Basic Information
Gene ID 50943 ; Check Expression Profles ; Check TFs & Targets Binding
Gene Name FOXP3; IPEX; JM2
Full Name Forkhead box protein P3
Organism Homo sapiens [9606]

Cross Reference
UniProt Q9BZS1 UniGene Hs.247700
PDB 3QRF OMIM 304790
KEGG hsa:50943 UCSC uc022bwa.1

Protein Interactions
DIP DIP-36584N
IntAct Q9BZS1
MINT NULL
STRING 9606.ENSP00000365380

Ensembl/RefSeq
Transcript ID
Protein ID
Gene ID
ENSEMBL
ENSEMBL
ENSEMBL
ENSEMBL
ENSEMBL
ENSEMBL
ENSEMBL
ENSEMBL
ENSEMBL
ENSEMBL
ENSEMBL
ENSEMBL
REFSEQ
REFSEQ
REFSEQ
REFSEQ

InterPro Annotation
Protein Program Term IPRS Start End Score Description
ENSP00000451208 Gene3D G3DSA:1.10.10.10 IPR011991 290 346 2.70e-30 Winged helix-turn-helix DNA-binding domain
ENSP00000451208 Gene3D G3DSA:1.10.10.10 IPR011991 407 435 2.70e-30 Winged helix-turn-helix DNA-binding domain
ENSP00000451208 Gene3D G3DSA:3.30.160.60 IPR013087 163 192 4.10e-05 Zinc finger C2H2-type/integrase DNA-binding domain
ENSP00000451208 Pfam PF00250 IPR001766 302 349 1.50e-10 Transcription factor, fork head
ENSP00000451208 Pfam PF00250 IPR001766 407 440 8.10e-06 Transcription factor, fork head
ENSP00000451208 PRINTS PR00053 IPR001766 302 315 9.90e-13 Transcription factor, fork head
ENSP00000451208 PRINTS PR00053 IPR001766 323 340 9.90e-13 Transcription factor, fork head
ENSP00000451208 PRINTS PR00053 IPR001766 406 423 9.90e-13 Transcription factor, fork head
ENSP00000451208 ProSitePatterns PS00028 IPR007087 164 187 - Zinc finger, C2H2
ENSP00000451208 ProSiteProfiles PS50039 IPR001766 302 448 0.00e-00 Transcription factor, fork head
ENSP00000451208 SMART SM00339 IPR001766 300 442 1.90e-32 Transcription factor, fork head
ENSP00000451208 SMART SM00355 IPR015880 162 187 7.10e-04 Zinc finger, C2H2-like

Pfam Annotation
Protein Pfam ID E.value Name Description
ENSP00000451208 PF00250 3e-19 Fork_head Fork head domain

Gene Ontology Annotation
Protein Entry Name Space Description
ENSP00000451208 GO:0006351 biological_process transcription, DNA-templated
ENSP00000451208 GO:0045892 biological_process negative regulation of transcription, DNA-templated
ENSP00000451208 GO:0005634 cellular_component nucleus
ENSP00000451208 GO:0003700 molecular_function sequence-specific DNA binding transcription factor activity
ENSP00000451208 GO:0042803 molecular_function protein homodimerization activity
ENSP00000451208 GO:0043565 molecular_function sequence-specific DNA binding
ENSP00000451208 GO:0046872 molecular_function metal ion binding

Orthologs
TAXID Organism Gene ID TAXID Organism Gene ID
10029 Cricetulus griseus 100757421 9597 Pan paniscus 100990082
9555 Papio anubis 101018460 9615 Canis familiaris 481793
10224 Saccoglossus kowalevskii 100303474 9986 Oryctolagus cuniculus 100348270
30611 Otolemur garnettii 100963348 39432 Saimiri boliviensis 101035423
9669 Mustela putorius furo 101690558 43179 Ictidomys tridecemlineatus 101976591
10090 Mus musculus 20371 9823 Sus scrofa 444998
7955 Danio rerio 569047 7070 Tribolium castaneum 657917
9598 Pan troglodytes 736525 28377 Anolis carolinensis ENSACAG00000013683
9646 Ailuropoda melanoleuca ENSAMEG00000012121 9358 Choloepus hoffmanni ENSCHOG00000011947
9483 Callithrix jacchus ENSCJAG00000002813 10141 Cavia porcellus ENSCPOG00000006945
9361 Dasypus novemcinctus ENSDNOG00000019347 9371 Echinops telfairi ENSETEG00000017197
9685 Felis catus ENSFCAG00000003823 69293 Gasterosteus aculeatus ENSGACG00000011839
9031 Gallus gallus ENSGALG00000003375 9595 Gorilla gorilla ENSGGOG00000000913
8049 Gadus morhua ENSGMOG00000007392 9785 Loxodonta africana ENSLAFG00000003504
9315 Macropus eugenii ENSMEUG00000008944 9103 Meleagris gallopavo ENSMGAG00000009549
30608 Microcebus murinus ENSMICG00000006391 9544 Macaca mulatta ENSMMUG00000008624
13616 Monodelphis domestica ENSMODG00000009847 61853 Nomascus leucogenys ENSNLEG00000008046
9258 Ornithorhynchus anatinus ENSOANG00000013584 8128 Oreochromis niloticus ENSONIG00000016955
8090 Oryzias latipes ENSORLG00000013419 9813 Procavia capensis ENSPCAG00000014312
9601 Pongo abelii ENSPPYG00000016596 13735 Pelodiscus sinensis ENSPSIG00000011832
132908 Pteropus vampyrus ENSPVAG00000011787 9305 Sarcophilus harrisii ENSSHAG00000002680
37347 Tupaia belangeri ENSTBEG00000007687 59729 Taeniopygia guttata ENSTGUG00000009872
99883 Tetraodon nigroviridis ENSTNIG00000012565 31033 Takifugu rubripes ENSTRUG00000001947
9478 Tarsius syrichta ENSTSYG00000008106 9739 Tursiops truncatus ENSTTRG00000016973
30538 Vicugna pacos ENSVPAG00000000576 8364 Xenopus tropicalis ENSXETG00000031498
9913 Bos taurus ENSBTAG00000014211 10020 Dipodomys ordii ENSDORG00000000868
9796 Equus caballus ENSECAG00000022667 9365 Erinaceus europaeus ENSEEUG00000011556
7897 Latimeria chalumnae ENSLACG00000010141 59463 Myotis lucifugus ENSMLUG00000005709
9978 Ochotona princeps ENSOPRG00000014706 10116 Rattus norvegicus ENSRNOG00000005429
42254 Sorex araneus ENSSARG00000004029 8083 Xiphophorus maculatus ENSXMAG00000016493