Basic Information
Gene ID 51176 ; Check Expression Profles ; Check TFs & Targets Binding
Gene Name LEF1
Full Name Lymphoid enhancer-binding factor 1
Organism Homo sapiens [9606]

Cross Reference
UniProt Q9UJU2 UniGene Hs.743478
PDB NULL OMIM 153245
KEGG hsa:51176 UCSC uc003hyv.2

Protein Interactions
DIP DIP-29946N
IntAct Q9UJU2
MINT MINT-8329835
STRING 9606.ENSP00000265165

Ensembl/RefSeq
Transcript ID
Protein ID
Gene ID
ENSEMBL
ENSEMBL
ENSEMBL
ENSEMBL
ENSEMBL
REFSEQ
REFSEQ
REFSEQ
REFSEQ

InterPro Annotation
Protein Program Term IPRS Start End Score Description
NP_057353 Gene3D G3DSA:1.10.30.10 IPR009071 297 379 8.30e-29 High mobility group box domain
NP_057353 Gene3D G3DSA:4.10.900.10 IPR027397 1 69 3.30e-26 Catenin binding domain
NP_057353 PANTHER PTHR10373 IPR024940 1 399 0.00e-00 Transcription factor TCF/LEF
NP_057353 PANTHER PTHR10373:SF11 IPR028769 1 399 0.00e-00 Lymphoid enhancer-binding factor 1
NP_057353 Pfam PF00505 IPR009071 299 366 1.20e-21 High mobility group box domain
NP_057353 Pfam PF08347 IPR013558 1 213 1.00e-73 CTNNB1 binding, N-teminal
NP_057353 ProSiteProfiles PS50118 IPR009071 299 367 0.00e-00 High mobility group box domain
NP_057353 SMART SM00398 IPR009071 298 368 2.50e-25 High mobility group box domain
NP_057353 SUPERFAMILY SSF47095 IPR009071 298 379 0.00e-00 High mobility group box domain

Pfam Annotation
Protein Pfam ID E.value Name Description
NP_057353 PF08347 0 CTNNB1_binding N-terminal CTNNB1 binding
NP_057353 PF00505 1.2e-21 HMG_box HMG (high mobility group) box
NP_057353 PF09011 2.9e-08 HMG_box_2 HMG-box domain

Gene Ontology Annotation
Protein Entry Name Space Description
NP_057353 GO:0060070 biological_process canonical Wnt signaling pathway
NP_057353 GO:0005634 cellular_component nucleus
NP_057353 GO:0003700 molecular_function sequence-specific DNA binding transcription factor activity
NP_057353 GO:0008013 molecular_function beta-catenin binding