Basic Information
Gene ID 7181 ; Check Expression Profles ; Check TFs & Targets Binding
Gene Name NR2C1; TR2
Full Name Nuclear receptor subfamily 2 group C member 1
Organism Homo sapiens [9606]

Cross Reference
UniProt P13056 UniGene Hs.707524
PDB NULL OMIM 601529
KEGG hsa:7181 UCSC uc001tdo.4

Protein Interactions
DIP NULL
IntAct P13056
MINT MINT-8247579
STRING 9606.ENSP00000333275

Ensembl/RefSeq
Transcript ID
Protein ID
Gene ID
ENSEMBL
ENSEMBL
ENSEMBL
REFSEQ
REFSEQ
REFSEQ

InterPro Annotation
Protein Program Term IPRS Start End Score Description
ENSP00000333275 Gene3D G3DSA:1.10.565.10 IPR008946 170 194 3.70e-64 Nuclear hormone receptor, ligand-binding
ENSP00000333275 Gene3D G3DSA:1.10.565.10 IPR008946 299 300 3.70e-64 Nuclear hormone receptor, ligand-binding
ENSP00000333275 Gene3D G3DSA:1.10.565.10 IPR008946 369 590 3.70e-64 Nuclear hormone receptor, ligand-binding
ENSP00000333275 Gene3D G3DSA:3.30.50.10 IPR013088 113 169 1.70e-26 Zinc finger, NHR/GATA-type
ENSP00000333275 Pfam PF00104 IPR000536 381 573 4.70e-29 Nuclear hormone receptor, ligand-binding, core
ENSP00000333275 Pfam PF00105 IPR001628 112 180 2.90e-31 Zinc finger, nuclear hormone receptor-type
ENSP00000333275 PRINTS PR00047 IPR001628 113 129 1.70e-18 Zinc finger, nuclear hormone receptor-type
ENSP00000333275 PRINTS PR00047 IPR001628 129 144 1.70e-18 Zinc finger, nuclear hormone receptor-type
ENSP00000333275 PRINTS PR00047 IPR001628 162 170 1.70e-18 Zinc finger, nuclear hormone receptor-type
ENSP00000333275 PRINTS PR00047 IPR001628 170 178 1.70e-18 Zinc finger, nuclear hormone receptor-type
ENSP00000333275 PRINTS PR00398 IPR001723 174 184 1.30e-18 Steroid hormone receptor
ENSP00000333275 PRINTS PR00398 IPR001723 396 417 1.30e-18 Steroid hormone receptor
ENSP00000333275 PRINTS PR00398 IPR001723 417 433 1.30e-18 Steroid hormone receptor
ENSP00000333275 PRINTS PR00398 IPR001723 492 507 1.30e-18 Steroid hormone receptor
ENSP00000333275 PRINTS PR00398 IPR001723 549 566 1.30e-18 Steroid hormone receptor
ENSP00000333275 ProSitePatterns PS00031 IPR001628 113 139 - Zinc finger, nuclear hormone receptor-type
ENSP00000333275 ProSiteProfiles PS51030 IPR001628 110 185 0.00e-00 Zinc finger, nuclear hormone receptor-type
ENSP00000333275 SMART SM00399 IPR001628 110 181 3.40e-40 Zinc finger, nuclear hormone receptor-type
ENSP00000333275 SMART SM00430 IPR000536 395 561 8.40e-37 Nuclear hormone receptor, ligand-binding, core
ENSP00000333275 SUPERFAMILY SSF48508 IPR008946 179 193 0.00e-00 Nuclear hormone receptor, ligand-binding
ENSP00000333275 SUPERFAMILY SSF48508 IPR008946 282 322 0.00e-00 Nuclear hormone receptor, ligand-binding
ENSP00000333275 SUPERFAMILY SSF48508 IPR008946 377 590 0.00e-00 Nuclear hormone receptor, ligand-binding

Pfam Annotation
Protein Pfam ID E.value Name Description
ENSP00000333275 PF00105 1.2e-31 zf-C4 Zinc finger, C4 type (two domains)
ENSP00000333275 PF00104 2.7e-29 Hormone_recep Ligand-binding domain of nuclear hormone receptor

Gene Ontology Annotation
Protein Entry Name Space Description
ENSP00000333275 GO:0005634 cellular_component nucleus
ENSP00000333275 GO:0003707 molecular_function steroid hormone receptor activity
ENSP00000333275 GO:0008270 molecular_function zinc ion binding
ENSP00000333275 GO:0043565 molecular_function sequence-specific DNA binding

Orthologs
TAXID Organism Gene ID TAXID Organism Gene ID
9796 Equus caballus 100052073 7425 Nasonia vitripennis 100120833
7029 Acyrthosiphon pisum 100163128 10224 Saccoglossus kowalevskii 100372393
9483 Callithrix jacchus 100392011 10029 Cricetulus griseus 100757017
34638 Metaseiulus occidentalis 100903959 9305 Sarcophilus harrisii 100928214
30611 Otolemur garnettii 100941314 9597 Pan paniscus 100991107
9555 Papio anubis 101003782 39432 Saimiri boliviensis 101049259
9685 Felis catus 101081907 9669 Mustela putorius furo 101674779
8083 Xiphophorus maculatus 102227843 7897 Latimeria chalumnae 102357289
10090 Mus musculus 22025 7668 Strongylocentrotus purpuratus 373398
7955 Danio rerio 569321 7070 Tribolium castaneum 660024
9544 Macaca mulatta 716524 9823 Sus scrofa 100516014
8128 Oreochromis niloticus 100703800 13735 Pelodiscus sinensis 102458031
7227 Drosophila melanogaster 40378 9615 Canis familiaris 611980
28377 Anolis carolinensis ENSACAG00000012771 7719 Ciona intestinalis ENSCING00000001639
9361 Dasypus novemcinctus ENSDNOG00000006388 10020 Dipodomys ordii ENSDORG00000007038
9365 Erinaceus europaeus ENSEEUG00000011354 30608 Microcebus murinus ENSMICG00000005857
9986 Oryctolagus cuniculus ENSOCUG00000004657 9978 Ochotona princeps ENSOPRG00000012468
7757 Petromyzon marinus ENSPMAG00000002959 10116 Rattus norvegicus ENSRNOG00000010536
43179 Ictidomys tridecemlineatus ENSSTOG00000027488 59729 Taeniopygia guttata ENSTGUG00000008363
9478 Tarsius syrichta ENSTSYG00000009271 30538 Vicugna pacos ENSVPAG00000008509
9646 Ailuropoda melanoleuca ENSAMEG00000002266 9913 Bos taurus ENSBTAG00000017729
9358 Choloepus hoffmanni ENSCHOG00000013048 10141 Cavia porcellus ENSCPOG00000007507
51511 Ciona savignyi ENSCSAVG00000008663 9371 Echinops telfairi ENSETEG00000010120
69293 Gasterosteus aculeatus ENSGACG00000010174 9031 Gallus gallus ENSGALG00000011327
9595 Gorilla gorilla ENSGGOG00000012884 8049 Gadus morhua ENSGMOG00000018291
9785 Loxodonta africana ENSLAFG00000010224 9315 Macropus eugenii ENSMEUG00000006517
9103 Meleagris gallopavo ENSMGAG00000010372 59463 Myotis lucifugus ENSMLUG00000015807
13616 Monodelphis domestica ENSMODG00000007047 61853 Nomascus leucogenys ENSNLEG00000005775
9258 Ornithorhynchus anatinus ENSOANG00000006617 8090 Oryzias latipes ENSORLG00000004114
9813 Procavia capensis ENSPCAG00000011043 9601 Pongo abelii ENSPPYG00000004840
9598 Pan troglodytes ENSPTRG00000005307 132908 Pteropus vampyrus ENSPVAG00000007565
42254 Sorex araneus ENSSARG00000001474 37347 Tupaia belangeri ENSTBEG00000013822
99883 Tetraodon nigroviridis ENSTNIG00000016018 31033 Takifugu rubripes ENSTRUG00000016957
9739 Tursiops truncatus ENSTTRG00000016305 8364 Xenopus tropicalis ENSXETG00000023840