Basic Information
Gene ID 6596 ; Check Expression Profles ; Check TFs & Targets Binding
Gene Name HLTF; HIP116A, RNF80, SMARCA3, SNF2L3, ZBU1
Full Name Helicase-like transcription factor
Organism Homo sapiens [9606]

Cross Reference
UniProt Q14527 UniGene Hs.3068
PDB 4HRH OMIM 603257
KEGG hsa:6596 UCSC uc003ewq.1

Protein Interactions
DIP DIP-29828N
IntAct Q14527
MINT MINT-1639589
STRING 9606.ENSP00000308944

Ensembl/RefSeq
Transcript ID
Protein ID
Gene ID
ENSEMBL
ENSEMBL
ENSEMBL
ENSEMBL
REFSEQ
REFSEQ
REFSEQ

InterPro Annotation
Protein Program Term IPRS Start End Score Description
ENSP00000376644 Gene3D G3DSA:3.30.40.10 IPR013083 756 811 4.10e-16 Zinc finger, RING/FYVE/PHD-type
ENSP00000376644 Pfam PF00176 IPR000330 243 721 4.70e-83 SNF2-related
ENSP00000376644 Pfam PF00271 IPR001650 871 950 2.30e-10 Helicase, C-terminal
ENSP00000376644 Pfam PF08797 IPR014905 61 153 1.10e-18 HIP116, Rad5p N-terminal
ENSP00000376644 Pfam PF13639 IPR001841 758 801 5.30e-08 Zinc finger, RING-type
ENSP00000376644 ProSitePatterns PS00518 IPR017907 775 784 - Zinc finger, RING-type, conserved site
ENSP00000376644 ProSiteProfiles PS50089 IPR001841 760 801 0.00e-00 Zinc finger, RING-type
ENSP00000376644 ProSiteProfiles PS51192 IPR014001 435 606 0.00e-00 Helicase, superfamily 1/2, ATP-binding domain
ENSP00000376644 ProSiteProfiles PS51194 IPR001650 837 996 0.00e-00 Helicase, C-terminal
ENSP00000376644 SMART SM00184 IPR001841 760 800 5.30e-09 Zinc finger, RING-type
ENSP00000376644 SMART SM00487 IPR014001 236 614 3.50e-36 Helicase, superfamily 1/2, ATP-binding domain
ENSP00000376644 SMART SM00490 IPR001650 865 950 8.20e-18 Helicase, C-terminal
ENSP00000376644 SMART SM00910 IPR014905 60 154 7.10e-31 HIP116, Rad5p N-terminal
ENSP00000376644 SUPERFAMILY SSF52540 IPR027417 214 321 0.00e-00 P-loop containing nucleoside triphosphate hydrolase
ENSP00000376644 SUPERFAMILY SSF52540 IPR027417 475 644 0.00e-00 P-loop containing nucleoside triphosphate hydrolase
ENSP00000376644 SUPERFAMILY SSF52540 IPR027417 651 750 0.00e-00 P-loop containing nucleoside triphosphate hydrolase
ENSP00000376644 SUPERFAMILY SSF52540 IPR027417 825 1008 0.00e-00 P-loop containing nucleoside triphosphate hydrolase

Pfam Annotation
Protein Pfam ID E.value Name Description
ENSP00000376644 PF00176 0 SNF2_N SNF2 family N-terminal domain
ENSP00000376644 PF08797 4.7e-19 HIRAN HIRAN domain
ENSP00000376644 PF00271 7.4e-11 Helicase_C Helicase conserved C-terminal domain
ENSP00000376644 PF13639 2.6e-08 zf-RING_2 Ring finger domain
ENSP00000376644 PF13923 9.6e-07 zf-C3HC4_2 Zinc finger, C3HC4 type (RING finger)
ENSP00000376644 PF00097 1.6e-06 zf-C3HC4 Zinc finger, C3HC4 type (RING finger)
ENSP00000376644 PF13920 1.7e-06 zf-C3HC4_3 Zinc finger, C3HC4 type (RING finger)
ENSP00000376644 PF15227 9e-05 zf-C3HC4_4 zinc finger of C3HC4-type, RING
ENSP00000376644 PF14634 0.00011 zf-RING_5 zinc-RING finger domain

Gene Ontology Annotation
Protein Entry Name Space Description
ENSP00000376644 GO:0005634 cellular_component nucleus
ENSP00000376644 GO:0003677 molecular_function DNA binding
ENSP00000376644 GO:0004386 molecular_function helicase activity
ENSP00000376644 GO:0005524 molecular_function ATP binding

Orthologs
TAXID Organism Gene ID TAXID Organism Gene ID
6087 Hydra magnipapillata 100209468 8128 Oreochromis niloticus 100711188
10029 Cricetulus griseus 100751958 39432 Saimiri boliviensis 101036702
9669 Mustela putorius furo 101694606 10116 Rattus norvegicus 295568
7668 Strongylocentrotus purpuratus 581625 9597 Pan paniscus 100991338
9555 Papio anubis 101002190 28377 Anolis carolinensis ENSACAG00000007116
9913 Bos taurus ENSBTAG00000019704 9358 Choloepus hoffmanni ENSCHOG00000010519
9595 Gorilla gorilla ENSGGOG00000001261 7897 Latimeria chalumnae ENSLACG00000007872
9785 Loxodonta africana ENSLAFG00000006515 9544 Macaca mulatta ENSMMUG00000005526
13616 Monodelphis domestica ENSMODG00000021258 9986 Oryctolagus cuniculus ENSOCUG00000003520
30611 Otolemur garnettii ENSOGAG00000008324 13735 Pelodiscus sinensis ENSPSIG00000014558
9823 Sus scrofa ENSSSCG00000025293 31033 Takifugu rubripes ENSTRUG00000014279
9478 Tarsius syrichta ENSTSYG00000014645 9739 Tursiops truncatus ENSTTRG00000004565
30538 Vicugna pacos ENSVPAG00000009002 8364 Xenopus tropicalis ENSXETG00000029917
8083 Xiphophorus maculatus ENSXMAG00000009324 9646 Ailuropoda melanoleuca ENSAMEG00000010901
9361 Dasypus novemcinctus ENSDNOG00000015496 10020 Dipodomys ordii ENSDORG00000016121
9796 Equus caballus ENSECAG00000024277 9365 Erinaceus europaeus ENSEEUG00000015484
9685 Felis catus ENSFCAG00000003221 69293 Gasterosteus aculeatus ENSGACG00000010755
8049 Gadus morhua ENSGMOG00000012840 59463 Myotis lucifugus ENSMLUG00000014077
9978 Ochotona princeps ENSOPRG00000009532 8090 Oryzias latipes ENSORLG00000012329
9813 Procavia capensis ENSPCAG00000015708 9601 Pongo abelii ENSPPYG00000014193
132908 Pteropus vampyrus ENSPVAG00000012583 42254 Sorex araneus ENSSARG00000011491
9305 Sarcophilus harrisii ENSSHAG00000000533 43179 Ictidomys tridecemlineatus ENSSTOG00000001694
37347 Tupaia belangeri ENSTBEG00000001461 99883 Tetraodon nigroviridis ENSTNIG00000019430