Basic Information
Gene ID 8841 ; Check Expression Profles ; Check TFs & Targets Binding
Gene Name HDAC3
Full Name Histone deacetylase 3
Organism Homo sapiens [9606]

Cross Reference
UniProt O15379 UniGene Hs.519632
PDB 4A69 OMIM 605166
KEGG hsa:8841 UCSC uc003lle.1

Protein Interactions
DIP DIP-24253N
IntAct O15379
MINT MINT-196172
STRING 9606.ENSP00000302967

Ensembl/RefSeq
Transcript ID
Protein ID
Gene ID
ENSEMBL
REFSEQ

InterPro Annotation
Protein Program Term IPRS Start End Score Description
ENSP00000302967 Gene3D G3DSA:3.40.800.20 IPR023801 3 380 3.40e-126 Histone deacetylase domain
ENSP00000302967 PANTHER PTHR10625 IPR000286 1 428 0.00e-00 Histone deacetylase superfamily
ENSP00000302967 Pfam PF00850 IPR023801 18 314 3.10e-76 Histone deacetylase domain
ENSP00000302967 PIRSF PIRSF037913 IPR003084 1 427 0.00e-00 Histone deacetylase
ENSP00000302967 PRINTS PR01270 IPR000286 131 154 1.80e-23 Histone deacetylase superfamily
ENSP00000302967 PRINTS PR01270 IPR000286 163 178 1.80e-23 Histone deacetylase superfamily
ENSP00000302967 PRINTS PR01270 IPR000286 249 259 1.80e-23 Histone deacetylase superfamily
ENSP00000302967 PRINTS PR01271 IPR003084 109 129 4.10e-64 Histone deacetylase
ENSP00000302967 PRINTS PR01271 IPR003084 150 166 4.10e-64 Histone deacetylase
ENSP00000302967 PRINTS PR01271 IPR003084 210 223 4.10e-64 Histone deacetylase
ENSP00000302967 PRINTS PR01271 IPR003084 227 245 4.10e-64 Histone deacetylase
ENSP00000302967 PRINTS PR01271 IPR003084 24 41 4.10e-64 Histone deacetylase
ENSP00000302967 PRINTS PR01271 IPR003084 57 75 4.10e-64 Histone deacetylase
ENSP00000302967 PRINTS PR01271 IPR003084 88 105 4.10e-64 Histone deacetylase

Pfam Annotation
Protein Pfam ID E.value Name Description
ENSP00000302967 PF00850 0 Hist_deacetyl Histone deacetylase domain

Gene Ontology Annotation
Protein Entry Name Space Description
ENSP00000302967 GO:0000122 biological_process negative regulation of transcription from RNA polymerase II promoter
ENSP00000302967 GO:0006351 biological_process transcription, DNA-templated
ENSP00000302967 GO:0016568 biological_process chromatin modification
ENSP00000302967 GO:0005634 cellular_component nucleus
ENSP00000302967 GO:0017053 cellular_component transcriptional repressor complex
ENSP00000302967 GO:0003682 molecular_function chromatin binding
ENSP00000302967 GO:0003714 molecular_function transcription corepressor activity
ENSP00000302967 GO:0004407 molecular_function histone deacetylase activity
ENSP00000302967 GO:0032041 molecular_function NAD-dependent histone deacetylase activity (H3-K14 specific)
ENSP00000302967 GO:0046969 molecular_function NAD-dependent histone deacetylase activity (H3-K9 specific)
ENSP00000302967 GO:0046970 molecular_function NAD-dependent histone deacetylase activity (H4-K16 specific)
ENSP00000302967 GO:0097372 molecular_function NAD-dependent histone deacetylase activity (H3-K18 specific)

Orthologs
TAXID Organism Gene ID TAXID Organism Gene ID
10029 Cricetulus griseus 100752639 8128 Oreochromis niloticus 100708372
7897 Latimeria chalumnae 102355924 10090 Mus musculus 15183
7719 Ciona intestinalis ENSCING00000002360 51511 Ciona savignyi ENSCSAVG00000009843
10020 Dipodomys ordii ENSDORG00000012591 69293 Gasterosteus aculeatus ENSGACG00000018752
37347 Tupaia belangeri ENSTBEG00000007520 30538 Vicugna pacos ENSVPAG00000001866
9361 Dasypus novemcinctus ENSDNOG00000008318