Organism Gene ID TAXID Organism Gene ID
10029 Cricetulus griseus 100756929 7463 Apis florea 100869092
143995 Megachile rotundata 100884063 9597 Pan paniscus 100971685
39432 Saimiri boliviensis 101052614 9595 Gorilla gorilla 101128296
10116 Rattus norvegicus 316351 7460 Apis mellifera 410757
9615 Canis familiaris 474552 7425 Nasonia vitripennis 100114103
8128 Oreochromis niloticus 100691220 34638 Metaseiulus occidentalis 100900259
9555 Papio anubis 101025212 9669 Mustela putorius furo 101689783
9913 Bos taurus ENSBTAG00000019697 9358 Choloepus hoffmanni ENSCHOG00000008122
10141 Cavia porcellus ENSCPOG00000002470 9361 Dasypus novemcinctus ENSDNOG00000002520
8049 Gadus morhua ENSGMOG00000012332 7897 Latimeria chalumnae ENSLACG00000011834
9103 Meleagris gallopavo ENSMGAG00000014799 30611 Otolemur garnettii ENSOGAG00000014490
9813 Procavia capensis ENSPCAG00000004689 9305 Sarcophilus harrisii ENSSHAG00000010526
59729 Taeniopygia guttata ENSTGUG00000010003 8083 Xiphophorus maculatus ENSXMAG00000012189
28377 Anolis carolinensis ENSACAG00000007946 10020 Dipodomys ordii ENSDORG00000015727
9796 Equus caballus ENSECAG00000000171 9371 Echinops telfairi ENSETEG00000008221
9685 Felis catus ENSFCAG00000005306 69293 Gasterosteus aculeatus ENSGACG00000020338
9031 Gallus gallus ENSGALG00000016774 9785 Loxodonta africana ENSLAFG00000016336
9315 Macropus eugenii ENSMEUG00000000949 30608 Microcebus murinus ENSMICG00000016027
9544 Macaca mulatta ENSMMUG00000009871 13616 Monodelphis domestica ENSMODG00000001691
9258 Ornithorhynchus anatinus ENSOANG00000011640 9986 Oryctolagus cuniculus ENSOCUG00000002384
9978 Ochotona princeps ENSOPRG00000001179 8090 Oryzias latipes ENSORLG00000009426
132908 Pteropus vampyrus ENSPVAG00000011717 9823 Sus scrofa ENSSSCG00000008171
43179 Ictidomys tridecemlineatus ENSSTOG00000008934 37347 Tupaia belangeri ENSTBEG00000012008
9478 Tarsius syrichta ENSTSYG00000005382 9739 Tursiops truncatus ENSTTRG00000016446
8364 Xenopus tropicalis ENSXETG00000021769