Basic Information
Gene ID 58508 ; Check Expression Profles ; Check TFs & Targets Binding
Gene Name KMT2C; HALR, KIAA1506, MLL3
Full Name Histone-lysine N-methyltransferase 2C
Organism Homo sapiens [9606]

Cross Reference
UniProt Q8NEZ4 UniGene Hs.647120
PDB 4ERY OMIM 606833
KEGG hsa:58508 UCSC uc003wla.3

Protein Interactions
DIP DIP-48649N
IntAct Q8NEZ4
MINT MINT-3042700
STRING 9606.ENSP00000262189

Ensembl/RefSeq
Transcript ID
Protein ID
Gene ID
ENSEMBL
ENSEMBL
REFSEQ

InterPro Annotation
Protein Program Term IPRS Start End Score Description
ENSP00000347325 Gene3D G3DSA:3.30.40.10 IPR013083 1008 1055 4.60e-14 Zinc finger, RING/FYVE/PHD-type
ENSP00000347325 Gene3D G3DSA:3.30.40.10 IPR013083 1086 1139 5.00e-07 Zinc finger, RING/FYVE/PHD-type
ENSP00000347325 Gene3D G3DSA:3.30.40.10 IPR013083 332 389 7.70e-09 Zinc finger, RING/FYVE/PHD-type
ENSP00000347325 Gene3D G3DSA:3.30.40.10 IPR013083 390 436 4.80e-13 Zinc finger, RING/FYVE/PHD-type
ENSP00000347325 Gene3D G3DSA:3.30.40.10 IPR013083 461 519 4.70e-06 Zinc finger, RING/FYVE/PHD-type
ENSP00000347325 Gene3D G3DSA:3.30.40.10 IPR013083 956 1007 3.00e-10 Zinc finger, RING/FYVE/PHD-type
ENSP00000347325 Pfam PF00628 IPR019787 1009 1055 1.20e-09 Zinc finger, PHD-finger
ENSP00000347325 Pfam PF00628 IPR019787 390 437 8.50e-09 Zinc finger, PHD-finger
ENSP00000347325 Pfam PF00856 IPR001214 4839 4943 4.20e-24 SET domain
ENSP00000347325 Pfam PF05964 IPR003888 4607 4659 2.60e-20 FY-rich, N-terminal
ENSP00000347325 Pfam PF05965 IPR003889 4663 4750 1.60e-24 FY-rich, C-terminal
ENSP00000347325 ProSitePatterns PS00354 IPR000637 31 42 - HMG-I/HMG-Y, DNA-binding, conserved site
ENSP00000347325 ProSiteProfiles PS50016 IPR019787 1007 1057 0.00e-00 Zinc finger, PHD-finger
ENSP00000347325 ProSiteProfiles PS50016 IPR019787 1084 1139 0.00e-00 Zinc finger, PHD-finger
ENSP00000347325 ProSiteProfiles PS50016 IPR019787 341 391 0.00e-00 Zinc finger, PHD-finger
ENSP00000347325 ProSiteProfiles PS50016 IPR019787 388 438 0.00e-00 Zinc finger, PHD-finger
ENSP00000347325 ProSiteProfiles PS50016 IPR019787 464 520 0.00e-00 Zinc finger, PHD-finger
ENSP00000347325 ProSiteProfiles PS50016 IPR019787 957 1010 0.00e-00 Zinc finger, PHD-finger
ENSP00000347325 ProSiteProfiles PS50089 IPR001841 344 389 0.00e-00 Zinc finger, RING-type
ENSP00000347325 ProSiteProfiles PS50216 IPR001594 436 473 0.00e-00 Zinc finger, DHHC-type, palmitoyltransferase
ENSP00000347325 ProSiteProfiles PS50280 IPR001214 4828 4944 0.00e-00 SET domain
ENSP00000347325 ProSiteProfiles PS50868 IPR003616 4952 4968 0.00e-00 Post-SET domain
ENSP00000347325 ProSiteProfiles PS51542 IPR003888 4602 4662 0.00e-00 FY-rich, N-terminal
ENSP00000347325 ProSiteProfiles PS51543 IPR003889 4663 4748 0.00e-00 FY-rich, C-terminal
ENSP00000347325 SMART SM00109 IPR002219 1000 1051 3.20e-04 Protein kinase C-like, phorbol ester/diacylglycerol binding
ENSP00000347325 SMART SM00109 IPR002219 318 385 3.10e-03 Protein kinase C-like, phorbol ester/diacylglycerol binding
ENSP00000347325 SMART SM00184 IPR001841 344 388 5.60e-04 Zinc finger, RING-type
ENSP00000347325 SMART SM00184 IPR001841 391 435 5.60e-03 Zinc finger, RING-type
ENSP00000347325 SMART SM00184 IPR001841 4519 4563 4.00e-02 Zinc finger, RING-type
ENSP00000347325 SMART SM00184 IPR001841 960 1007 1.80e-02 Zinc finger, RING-type
ENSP00000347325 SMART SM00249 IPR001965 1009 1055 5.20e-15 Zinc finger, PHD-type
ENSP00000347325 SMART SM00249 IPR001965 1086 1137 9.40e-06 Zinc finger, PHD-type
ENSP00000347325 SMART SM00249 IPR001965 284 331 1.60e-03 Zinc finger, PHD-type
ENSP00000347325 SMART SM00249 IPR001965 343 389 2.10e-09 Zinc finger, PHD-type
ENSP00000347325 SMART SM00249 IPR001965 390 436 2.40e-13 Zinc finger, PHD-type
ENSP00000347325 SMART SM00249 IPR001965 4518 4564 2.10e-04 Zinc finger, PHD-type
ENSP00000347325 SMART SM00249 IPR001965 466 518 4.60e-08 Zinc finger, PHD-type
ENSP00000347325 SMART SM00249 IPR001965 959 1008 1.50e-12 Zinc finger, PHD-type
ENSP00000347325 SMART SM00317 IPR001214 4828 4950 1.30e-36 SET domain
ENSP00000347325 SMART SM00384 IPR017956 34 46 4.70e-03 AT hook, DNA-binding motif
ENSP00000347325 SMART SM00384 IPR017956 904 916 6.60e-01 AT hook, DNA-binding motif
ENSP00000347325 SMART SM00398 IPR009071 1649 1713 8.90e-06 High mobility group box domain
ENSP00000347325 SMART SM00508 IPR003616 4952 4968 7.30e-09 Post-SET domain
ENSP00000347325 SMART SM00541 IPR003888 4618 4661 3.90e-24 FY-rich, N-terminal
ENSP00000347325 SMART SM00542 IPR003889 4667 4754 1.20e-33 FY-rich, C-terminal
ENSP00000347325 SUPERFAMILY SSF47095 IPR009071 1655 1702 0.00e-00 High mobility group box domain
ENSP00000347325 SUPERFAMILY SSF57903 IPR011011 1000 1061 0.00e-00 Zinc finger, FYVE/PHD-type
ENSP00000347325 SUPERFAMILY SSF57903 IPR011011 1074 1141 0.00e-00 Zinc finger, FYVE/PHD-type
ENSP00000347325 SUPERFAMILY SSF57903 IPR011011 337 394 0.00e-00 Zinc finger, FYVE/PHD-type
ENSP00000347325 SUPERFAMILY SSF57903 IPR011011 381 443 0.00e-00 Zinc finger, FYVE/PHD-type
ENSP00000347325 SUPERFAMILY SSF57903 IPR011011 457 520 0.00e-00 Zinc finger, FYVE/PHD-type
ENSP00000347325 SUPERFAMILY SSF57903 IPR011011 950 1008 0.00e-00 Zinc finger, FYVE/PHD-type

Pfam Annotation
Protein Pfam ID E.value Name Description
ENSP00000347325 PF00628 8.1e-38 PHD PHD-finger
ENSP00000347325 PF05965 3.5e-25 FYRC F/Y rich C-terminus
ENSP00000347325 PF00856 4.2e-24 SET SET domain
ENSP00000347325 PF13771 3.9e-22 zf-HC5HC2H PHD-like zinc-binding domain
ENSP00000347325 PF05964 1.3e-20 FYRN F/Y-rich N-terminus
ENSP00000347325 PF13832 8.1e-14 zf-HC5HC2H_2 PHD-zinc-finger like domain
ENSP00000347325 PF00505 7.7e-05 HMG_box HMG (high mobility group) box

Gene Ontology Annotation
Protein Entry Name Space Description
ENSP00000347325 GO:0051568 biological_process histone H3-K4 methylation
ENSP00000347325 GO:0005634 cellular_component nucleus
ENSP00000347325 GO:0035097 cellular_component histone methyltransferase complex
ENSP00000347325 GO:0008270 molecular_function zinc ion binding

Orthologs
TAXID Organism Gene ID TAXID Organism Gene ID
9597 Pan paniscus 100992231 39432 Saimiri boliviensis 101043552
9646 Ailuropoda melanoleuca ENSAMEG00000013308 10020 Dipodomys ordii ENSDORG00000002330
9685 Felis catus ENSFCAG00000008632 9103 Meleagris gallopavo ENSMGAG00000004716
9669 Mustela putorius furo ENSMPUG00000009228 9258 Ornithorhynchus anatinus ENSOANG00000006160
8128 Oreochromis niloticus ENSONIG00000009769 9305 Sarcophilus harrisii ENSSHAG00000011852
43179 Ictidomys tridecemlineatus ENSSTOG00000013723 28377 Anolis carolinensis ENSACAG00000014195
9913 Bos taurus ENSBTAG00000024199 9615 Canis familiaris ENSCAFG00000004955
7955 Danio rerio ENSDARG00000075560 9796 Equus caballus ENSECAG00000022544
9371 Echinops telfairi ENSETEG00000014286 69293 Gasterosteus aculeatus ENSGACG00000013375
9031 Gallus gallus ENSGALG00000006264 9595 Gorilla gorilla ENSGGOG00000025173
8049 Gadus morhua ENSGMOG00000003449 7897 Latimeria chalumnae ENSLACG00000009033
9785 Loxodonta africana ENSLAFG00000007897 59463 Myotis lucifugus ENSMLUG00000010947
9544 Macaca mulatta ENSMMUG00000007212 61853 Nomascus leucogenys ENSNLEG00000004634
9986 Oryctolagus cuniculus ENSOCUG00000011322 30611 Otolemur garnettii ENSOGAG00000006574
8090 Oryzias latipes ENSORLG00000016772 7757 Petromyzon marinus ENSPMAG00000002341
9598 Pan troglodytes ENSPTRG00000019892 132908 Pteropus vampyrus ENSPVAG00000008322
9823 Sus scrofa ENSSSCG00000020663 59729 Taeniopygia guttata ENSTGUG00000000616
99883 Tetraodon nigroviridis ENSTNIG00000015229 31033 Takifugu rubripes ENSTRUG00000005765
9478 Tarsius syrichta ENSTSYG00000014542 9739 Tursiops truncatus ENSTTRG00000017060
30538 Vicugna pacos ENSVPAG00000001618 8083 Xiphophorus maculatus ENSXMAG00000016422