Basic Information
Gene ID 6929 ; Check Expression Profles ; Check TFs & Targets Binding
Gene Name TCF3; BHLHB21, E2A, ITF1
Full Name Transcription factor E2-alpha
Organism Homo sapiens [9606]

Cross Reference
UniProt P15923 UniGene Hs.657044
PDB 3U5V OMIM 147141
KEGG hsa:6929 UCSC uc002lts.1

Protein Interactions
DIP DIP-74N
IntAct P15923
MINT MINT-190187
STRING 9606.ENSP00000262965

Ensembl/RefSeq
Transcript ID
Protein ID
Gene ID
ENSEMBL
ENSEMBL
ENSEMBL
ENSEMBL
ENSEMBL
REFSEQ
REFSEQ
REFSEQ
REFSEQ

InterPro Annotation
Protein Program Term IPRS Start End Score Description
ENSP00000378813 Gene3D G3DSA:4.10.280.10 IPR011598 554 613 2.00e-26 Myc-type, basic helix-loop-helix (bHLH) domain
ENSP00000378813 Pfam PF00010 IPR011598 554 607 7.50e-10 Myc-type, basic helix-loop-helix (bHLH) domain
ENSP00000378813 ProSiteProfiles PS50888 IPR011598 553 606 0.00e-00 Myc-type, basic helix-loop-helix (bHLH) domain
ENSP00000378813 SMART SM00353 IPR011598 559 612 1.90e-12 Myc-type, basic helix-loop-helix (bHLH) domain
ENSP00000378813 SUPERFAMILY SSF47459 IPR011598 544 612 0.00e-00 Myc-type, basic helix-loop-helix (bHLH) domain

Pfam Annotation
Protein Pfam ID E.value Name Description
ENSP00000378813 PF00010 3.7e-10 HLH Helix-loop-helix DNA-binding domain

Gene Ontology Annotation
Protein Entry Name Space Description
ENSP00000378813 GO:0006351 biological_process transcription, DNA-templated
ENSP00000378813 GO:0006355 biological_process regulation of transcription, DNA-templated
ENSP00000378813 GO:0045666 biological_process positive regulation of neuron differentiation
ENSP00000378813 GO:0005634 cellular_component nucleus
ENSP00000378813 GO:0046982 molecular_function protein heterodimerization activity
ENSP00000378813 GO:0070888 molecular_function E-box binding

Orthologs
TAXID Organism Gene ID TAXID Organism Gene ID
10029 Cricetulus griseus 100768423 9597 Pan paniscus 100969894
9555 Papio anubis 100998266 39432 Saimiri boliviensis 101028931
9669 Mustela putorius furo 101691224 13735 Pelodiscus sinensis 102460048
10116 Rattus norvegicus 171046 9031 Gallus gallus 395146
9258 Ornithorhynchus anatinus ENSOANG00000014335 132908 Pteropus vampyrus ENSPVAG00000014587
59729 Taeniopygia guttata ENSTGUG00000000208 9646 Ailuropoda melanoleuca ENSAMEG00000003503
9483 Callithrix jacchus ENSCJAG00000004642 10141 Cavia porcellus ENSCPOG00000023586
10020 Dipodomys ordii ENSDORG00000004745 9796 Equus caballus ENSECAG00000000623
9371 Echinops telfairi ENSETEG00000015388 9685 Felis catus ENSFCAG00000023514
69293 Gasterosteus aculeatus ENSGACG00000012737 9595 Gorilla gorilla ENSGGOG00000003667
9785 Loxodonta africana ENSLAFG00000026277 9315 Macropus eugenii ENSMEUG00000014058
59463 Myotis lucifugus ENSMLUG00000011221 9544 Macaca mulatta ENSMMUG00000009017
13616 Monodelphis domestica ENSMODG00000004143 61853 Nomascus leucogenys ENSNLEG00000001742
30611 Otolemur garnettii ENSOGAG00000003587 9978 Ochotona princeps ENSOPRG00000008737
9601 Pongo abelii ENSPPYG00000009327 9598 Pan troglodytes ENSPTRG00000010211
9305 Sarcophilus harrisii ENSSHAG00000013735 9823 Sus scrofa ENSSSCG00000013437
43179 Ictidomys tridecemlineatus ENSSTOG00000010293 99883 Tetraodon nigroviridis ENSTNIG00000015322
31033 Takifugu rubripes ENSTRUG00000017901 8083 Xiphophorus maculatus ENSXMAG00000012718