Basic Information | |||
Gene ID | 6929 ; Check Expression Profles ; Check TFs & Targets Binding | ||
Gene Name | TCF3; BHLHB21, E2A, ITF1 | ||
Full Name | Transcription factor E2-alpha | ||
Organism | Homo sapiens [9606] |
Cross Reference | |||
UniProt | P15923 | UniGene | Hs.657044 |
PDB | 3U5V | OMIM | 147141 |
KEGG | hsa:6929 | UCSC | uc002lts.1 |
Protein Interactions | |
DIP | DIP-74N |
IntAct | P15923 |
MINT | MINT-190187 |
STRING | 9606.ENSP00000262965 |
Ensembl/RefSeq | Transcript ID | Protein ID | Gene ID |
ENSEMBL | |||
ENSEMBL | |||
ENSEMBL | |||
ENSEMBL | |||
ENSEMBL | |||
REFSEQ | |||
REFSEQ | |||
REFSEQ | |||
REFSEQ |
InterPro Annotation | |||||||
Protein | Program | Term | IPRS | Start | End | Score | Description |
ENSP00000378813 | Gene3D | G3DSA:4.10.280.10 | IPR011598 | 554 | 613 | 2.00e-26 | Myc-type, basic helix-loop-helix (bHLH) domain |
ENSP00000378813 | Pfam | PF00010 | IPR011598 | 554 | 607 | 7.50e-10 | Myc-type, basic helix-loop-helix (bHLH) domain |
ENSP00000378813 | ProSiteProfiles | PS50888 | IPR011598 | 553 | 606 | 0.00e-00 | Myc-type, basic helix-loop-helix (bHLH) domain |
ENSP00000378813 | SMART | SM00353 | IPR011598 | 559 | 612 | 1.90e-12 | Myc-type, basic helix-loop-helix (bHLH) domain |
ENSP00000378813 | SUPERFAMILY | SSF47459 | IPR011598 | 544 | 612 | 0.00e-00 | Myc-type, basic helix-loop-helix (bHLH) domain |
Pfam Annotation | ||||
Protein | Pfam ID | E.value | Name | Description |
ENSP00000378813 | PF00010 | 3.7e-10 | HLH | Helix-loop-helix DNA-binding domain |
Gene Ontology Annotation | |||
Protein | Entry | Name Space | Description |
ENSP00000378813 | GO:0006351 | biological_process | transcription, DNA-templated |
ENSP00000378813 | GO:0006355 | biological_process | regulation of transcription, DNA-templated |
ENSP00000378813 | GO:0045666 | biological_process | positive regulation of neuron differentiation |
ENSP00000378813 | GO:0005634 | cellular_component | nucleus |
ENSP00000378813 | GO:0046982 | molecular_function | protein heterodimerization activity |
ENSP00000378813 | GO:0070888 | molecular_function | E-box binding |
Orthologs | |||||
TAXID | Organism | Gene ID | TAXID | Organism | Gene ID |
10029 | Cricetulus griseus | 100768423 | 9597 | Pan paniscus | 100969894 |
9555 | Papio anubis | 100998266 | 39432 | Saimiri boliviensis | 101028931 |
9669 | Mustela putorius furo | 101691224 | 13735 | Pelodiscus sinensis | 102460048 |
10116 | Rattus norvegicus | 171046 | 9031 | Gallus gallus | 395146 |
9258 | Ornithorhynchus anatinus | ENSOANG00000014335 | 132908 | Pteropus vampyrus | ENSPVAG00000014587 |
59729 | Taeniopygia guttata | ENSTGUG00000000208 | 9646 | Ailuropoda melanoleuca | ENSAMEG00000003503 |
9483 | Callithrix jacchus | ENSCJAG00000004642 | 10141 | Cavia porcellus | ENSCPOG00000023586 |
10020 | Dipodomys ordii | ENSDORG00000004745 | 9796 | Equus caballus | ENSECAG00000000623 |
9371 | Echinops telfairi | ENSETEG00000015388 | 9685 | Felis catus | ENSFCAG00000023514 |
69293 | Gasterosteus aculeatus | ENSGACG00000012737 | 9595 | Gorilla gorilla | ENSGGOG00000003667 |
9785 | Loxodonta africana | ENSLAFG00000026277 | 9315 | Macropus eugenii | ENSMEUG00000014058 |
59463 | Myotis lucifugus | ENSMLUG00000011221 | 9544 | Macaca mulatta | ENSMMUG00000009017 |
13616 | Monodelphis domestica | ENSMODG00000004143 | 61853 | Nomascus leucogenys | ENSNLEG00000001742 |
30611 | Otolemur garnettii | ENSOGAG00000003587 | 9978 | Ochotona princeps | ENSOPRG00000008737 |
9601 | Pongo abelii | ENSPPYG00000009327 | 9598 | Pan troglodytes | ENSPTRG00000010211 |
9305 | Sarcophilus harrisii | ENSSHAG00000013735 | 9823 | Sus scrofa | ENSSSCG00000013437 |
43179 | Ictidomys tridecemlineatus | ENSSTOG00000010293 | 99883 | Tetraodon nigroviridis | ENSTNIG00000015322 |
31033 | Takifugu rubripes | ENSTRUG00000017901 | 8083 | Xiphophorus maculatus | ENSXMAG00000012718 |