Basic Information | |||
Gene ID | 7013 ; Check Expression Profles ; Check TFs & Targets Binding | ||
Gene Name | TERF1; PIN2, TRBF1, TRF, TRF1 | ||
Full Name | Telomeric repeat-binding factor 1 | ||
Organism | Homo sapiens [9606] |
Cross Reference | |||
UniProt | P54274 | UniGene | Hs.442707 |
PDB | 3L82 | OMIM | 600951 |
KEGG | hsa:7013 | UCSC | uc003xze.2 |
Protein Interactions | |
DIP | DIP-29412N |
IntAct | P54274 |
MINT | MINT-221323 |
STRING | 9606.ENSP00000276603 |
Ensembl/RefSeq | Transcript ID | Protein ID | Gene ID |
ENSEMBL | |||
ENSEMBL | |||
REFSEQ | |||
REFSEQ |
InterPro Annotation | |||||||
Protein | Program | Term | IPRS | Start | End | Score | Description |
ENSP00000276603 | Gene3D | G3DSA:1.10.10.60 | IPR009057 | 374 | 431 | 2.20e-16 | Homeodomain-like |
ENSP00000276603 | Gene3D | G3DSA:1.25.40.210 | IPR013867 | 58 | 268 | 2.20e-109 | Telomere repeat-binding factor, dimerisation domain |
ENSP00000276603 | Pfam | PF00249 | IPR001005 | 380 | 427 | 9.50e-10 | SANT/Myb domain |
ENSP00000276603 | Pfam | PF08558 | IPR013867 | 77 | 268 | 1.40e-37 | Telomere repeat-binding factor, dimerisation domain |
ENSP00000276603 | PIRSF | PIRSF038016 | IPR017357 | 1 | 439 | 0.00e-00 | Telomeric repeat-binding factor 1/2 |
ENSP00000276603 | ProDom | PD014243 | IPR013867 | 77 | 258 | 0.00e-00 | Telomere repeat-binding factor, dimerisation domain |
ENSP00000276603 | ProSiteProfiles | PS51294 | IPR017930 | 375 | 432 | 0.00e-00 | Myb domain |
ENSP00000276603 | SMART | SM00717 | IPR001005 | 379 | 430 | 1.80e-13 | SANT/Myb domain |
ENSP00000276603 | SUPERFAMILY | SSF46689 | IPR009057 | 382 | 435 | 0.00e-00 | Homeodomain-like |
ENSP00000276603 | SUPERFAMILY | SSF63600 | IPR013867 | 63 | 265 | 0.00e-00 | Telomere repeat-binding factor, dimerisation domain |
Pfam Annotation | ||||
Protein | Pfam ID | E.value | Name | Description |
ENSP00000276603 | PF08558 | 6.4e-38 | TRF | Telomere repeat binding factor (TRF) |
ENSP00000276603 | PF00249 | 3.9e-10 | Myb_DNA-binding | Myb-like DNA-binding domain |
ENSP00000276603 | PF13921 | 8.9e-06 | Myb_DNA-bind_6 | Myb-like DNA-binding domain |
Gene Ontology Annotation | |||
Protein | Entry | Name Space | Description |
ENSP00000276603 | GO:0000723 | biological_process | telomere maintenance |
ENSP00000276603 | GO:0007049 | biological_process | cell cycle |
ENSP00000276603 | GO:0000781 | cellular_component | chromosome, telomeric region |
ENSP00000276603 | GO:0005634 | cellular_component | nucleus |
ENSP00000276603 | GO:0005654 | cellular_component | nucleoplasm |
ENSP00000276603 | GO:0005737 | cellular_component | cytoplasm |
ENSP00000276603 | GO:0003682 | molecular_function | chromatin binding |
ENSP00000276603 | GO:0003691 | molecular_function | double-stranded telomeric DNA binding |
ENSP00000276603 | GO:0042162 | molecular_function | telomeric DNA binding |
ENSP00000276603 | GO:0042803 | molecular_function | protein homodimerization activity |
Orthologs | |||||
TAXID | Organism | Gene ID | TAXID | Organism | Gene ID |
9796 | Equus caballus | 100051302 | 9483 | Callithrix jacchus | 100407389 |
9615 | Canis familiaris | 100684790 | 8128 | Oreochromis niloticus | 100706372 |
9597 | Pan paniscus | 100972138 | 9555 | Papio anubis | 101019317 |
39432 | Saimiri boliviensis | 101036191 | 9685 | Felis catus | 101098684 |
10090 | Mus musculus | 21749 | 9544 | Macaca mulatta | 695119 |
28377 | Anolis carolinensis | ENSACAG00000014468 | 9646 | Ailuropoda melanoleuca | ENSAMEG00000006001 |
9913 | Bos taurus | ENSBTAG00000032982 | 10141 | Cavia porcellus | ENSCPOG00000009638 |
9361 | Dasypus novemcinctus | ENSDNOG00000011332 | 10020 | Dipodomys ordii | ENSDORG00000003657 |
9365 | Erinaceus europaeus | ENSEEUG00000008963 | 9371 | Echinops telfairi | ENSETEG00000013470 |
9031 | Gallus gallus | ENSGALG00000015633 | 9595 | Gorilla gorilla | ENSGGOG00000026727 |
7897 | Latimeria chalumnae | ENSLACG00000006192 | 9785 | Loxodonta africana | ENSLAFG00000004308 |
9103 | Meleagris gallopavo | ENSMGAG00000011491 | 59463 | Myotis lucifugus | ENSMLUG00000012171 |
13616 | Monodelphis domestica | ENSMODG00000025642 | 9669 | Mustela putorius furo | ENSMPUG00000010251 |
61853 | Nomascus leucogenys | ENSNLEG00000026599 | 9986 | Oryctolagus cuniculus | ENSOCUG00000002793 |
30611 | Otolemur garnettii | ENSOGAG00000005848 | 9978 | Ochotona princeps | ENSOPRG00000008452 |
8090 | Oryzias latipes | ENSORLG00000008002 | 9813 | Procavia capensis | ENSPCAG00000007698 |
13735 | Pelodiscus sinensis | ENSPSIG00000018172 | 42254 | Sorex araneus | ENSSARG00000011603 |
9823 | Sus scrofa | ENSSSCG00000006184 | 43179 | Ictidomys tridecemlineatus | ENSSTOG00000004560 |
37347 | Tupaia belangeri | ENSTBEG00000011779 | 31033 | Takifugu rubripes | ENSTRUG00000012540 |
9478 | Tarsius syrichta | ENSTSYG00000006478 | 9739 | Tursiops truncatus | ENSTTRG00000003745 |
30538 | Vicugna pacos | ENSVPAG00000000533 | 8364 | Xenopus tropicalis | ENSXETG00000033317 |
9315 | Macropus eugenii | ENSMEUG00000014906 | 9258 | Ornithorhynchus anatinus | ENSOANG00000001722 |
9601 | Pongo abelii | ENSPPYG00000018669 | 132908 | Pteropus vampyrus | ENSPVAG00000003792 |
9305 | Sarcophilus harrisii | ENSSHAG00000015315 | 59729 | Taeniopygia guttata | ENSTGUG00000011513 |