Basic Information
Gene ID 6662 ; Check Expression Profles ; Check TFs & Targets Binding
Gene Name SOX9
Full Name Transcription factor SOX-9
Organism Homo sapiens [9606]

Cross Reference
UniProt P48436 UniGene Hs.647409
PDB 4EUW OMIM 608160
KEGG hsa:6662 UCSC uc002jiw.3

Protein Interactions
DIP NULL
IntAct P48436
MINT NULL
STRING 9606.ENSP00000245479

Ensembl/RefSeq
Transcript ID
Protein ID
Gene ID
ENSEMBL
REFSEQ

InterPro Annotation
Protein Program Term IPRS Start End Score Description
NP_000337 Gene3D G3DSA:1.10.30.10 IPR009071 103 183 6.60e-34 High mobility group box domain
NP_000337 Pfam PF00505 IPR009071 105 173 1.00e-24 High mobility group box domain
NP_000337 Pfam PF12444 IPR022151 22 95 1.60e-27 Sox developmental protein N-terminal
NP_000337 ProSiteProfiles PS50118 IPR009071 105 173 0.00e-00 High mobility group box domain
NP_000337 SMART SM00398 IPR009071 104 174 7.40e-30 High mobility group box domain
NP_000337 SUPERFAMILY SSF47095 IPR009071 87 177 0.00e-00 High mobility group box domain

Pfam Annotation
Protein Pfam ID E.value Name Description
NP_000337 PF12444 1.6e-27 Sox_N Sox developmental protein N terminal
NP_000337 PF00505 4.1e-25 HMG_box HMG (high mobility group) box
NP_000337 PF09011 1.6e-10 HMG_box_2 HMG-box domain

Gene Ontology Annotation
Protein Entry Name Space Description
NP_000337 GO:0001501 biological_process skeletal system development
NP_000337 GO:0001502 biological_process cartilage condensation
NP_000337 GO:0001708 biological_process cell fate specification
NP_000337 GO:0001837 biological_process epithelial to mesenchymal transition
NP_000337 GO:0001894 biological_process tissue homeostasis
NP_000337 GO:0001934 biological_process positive regulation of protein phosphorylation
NP_000337 GO:0001942 biological_process hair follicle development
NP_000337 GO:0002053 biological_process positive regulation of mesenchymal cell proliferation
NP_000337 GO:0002683 biological_process negative regulation of immune system process
NP_000337 GO:0003170 biological_process heart valve development
NP_000337 GO:0003179 biological_process heart valve morphogenesis
NP_000337 GO:0003203 biological_process endocardial cushion morphogenesis
NP_000337 GO:0003413 biological_process chondrocyte differentiation involved in endochondral bone morphogenesis
NP_000337 GO:0003415 biological_process chondrocyte hypertrophy
NP_000337 GO:0006334 biological_process nucleosome assembly
NP_000337 GO:0006338 biological_process chromatin remodeling
NP_000337 GO:0006351 biological_process transcription, DNA-templated
NP_000337 GO:0006355 biological_process regulation of transcription, DNA-templated
NP_000337 GO:0006366 biological_process transcription from RNA polymerase II promoter
NP_000337 GO:0006461 biological_process protein complex assembly
NP_000337 GO:0006468 biological_process protein phosphorylation
NP_000337 GO:0007165 biological_process signal transduction
NP_000337 GO:0007173 biological_process epidermal growth factor receptor signaling pathway
NP_000337 GO:0007283 biological_process spermatogenesis
NP_000337 GO:0008284 biological_process positive regulation of cell proliferation
NP_000337 GO:0010564 biological_process regulation of cell cycle process
NP_000337 GO:0010634 biological_process positive regulation of epithelial cell migration
NP_000337 GO:0014068 biological_process positive regulation of phosphatidylinositol 3-kinase signaling
NP_000337 GO:0019100 biological_process male germ-line sex determination
NP_000337 GO:0019933 biological_process cAMP-mediated signaling
NP_000337 GO:0030279 biological_process negative regulation of ossification
NP_000337 GO:0030858 biological_process positive regulation of epithelial cell differentiation
NP_000337 GO:0030916 biological_process otic vesicle formation
NP_000337 GO:0032331 biological_process negative regulation of chondrocyte differentiation
NP_000337 GO:0032332 biological_process positive regulation of chondrocyte differentiation
NP_000337 GO:0035019 biological_process somatic stem cell maintenance
NP_000337 GO:0042127 biological_process regulation of cell proliferation
NP_000337 GO:0042981 biological_process regulation of apoptotic process
NP_000337 GO:0043066 biological_process negative regulation of apoptotic process
NP_000337 GO:0043491 biological_process protein kinase B signaling
NP_000337 GO:0045662 biological_process negative regulation of myoblast differentiation
NP_000337 GO:0045892 biological_process negative regulation of transcription, DNA-templated
NP_000337 GO:0045944 biological_process positive regulation of transcription from RNA polymerase II promoter
NP_000337 GO:0046533 biological_process negative regulation of photoreceptor cell differentiation
NP_000337 GO:0050679 biological_process positive regulation of epithelial cell proliferation
NP_000337 GO:0050680 biological_process negative regulation of epithelial cell proliferation
NP_000337 GO:0051216 biological_process cartilage development
NP_000337 GO:0060008 biological_process Sertoli cell differentiation
NP_000337 GO:0060041 biological_process retina development in camera-type eye
NP_000337 GO:0060221 biological_process retinal rod cell differentiation
NP_000337 GO:0060517 biological_process epithelial cell proliferation involved in prostatic bud elongation
NP_000337 GO:0060729 biological_process intestinal epithelial structure maintenance
NP_000337 GO:0060784 biological_process regulation of cell proliferation involved in tissue homeostasis
NP_000337 GO:0061138 biological_process morphogenesis of a branching epithelium
NP_000337 GO:0070168 biological_process negative regulation of biomineral tissue development
NP_000337 GO:0070371 biological_process ERK1 and ERK2 cascade
NP_000337 GO:0071260 biological_process cellular response to mechanical stimulus
NP_000337 GO:0071364 biological_process cellular response to epidermal growth factor stimulus
NP_000337 GO:0071504 biological_process cellular response to heparin
NP_000337 GO:0072034 biological_process renal vesicle induction
NP_000337 GO:0072289 biological_process metanephric nephron tubule formation
NP_000337 GO:0090090 biological_process negative regulation of canonical Wnt signaling pathway
NP_000337 GO:0090103 biological_process cochlea morphogenesis
NP_000337 GO:0090184 biological_process positive regulation of kidney development
NP_000337 GO:0090190 biological_process positive regulation of branching involved in ureteric bud morphogenesis
NP_000337 GO:2000020 biological_process positive regulation of male gonad development
NP_000337 GO:2000741 biological_process positive regulation of mesenchymal stem cell differentiation
NP_000337 GO:0005634 cellular_component nucleus
NP_000337 GO:0043234 cellular_component protein complex
NP_000337 GO:0001046 molecular_function core promoter sequence-specific DNA binding
NP_000337 GO:0001077 molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
NP_000337 GO:0001158 molecular_function enhancer sequence-specific DNA binding
NP_000337 GO:0003677 molecular_function DNA binding
NP_000337 GO:0003682 molecular_function chromatin binding
NP_000337 GO:0003705 molecular_function RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
NP_000337 GO:0004672 molecular_function protein kinase activity
NP_000337 GO:0035326 molecular_function enhancer binding