PredictBias

		>PF00577#Outer membrane usher protein FimD

		          Length = 878

		

		 Score =  764 bits (1975), Expect = 0.0

		 Identities = 331/870 (38%), Positives = 487/870 (55%), Gaps = 54/870 (6%)

		

		Query: 6   IVVGLTAGTCLIFSQNLMAEVSVFNPALLEIDHQSGVDIRQFNRANLMPPGVYSVDIFIN 65

		             V L           L +    FNP  L  D Q+  D+ +F     +PPG Y VDI++N

		Sbjct: 26  FFVRLFVACAFAAQAPLSSAELYFNPRFLADDPQAVADLSRFENGQELPPGTYRVDIYLN 85

		

		Query: 66  GKMFERQDVTFVQDNPDADLHACFIAIKKTLSSFGIKVDALKSFNDVDETVCLDPAPRIE 125

		                 +DVTF   + +  +  C       L+S G+   ++   N + +  C+     I 

		Sbjct: 86  NGYMATRDVTFNTGDSEQGIVPCLTR--AQLASMGLNTASVSGMNLLADDACVPLTSMIH 143

		

		Query: 126 GSSWQFDSDKLQLNISIPQIYMDAMAYDYISPTRWDEGINALTINYDFSGSHTLRSDYGS 185

		            ++ Q D  + +LN++IPQ +M   A  YI P  WD GINA  +NY+FSG+     +   

		Sbjct: 144 DATAQLDVGQQRLNLTIPQAFMSNRARGYIPPELWDPGINAGLLNYNFSGNSV--QNRIG 201

		

		Query: 186 QETDTSYLNLRNGLNIGPWRLRNYSTLN------TSDGRAEYNSISTWIQRDIAALRSQI 239

		             +  +YLNL++GLNIG WRLR+ +T +      +S  + ++  I+TW++RDI  LRS++

		Sbjct: 202 GNSHYAYLNLQSGLNIGAWRLRDNTTWSYNSSDSSSGSKNKWQHINTWLERDIIPLRSRL 261

		

		Query: 240 MIGDTWTASDIFDSTQIRGARLYTDNDMLPASQNGFAPVVRGIAKSNATVIIRQNGYVIY 299

		            +GD +T  DIFD    RGA+L +D++MLP SQ GFAPV+ GIA+  A V I+QNGY IY

		Sbjct: 262 TLGDGYTQGDIFDGINFRGAQLASDDNMLPDSQRGFAPVIHGIARGTAQVTIKQNGYDIY 321

		

		Query: 300 QSAVPQGAFEITDLNTASTGGDLDVTIKEEDGSEQRFTQPYASLAILKREGQTDVDVSVG 359

		            S VP G F I D+  A   GDL VTIKE DGS Q FT PY+S+ +L+REG T   ++ G

		Sbjct: 322 NSTVPPGPFTINDIYAAGNSGDLQVTIKEADGSTQIFTVPYSSVPLLQREGHTRYSITAG 381

		

		Query: 360 ELRDEDG--FTPDVLQAQILHGFSHGITLYGGMQAAENYGSAALGVGKDLGALGAISFDV 417

		           E R  +     P   Q+ +LHG   G T+YGG Q A+ Y +   G+GK++GALGA+S D+

		Sbjct: 382 EYRSGNAQQEKPRFFQSTLLHGLPAGWTIYGGTQLADRYRAFNFGIGKNMGALGALSVDM 441

		

		Query: 418 THARANFSHDDTETGQSYRFLYSKRFDDTDTSLRLVGYRYSTEGYYTLNEWASRRNS--- 474

		           T A +    D    GQS RFLY+K  +++ T+++LVGYRYST GY+   +    R +   

		Sbjct: 442 TQANSTLPDDSQHDGQSVRFLYNKSLNESGTNIQLVGYRYSTSGYFNFADTTYSRMNGYN 501

		

		Query: 475 --------------PEDFWETGNRRSRVEGTLTQSLGRDYGNLYLTLSRQQYWHTDDVER 520

		                          + +    N+R +++ T+TQ LGR    LYL+ S Q YW T +V+ 

		Sbjct: 502 IETQDGVIQVKPKFTDYYNLAYNKRGKLQLTVTQQLGR-TSTLYLSGSHQTYWGTSNVDE 560

		

		Query: 521 LMQFGYSSSWKRLSWNVSWSYSNTARQRTGNNHASDNTSEQIYMLSLSVPLSGW------ 574

		             Q G +++++ ++W +S+S +  A Q+  +          +  L++++P S W      

		Sbjct: 561 QFQAGLNTAFEDINWTLSYSLTKNAWQKGRDQ---------MLALNVNIPFSHWLRSDSK 611

		

		Query: 575 --WGNSYATYSVSQNDNSGSSHQLGLSGTALERNNLSWNLMQSYNSHDDEVGGN---MSL 629

		             W ++ A+YS+S + N   ++  G+ GT LE NNLS+++   Y    D   G+    +L

		Sbjct: 612 SQWRHASASYSMSHDLNGRMTNLAGVYGTLLEDNNLSYSVQTGYAGGGDGNSGSTGYATL 671

		

		Query: 630 TYDGSYGTVNGSYNYSQNSQRLNYGIRGGILAHSEGVTLSQELGETIALVKAPGAAGLEI 689

		            Y G YG  N  Y++S + ++L YG+ GG+LAH+ GVTL Q L +T+ LVKAPGA   ++

		Sbjct: 672 NYRGGYGNANIGYSHSDDIKQLYYGVSGGVLAHANGVTLGQPLNDTVVLVKAPGAKDAKV 731

		

		Query: 690 DNMRGAATDWRGYTVKTQLNPYDENRVAISDNYFSKSNIELDNTVVTMVPTRGAVVKAEF 749

		           +N  G  TDWRGY V      Y ENRVA+  N  +  N++LDN V  +VPTRGA+V+AEF

		Sbjct: 732 ENQTGVRTDWRGYAVLPYATEYRENRVALDTNTLA-DNVDLDNAVANVVPTRGAIVRAEF 790

		

		Query: 750 VTHVGYRVLFRVLNANGKPVPFGAIAAIQDASLADSGIVGDRGELYLSGLPEKGQVTLSW 809

		              VG ++L   L  N KP+PFG  A +   S   SGIV D G++YLSG+P  G+V + W

		Sbjct: 791 KARVGIKLLMT-LTHNNKPLPFG--AMVTSESSQSSGIVADNGQVYLSGMPLAGKVQVKW 847

		

		Query: 810 GENASTKCIFNYSLSTPESESGLIEQGVTC 839

		           GE  +  C+ NY L     +  L +    C

		Sbjct: 848 GEEENAHCVANYQLPPESQQQLLTQLSAEC 877

		

		

		>RTXTOXINA#Gram-negative bacterial RTX toxin determinant A family

		           signature.

		          Length = 1024

		

		 Score = 29.2 bits (65), Expect = 0.048

		 Identities = 23/80 (28%), Positives = 31/80 (38%), Gaps = 10/80 (12%)

		

		Query: 367 LGDAEIGDNVNIGAGTITCNYDGANKFKTIIGDDVFVGSDTQLVAPVTVGKGATIAAGTT 426

		           LGD +  D V + AG+   N           G DV     T        G  AT A   T

		Sbjct: 616 LGDGD--DKVFLSAGSA--NIYAGK------GHDVVYYDKTDTGYLTIDGTKATEAGNYT 665

		

		Query: 427 VTRNVGENALAISRVPQTQK 446

		           VTR +G +   +  V + Q+

		Sbjct: 666 VTRVLGGDVKVLQEVVKEQE 685

		

		

		>IGASERPTASE#IgA-specific serine endopeptidase (S6) signature.

		          Length = 1541

		

		 Score = 28.1 bits (62), Expect = 0.025

		 Identities = 19/59 (32%), Positives = 24/59 (40%), Gaps = 8/59 (13%)

		

		Query: 68   FSVNGVAGANAFAN-GGGSTTCCGDVSGDTAEVIWTLSTTRTQYNAGMRLEKRNMTLPL 125

		            FSV  +  A   AN G G     G       E          QYNAG++L+  N+ L L

		Sbjct: 1466 FSVTPILSARYDANQGSGKINVNGYDFAYNVENQQ-------QYNAGLKLKYHNVKLSL 1517

		

		

		>PHPHLIPASEA1#Bacterial phospholipase A1 protein signature.

		          Length = 289

		

		 Score =  499 bits (1286), Expect = 0.0

		 Identities = 289/289 (100%), Positives = 289/289 (100%)

		

		Query: 1   MRTLQGWLLPVFMLPMAVYAQEATVKEVHDAPAVRGSIIANMLQEHDNPFTLYPYDTNYL 60

		           MRTLQGWLLPVFMLPMAVYAQEATVKEVHDAPAVRGSIIANMLQEHDNPFTLYPYDTNYL

		Sbjct: 1   MRTLQGWLLPVFMLPMAVYAQEATVKEVHDAPAVRGSIIANMLQEHDNPFTLYPYDTNYL 60

		

		Query: 61  IYTQTSDLNKEAIASYDWAENARKDEVKFQLSLAFPLWRGILGPNSVLGASYTQKSWWQL 120

		           IYTQTSDLNKEAIASYDWAENARKDEVKFQLSLAFPLWRGILGPNSVLGASYTQKSWWQL

		Sbjct: 61  IYTQTSDLNKEAIASYDWAENARKDEVKFQLSLAFPLWRGILGPNSVLGASYTQKSWWQL 120

		

		Query: 121 SNSEESSPFRETNYEPQLFLGFATDYRFAGWTLRDVEMGYNHDSNGRSDPTSRSWNRLYT 180

		           SNSEESSPFRETNYEPQLFLGFATDYRFAGWTLRDVEMGYNHDSNGRSDPTSRSWNRLYT

		Sbjct: 121 SNSEESSPFRETNYEPQLFLGFATDYRFAGWTLRDVEMGYNHDSNGRSDPTSRSWNRLYT 180

		

		Query: 181 RLMAENGNWLVEVKPWYVVGNTDDNPDITKYMGYYQLKIGYHLGDAVLSAKGQYNWNTGY 240

		           RLMAENGNWLVEVKPWYVVGNTDDNPDITKYMGYYQLKIGYHLGDAVLSAKGQYNWNTGY

		Sbjct: 181 RLMAENGNWLVEVKPWYVVGNTDDNPDITKYMGYYQLKIGYHLGDAVLSAKGQYNWNTGY 240

		

		Query: 241 GGAELGLSYPITKHVRLYTQVYSGYGESLIDYNFNQTRVGVGVMLNDLF 289

		           GGAELGLSYPITKHVRLYTQVYSGYGESLIDYNFNQTRVGVGVMLNDLF

		Sbjct: 241 GGAELGLSYPITKHVRLYTQVYSGYGESLIDYNFNQTRVGVGVMLNDLF 289

		

		

		>SECA#SecA protein signature.

		          Length = 901

		

		 Score = 30.2 bits (68), Expect = 0.004

		 Identities = 11/71 (15%), Positives = 30/71 (42%)

		

		Query: 14  AKARRKTREELDQEARDRKRQKKRRGHAPGSRAAGGNTTSGSKGQNAPKDPRIGSKTPIP 73

		           +K + +  EE+++  + R+ + +R            ++ + +       + ++G   P P

		Sbjct: 827 SKVQVRMPEEVEELEQQRRMEAERLAQMQQLSHQDDDSAAAAALAAQTGERKVGRNDPCP 886

		

		Query: 74  LGVTEKVTKQH 84

		            G  +K  + H

		Sbjct: 887 CGSGKKYKQCH 897

		

		

		>HTHFIS#FIS bacterial regulatory protein HTH signature.

		          Length = 484

		

		 Score =  601 bits (1550), Expect = 0.0

		 Identities = 206/478 (43%), Positives = 300/478 (62%), Gaps = 11/478 (2%)

		

		Query: 1   MQRGIVWVVDDDSSIRWVLERALAGAGLTCTTFENGAEVLEALASKTPDVLLSDIRMPGM 60

		           M    + V DDD++IR VL +AL+ AG       N A +   +A+   D++++D+ MP  

		Sbjct: 1   MTGATILVADDDAAIRTVLNQALSRAGYDVRITSNAATLWRWIAAGDGDLVVTDVVMPDE 60

		

		Query: 61  DGLALLKQIKQRHPMLPVIIMTAHSDLDAAVSAYQQGAFDYLPKPFDIDEAVALVERAIS 120

		           +   LL +IK+  P LPV++M+A +    A+ A ++GA+DYLPKPFD+ E + ++ RA++

		Sbjct: 61  NAFDLLPRIKKARPDLPVLVMSAQNTFMTAIKASEKGAYDYLPKPFDLTELIGIIGRALA 120

		

		Query: 121 HYQEQQQPRNIQLNGPTTDIIGEAPAMQDVFRIIGRLSRSSISVLINGESGTGKELVAHA 180

		             + +              ++G + AMQ+++R++ RL ++ ++++I GESGTGKELVA A

		Sbjct: 121 EPKRRPSKLEDDSQDGM-PLVGRSAAMQEIYRVLARLMQTDLTLMITGESGTGKELVARA 179

		

		Query: 181 LHRHSPRAKAPFIALNMAAIPKDLIESELFGHEKGAFTGANTIRQGRFEQADGGTLFLDE 240

		           LH +  R   PF+A+NMAAIP+DLIESELFGHEKGAFTGA T   GRFEQA+GGTLFLDE

		Sbjct: 180 LHDYGKRRNGPFVAINMAAIPRDLIESELFGHEKGAFTGAQTRSTGRFEQAEGGTLFLDE 239

		

		Query: 241 IGDMPLDVQTRLLRVLADGQFYRVGGYAPVKVDVRIIAATHQNLEQRVQEGKFREDLFHR 300

		           IGDMP+D QTRLLRVL  G++  VGG  P++ DVRI+AAT+++L+Q + +G FREDL++R

		Sbjct: 240 IGDMPMDAQTRLLRVLQQGEYTTVGGRTPIRSDVRIVAATNKDLKQSINQGLFREDLYYR 299

		

		Query: 301 LNVIRVHLPPLRERREDIPRLARHFLQVAARELGVEAKLLHPETEAALTRLAWPGNVRQL 360

		           LNV+ + LPPLR+R EDIP L RHF+Q A +E G++ K    E    +    WPGNVR+L

		Sbjct: 300 LNVVPLRLPPLRDRAEDIPDLVRHFVQQAEKE-GLDVKRFDQEALELMKAHPWPGNVREL 358

		

		Query: 361 ENTCRWLTVMAAGQEVLIQDLPGELFESTVAESTSQMQPDSWATLLAQWADRALRS---- 416

		           EN  R LT +     +  + +  EL          +    S +  ++Q  +  +R     

		Sbjct: 359 ENLVRRLTALYPQDVITREIIENELRSEIPDSPIEKAAARSGSLSISQAVEENMRQYFAS 418

		

		Query: 417 -----GHQNLLSEAQPELERTLLTTALRHTQGHKQEAARLLGWGRNTLTRKLKELGME 469

		                    L      E+E  L+  AL  T+G++ +AA LLG  RNTL +K++ELG+ 

		Sbjct: 419 FGDALPPSGLYDRVLAEMEYPLILAALTATRGNQIKAADLLGLNRNTLRKKIRELGVS 476

		

		

		>PF06580#Sensor histidine kinase

		          Length = 349

		

		 Score = 28.3 bits (63), Expect = 0.042

		 Identities = 34/190 (17%), Positives = 72/190 (37%), Gaps = 41/190 (21%)

		

		Query: 171 IIEQADRLRNLVDRL---LGPQLPGTRVTE-SIHKVAERV---VTLVSMELPDNVRLIRD 223

		           I+E   + R ++  L   +   L  +   + S+      V   + L S++  D ++    

		Sbjct: 186 ILEDPTKAREMLTSLSELMRYSLRYSNARQVSLADELTVVDSYLQLASIQFEDRLQFENQ 245

		

		Query: 224 YDPSLPELAHDPDQIEQVLLN-IVRNALQ---ALGPEGGEIILRTRTAFQLTLHGERYRL 279

		            +P++ ++     Q+  +L+  +V N ++   A  P+GG+I+L+                

		Sbjct: 246 INPAIMDV-----QVPPMLVQTLVENGIKHGIAQLPQGGKILLKGT------KDNGTVT- 293

		

		Query: 280 AARIDVEDNGPGIPPHLQDTLFYPMVSGREGGTGLGLSIARNLIDQHSGK---IEFTSWP 336

		              ++VE+ G     + ++             TG GL   R  +    G    I+ +   

		Sbjct: 294 ---LEVENTGSLALKNTKE------------STGTGLQNVRERLQMLYGTEAQIKLSEKQ 338

		

		Query: 337 GHTEFSVYLP 346

		           G     V +P

		Sbjct: 339 GKVNAMVLIP 348

		

		

		>TCRTETOQM#Tetracycline resistance protein TetO/TetQ/TetM family

		           signature.

		          Length = 639

		

		 Score =  180 bits (458), Expect = 4e-51

		 Identities = 97/445 (21%), Positives = 170/445 (38%), Gaps = 81/445 (18%)

		

		Query: 4   KLRNIAIIAHVDHGKTTLVDKLLQQSGTFDSRAETQE--RVMDSNDLEKERGITILAKNT 61

		           K+ NI ++AHVD GKTTL + LL  SG         +     D+  LE++RGITI    T

		Sbjct: 2   KIINIGVLAHVDAGKTTLTESLLYNSGAITELGSVDKGTTRTDNTLLERQRGITIQTGIT 61

		

		Query: 62  AIKWNDYRINIVDTPGHADFGGEVERVMSMVDSVLLVVDAFDGPMPQTRFVTKKAFAYGL 121

		           + +W + ++NI+DTPGH DF  EV R +S++D  +L++ A DG   QTR +       G+

		Sbjct: 62  SFQWENTKVNIIDTPGHMDFLAEVYRSLSVLDGAILLISAKDGVQAQTRILFHALRKMGI 121

		

		Query: 122 KPIVVINKVDRPGARPDWVVDQVFD-------------LFVNLDATDEQLD--------- 159

		             I  INK+D+ G     V   + +             L+ N+  T+             

		Sbjct: 122 PTIFFINKIDQNGIDLSTVYQDIKEKLSAEIVIKQKVELYPNMCVTNFTESEQWDTVIEG 181

		

		Query: 160 --------------------------------FPIVYASALNGIAGLDHEDMAEDMTPLY 187

		                                           FP+ + SA N I G+D+         L 

		Sbjct: 182 NDDLLEKYMSGKSLEALELEQEESIRFHNCSLFPVYHGSAKNNI-GIDN---------LI 231

		

		Query: 188 QAIVDHVPAPDVDLDGPFQMQISQLDYNSYVGVIGIGRIKRGKVKPNQQVTIIDSEGKTR 247

		           + I +   +           ++ +++Y+     +   R+  G +     V I + E    

		Sbjct: 232 EVITNKFYSSTHRGQSELCGKVFKIEYSEKRQRLAYIRLYSGVLHLRDSVRISEKEKI-- 289

		

		Query: 248 NAKVGKVLGHLGLERIETDLAEAGDIVAITGLGELNISDTVCDTQNVEALPALSVDEPTV 307

		             K+ ++   +  E  + D A +G+IV +     L ++  + DT+ +     +    P +

		Sbjct: 290 --KITEMYTSINGELCKIDKAYSGEIVILQNEF-LKLNSVLGDTKLLPQRERIENPLPLL 346

		

		Query: 308 SMFFCVNTSPFCGKEGKFVTSRQILDRLNKELVHNVALRVEETEDADAFRVSGRGELHLS 367

		                 +           +      D L         LR           +S  G++ + 

		Sbjct: 347 QTTVEPSKPQQREMLLDALLEISDSDPL---------LRYYVDSATHEIILSFLGKVQME 397

		

		Query: 368 VLIENMRRE-GFELAVSRPKVIFRE 391

		           V    ++ +   E+ +  P VI+ E

		Sbjct: 398 VTCALLQEKYHVEIEIKEPTVIYME 422

		

		

		

		 Score = 32.5 bits (74), Expect = 0.005

		 Identities = 13/75 (17%), Positives = 29/75 (38%), Gaps = 1/75 (1%)

		

		Query: 398 EPYENVTLDVEEQHQGSVMQALGERKGDLKNMNPDGKGRVRLDYVIPSRGLIGFRSEFMT 457

		           EPY +  +   +++         +   ++ +        V L   IP+R +  +RS+   

		Sbjct: 537 EPYLSFKIYAPQEYLSRAYTDAPKYCANIVDTQLKN-NEVILSGEIPARCIQEYRSDLTF 595

		

		Query: 458 MTSGTGLLYSTFSHY 472

		            T+G  +  +    Y

		Sbjct: 596 FTNGRSVCLTELKGY 610

		

		

		>TCRTETB#Tetracycline resistance protein TetB signature.

		          Length = 458

		

		 Score = 29.5 bits (66), Expect = 0.028

		 Identities = 31/161 (19%), Positives = 64/161 (39%), Gaps = 15/161 (9%)

		

		Query: 227 NVFFVYAVYCGLTFFIPFLKNIYLLP----------VALVGAYGIINQYCLKMIGGPIGG 276

		           N+ F+  V CG   F      + ++P           A +G+  I       +I G IGG

		Sbjct: 255 NIPFMIGVLCGGIIFGTVAGFVSMVPYMMKDVHQLSTAEIGSVIIFPGTMSVIIFGYIGG 314

		

		Query: 277 MISDKILKSPSKYLCYTFIISTAALVLLIMLPHESMPVYLGMACTLGFGAIVFTQRAVFF 336

		           ++ D+  + P   L       + + +    L  E+   ++ +      G + FT+     

		Sbjct: 315 ILVDR--RGPLYVLNIGVTFLSVSFLTASFLL-ETTSWFMTIIIVFVLGGLSFTK--TVI 369

		

		Query: 337 APIGEAKIAENKTGAAMALGSFIGYAPAMFCFSLYGYILDL 377

		           + I  + + + + GA M+L +F  +       ++ G +L +

		Sbjct: 370 STIVSSSLKQQEAGAGMSLLNFTSFLSEGTGIAIVGGLLSI 410

		

		

		>IGASERPTASE#IgA-specific serine endopeptidase (S6) signature.

		          Length = 1541

		

		 Score = 42.0 bits (98), Expect = 2e-06

		 Identities = 32/155 (20%), Positives = 64/155 (41%), Gaps = 5/155 (3%)

		

		Query: 79   LTPEQRQLLEQMQADMRQQPTQLVEVPWNEQTPEQRQQTLQRQRQAQQLAEQQRLAQQSR 138

		            +          +QAD+   P+   E+   ++ P             + +AE  +  Q+S+

		Sbjct: 992  VDTTNITTPNNIQADVPSVPSNNEEIARVDEAPVPPPAPATPSETTETVAENSK--QESK 1049

		

		Query: 139  TTEQSWQQQT-RTSQAAPVQAQPRQSKPASTQQPYQDLLQTPAHTTAQSKPQQAAPVARA 197

		            T E++ Q  T  T+Q   V  + + +  A+TQ        +    T  ++ ++ A V + 

		Sbjct: 1050 TVEKNEQDATETTAQNREVAKEAKSNVKANTQTNEVAQSGSETKETQTTETKETATVEKE 1109

		

		Query: 198  ADAPKPTAEKKDERRWMVQCGSFRGAEQAETVRAQ 232

		              A   T + ++  +   Q    +  EQ+ETV+ Q

		Sbjct: 1110 EKAKVETEKTQEVPKVTSQVSPKQ--EQSETVQPQ 1142

		

		

		>TCRTETOQM#Tetracycline resistance protein TetO/TetQ/TetM family

		           signature.

		          Length = 639

		

		 Score = 79.5 bits (196), Expect = 3e-18

		 Identities = 57/198 (28%), Positives = 87/198 (43%), Gaps = 13/198 (6%)

		

		Query: 13  VNVGTIGHVDHGKTTLTAAI------TTVLAKTYGGAARAFDQIDNAPEEKARGITINTS 66

		           +N+G + HVD GKTTLT ++       T L     G  R     DN   E+ RGITI T 

		Sbjct: 4   INIGVLAHVDAGKTTLTESLLYNSGAITELGSVDKGTTRT----DNTLLERQRGITIQTG 59

		

		Query: 67  HVEYDTPTRHYAHVDCPGHADYVKNMITGAAQMDGAILVVAATDGPMPQTREHILLGRQV 126

		              +         +D PGH D++  +    + +DGAIL+++A DG   QTR      R++

		Sbjct: 60  ITSFQWENTKVNIIDTPGHMDFLAEVYRSLSVLDGAILLISAKDGVQAQTRILFHALRKM 119

		

		Query: 127 GVPYIIVFLNKCDMVDDEELLELVEMEVRELLSQYDFPGDDTPIVRGSALKALEGDAEWE 186

		           G+P  I F+NK D    +  L  V  +++E LS          +     +       +W+

		Sbjct: 120 GIP-TIFFINKIDQNGID--LSTVYQDIKEKLSAEIVIKQKVELYPNMCVTNFTESEQWD 176

		

		Query: 187 AKILELAGFLDSYIPEPE 204

		             I      L+ Y+    

		Sbjct: 177 TVIEGNDDLLEKYMSGKS 194

		

		

		>SECETRNLCASE#Bacterial translocase SecE signature.

		          Length = 127

		

		 Score =  165 bits (420), Expect = 2e-56

		 Identities = 127/127 (100%), Positives = 127/127 (100%)

		

		Query: 1   MSANTEAQGSGRGLEAMKWVVVVALLLVAIVGNYLYRDIMLPLRALAVVILIAAAGGVAL 60

		           MSANTEAQGSGRGLEAMKWVVVVALLLVAIVGNYLYRDIMLPLRALAVVILIAAAGGVAL

		Sbjct: 1   MSANTEAQGSGRGLEAMKWVVVVALLLVAIVGNYLYRDIMLPLRALAVVILIAAAGGVAL 60

		

		Query: 61  LTTKGKATVAFAREARTEVRKVIWPTRQETLHTTLIVAAVTAVMSLILWGLDGILVRLVS 120

		           LTTKGKATVAFAREARTEVRKVIWPTRQETLHTTLIVAAVTAVMSLILWGLDGILVRLVS

		Sbjct: 61  LTTKGKATVAFAREARTEVRKVIWPTRQETLHTTLIVAAVTAVMSLILWGLDGILVRLVS 120

		

		Query: 121 FITGLRF 127

		           FITGLRF

		Sbjct: 121 FITGLRF 127

		

		

		>ACRIFLAVINRP#Acriflavin resistance protein family signature.

		          Length = 1034

		

		 Score = 27.9 bits (62), Expect = 0.011

		 Identities = 12/57 (21%), Positives = 22/57 (38%), Gaps = 7/57 (12%)

		

		Query: 57  VILKAAGANKVAVIKAVRGATGLGLKEAKDLVESAPAALKEGVSKDDAEALKKALEE 113

		            I  A GAN +   KA++        +  +L    P  +K     D    ++ ++ E

		Sbjct: 290 GIKLATGANALDTAKAIK-------AKLAELQPFFPQGMKVLYPYDTTPFVQLSIHE 339

		

		

		>OMADHESIN#Yersinia outer membrane adhesin signature.

		          Length = 455

		

		 Score = 30.6 bits (68), Expect = 0.004

		 Identities = 18/58 (31%), Positives = 26/58 (44%), Gaps = 8/58 (13%)

		

		Query: 127 ALGHVFPTQTKQMPSAPQGLEQLARHVERLADYPTVAIGGISLARAPAVIATGVGSIA 184

		           ALG  +P +         GL   A+ +       ++AIG  + A   A +A G GSIA

		Sbjct: 46  ALGLEYPVRPP--VPGAGGLNASAKGIH------SIAIGATAEAAKGAAVAVGAGSIA 95

		

		

		>ABC2TRNSPORT#ABC-2 type transport system membrane protein

		           signature.

		          Length = 262

		

		 Score = 29.5 bits (66), Expect = 0.040

		 Identities = 21/84 (25%), Positives = 35/84 (41%), Gaps = 17/84 (20%)

		

		Query: 459 FYTLGPLTTDIAPGYDHFT---SGIGAAMIGWFGCAMLCYVTPKEHLGLPNKEDVKQGLI 515

		           F +LG + T +AP YD+F    + +   ++   G      V P + L       V Q   

		Sbjct: 161 FASLGMVVTALAPSYDYFIFYQTLVITPILFLSGA-----VFPVDQL-----PIVFQTAA 210

		

		Query: 516 TYKIAAHAADLAK----GHPGAQI 535

		            +   +H+ DL +    GHP   +

		Sbjct: 211 RFLPLSHSIDLIRPIMLGHPVVDV 234

		

		

		>DNABINDINGHU#Prokaryotic integration host factor signature.

		          Length = 91

		

		 Score =  120 bits (302), Expect = 2e-39

		 Identities = 50/89 (56%), Positives = 66/89 (74%)

		

		Query: 2  NKTQLIDVIAEKAELSKTQAKAALESTLAAITESLKEGDAVQLVGFGTFKVNHRAERTGR 61

		          NK  LI  +AE  EL+K  + AA+++  +A++  L +G+ VQL+GFG F+V  RA R GR

		Sbjct: 3  NKQDLIAKVAEATELTKKDSAAAVDAVFSAVSSYLAKGEKVQLIGFGNFEVRERAARKGR 62

		

		Query: 62 NPQTGKEIKIAAANVPAFVSGKALKDAVK 90

		          NPQTG+EIKI A+ VPAF +GKALKDAVK

		Sbjct: 63 NPQTGEEIKIKASKVPAFKAGKALKDAVK 91

		

		

		>PF06580#Sensor histidine kinase

		          Length = 349

		

		 Score = 36.0 bits (83), Expect = 3e-04

		 Identities = 49/262 (18%), Positives = 104/262 (39%), Gaps = 43/262 (16%)

		

		Query: 197 ILFALATVLLA-SVLSFFW-YRRYLRSRQLLQDEMKRKEKLVALGHLAAGV-AHEIRNPL 253

		           I+F +  V    S+L F W + +  +  ++ Q +M    +   L  L A +  H + N L

		Sbjct: 120 IIFNVVVVTFMWSLLYFGWHFFKNYKQAEIDQWKMASMAQEAQLMALKAQINPHFMFNAL 179

		

		Query: 254 SSIKGLAKYFAERAPAGGEAHQLAQVM---AKEADRLNRVVSELLELVKPTHLALQAVDL 310

		           ++I+ L      +A        L+++M    + ++     +++ L +V  ++L L ++  

		Sbjct: 180 NNIRALILEDPTKAREM--LTSLSELMRYSLRYSNARQVSLADELTVVD-SYLQLASIQF 236

		

		Query: 311 NTLINHSLQLVSQDANSREIQLRFTANDTLPEIQADPDRLTQVLL-NLYLNAIQAIGQHG 369

		              +    Q+   +    ++Q+              P  L Q L+ N   + I  + Q G

		Sbjct: 237 EDRLQFENQI---NPAIMDVQV--------------PPMLVQTLVENGIKHGIAQLPQGG 279

		

		Query: 370 VISVTVSESGAGVKISVTDSGKGIAADQLEAIFTPYFTTKAEGTGLGLAVVHNIVEQHGG 429

		            I +  ++    V + V ++G     +              E TG GL  V   ++   G

		Sbjct: 280 KILLKGTKDNGTVTLEVENTGSLALKNT------------KESTGTGLQNVRERLQMLYG 327

		

		Query: 430 ---TIQVASQEGKGSTFTLWLP 448

		               I+++ ++GK     + +P

		Sbjct: 328 TEAQIKLSEKQGKV-NAMVLIP 348

		

		

		>PF05272#Virulence-associated E family protein

		          Length = 892

		

		 Score = 34.7 bits (79), Expect = 6e-04

		 Identities = 13/35 (37%), Positives = 18/35 (51%)

		

		Query: 32  VVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKR 66

		           VV  G  G GKSTL+  + GL+  +     IG  +

		Sbjct: 599 VVLEGTGGIGKSTLINTLVGLDFFSDTHFDIGTGK 633

		

		

		>RTXTOXIND#Gram-negative bacterial RTX secretion protein D

		          signature.

		          Length = 478

		

		 Score = 26.7 bits (59), Expect = 0.020

		 Identities = 5/33 (15%), Positives = 13/33 (39%), Gaps = 1/33 (3%)

		

		Query: 17 ELVEKR-QRFATILSIIMLAVYIGFILLIAFAP 48

		          EL+E    R   +++  ++   +   +L     

		Sbjct: 47 ELIETPVSRRPRLVAYFIMGFLVIAFILSVLGQ 79

		

		

		>VACJLIPOPROT#VacJ lipoprotein signature.

		          Length = 251

		

		 Score = 29.9 bits (67), Expect = 0.006

		 Identities = 6/21 (28%), Positives = 11/21 (52%)

		

		Query: 179 FGNLDDPNSEISQLLRQKPTY 199

		            GNL++P   ++  L+  P  

		Sbjct: 75  TGNLEEPAVMVNYFLQGDPYQ 95

		

		

		>HTHFIS#FIS bacterial regulatory protein HTH signature.

		          Length = 484

		

		 Score = 70.2 bits (172), Expect = 4e-16

		 Identities = 31/109 (28%), Positives = 50/109 (45%), Gaps = 4/109 (3%)

		

		Query: 4   VLIIDDDAMVAELNRRYVAQIPGFQCCGTASTLEKAKEIIFNSDTPIDLILLDIYMQKEN 63

		           +L+ DDDA +  +  + +++  G+      S        I  +    DL++ D+ M  EN

		Sbjct: 6   ILVADDDAAIRTVLNQALSRA-GYDVR-ITSNAATLWRWI--AAGDGDLVVTDVVMPDEN 61

		

		Query: 64  GLDLLPVLHNARCKSDVIVISSAADAATIKDSLHYGVVDYLIKPFQASR 112

		             DLLP +  AR    V+V+S+     T   +   G  DYL KPF  + 

		Sbjct: 62  AFDLLPRIKKARPDLPVLVMSAQNTFMTAIKASEKGAYDYLPKPFDLTE 110

		

		

		>PF06580#Sensor histidine kinase

		          Length = 349

		

		 Score = 41.0 bits (96), Expect = 7e-06

		 Identities = 21/99 (21%), Positives = 38/99 (38%), Gaps = 18/99 (18%)

		

		Query: 442 LIENALE-ALGP-EPGGEISVTLHYRHGWLHCEVNDDGPGIAPDKIDHIFDKGVSTKGSE 499

		           L+EN ++  +     GG+I +     +G +  EV + G     +                

		Sbjct: 263 LVENGIKHGIAQLPQGGKILLKGTKDNGTVTLEVENTGSLALKN------------TKES 310

		

		Query: 500 RGVGLALVKQQVENLGG---SIAVESEPGIFTQFFVQIP 535

		            G GL  V+++++ L G    I +  + G      V IP

		Sbjct: 311 TGTGLQNVRERLQMLYGTEAQIKLSEKQGKVN-AMVLIP 348

		

		

		>SACTRNSFRASE#Streptothricin acetyltransferase signature.

		          Length = 173

		

		 Score = 26.4 bits (58), Expect = 0.012

		 Identities = 9/28 (32%), Positives = 16/28 (57%)

		

		Query: 32  LAIIEHTDVDESLKGQGIGKQLVAKVVE 59

		            A+IE   V +  + +G+G  L+ K +E

		Sbjct: 89  YALIEDIAVAKDYRKKGVGTALLHKAIE 116

		

		

		>TCRTETA#Tetracycline resistance protein signature.

		          Length = 399

		

		 Score = 30.2 bits (68), Expect = 0.022

		 Identities = 36/190 (18%), Positives = 66/190 (34%), Gaps = 14/190 (7%)

		

		Query: 44  NHAISLFSAYA-SLVYVTPILGGWLADRLLGNRTAVIAGALLMTLGHVVLGIDTNSTFSL 102

		            H   L + YA       P+LG   +DR  G R  ++       + + ++       + L

		Sbjct: 43  AHYGILLALYALMQFACAPVLGAL-SDRF-GRRPVLLVSLAGAAVDYAIMAT-APFLWVL 99

		

		Query: 103 YLALAIIICGYGLFKSNISCLLGELYDEND-HRRDGGFSLLYAAGNIGSIAAPIACGLAA 161

		           Y+   +     G+  +  +     + D  D   R   F  + A    G +A P+  GL  

		Sbjct: 100 YIGRIV----AGITGATGAVAGAYIADITDGDERARHFGFMSACFGFGMVAGPVLGGLMG 155

		

		Query: 162 QWYGWHVGFALAGGGMFIGLLIFLSGHRHFQSTRSMDKKALTSVKF-ALPVWSWLVVMLC 220

		             +  H  F  A     +  L FL+G      +   +++ L       L  + W   M  

		Sbjct: 156 G-FSPHAPFFAAA---ALNGLNFLTGCFLLPESHKGERRPLRREALNPLASFRWARGMTV 211

		

		Query: 221 LAPVFFTLLL 230

		           +A +     +

		Sbjct: 212 VAALMAVFFI 221

		

		

		>GPOSANCHOR#Gram-positive coccus surface protein anchor signature.

		          Length = 539

		

		 Score = 51.6 bits (123), Expect = 1e-08

		 Identities = 60/392 (15%), Positives = 118/392 (30%), Gaps = 80/392 (20%)

		

		Query: 33  EQAKAAKPAQPEVVEALQSALNALEERKGSL-ERIKQYQEVIDNYPKLSATLRAQLNNMR 91

		           E +  A  +Q + +E +Q   +  E    +L  +              +  L  +L+N +

		Sbjct: 39  EVSAVATRSQTDTLEKVQERADKFEIENNTLKLKNSDLSFNNKALKDHNDELTEELSNAK 98

		

		Query: 92  DEPRSVSPGMSTDALNQEILQVSSQLLDKSRQAQQEQERAREIADSLNQLPQQQTDARRQ 151

		           ++ R     +S  A   + L+      D  +  +     +   +  +  L  ++     +

		Sbjct: 99  EKLRKNDKSLSEKASKIQELEARKA--DLEKALEGAMNFSTADSAKIKTLEAEKAALAAR 156

		

		Query: 152 LNEIERRLGTLTGNTPLNQAQNFALQSDSARLKALVDELELAQLSANNRQELARLRSELA 211

		             ++E+ L      +  + A+   L+++ A L+A   ELE          E A   S   

		Sbjct: 157 KADLEKALEGAMNFSTADSAKIKTLEAEKAALEARQAELE-------KALEGAMNFSTAD 209

		

		Query: 212 EKESQQLDAYLQALRNQLNSQRQLEAERALESTELLAENSADLPKDIVAQFKINRELSAA 271

		             + + L+A   AL  +     +        ST   +     L  +  A      EL  A

		Sbjct: 210 SAKIKTLEAEKAALAARKADLEKALEGAMNFSTA-DSAKIKTLEAEKAALEARQAELEKA 268

		

		Query: 272 LNQQAQRMDLVASQQRQATSQTLQVRQALNTLREQSQWLGSSNLLGEALRAQVARLPEMP 331

		           L                A  +TL+  +A                                

		Sbjct: 269 LEGAMNFST-----ADSAKIKTLEAEKA-------------------------------- 291

		

		Query: 332 KPQQLDTEMAQLRVQRLRYEDLLNKQPLLRQIHQADGQPLTAEQNRILEAQLRTQRELLN 391

		               L+ E A L                               Q+++L A  ++ R  L+

		Sbjct: 292 ---ALEAEKADLE-----------------------------HQSQVLNANRQSLRRDLD 319

		

		Query: 392 SLLQGGDTLLLELTKLKVSNGQLEDALKEVNE 423

		           +  +    L  E  KL+  N   E + + +  

		Sbjct: 320 ASREAKKQLEAEHQKLEEQNKISEASRQSLRR 351

		

		

		

		 Score = 42.7 bits (100), Expect = 8e-06

		 Identities = 48/239 (20%), Positives = 92/239 (38%), Gaps = 23/239 (9%)

		

		Query: 20  ATAPDSKQISQELEQAKAAKPAQPEVVEALQSALNALEERKGSLER-IKQYQEVIDNYPK 78

		           A A     + + LE A     A    ++ L++   ALE R+  LE+ ++           

		Sbjct: 222 ALAARKADLEKALEGAMNFSTADSAKIKTLEAEKAALEARQAELEKALEGAMNFSTADSA 281

		

		Query: 79  LSATLRAQLNNMRDEPRSVSPGMSTDALNQEILQVSSQLLDKSRQAQQEQERAREIADSL 138

		              TL A+   +  E   +        +     Q   + LD SR+A+++ E   +  +  

		Sbjct: 282 KIKTLEAEKAALEAEKADL---EHQSQVLNANRQSLRRDLDASREAKKQLEAEHQKLEEQ 338

		

		Query: 139 NQLPQQQTDARRQLNEIERRLGTLTGNTPLNQAQNFALQSDSARLKAL--VDELELAQLS 196

		           N++    ++A RQ   + R L                L+++  +L+    + E     L 

		Sbjct: 339 NKI----SEASRQ--SLRRDLDASR-------EAKKQLEAEHQKLEEQNKISEASRQSLR 385

		

		Query: 197 AN---NRQELARLRSELAEKESQQLDAYLQALRNQLNSQRQLEAERALESTELLAENSA 252

		            +   +R+   ++   L E  S +L A  +  +    S++  E E+A    +L AE  A

		Sbjct: 386 RDLDASREAKKQVEKALEEANS-KLAALEKLNKELEESKKLTEKEKAELQAKLEAEAKA 443

		

		

		>SECA#SecA protein signature.

		          Length = 901

		

		 Score = 32.2 bits (73), Expect = 0.005

		 Identities = 26/144 (18%), Positives = 54/144 (37%), Gaps = 6/144 (4%)

		

		Query: 282 HVIDAADVRVQENIEAVNTVLEEIDAHEIPTLLVMNKIDMLEDFEPRIDRDEENK-PIRV 340

		            ++D +DV    N    +     IDA+  P  L   ++  +   + R+  D +   PI  

		Sbjct: 665 ELLDVSDVSETINSIREDVFKATIDAYIPPQSL--EEMWDIPGLQERLKNDFDLDLPIAE 722

		

		Query: 341 WLSAQTGAGIPQLFQALTERLSGEVAQHTLRLPPQEGRLRSRFYQLQAIEKEWMEEDGSV 400

		           WL  +       L + +  +      +    +  +  R   +   LQ ++  W E   ++

		Sbjct: 723 WLDKEPELHEETLRERILAQSIEVYQRKEEVVGAEMMRHFEKGVMLQTLDSLWKEHLAAM 782

		

		Query: 401 SLQVRMPIVDWRRLCKQEPALIDY 424

		              +R  I   R   +++P   +Y

		Sbjct: 783 D-YLRQGIH-LRGYAQKDP-KQEY 803

		

		

		>cloacin#Cloacin signature.

		          Length = 551

		

		 Score = 31.6 bits (71), Expect = 0.006

		 Identities = 25/81 (30%), Positives = 30/81 (37%), Gaps = 10/81 (12%)

		

		Query: 17  GSSKPGGNSEGNGNKGGRDQGPPDLDDIFRKLSKKLGGLGGGKGTGSGGGSSSQGP---- 72

		            S   G +SE N   GG   G               G  GGG GTG G  S+   P    

		Sbjct: 33  ASDGSGWSSENNPWGGGSGSGIHWGGGSGHGNGGGNGNSGGGSGTG-GNLSAVAAPVAFG 91

		

		Query: 73  -----RPQLGGRVVTIAAAAI 88

		                 P  GG  V+I+A A+

		Sbjct: 92  FPALSTPGAGGLAVSISAGAL 112

		

		

		>RTXTOXIND#Gram-negative bacterial RTX secretion protein D

		           signature.

		          Length = 478

		

		 Score = 30.6 bits (69), Expect = 0.029

		 Identities = 12/55 (21%), Positives = 24/55 (43%), Gaps = 1/55 (1%)

		

		Query: 165 VVPDDSRLSFDILIPPDQIMGARMGFVVVVELTQRPTRRTKAV-GKIVEVLGDNM 218

		           +VP+D  L    L+    I    +G   ++++   P  R   + GK+  +  D +

		Sbjct: 359 IVPEDDTLEVTALVQNKDIGFINVGQNAIIKVEAFPYTRYGYLVGKVKNINLDAI 413

		

		

		>DHBDHDRGNASE#2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase

		           signature.

		          Length = 261

		

		 Score = 62.4 bits (151), Expect = 8e-14

		 Identities = 60/248 (24%), Positives = 103/248 (41%), Gaps = 33/248 (13%)

		

		Query: 6   GKTVLILGGSRGIGAAIVRRFVTDGANVR-FTYAGSKD---AAKRLAQETGATAVFTDSA 61

		           GK   I G ++GIG A+ R   + GA++    Y   K     +   A+   A A   D  

		Sbjct: 8   GKIAFITGAAQGIGEAVARTLASQGAHIAAVDYNPEKLEKVVSSLKAEARHAEAFPADVR 67

		

		Query: 62  DRDAVIDVV----RKSGALDILVVNAGIGVFGEALELNADDIDRLFKINIHAPYHASVEA 117

		           D  A+ ++     R+ G +DILV  AG+   G    L+ ++ +  F +N    ++AS   

		Sbjct: 68  DSAAIDEITARIEREMGPIDILVNVAGVLRPGLIHSLSDEEWEATFSVNSTGVFNASRSV 127

		

		Query: 118 ARQMP--EGGRILIIGS--VNGDRMPVAG----------MARGLARDFGPRGITINVVQP 163

		           ++ M     G I+ +GS      R  +A             + L  +     I  N+V P

		Sbjct: 128 SKYMMDRRSGSIVTVGSNPAGVPRTSMAAYASSKAAAVMFTKCLGLELAEYNIRCNIVSP 187

		

		Query: 164 GPIDTDA--------NPANGPMRDMLHSL---MAIKRHGQPEEVAGMVAWLAGPEASFVT 212

		           G  +TD         N A   ++  L +    + +K+  +P ++A  V +L   +A  +T

		Sbjct: 188 GSTETDMQWSLWADENGAEQVIKGSLETFKTGIPLKKLAKPSDIADAVLFLVSGQAGHIT 247

		

		Query: 213 GAMHTIDG 220

		                +DG

		Sbjct: 248 MHNLCVDG 255

		

		

		>HTHTETR#TetR bacterial regulatory protein HTH signature.

		          Length = 215

		

		 Score = 50.8 bits (121), Expect = 4e-10

		 Identities = 20/100 (20%), Positives = 38/100 (38%), Gaps = 6/100 (6%)

		

		Query: 5   KQSRVPGRPRRFAPEQAISAAKVLFHQKGFDAVSVAEVTDYLGINPPSLYAAFGSKAGLF 64

		           ++++   +  R   +  +  A  LF Q+G  + S+ E+    G+   ++Y  F  K+ LF

		Sbjct: 3   RKTKQEAQETR---QHILDVALRLFSQQGVSSTSLGEIAKAAGVTRGAIYWHFKDKSDLF 59

		

		Query: 65  SRVLNEYVGTEAIPLVDILRDDRPVGECLAEVLKEAARRY 104

		           S +           L    +   P       VL+E     

		Sbjct: 60  SEIWELSESN-IGELELEYQAKFP--GDPLSVLREILIHV 96

		

		

		>DHBDHDRGNASE#2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase

		           signature.

		          Length = 261

		

		 Score =  145 bits (368), Expect = 7e-45

		 Identities = 86/256 (33%), Positives = 134/256 (52%), Gaps = 8/256 (3%)

		

		Query: 7   LAGKNILITGSAQGIGFLLATGLGKYGAQIIINDITAERAELAVEKLRQEGIRAVAAPFN 66

		           + GK   ITG+AQGIG  +A  L   GA I   D   E+ E  V  L+ E   A A P +

		Sbjct: 6   IEGKIAFITGAAQGIGEAVARTLASQGAHIAAVDYNPEKLEKVVSSLKAEARHAEAFPAD 65

		

		Query: 67  VTHKHEIDTAVEHIEKDIGPIDVLVNNAGIQRRHPFTEFPEQEWNDVIAVNQTAVFLVSQ 126

		           V     ID     IE+++GPID+LVN AG+ R        ++EW    +VN T VF  S+

		Sbjct: 66  VRDSAAIDEITARIEREMGPIDILVNVAGVLRPGLIHSLSDEEWEATFSVNSTGVFNASR 125

		

		Query: 127 AVTRHMVERKAGKVINICSMQSELGRDTITPYAASKGAVKMLTRGMCVELARHNIQVNGI 186

		           +V+++M++R++G ++ + S  + + R ++  YA+SK A  M T+ + +ELA +NI+ N +

		Sbjct: 126 SVSKYMMDRRSGSIVTVGSNPAGVPRTSMAAYASSKAAAVMFTKCLGLELAEYNIRCNIV 185

		

		Query: 187 APGYFKTEMTKALVEDE--------AFTAWLCKRTPAARWGDPQELIGAAVFLSSKASDF 238

		           +PG  +T+M  +L  DE                  P  +   P ++  A +FL S  +  

		Sbjct: 186 SPGSTETDMQWSLWADENGAEQVIKGSLETFKTGIPLKKLAKPSDIADAVLFLVSGQAGH 245

		

		Query: 239 VNGHLLFVDGGMLVAV 254

		           +  H L VDGG  + V

		Sbjct: 246 ITMHNLCVDGGATLGV 261

		

		

		>TCRTETA#Tetracycline resistance protein signature.

		          Length = 399

		

		 Score = 50.6 bits (121), Expect = 5e-09

		 Identities = 49/310 (15%), Positives = 121/310 (39%), Gaps = 20/310 (6%)

		

		Query: 69  FFGAMADKYGRKPMMMWAIIIYSVGTGLSGIATNLYMLAVCRFIVGL-GMSGEYACASTY 127

		             GA++D++GR+P+++ ++   +V   +   A  L++L + R + G+ G +G  A A  Y

		Sbjct: 62  VLGALSDRFGRRPVLLVSLAGAAVDYAIMATAPFLWVLYIGRIVAGITGATG--AVAGAY 119

		

		Query: 128 AVESWPKNLQSKASAFLVSGFSVGNIIAAQIIPQFAEVYGWRNSFFI-----GLLPVLLV 182

		             +    + +++   F+ + F  G ++A  ++      +     FF      GL  +   

		Sbjct: 120 IADITDGDERARHFGFMSACFGFG-MVAGPVLGGLMGGFSPHAPFFAAAALNGLNFLTGC 178

		

		Query: 183 LWIRKSAPESQEWIEDKYKDKSTFLSVFRKPHLSISMIVFLVCFCLFGANWPINGLLPSY 242

		             + +S    +     + +  +   + FR       +   +  F +      +   L   

		Sbjct: 179 FLLPESHKGERR--PLRREALNPL-ASFRWARGMTVVAALMAVFFIMQLVGQVPAALWVI 235

		

		Query: 243 LADNGVNTVVISTLMTIAGLG---TLTGTIFFGFVGDKIGVKKAFVVGLITSFVFLCPLF 299

		             ++  +    +  +++A  G   +L   +  G V  ++G ++A ++G+I        L 

		Sbjct: 236 FGEDRFHWDATTIGISLAAFGILHSLAQAMITGPVAARLGERRALMLGMIADGTGYILLA 295

		

		Query: 300 FISVKNSSLIGLCLFGLM-FTNLGIAGLVPKFIYDYFPTKLRGLGTGLIYNLGATGGMAA 358

		           F +    +   + L          +  ++ + + +    +L+G    L     +   +  

		Sbjct: 296 FATRGWMAFPIMVLLASGGIGMPALQAMLSRQVDEERQGQLQGSLAALT----SLTSIVG 351

		

		Query: 359 PVLATYISGY 368

		           P+L T I   

		Sbjct: 352 PLLFTAIYAA 361

		

		

		>FERRIBNDNGPP#Ferrichrome-binding periplasmic protein signature.

		          Length = 296

		

		 Score = 64.2 bits (156), Expect = 6e-14

		 Identities = 44/240 (18%), Positives = 91/240 (37%), Gaps = 13/240 (5%)

		

		Query: 36  TPQRIVVLELSFADALAAVDVSPIGIADDNDAKRILPEVRAHLKPWQSVGTRAQPSLEAI 95

		            P RIV LE    + L A+ + P G+AD  + +  + E          VG R +P+LE +

		Sbjct: 34  DPNRIVALEWLPVELLLALGIVPYGVADTINYRLWVSE-PPLPDSVIDVGLRTEPNLELL 92

		

		Query: 96  AALKPDLIIADSSRHAGVYIALQQIAPVLLLKSR--NETYAENLQSAAIIGEMVGKKREM 153

		             +KP  ++  S+ +      L +IAP          +  A   +S   + +++  +   

		Sbjct: 93  TEMKPSFMVW-SAGYGPSPEMLARIAPGRGFNFSDGKQPLAMARKSLTEMADLLNLQSAA 151

		

		Query: 154 QARLEQHKERMAQWASQLPKGTR---VAFGTSREQQFNLHTQETWTGSVLASLGLNVPAA 210

		           +  L Q+++ +     +  K      +       +   +    +    +L   G  +P A

		Sbjct: 152 ETHLAQYEDFIRSMKPRFVKRGARPLLLTTLIDPRHMLVFGPNSLFQEILDEYG--IPNA 209

		

		Query: 211 MAGAS----MPSIGLEQLLAVNPAWLLVAHYREESIVKRWQQDPLWQMLTAAQKQQVASV 266

		             G +      ++ +++L A     +L   +     +      PLWQ +   +  +   V

		Sbjct: 210 WQGETNFWGSTAVSIDRLAAYKDVDVLCFDHDNSKDMDALMATPLWQAMPFVRAGRFQRV 269

		

		

		>ECOLNEIPORIN#E.coli/Neisseria porin superfamily signature.

		          Length = 331

		

		 Score = 32.9 bits (75), Expect = 0.004

		 Identities = 19/89 (21%), Positives = 29/89 (32%), Gaps = 9/89 (10%)

		

		Query: 546 GSFGTVQYSQIGKAVQSGNVEPEKARTWELGTRYDDGALTAEMGLFLINFNNQYDSNQTN 605

		           G F     +         NV  EK +   L + YD+ AL A +         Q D+    

		Sbjct: 187 GFFVQYGGAYKRHHQVQENVNIEKYQIHRLVSGYDNDALYASV------AVQQQDAKLVE 240

		

		Query: 606 DTVTARGKTRHTGLETQARYDLGTLTPTL 634

		           +          T +     Y  G +TP +

		Sbjct: 241 E---NYSHNSQTEVAATLAYRFGNVTPRV 266

		

		

		>PF00577#Outer membrane usher protein FimD

		          Length = 878

		

		 Score = 33.7 bits (77), Expect = 5e-04

		 Identities = 10/51 (19%), Positives = 18/51 (35%), Gaps = 2/51 (3%)

		

		Query: 17  MNASGLNQGTSGNVSARYTGGMLITPSGIAYSKMTPDMIVFVDDKGIPEAG 67

		           +  S  +            GG+L   +G+   +   D +V V   G  +A 

		Sbjct: 682 IGYSHSDDIKQLYYGVS--GGVLAHANGVTLGQPLNDTVVLVKAPGAKDAK 730

		

		

		>SACTRNSFRASE#Streptothricin acetyltransferase signature.

		          Length = 173

		

		 Score = 28.8 bits (64), Expect = 0.008

		 Identities = 20/77 (25%), Positives = 30/77 (38%), Gaps = 10/77 (12%)

		

		Query: 85  LAVIPEYQGMGVGGRLIRTGIE--------HLRLMGCQTVFVLGHATYYPRHGFEPCAGD 136

		           +AV  +Y+  GVG  L+   IE         L L   Q + +     +Y +H F   A D

		Sbjct: 95  IAVAKDYRKKGVGTALLHKAIEWAKENHFCGLMLE-TQDINISA-CHFYAKHHFIIGAVD 152

		

		Query: 137 KGYPAPYPIPEEHKACW 153

		               + +P   E    W

		Sbjct: 153 TMLYSNFPTANEIAIFW 169

		

		

		>SACTRNSFRASE#Streptothricin acetyltransferase signature.

		          Length = 173

		

		 Score = 27.6 bits (61), Expect = 0.007

		 Identities = 17/83 (20%), Positives = 30/83 (36%), Gaps = 10/83 (12%)

		

		Query: 21  QVLIGDIYLRQQCDVFWLGY------TISPAYTRQGYAIEAITATIDWIKENGFSLIKAG 74

		              IG I +R      W GY       ++  Y ++G     +   I+W KEN F  +   

		Sbjct: 74  NNCIGRIKIRSN----WNGYALIEDIAVAKDYRKKGVGTALLHKAIEWAKENHFCGLMLE 129

		

		Query: 75  VNPENTLSKKLLIRIGFNFSSIE 97

		               N  +     +  F   +++

		Sbjct: 130 TQDINISACHFYAKHHFIIGAVD 152

		

		

		>TCRTETA#Tetracycline resistance protein signature.

		          Length = 399

		

		 Score = 29.4 bits (66), Expect = 0.027

		 Identities = 69/407 (16%), Positives = 120/407 (29%), Gaps = 45/407 (11%)

		

		Query: 40  LFVLFIFSFLDRINIGFAGL---TMGRDLGLS---ATMFGLATTLFYAAYVIFGIPSNIM 93

		           L V+     LD + IG        + RDL  S      +G+   L+             +

		Sbjct: 7   LIVILSTVALDAVGIGLIMPVLPGLLRDLVHSNDVTAHYGILLALYALMQFACAPVLGAL 66

		

		Query: 94  LSIVGARRWIATIMVLWGIASTATMFATGPT--SLYVLRILVGITEAGFLPGILLYLTFW 151

		               G R     ++ L G A    + AT P    LY+ RI+ GIT A        Y+   

		Sbjct: 67  SDRFGRR--PVLLVSLAGAAVDYAIMATAPFLWVLYIGRIVAGITGATG-AVAGAYIADI 123

		

		Query: 152 FPAYFRARANALFMVAMPVTTALGSIVSGYILSLDGVMALKGWQWLFLLEGFPSVLLGVM 211

		                RAR               G ++ G        M        F      + L  + 

		Sbjct: 124 TDGDERARHFGFMSACFGFGMVAGPVLGGL-------MGGFSPHAPFFAAAALNGLNFLT 176

		

		Query: 212 VWFWLDDSPDKAKWLTKEDKKCLQEMMDNDRLTLVQPEGAISHHAMQQRSMWREIFTPVV 271

		             F L +S    +                 R   + P  +           W    T V 

		Sbjct: 177 GCFLLPESHKGER--------------RPLRREALNPLASFR---------WARGMTVVA 213

		

		Query: 272 MMYTLAYFCLTNTLSAISIWTPQILQSFNQGSSNITIGLLAAVPQICTILGMVYWSRHSD 331

		            +  + +          ++W       F+      TIG+  A   I   L     +    

		Sbjct: 214 ALMAVFFIMQLVGQVPAALWVIFGEDRFHW--DATTIGISLAAFGILHSLAQAMITGPVA 271

		

		Query: 332 RRQERRHHTALPYLFAAAGWLLASATDHNMIQMLGIIMASTGSFSAMAIFWTTPDQSISL 391

		            R   R    L  +    G++L +      +    +++ ++G     A+      Q    

		Sbjct: 272 ARLGERRALMLGMIADGTGYILLAFATRGWMAFPIMVLLASGGIGMPALQAMLSRQVDEE 331

		

		Query: 392 RARAIGIAVINATGNIGSALSPFMIGWLKDLT-GSFNSGLWFVAALL 437

		           R   +  ++   T ++ S + P +   +   +  ++N   W   A L

		Sbjct: 332 RQGQLQGSLAALT-SLTSIVGPLLFTAIYAASITTWNGWAWIAGAAL 377

		

		

		>PHPHTRNFRASE#Phosphoenolpyruvate-protein phosphotransferase

		           signature.

		          Length = 572

		

		 Score = 29.8 bits (67), Expect = 0.011

		 Identities = 32/182 (17%), Positives = 59/182 (32%), Gaps = 34/182 (18%)

		

		Query: 78  QIKQLLDVGTQT---LLVPMVQNADEAREAVRATRYPPAGIRGVGSALARASRWNRIPDY 134

		           Q++ LL   T     ++ PM+   +E R+A    +     +   G  ++ +         

		Sbjct: 374 QLRALLRASTYGNLKVMFPMIATLEELRQAKAIMQEEKDKLLSEGVDVSDSIEVG----- 428

		

		Query: 135 LQKANDQMCVLVQIETREAMKNLPQILDVEGVDGVFIGPADL----------SADMGYAG 184

		                      + +E              + VD   IG  DL          +  + Y  

		Sbjct: 429 -----------IMVEIPSTAVAANLFA--KEVDFFSIGTNDLIQYTMAADRMNERVSYLY 475

		

		Query: 185 NPQHPEVQAAIEQAIVQIRESGKAPGI---LIANEQLAKRYLELGALFVAVGVDTTLLAR 241

		            P HP +   ++  I      GK  G+   +  +E      L LG    ++   + L AR

		Sbjct: 476 QPYHPAILRLVDMVIKAAHSEGKWVGMCGEMAGDEVAIPLLLGLGLDEFSMSATSILPAR 535

		

		Query: 242 AA 243

		           + 

		Sbjct: 536 SQ 537

		

		

		>PF07201#Hypersensitivity response secretion protein HrpJ

		          Length = 293

		

		 Score = 30.2 bits (68), Expect = 0.007

		 Identities = 9/51 (17%), Positives = 24/51 (47%)

		

		Query: 138 LHAVDARVNELEELLPLLMKDKLLAKGVSHLLSSQLTRILRTHAAMSVLGH 188

		           +  V+ +VN+    +P L + + +++ +S L +S    + +  A +     

		Sbjct: 80  VSDVEEQVNQYLSKVPELEQKQNVSELLSLLSNSPNISLSQLKAYLEGKSE 130

		

		

		>SHAPEPROTEIN#Bacterial cell shape determinant MreB/Mbl protein

		           signature.

		          Length = 347

		

		 Score =  143 bits (362), Expect = 6e-40

		 Identities = 83/387 (21%), Positives = 149/387 (38%), Gaps = 84/387 (21%)

		

		Query: 5   IGIDLGTTNSCVAIMDGTTPRVLENAEGDRTTPSIIAYTQDGET------LVGQPAKRQA 58

		           + IDLGT N+ + +       + E        PS++A  QD          VG  AK+  

		Sbjct: 13  LSIDLGTANTLIYVKGQGIV-LNE--------PSVVAIRQDRAGSPKSVAAVGHDAKQML 63

		

		Query: 59  VTNPQNTLFAIKRLIGRRFQDEEVQRDVSIMPFKIIAADNGDAWVEVKGQKMAPPQISAE 118

		              P N + AI+ +           +D  I  F +                     +   

		Sbjct: 64  GRTPGN-IAAIRPM-----------KDGVIADFFVTEK------------------MLQH 93

		

		Query: 119 VLKKMKKTAEDYLGEPVTEAVITVPAYFNDAQRQATKDAGRIAGLEVKRIINEPTAAALA 178

		            +K++     +    P    ++ VP      +R+A +++ + AG     +I EP AAA+ 

		Sbjct: 94  FIKQVHS---NSFMRPSPRVLVCVPVGATQVERRAIRESAQGAGAREVFLIEEPMAAAIG 150

		

		Query: 179 YGL--DKGTGNRTIAVYDLGGGTFDISIIEIDEVDGEKTFEVLATNGDTHLGGEDFDSRL 236

		            GL   + TG+    V D+GGGT ++++I ++ V           +    +GG+ FD  +

		Sbjct: 151 AGLPVSEATGS---MVVDIGGGTTEVAVISLNGV---------VYSSSVRIGGDRFDEAI 198

		

		Query: 237 INYLVEEFKKDQGIDLRNDPLAMQRLKEAAEKAKIELSSA----QQTDVNLPYITADATG 292

		           INY+   +    G             +  AE+ K E+ SA    +  ++ +         

		Sbjct: 199 INYVRRNYGSLIG-------------EATAERIKHEIGSAYPGDEVREIEVRGRNLAEGV 245

		

		Query: 293 PKHMNIKVTRAKLESLVEDLVNRSIEPLKVALQD-AGLSVSDIDD--VILVGGQTRMPMV 349

		           P+   +  +   LE+L E  +   +  + VAL+       SDI +  ++L GG   +  +

		Sbjct: 246 PRGFTLN-SNEILEALQEP-LTGIVSAVMVALEQCPPELASDISERGMVLTGGGALLRNL 303

		

		Query: 350 QKKVAEFFGKEPRKDVNPDEAVAIGAA 376

		            + + E  G       +P   VA G  

		Sbjct: 304 DRLLMEETGIPVVVAEDPLTCVARGGG 330

		

		

		>HOKGEFTOXIC#Hok/Gef cell toxic protein family signature.

		          Length = 52

		

		 Score = 61.4 bits (149), Expect = 4e-17

		 Identities = 18/46 (39%), Positives = 30/46 (65%)

		

		Query: 23 HKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYES 68

		            +++  ++++C+T ++   +TRK LCE+  R G  EVA F AYES

		Sbjct: 5  RSSLVWCVLIVCLTLLIFTYLTRKSLCEIRYRDGYREVAAFMAYES 50

		

		

		>PF00577#Outer membrane usher protein FimD

		          Length = 878

		

		 Score =  255 bits (653), Expect = 1e-79

		 Identities = 87/387 (22%), Positives = 164/387 (42%), Gaps = 20/387 (5%)

		

		Query: 1   MAAWRYASQDYRTFSDHLYENDKHYH----------QSDYNDFYDIG--RKNSLSANIMQ 48

		           +  +RY++  Y  F+D  Y     Y+          +  + D+Y++   ++  L   + Q

		Sbjct: 476 LVGYRYSTSGYFNFADTTYSRMNGYNIETQDGVIQVKPKFTDYYNLAYNKRGKLQLTVTQ 535

		

		Query: 49  PLSNNLGNVSLSALWRNYWGRSGNAKDYQFSYSNNWQHISYTFSASQSYDENNKEEER-F 107

		            L      + LS   + YWG S   + +Q   +  ++ I++T S S + +   K  ++  

		Sbjct: 536 QL-GRTSTLYLSGSHQTYWGTSNVDEQFQAGLNTAFEDINWTLSYSLTKNAWQKGRDQML 594

		

		Query: 108 NLFISIPF--YWGDDIAKTRHQINLSNSTSFSKDGYSSNNTGITGIAGEHDQLNYGI--- 162

		            L ++IPF  +   D        + S S S   +G  +N  G+ G   E + L+Y +   

		Sbjct: 595 ALNVNIPFSHWLRSDSKSQWRHASASYSMSHDLNGRMTNLAGVYGTLLEDNNLSYSVQTG 654

		

		Query: 163 YVNQQQQNNDTSLGTNLSWRTPIAIIDGSYSHSKNAWQSGGSISSGLVVWSGGINITNQL 222

		           Y      N+ ++    L++R      +  YSHS +  Q    +S G++  + G+ +   L

		Sbjct: 655 YAGGGDGNSGSTGYATLNYRGGYGNANIGYSHSDDIKQLYYGVSGGVLAHANGVTLGQPL 714

		

		Query: 223 SDTFAILDAPGLEGAHINGQKYNRTNSKGQVVYDLIIPHRENHLVLDIANSESETELQGN 282

		           +DT  ++ APG + A +  Q   RT+ +G  V      +REN + LD        +L   

		Sbjct: 715 NDTVVLVKAPGAKDAKVENQTGVRTDWRGYAVLPYATEYRENRVALDTNTLADNVDLDNA 774

		

		Query: 283 RQIIAPYRGAVSYVQFTTDQRKPWYIQALRPDGSPLTFGYDVLDLQENNIGVVGQGSRLF 342

		              + P RGA+   +F         +  L  +  PL FG  V      + G+V    +++

		Sbjct: 775 VANVVPTRGAIVRAEFKARVGIKLLMT-LTHNNKPLPFGAMVTSESSQSSGIVADNGQVY 833

		

		Query: 343 IRVDEIPTGIKVALNDEQNLFCTITFQ 369

		           +    +   ++V   +E+N  C   +Q

		Sbjct: 834 LSGMPLAGKVQVKWGEEENAHCVANYQ 860

		

		

		>INFPOTNTIATR#Macrophage infectivity potentiator signature.

		          Length = 233

		

		 Score = 30.7 bits (69), Expect = 0.002

		 Identities = 14/32 (43%), Positives = 19/32 (59%)

		

		Query: 8   NSAVLVHFTLKLDDGTTAESTRNNGKPALFRL 39

		           +  V V +T  L DGT  +ST   GKPA F++

		Sbjct: 144 SDTVTVEYTGTLIDGTVFDSTEKAGKPATFQV 175

		

		

		>HTHFIS#FIS bacterial regulatory protein HTH signature.

		          Length = 484

		

		 Score = 32.5 bits (74), Expect = 0.009

		 Identities = 20/110 (18%), Positives = 38/110 (34%), Gaps = 18/110 (16%)

		

		Query: 34  CKALREEGYRVILVNS-----------NPATIMTDPEMADATYIEPIHWEVVRKIIEKER 82

		            +AL   GY V + ++           +   ++TD  M D    +      +   I+K R

		Sbjct: 20  NQALSRAGYDVRITSNAATLWRWIAAGDGDLVVTDVVMPDENAFD------LLPRIKKAR 73

		

		Query: 83  PDAVLPTMGGQTALNCALELERQGVLEEFGVTM-IGATADAIDKAEDRRR 131

		           PD  +  M  Q     A++   +G  +       +      I +A    +

		Sbjct: 74  PDLPVLVMSAQNTFMTAIKASEKGAYDYLPKPFDLTELIGIIGRALAEPK 123

		

		

		>TCRTETOQM#Tetracycline resistance protein TetO/TetQ/TetM family

		           signature.

		          Length = 639

		

		 Score = 29.4 bits (66), Expect = 0.040

		 Identities = 19/103 (18%), Positives = 39/103 (37%), Gaps = 18/103 (17%)

		

		Query: 300 ILIADKQSVGERAVKGICGQVDGSVV------PGFIGLEAGQS-AFGDIYAWFGRVLGWP 352

		           + I++K+ +    +  +   ++G +        G I +   +      +    G     P

		Sbjct: 281 VRISEKEKIK---ITEMYTSINGELCKIDKAYSGEIVILQNEFLKLNSV---LGDTKLLP 334

		

		Query: 353 L-EQLAAQHPELKAQINASQKQ----LLPALTEAWAKNPSLDH 390

		             E++    P L+  +  S+ Q    LL AL E    +P L +

		Sbjct: 335 QRERIENPLPLLQTTVEPSKPQQREMLLDALLEISDSDPLLRY 377

		

		

		>PF05616#Neisseria meningitidis TspB protein

		          Length = 501

		

		 Score = 29.3 bits (65), Expect = 0.022

		 Identities = 26/118 (22%), Positives = 47/118 (39%), Gaps = 21/118 (17%)

		

		Query: 82  YGRHPEAREWYHQWVYFRPRAYWHEWLNWPSIFVNTGFFRPDEAHQPHFSDLFGQ-IINA 140

		           Y R PE +E     +    R YW +  N P ++    +F+     + +F    G  ++  

		Sbjct: 158 YSRFPEVKELMESQMERLARPYWEKLRNRPDMY----YFKNYNFKRCYFGLNGGDCLVAK 213

		

		Query: 141 G-----------QGEGRYSELLAINLLEQLLLRRMEA-----INESLHPPMDNRVREA 182

		           G           QG  +Y E +    LE++L  +++A     I  + +P    +V  A

		Sbjct: 214 GDDGRTFISFSLQGNSKYKEEMDAKKLEEILSLKVDANPDKYIKATGYPGYSEKVEVA 271

		

		

		>FLGMRINGFLIF#Flagellar M-ring protein signature.

		          Length = 559

		

		 Score = 29.2 bits (65), Expect = 0.020

		 Identities = 26/99 (26%), Positives = 39/99 (39%), Gaps = 20/99 (20%)

		

		Query: 110 MVKIEGGEWL----VETVKMLTERAVPVCGHLGLTPQSVNIFGGYKVQGRGDEAGDQL-L 164

		            V +E G  L    +  V  L   AV      GL P +V +          D++G  L  

		Sbjct: 176 TVTLEPGRALDEGQISAVVHLVSSAVA-----GLPPGNVTLV---------DQSGHLLTQ 221

		

		Query: 165 SDALALEAAGAQLLVLECVPVELAKRITEALAIPVIGIG 203

		           S+    +   AQL     V   + +RI   L+ P++G G

		Sbjct: 222 SNTSGRDLNDAQLKFANDVESRIQRRIEAILS-PIVGNG 259

		

		

		>PF00577#Outer membrane usher protein FimD

		          Length = 878

		

		 Score =  790 bits (2043), Expect = 0.0

		 Identities = 267/850 (31%), Positives = 426/850 (50%), Gaps = 38/850 (4%)

		

		Query: 15  RIATFCALLYCNSAFCAELVEYDHTFLMGQNASNIDLSRYSEGNPAIPGMYDVSVYVNDQ 74

		           R+   CA         AE + ++  FL     +  DLSR+  G    PG Y V +Y+N+ 

		Sbjct: 29  RLFVACAFAAQAPLSSAE-LYFNPRFLADDPQAVADLSRFENGQELPPGTYRVDIYLNNG 87

		

		Query: 75  PIINQSITFIEIEGKKNAQACITLKNLLQFHINSPDINNEKAVLLARDETLGNCLNLTEI 134

		            +  + +TF   + ++    C+T   L    +N+  +      LLA D     C+ LT +

		Sbjct: 88  YMATRDVTFNTGDSEQGIVPCLTRAQLASMGLNTASV--SGMNLLADDA----CVPLTSM 141

		

		Query: 135 IPQASVRYDVNEQRLDIDVPQAWVMKNYQNYVDPSLWENGINAAMLSYNLNGYHSETP-G 193

		           I  A+ + DV +QRL++ +PQA++    + Y+ P LW+ GINA +L+YN +G   +   G

		Sbjct: 142 IHDATAQLDVGQQRLNLTIPQAFMSNRARGYIPPELWDPGINAGLLNYNFSGNSVQNRIG 201

		

		Query: 194 RRNDSIYAAFNGGMNLGAWRLRASGNYNWMTDSGS-----NYDFKNRYIQRDIASLRSQL 248

		             +   Y     G+N+GAWRLR +  +++ +   S      +   N +++RDI  LRS+L

		Sbjct: 202 GNSHYAYLNLQSGLNIGAWRLRDNTTWSYNSSDSSSGSKNKWQHINTWLERDIIPLRSRL 261

		

		Query: 249 ILGESYTTGETFDSVSIRGIRLYSDSRMLPPTLASFAPIIHGVANTNAKVTITQGGYKIY 308

		            LG+ YT G+ FD ++ RG +L SD  MLP +   FAP+IHG+A   A+VTI Q GY IY

		Sbjct: 262 TLGDGYTQGDIFDGINFRGAQLASDDNMLPDSQRGFAPVIHGIARGTAQVTIKQNGYDIY 321

		

		Query: 309 ETTVPPGAFVIDDLSPSGYGSDLIVTVEESDGSKRTFSQPFSSVVQMLRPGVGRWDISGG 368

		            +TVPPG F I+D+  +G   DL VT++E+DGS + F+ P+SSV  + R G  R+ I+ G

		Sbjct: 322 NSTVPPGPFTINDIYAAGNSGDLQVTIKEADGSTQIFTVPYSSVPLLQREGHTRYSITAG 381

		

		Query: 369 QVLKDD-IQDEPNLFQASYYYGLNNYLTGYTGIQITDNNYTAGLLGLGLNT-SVGAFSFD 426

		           +    +  Q++P  FQ++  +GL    T Y G Q+ D  Y A   G+G N  ++GA S D

		Sbjct: 382 EYRSGNAQQEKPRFFQSTLLHGLPAGWTIYGGTQLAD-RYRAFNFGIGKNMGALGALSVD 440

		

		Query: 427 VTHSNVRIPDDKTYQGQSYRVSWNKLFEETSTSLNIAAYRYSTQNYLGLNDALTLIDEVK 486

		           +T +N  +PDD  + GQS R  +NK   E+ T++ +  YRYST  Y    D         

		Sbjct: 441 MTQANSTLPDDSQHDGQSVRFLYNKSLNESGTNIQLVGYRYSTSGYFNFADTTYSRMNGY 500

		

		Query: 487 HPE-----QDLEPKSMRNYSRM---KNQVTVSINQPLKFEKKDYGSFYLSGSWSDYWASG 538

		           + E       ++PK    Y+     + ++ +++ Q L        + YLSGS   YW + 

		Sbjct: 501 NIETQDGVIQVKPKFTDYYNLAYNKRGKLQLTVTQQL----GRTSTLYLSGSHQTYWGTS 556

		

		Query: 539 QNRSNYSIGYSNSASWGSYSVSAQRSWNE-DGDTDDSVYLSFTIPIEKLLGTEQRTS-GF 596

		                +  G + +    ++++S   + N      D  + L+  IP    L ++ ++    

		Sbjct: 557 NVDEQFQAGLNTAFEDINWTLSYSLTKNAWQKGRDQMLALNVNIPFSHWLRSDSKSQWRH 616

		

		Query: 597 QSIDTQMSSDFKGNNQLNVSSSGYS-DNARVSYSVNTGYTMNKASKDLSYVGGYASYESP 655

		            S    MS D  G         G   ++  +SYSV TGY         S      +Y   

		Sbjct: 617 ASASYSMSHDLNGRMTNLAGVYGTLLEDNNLSYSVQTGYAGGGDGNSGSTGYATLNYRGG 676

		

		Query: 656 WGSLAGSVSANSDNSRQVSLSTDGGFVLHSGGLTFSNDSFSDSDTLAVVQAPGAQGARIN 715

		           +G+     S + D  +Q+     GG + H+ G+T        +DT+ +V+APGA+ A++ 

		Sbjct: 677 YGNANIGYSHSDDI-KQLYYGVSGGVLAHANGVTLGQPL---NDTVVLVKAPGAKDAKVE 732

		

		Query: 716 YGNST-IDRWGYGVTSALSPYHENRIALDINDLENDVELKSTSAVAVPRQGSVVFADFET 774

		                  D  GY V    + Y ENR+ALD N L ++V+L +  A  VP +G++V A+F+ 

		Sbjct: 733 NQTGVRTDWRGYAVLPYATEYRENRVALDTNTLADNVDLDNAVANVVPTRGAIVRAEFKA 792

		

		Query: 775 VQGQSAIMNITRSDGKNIPFAADIYDEQGNVIGNVGQGGQAFVRGIEQQGNISIKWLEES 834

		             G   +M +T  + K +PF A +  E     G V   GQ ++ G+   G + +KW EE 

		Sbjct: 793 RVGIKLLMTLTH-NNKPLPFGAMVTSESSQSSGIVADNGQVYLSGMPLAGKVQVKWGEEE 851

		

		Query: 835 KPVSCLAHYQ 844

		               C+A+YQ

		Sbjct: 852 NA-HCVANYQ 860

		

		

		>FERRIBNDNGPP#Ferrichrome-binding periplasmic protein signature.

		          Length = 296

		

		 Score =  507 bits (1308), Expect = 0.0

		 Identities = 293/296 (98%), Positives = 293/296 (98%)

		

		Query: 1   MSGLPLISRRRLLTAMALSPLLWQMNTAHAAAIDPNRIVALEWLPVELLLALGIVPYGVA 60

		           MSGLPLISRRRLLTAMALSPLLWQMNTAHAAAIDPNRIVALEWLPVELLLALGIVPYGVA

		Sbjct: 1   MSGLPLISRRRLLTAMALSPLLWQMNTAHAAAIDPNRIVALEWLPVELLLALGIVPYGVA 60

		

		Query: 61  DTINYRLWVSEPPLPDSVIDVGLRTEPNLELLTEMKPSFMVWSAGYGPSSEMLARIAPGR 120

		           DTINYRLWVSEPPLPDSVIDVGLRTEPNLELLTEMKPSFMVWSAGYGPS EMLARIAPGR

		Sbjct: 61  DTINYRLWVSEPPLPDSVIDVGLRTEPNLELLTEMKPSFMVWSAGYGPSPEMLARIAPGR 120

		

		Query: 121 GFNFSDGKQPLAMARKSLTEMADLLNLQSAAETHLAQYEDFILSMKPRFVKRGARPLLLT 180

		           GFNFSDGKQPLAMARKSLTEMADLLNLQSAAETHLAQYEDFI SMKPRFVKRGARPLLLT

		Sbjct: 121 GFNFSDGKQPLAMARKSLTEMADLLNLQSAAETHLAQYEDFIRSMKPRFVKRGARPLLLT 180

		

		Query: 181 TLIDPRHMLVFGPNSLFQEILDEYGIPNAWQGETNFWGSTAVSIDRLAAYKDVDVLCFDH 240

		           TLIDPRHMLVFGPNSLFQEILDEYGIPNAWQGETNFWGSTAVSIDRLAAYKDVDVLCFDH

		Sbjct: 181 TLIDPRHMLVFGPNSLFQEILDEYGIPNAWQGETNFWGSTAVSIDRLAAYKDVDVLCFDH 240

		

		Query: 241 DNSKDMDALMATPLWQAMPFVRTGRFQRVPAVWFYGATLSAMHFVRVLDNAIGGKA 296

		           DNSKDMDALMATPLWQAMPFVR GRFQRVPAVWFYGATLSAMHFVRVLDNAIGGKA

		Sbjct: 241 DNSKDMDALMATPLWQAMPFVRAGRFQRVPAVWFYGATLSAMHFVRVLDNAIGGKA 296

		

		

		>BINARYTOXINB#Binary toxin B family signature.

		          Length = 764

		

		 Score = 34.3 bits (78), Expect = 4e-04

		 Identities = 12/55 (21%), Positives = 28/55 (50%), Gaps = 4/55 (7%)

		

		Query: 186 NDYYRKVKELRAKNQITLPVILKNERQINVFLRT----EDIDLINVINEETLLQQ 236

		            +   ++ EL A N  T+   +K   ++N+ +R      D + I V  +E+++++

		Sbjct: 589 QNIKNQLAELNATNIYTVLDKIKLNAKMNILIRDKRFHYDRNNIAVGADESVVKE 643

		

		

		>PF06580#Sensor histidine kinase

		          Length = 349

		

		 Score = 31.8 bits (72), Expect = 0.016

		 Identities = 15/95 (15%), Positives = 29/95 (30%), Gaps = 9/95 (9%)

		

		Query: 18  RPAMPRFKVSAFWLLILAWIFL-LVWIWWKGPTWTLYEEQWLKPLANRWLATAAWG---- 72

		           +  +          ++ A + + +VW       W L      KP+A       +      

		Sbjct: 66  QGWLKLNMGQIILRVLPACVVIGMVWFVANTSIWRLLAFINTKPVAFTLPLALSIIFNVV 125

		

		Query: 73  IIALMW----LTVRVMKRLQQLEKMQKQQREEAVD 103

		           ++  MW          K  +Q E  Q +    A +

		Sbjct: 126 VVTFMWSLLYFGWHFFKNYKQAEIDQWKMASMAQE 160

		

		

		>IGASERPTASE#IgA-specific serine endopeptidase (S6) signature.

		          Length = 1541

		

		 Score = 35.0 bits (80), Expect = 0.002

		 Identities = 33/213 (15%), Positives = 71/213 (33%), Gaps = 11/213 (5%)

		

		Query: 432  SALTTLSHQQEAEIRQLERELRIGLRTDTSRMTEVLVQYDETLTALDELEAAWHQQQTLV 491

		            +     ++ Q  E+ Q   E +    T+T     V  +    +      E      Q   

		Sbjct: 1072 AKSNVKANTQTNEVAQSGSETKETQTTETKETATVEKEEKAKVETEKTQEVPKVTSQVSP 1131

		

		Query: 492  REIIALRQQLLGVAEDDAAP---LPDADTVEDTQPESESESESESESESESESESEQDNT 548

		            ++  +   Q       +  P   + +  +  +T  ++E  ++  S +  +  +ES   NT

		Sbjct: 1132 KQEQSETVQPQAEPARENDPTVNIKEPQSQTNTTADTEQPAKETSSNVEQPVTESTTVNT 1191

		

		Query: 549  GAEPADEAGSE-----QPEETAETVSPVQRLAHLTAELDALHNDRLLVSPHVDKKQIAA- 602

		            G    +   +      QP   +E+ S   +  H  +     HN     +   D+  +A  

		Sbjct: 1192 GNSVVENPENTTPATTQPTVNSES-SNKPKNRHRRSVRSVPHNVEPATTSSNDRSTVALC 1250

		

		Query: 603  -VIAEWTGVPLNRLSQNEMSVITDLPKWLGDTI 634

		             + +  T   L+        V  ++ K +   I

		Sbjct: 1251 DLTSTNTNAVLSDARAKAQFVALNVGKAVSQHI 1283

		

		

		>OUTRSURFACE#Outer surface protein signature.

		          Length = 273

		

		 Score = 36.4 bits (84), Expect = 6e-04

		 Identities = 42/184 (22%), Positives = 73/184 (39%), Gaps = 21/184 (11%)

		

		Query: 395 RVTITDSLNRR--EVLYTEGEGGLKRVVKKEHADGSITRSEYDEAGRL--KAQTDAAGRR 450

		           ++TI D L++   E+   +G+  + R V  +  D + T   ++E G L  K  T   G +

		Sbjct: 87  KLTIADDLSKTTFELFKEDGKTLVSRKVSSK--DKTSTDEMFNEKGELSAKTMTRENGTK 144

		

		Query: 451 TEYRLHMASGAVTAVTGPDGRTVRYGYNSQRQVTSVTYPDGLRSSREYDEKGRLTAETSR 510

		            EY    + G   A       T+     + +   ++   +G  +         L+ E ++

		Sbjct: 145 LEYTEMKSDGTGKAKEVLKNFTLEGKVANDK--VTLEVKEGTVT---------LSKEIAK 193

		

		Query: 511 SGETTRYSYDDPASEL--PTGIQDATGSTKQM-AWSRYGQLLAFTDCSGYTTRYEYDRYG 567

		           SGE T    D   ++    TG  D+  ST  +   S+    L FT      T  +YD  G

		Sbjct: 194 SGEVTVALNDTNTTQATKKTGAWDSKTSTLTISVNSKKTTQLVFTK-QDTITVQKYDSAG 252

		

		Query: 568 QQIA 571

		             + 

		Sbjct: 253 TNLE 256

		

		

		

		 Score = 34.1 bits (78), Expect = 0.003

		 Identities = 23/100 (23%), Positives = 46/100 (46%), Gaps = 10/100 (10%)

		

		Query: 572 VHREEGISTYSSYNPRGQLVSQKDAQGRETRYEYSAAGDLTATVSPDGKRSTIEYDKRGR 631

		           V  ++  ST   +N +G+L ++   +   T+ EY+   ++ +  +   K     +   G+

		Sbjct: 114 VSSKDKTSTDEMFNEKGELSAKTMTRENGTKLEYT---EMKSDGTGKAKEVLKNFTLEGK 170

		

		Query: 632 ------PVSVTEGGLTRSMGYDAAGRITV-LTNENGSQST 664

		                  + V EG +T S     +G +TV L + N +Q+T

		Sbjct: 171 VANDKVTLEVKEGTVTLSKEIAKSGEVTVALNDTNTTQAT 210

		

		

		>ECOLIPORIN#E.coli/Salmonella-type porin signature.

		          Length = 383

		

		 Score =  549 bits (1416), Expect = 0.0

		 Identities = 232/384 (60%), Positives = 269/384 (70%), Gaps = 34/384 (8%)

		

		Query: 1   MKKSTLALVVMGIVASASVQAAEIYNKDGNKLDVYGKVKAMHYMSDNASKDGDQSYIRFG 60

		           MK+  LALV+  ++A+ +  AAEIYNKDGNKLD+YGKV  +HY SD++SKDGDQ+Y+R G

		Sbjct: 1   MKRKVLALVIPALLAAGAAHAAEIYNKDGNKLDLYGKVDGLHYFSDDSSKDGDQTYMRVG 60

		

		Query: 61  FKGETQINDQLTGYGRWEAEFAGNKAESDTAQQKTRLAFAGLKYKDLGSFDYGRNLGALY 120

		           FKGETQINDQLTGYG+WE     N  E + A   TRLAFAGLK+ D GSFDYGRN G LY

		Sbjct: 61  FKGETQINDQLTGYGQWEYNVQANTTEGEGANSWTRLAFAGLKFGDYGSFDYGRNYGVLY 120

		

		Query: 121 DVEAWTDMFPEFGGDSSAQTDNFMTKRASGLATYRNTDFFGVIDGLNLTLQYQGKNEN-- 178

		           DVE WTDM PEFGGDS    DN+MT RA+G+ATYRNTDFFG++DGLN  LQYQGKNE+  

		Sbjct: 121 DVEGWTDMLPEFGGDSYTYADNYMTGRANGVATYRNTDFFGLVDGLNFALQYQGKNESQS 180

		

		Query: 179 --------------RDVKKQNGDGFGTSLTYDFGGSDFAISGAYTNSDRTNEQNLQSR-- 222

		                          D++  NGDGFG S TYD  G  F+   AYT SDRTNEQ       

		Sbjct: 181 ADDVNIGTNNRNNGDDIRYDNGDGFGISTTYDI-GMGFSAGAAYTTSDRTNEQVNAGGTI 239

		

		Query: 223 GTGKRAEAWATGLKYDANNIYLATFYSETRKMTP-------ITGGFANKTQNFEAVAQYQ 275

		             G +A+AW  GLKYDANNIYLAT YSETR MTP         GG ANKTQNFE  AQYQ

		Sbjct: 240 AGGDKADAWTAGLKYDANNIYLATMYSETRNMTPYGKTDKGYDGGVANKTQNFEVTAQYQ 299

		

		Query: 276 FDFGLRPSLGYVLSKGKDIE----GIGDEDLVNYIDVGATYYFNKNMSAFVDYKINQLDS 331

		           FDFGLRP++ +++SKGKD+        D+DLV Y DVGATYYFNKN S +VDYKIN LD 

		Sbjct: 300 FDFGLRPAVSFLMSKGKDLTYNNVNGDDKDLVKYADVGATYYFNKNFSTYVDYKINLLDD 359

		

		Query: 332 DNKL----NINNDDIVAVGMTYQF 351

		           D+       I+ DDIVA+GM YQF

		Sbjct: 360 DDPFYKDAGISTDDIVALGMVYQF 383

		

		

		>CARBMTKINASE#Bacterial carbamate kinase signature.

		          Length = 314

		

		 Score = 37.5 bits (87), Expect = 6e-05

		 Identities = 28/127 (22%), Positives = 48/127 (37%), Gaps = 17/127 (13%)

		

		Query: 119 DTLRALLDNNI---------VPVINENDAVATAEIKVGDNDNLSALAAILAGADKLLLLT 169

		           +T++ L++  +         VPVI E+  +   E  V D D      A    AD  ++LT

		Sbjct: 177 ETIKKLVERGVIVIASGGGGVPVILEDGEIKGVE-AVIDKDLAGEKLAEEVNADIFMILT 235

		

		Query: 170 DQKGLYTADPRSNPQAELIKDVYGIDDALRAIAGDSVSGLGTGGMSTKLQAA-DVACRAG 228

		           D  G          + + +++V  +++  +            G M  K+ AA       G

		Sbjct: 236 DVNGAALY--YGTEKEQWLREV-KVEELRKYYEEG---HFKAGSMGPKVLAAIRFIEWGG 289

		

		Query: 229 IDTIIAA 235

		              IIA 

		Sbjct: 290 ERAIIAH 296

		

		

		

		 Score = 30.2 bits (68), Expect = 0.013

		 Identities = 16/76 (21%), Positives = 33/76 (43%), Gaps = 13/76 (17%)

		

		Query: 4  SQTLVVKLGTSVLTGGSRRLNRAHIVELVRQCAQ----LHAAGHRIVIVTSG-------- 51

		           + +V+ LG + L    ++ +   +++ VR+ A+    + A G+ +VI            

		Sbjct: 2  GKRVVIALGGNALQQRGQKGSYEEMMDNVRKTARQIAEIIARGYEVVITHGNGPQVGSLL 61

		

		Query: 52 -AIAAGREHLGYPELP 66

		            + AG+   G P  P

		Sbjct: 62 LHMDAGQATYGIPAQP 77

		

		

		>PF00577#Outer membrane usher protein FimD

		          Length = 878

		

		 Score = 62.9 bits (153), Expect = 4e-12

		 Identities = 30/247 (12%), Positives = 72/247 (29%), Gaps = 23/247 (9%)

		

		Query: 487 TLNLNSLWSKLGTFSISYNDDRRYNSHYYTADYYQNVYSGTFGSLGLRAGIQRYNNGDSN 546

		            L +     +  T  +S    + Y       + +Q   +  F  +          N    

		Sbjct: 530 QLTVTQQLGRTSTLYLSG-SHQTYWGTSNVDEQFQAGLNTAFEDINWTLSYSLTKNAWQK 588

		

		Query: 547 ANTGKYIALDLSLPLGNWFSAGMTHQNGYTMANLSARKQFDEGT------------IRTV 594

		               + +AL++++P  +W  +    Q  +  A+ S     +                  +

		Sbjct: 589 -GRDQMLALNVNIPFSHWLRSDSKSQWRHASASYSMSHDLNGRMTNLAGVYGTLLEDNNL 647

		

		Query: 595 GANLSRAISGDTGDDKTLSGGAYAQFDARYASGTLNVNSAADGYINTNLTANGSVGWQGK 654

		             ++    +G    +   +G A   +   Y +  +   S +D         +G V     

		Sbjct: 648 SYSVQTGYAGGGDGNSGSTGYATLNYRGGYGNANIGY-SHSDDIKQLYYGVSGGVLAHAN 706

		

		Query: 655 NIAASGRTDGNAGVIFNTGLED---DGQISAKINGRIFPLNGKRNYLPLSPYGRYEVELQ 711

		            +      +    ++   G +D   + Q   + + R     G       + Y    V L 

		Sbjct: 707 GVTLGQPLNDTVVLVKAPGAKDAKVENQTGVRTDWR-----GYAVLPYATEYRENRVALD 761

		

		Query: 712 NSKNSLD 718

		            +  + +

		Sbjct: 762 TNTLADN 768

		

		

		>INTIMIN#Intimin signature.

		          Length = 939

		

		 Score =  556 bits (1433), Expect = 0.0

		 Identities = 232/820 (28%), Positives = 364/820 (44%), Gaps = 53/820 (6%)

		

		Query: 41  PVMAARAQHAVQPRLSMGNTTVTADNNVEKNVASFAANAGTFLSSQPDS-----DATRNF 95

		           P++AA        +L+  +  VT  N  +    ++AA     L SQ  S     D  ++ 

		Sbjct: 131 PLVAAGGVAGHTNKLTKMSPDVTKSNMTDDKALNYAAQQAASLGSQLQSRSLNGDYAKDT 190

		

		Query: 96  ITGMATAKANQEIQEWLGKYGTARVKLNVDKDFSLKDSSLEMLYPIYDTPTNMLFTQGAI 155

		             G+A  +A+ ++Q WL  YGTA V L    +F    SSL+ L P YD+   + F Q   

		Sbjct: 191 ALGIAGNQASSQLQAWLQHYGTAEVNLQSGNNFD--GSSLDFLLPFYDSEKMLAFGQVGA 248

		

		Query: 156 HRTDDRTQSNIGFGWRHFSGNDWMAGVNTFIDHDLSRSHTRIGVGAEYWRDYLKLSANGY 215

		              D R  +N+G G R F     M G N FID D S  +TR+G+G EYWRDY K S NGY

		Sbjct: 249 RYIDSRFTANLGAGQRFFLPE-NMLGYNVFIDQDFSGDNTRLGIGGEYWRDYFKSSVNGY 307

		

		Query: 216 IRASGWKKSPDIEDYQERPANGWDIRAEGYLPAWPQLGASLMYEQYYGDEVGLFGKDKRQ 275

		            R SGW +S + +DY ERPANG+DIR  GYLP++P LGA LMYEQYYGD V LF  DK Q

		Sbjct: 308 FRMSGWHESYNKKDYDERPANGFDIRFNGYLPSYPALGAKLMYEQYYGDNVALFNSDKLQ 367

		

		Query: 276 KDPHAISAEVTYTPVPLLTLSAGHKQGKSGENDTRFGLEVNYRIGEPLEKQLDTDSIRER 335

		            +P A +  V YTP+PL+T+   ++ G   END  + ++  Y+  +P  +Q++   + E 

		Sbjct: 368 SNPGAATVGVNYTPIPLVTMGIDYRHGTGNENDLLYSMQFRYQFDKPWSQQIEPQYVNEL 427

		

		Query: 336 RMLAGSRYDLVERNNNIVLEYRKSEVIRIALPERIEGKGGQTLSLGLVVSKATHGLKNVQ 395

		           R L+GSRYDLV+RNNNI+LEY+K +++ + +P  I G    T  + L+V K+ +GL  + 

		Sbjct: 428 RTLSGSRYDLVQRNNNIILEYKKQDILSLNIPHDINGTERSTQKIQLIV-KSKYGLDRIV 486

		

		Query: 396 WEAPSLLAEGGKITGQGSQ----WQVTLPAYRPGKDNYYAISAVAYDNKGNASKRVQTEV 451

		           W+  +L ++GG+I   GSQ    +Q  LPAY  G  N Y ++A AYD  GN+S  V   +

		Sbjct: 487 WDDSALRSQGGQIQHSGSQSAQDYQAILPAYVQGGSNVYKVTARAYDRNGNSSNNVLLTI 546

		

		Query: 452 VITGAGMSADRTALTLDGQSRIQMLANGNEQRPLVLSLR----DAEGQPVTGMKDQIKTE 507

		            +   G   D+  +T     +    A+G E      +++         PV+         

		Sbjct: 547 TVLSNGQVVDQVGVTDFTADKTSAKADGTEAITYTATVKKNGVAQANVPVS--------- 597

		

		Query: 508 LTFKPAGNIVTRTLKATKSQAKPTLGEFTETEAGVYQSVFTTGTQSGEATITVSVDGMSK 567

		                  NIV+ T   + + A           +G       +    G+  ++     M+ 

		Sbjct: 598 ------FNIVSGTAVLSANSAN-------TNGSGKATVTLKSDK-PGQVVVSAKTAEMTS 643

		

		Query: 568 TVTAELRATMMDVANSTLSANEPSGDVVADGQQAYTLTLTAVDTDGNPVTGEASRLRFVP 627

		            + A     +     S           VA+GQ A T T+  V     PV+ +        

		Sbjct: 644 ALNANAVIFVDQTKASITEIKADKTTAVANGQDAITYTVK-VMKGDKPVSNQEVTFT--- 699

		

		Query: 628 QDTNGVTIGTISEIKPGVYSATVSSTRAGNVVVRAFSEQYQLGTLQQTLKFVAGP-LDAA 686

		                ++  T      G    T++ST  G  +V A      +      ++F     +D  

		Sbjct: 700 TTLGKLSNSTEKTDTNGYAKVTLTSTTPGKSLVSARVSDVAVDVKAPEVEFFTTLTIDDG 759

		

		Query: 687 HSSITLNPDKPVVGGTVTAIWTVKDAYDNPVTSLTPE---APSLAGAAAVGSTASGWTNN 743

		           +  I        V G +  +W      +   +    +     +    A+V +++   T  

		Sbjct: 760 NIEIVGTG----VKGKLPTVWLQYGQVNLKASGGNGKYTWRSANPAIASVDASSGQVTLK 815

		

		Query: 744 GDGTWTAQITLGSTAGELEVMPKLNGQDAAANAAKVTVVADALSSNQSKVSVAEDHVKAG 803

		             GT T  +           +   N      N +K     DA+++ ++            

		Sbjct: 816 EKGTTTISVISSDNQTATYTIATPNSL-IVPNMSKRVTYNDAVNTCKNFGGKLPSSQNEL 874

		

		Query: 804 ESTTVTLIAKDAHGNAISGLSLSASLTGTASEGATVSSWT 843

		           E+      A + +    S  ++ + +  TA +  +  + T

		Sbjct: 875 ENVFKAWGAANKYEYYKSSQTIISWVQQTAQDAKSGVAST 914

		

		

		

		 Score = 80.5 bits (198), Expect = 4e-17

		 Identities = 82/396 (20%), Positives = 128/396 (32%), Gaps = 45/396 (11%)

		

		Query: 905  KTTTELTFTVKDAYGNPVTGMKPDAPVFSGAASTGTERPSTGDWTETSNGVYVATLTLGS 964

		                  T TVK        G+       S    +GT   S        +G    TL    

		Sbjct: 575  TEAITYTATVKK------NGVAQANVPVSFNIVSGTAVLSANSANTNGSGKATVTLKSDK 628

		

		Query: 965  AAGQLSVMPRVNGQNAVAQPLVLNVAGDASKAEIRDMTVKVDNQLANGQSTNQVTLTVVD 1024

		                +         +A+    V+ V  D +KA I ++       +ANGQ    +T TV  

		Sbjct: 629  PGQVVVSAKTAEMTSALNANAVIFV--DQTKASITEIKADKTTAVANGQDA--ITYTVKV 684

		

		Query: 1025 TY-GNPLQGQNVTLTLPKGVTSKTGNTVTTDAAGKADIELMSTVAGEHSITASVNNAQ-- 1081

		                 P+  Q VT T   G  S +  T  TD  G A + L ST  G+  ++A V++    

		Sbjct: 685  MKGDKPVSNQEVTFTTTLGKLSNS--TEKTDTNGYAKVTLTSTTPGKSLVSARVSDVAVD 742

		

		Query: 1082 -KTVTVKFKADFSTGQASLEVDSAAPKVANGKDAFTLTATVEDKNGNPVPGSLVTFNLPR 1140

		             K   V+F    +    ++E+      V  G      T  ++              NL  

		Sbjct: 743  VKAPEVEFFTTLTIDDGNIEI------VGTGVKGKLPTVWLQYG----------QVNLK- 785

		

		Query: 1141 GVKPLTGDNVWVKANGE----GKAELQVVSVTAGTYEITASAGNSQPSDTQTITFVADKA 1196

		                  G   W  AN        +  QV     GT  I+  +      D QT T+     

		Sbjct: 786  -ASGGNGKYTWRSANPAIASVDASSGQVTLKEKGTTTISVISS-----DNQTATYTIATP 839

		

		Query: 1197 TATVSGIEVMGNYALADGKAKQTYKVTVTDANNNLVKDSEVTLTASPASLNLEPNGTATT 1256

		             + +    +       D             ++ N +++      A+      + + T  +

		Sbjct: 840  NSLIV-PNMSKRVTYNDAVNTCKNFGGKLPSSQNELENVFKAWGAANKYEYYKSSQTIIS 898

		

		Query: 1257 NEQGQAIFTATTTVAATYTLKAQVSQTNGQVSTKTA 1292

		              Q Q    A + VA+TY L  Q    N + S   A

		Sbjct: 899  WVQ-QTAQDAKSGVASTYDLVKQNPLNNIKASESNA 933

		

		

		

		 Score = 76.6 bits (188), Expect = 5e-16

		 Identities = 73/337 (21%), Positives = 121/337 (35%), Gaps = 21/337 (6%)

		

		Query: 976  NGQNAVAQPLVLNVAGDAS-KAEIRDMTVKVDNQLANGQSTNQVTLTVVDTYGNPLQGQN 1034

		            N  N V   + +   G    +  + D T    +  A+G      T TV    G       

		Sbjct: 537  NSSNNVLLTITVLSNGQVVDQVGVTDFTADKTSAKADGTEAITYTATVKKN-GVAQANVP 595

		

		Query: 1035 VTLTLPKGVTSKTGNTVTTDAAGKADIELMSTVAGEHSITASVNNAQKTVTVKFKADFST 1094

		            V+  +  G    + N+  T+ +GKA + L S   G+  ++A        +          

		Sbjct: 596  VSFNIVSGTAVLSANSANTNGSGKATVTLKSDKPGQVVVSAKTAEMTSALNANAVIFVDQ 655

		

		Query: 1095 GQASLEVDSAAPK--VANGKDAFTLTATVEDKNGNPVPGSLVTFNLPRGVKPLTGDNVWV 1152

		             +AS+    A     VANG+DA T T  V  K   PV    VTF    G    + +    

		Sbjct: 656  TKASITEIKADKTTAVANGQDAITYTVKV-MKGDKPVSNQEVTFTTTLGKLSNSTE---- 710

		

		Query: 1153 KANGEGKAELQVVSVTAGTYEITASAGNSQPSDTQTITFVADKATATVSGIEVMGNYALA 1212

		            K +  G A++ + S T G   ++A   +                T     IE++G     

		Sbjct: 711  KTDTNGYAKVTLTSTTPGKSLVSARVSDVAVDVKAPEVEFFTTLTIDDGNIEIVGT---- 766

		

		Query: 1213 DGKAKQTYKVTVTDANNNLVK---DSEVTLTAS-PASLNLEPN-GTATTNEQGQAIFTAT 1267

		             G   +   V +     NL     + + T  ++ PA  +++ + G  T  E+G    +  

		Sbjct: 767  -GVKGKLPTVWLQYGQVNLKASGGNGKYTWRSANPAIASVDASSGQVTLKEKGTTTISVI 825

		

		Query: 1268 T--TVAATYTLKAQVSQTNGQVSTKTAESKFVADDKN 1302

		            +     ATYT+    S     +S +   +  V   KN

		Sbjct: 826  SSDNQTATYTIATPNSLIVPNMSKRVTYNDAVNTCKN 862

		

		

		

		 Score = 58.5 bits (141), Expect = 2e-10

		 Identities = 60/374 (16%), Positives = 109/374 (29%), Gaps = 54/374 (14%)

		

		Query: 779  VTVVADALSSNQSKV---SVAEDHVKAGESTTVTLIA------KDAHGNAISGLSLSASL 829

		            +TV+++    +Q  V   +  +   KA  +  +T  A             +S   +S   

		Sbjct: 546  ITVLSNGQVVDQVGVTDFTADKTSAKADGTEAITYTATVKKNGVAQANVPVSFNIVS--- 602

		

		Query: 830  TGTASEGATVSSWTEKGDGSYVATLTTGGKTGELRVMPLFNGQPAATEAAQLTVIAGEMS 889

		             GTA   A  +S    G G    TL +      +          A    A   +   +  

		Sbjct: 603  -GTAVLSA--NSANTNGSGKATVTLKSDKPGQVVVSAKTAEMTSALN--ANAVIFVDQTK 657

		

		Query: 890  SANSTLVADNKAPTVKTTTELTFTVKDAY-GNPVTGMKPDAPVFSGAASTGTERPSTGDW 948

		            ++ + + AD           +T+TVK      PV+  +          +T   + S    

		Sbjct: 658  ASITEIKADKTTAVANGQDAITYTVKVMKGDKPVSNQEV-------TFTTTLGKLSNSTE 710

		

		Query: 949  TETSNGVYVATLTLGSAAGQLSVMPRVNGQN-AVAQPLVLNVAG---DASKAEIRDMTVK 1004

		               +NG    TLT  +  G+  V  RV+     V  P V        D    EI      

		Sbjct: 711  KTDTNGYAKVTLT-STTPGKSLVSARVSDVAVDVKAPEVEFFTTLTIDDGNIEI------ 763

		

		Query: 1005 VDNQLANGQSTNQVTLTV-VDTYGNPLQGQNVTLTLPKGVTSKTGNTVTTDA-AGKADIE 1062

		                +  G      T+ +          G N   T      S      + DA +G+  ++

		Sbjct: 764  ----VGTGVKGKLPTVWLQYGQVNLKASGGNGKYTW----RSANPAIASVDASSGQVTLK 815

		

		Query: 1063 LMSTVAGEHSITASVNNAQKTVTVKFKADFSTGQASLEVDSAAPKVANGKDAFTLTATVE 1122

		                  G  +I+   ++ Q   T  +            +        +  +         

		Sbjct: 816  ----EKGTTTISVISSDNQ---TATYTIATPNSLIVPNMSKRV-TYNDAVNTCKNFGGKL 867

		

		Query: 1123 DKNGNPVPGSLVTF 1136

		              + N +      +

		Sbjct: 868  PSSQNELENVFKAW 881

		

		

		

		 Score = 54.7 bits (131), Expect = 2e-09

		 Identities = 40/178 (22%), Positives = 63/178 (35%), Gaps = 13/178 (7%)

		

		Query: 1168 TAGTYEITASA----GNSQPSDTQTITFVADKATATVSGI---EVMGNYALADGKAKQTY 1220

		             +  Y++TA A    GNS  +   TIT +++       G+         A ADG    TY

		Sbjct: 521  GSNVYKVTARAYDRNGNSSNNVLLTITVLSNGQVVDQVGVTDFTADKTSAKADGTEAITY 580

		

		Query: 1221 KVTVTDANNNLVKDSEVTLTAS-PASLNLEPNGTATTNEQGQAIFTATTTVAATYTLKAQ 1279

		              TV                 S  A L+     +A TN  G+A  T  +       + A+

		Sbjct: 581  TATVKKNGVAQANVPVSFNIVSGTAVLSAN---SANTNGSGKATVTLKSDKPGQVVVSAK 637

		

		Query: 1280 VSQTNGQVSTKTAESKFVADDKNAVLTASSDMQSLVADGKSTAKLEVTLMSANNPVGG 1337

		                    +       FV   K ++    +D  + VA+G+      V +M  + PV  

		Sbjct: 638  --TAEMTSALNANAVIFVDQTKASITEIKADKTTAVANGQDAITYTVKVMKGDKPVSN 693

		

		

		>HTHTETR#TetR bacterial regulatory protein HTH signature.

		          Length = 215

		

		 Score = 28.4 bits (63), Expect = 0.025

		 Identities = 12/42 (28%), Positives = 19/42 (45%)

		

		Query: 3  RQKILQQLLEWIECNLEHPISIEDIAQKSGYSRRNIQLLFRN 44

		          RQ IL   L           S+ +IA+ +G +R  I   F++

		Sbjct: 13 RQHILDVALRLFSQQGVSSTSLGEIAKAAGVTRGAIYWHFKD 54

		

		

		>HTHTETR#TetR bacterial regulatory protein HTH signature.

		          Length = 215

		

		 Score = 64.3 bits (156), Expect = 5e-15

		 Identities = 32/172 (18%), Positives = 59/172 (34%), Gaps = 15/172 (8%)

		

		Query: 10  RRRQLIDATLEAINEVGMHDATIAQIARRAGVSTGIISHYFRDKNGLLEATMRDITSQLR 69

		            R+ ++D  L   ++ G+   ++ +IA+ AGV+ G I  +F+DK+ L         S + 

		Sbjct: 12  TRQHILDVALRLFSQQGVSSTSLGEIAKAAGVTRGAIYWHFKDKSDLFSEIWELSESNIG 71

		

		Query: 70  DAVLNRLHALPQGSAEQRLQAIVGGNFDETQVSSAAMKAWLAFWASSMHQP-------ML 122

		           +  L      P G     L+ I+    + T V+    +  +                   

		Sbjct: 72  ELELEYQAKFP-GDPLSVLREILIHVLEST-VTEERRRLLMEIIFHKCEFVGEMAVVQQA 129

		

		Query: 123 YRLQQVSSRRLLSNLVSEFRRE---LPREQAQEAGYGLAALIDGL---WLRA 168

		            R   + S   +   +               + A   +   I GL   WL A

		Sbjct: 130 QRNLCLESYDRIEQTLKHCIEAKMLPADLMTRRAAIIMRGYISGLMENWLFA 181

		

		

		>PRTACTNFAMLY#Pertactin virulence factor family signature.

		          Length = 910

		

		 Score =  128 bits (323), Expect = 4e-32

		 Identities = 120/469 (25%), Positives = 187/469 (39%), Gaps = 65/469 (13%)

		

		Query: 854  QAGNVLVVKGNYHGNNGQLVMNTVLNGDDSVTDKLVVEGDTSGTTAVTVNNAGGTGAKTL 913

		            +AG   V+  N    +G   MN     D  ++DKLVV  D SG   + V N+G     + 

		Sbjct: 466  EAGRFKVLTVNTLAGSGLFRMNV--FADLGLSDKLVVMQDASGQHRLWVRNSGS-EPASA 522

		

		Query: 914  NGIELIHVDGKSEGEFVQA---GRIVAGAYDYTLARGQGANSGNWYLTSGSDSPELQPEP 970

		            N + L+     S   F  A   G++  G Y Y LA      +G W L      P  +P P

		Sbjct: 523  NTLLLVQTPLGSAATFTLANKDGKVDIGTYRYRLA---ANGNGQWSLVGAKAPPAPKPAP 579

		

		Query: 971  DPMPNPEPNPNPEPN-PNPTPTPGPDLNVDNDLRPEAGSYIANLAAANTMFTTRLHERLG 1029

		             P P P   P P+P  P P P  G +L+                AAAN    T       

		Sbjct: 580  QPGPQPPQPPQPQPEAPAPQPPAGRELS----------------AAANAAVNTGGVGLAS 623

		

		Query: 1030 NTYYTDMVTGEQKQTTMWMRHEGGHNKWRDGSGQLKTQSNRYV---------LQLGGDVA 1080

		              +Y +     ++   + +  + G   W  G  Q +   NR            +LG D A

		Sbjct: 624  TLWYAESNALSKRLGELRLNPDAG-GAWGRGFAQRQQLDNRAGRRFDQKVAGFELGADHA 682

		

		Query: 1081 QWSQNGSDSWHVGVMAGYGNSDSKTISSRTGYRAKASVNGYSTGLYATWYADDESRNGAY 1140

		                 G   WH+G +AGY   D        G+      +    G YAT+ AD    +G Y

		Sbjct: 683  VAVAGGR--WHLGGLAGYTRGDRGFTGDGGGH-----TDSVHVGGYATYIAD----SGFY 731

		

		Query: 1141 LDSWAQYSWFDN--TVKGDDLQS--ESYKSKGFTASLEAGYKHKLAEFNGSQGTRNEWYV 1196

		            LD+  + S  +N   V G D  +    Y++ G  ASLEAG +   A         + W++

		Sbjct: 732  LDATLRASRLENDFKVAGSDGYAVKGKYRTHGVGASLEAGRRFTHA---------DGWFL 782

		

		Query: 1197 QPQAQVTWMGVKADKHRESNGTLVHSNGDGNVQTRLGVKTWLKSHHKMDDGKSREFQPFV 1256

		            +PQA++         +R +NG  V   G  +V  RLG    L+   +++    R+ QP++

		Sbjct: 783  EPQAELAVFRAGGGAYRAANGLRVRDEGGSSVLGRLG----LEVGKRIELAGGRQVQPYI 838

		

		Query: 1257 EVNWLHNSKDFST-SMDGVSVTQDGARNIAEIKTGVEGQLNANLNVWGN 1304

		            + + L       T   +G++   +     AE+  G+   L    +++ +

		Sbjct: 839  KASVLQEFDGAGTVHTNGIAHRTELRGTRAELGLGMAAALGRGHSLYAS 887

		

		

		>HTHFIS#FIS bacterial regulatory protein HTH signature.

		          Length = 484

		

		 Score = 30.6 bits (69), Expect = 0.009

		 Identities = 15/50 (30%), Positives = 24/50 (48%), Gaps = 2/50 (4%)

		

		Query: 6   TEENLLAFTTAARFGSFSKAAEELGLTTSAISYTIKRMETGLDVVLFTRS 55

		            E  L+     A  G+  KAA+ LGL  + +   I+ +  G+ V   +RS

		Sbjct: 436 MEYPLILAALTATRGNQIKAADLLGLNRNTLRKKIREL--GVSVYRSSRS 483

		

		

		>HTHFIS#FIS bacterial regulatory protein HTH signature.

		          Length = 484

		

		 Score =  336 bits (864), Expect = e-112

		 Identities = 122/401 (30%), Positives = 199/401 (49%), Gaps = 54/401 (13%)

		

		Query: 164 DLAEEAGMTGIFIYSAATVRQAFSDALDMTRMSLRHNTHDATRNALRTRYVLGDMLGQSP 223

		             A +A   G + Y         ++ + +   +L       ++           ++G+S 

		Sbjct: 88  MTAIKASEKGAYDYLPKPFDL--TELIGIIGRALAEPKRRPSK-LEDDSQDGMPLVGRSA 144

		

		Query: 224 QMEQVRQTILLYARSSAAVLIEGETGTGKELAAQAIHREYFARHDARQGKKSHPFVAVNC 283

		            M+++ + +    ++   ++I GE+GTGKEL A+A+H      +  R+     PFVA+N 

		Sbjct: 145 AMQEIYRVLARLMQTDLTLMITGESGTGKELVARALHD-----YGKRRNG---PFVAINM 196

		

		Query: 284 GAIAESLLEAELFGYEEGAFTGSRRGGRAGLFEIAHGGTLFLDEIGEMPLPLQTRLLRVL 343

		            AI   L+E+ELFG+E+GAFTG++     G FE A GGTLFLDEIG+MP+  QTRLLRVL

		Sbjct: 197 AAIPRDLIESELFGHEKGAFTGAQTR-STGRFEQAEGGTLFLDEIGDMPMDAQTRLLRVL 255

		

		Query: 344 EEKEVTRVGGHQPVPVDVRVISATHCKLEEDMQQGRFRRDLFYRLSILRLQLPPLRERVA 403

		           ++ E T VGG  P+  DVR+++AT+  L++ + QG FR DL+YRL+++ L+LPPLR+R  

		Sbjct: 256 QQGEYTTVGGRTPIRSDVRIVAATNKDLKQSINQGLFREDLYYRLNVVPLRLPPLRDRAE 315

		

		Query: 404 DILPLAESFLKVSLAALSAPFSAALRQGLQASETVLVHYDWPGNIRELRNMMERLALFLS 463

		           DI  L   F++              ++ L+     +  + WPGN+REL N++ RL     

		Sbjct: 316 DIPDLVRHFVQ-QAEKEGLDVKRFDQEALEL----MKAHPWPGNVRELENLVRRLTALYP 370

		

		Query: 464 VEP-TPDLTPQFLQLLLPELARESAKTPAPRLLTP------------------------- 497

		            +  T ++    L+  +P+   E A   +  L                            

		Sbjct: 371 QDVITREIIENELRSEIPDSPIEKAAARSGSLSISQAVEENMRQYFASFGDALPPSGLYD 430

		

		Query: 498 -----------QQALEKFNGDKTAAANYLGISRTTFWRRLK 527

		                        AL    G++  AA+ LG++R T  ++++

		Sbjct: 431 RVLAEMEYPLILAALTATRGNQIKAADLLGLNRNTLRKKIR 471

		

		

		>PHPHTRNFRASE#Phosphoenolpyruvate-protein phosphotransferase

		           signature.

		          Length = 572

		

		 Score = 29.8 bits (67), Expect = 0.023

		 Identities = 11/33 (33%), Positives = 19/33 (57%), Gaps = 1/33 (3%)

		

		Query: 65  LIHGKLPTRDE-LAAYKTKLKALRGLPANVRTV 96

		           +   +LPT +E   AYK  ++ + G P  +RT+

		Sbjct: 303 MDRDQLPTEEEQFEAYKEVVQRMDGKPVVIRTL 335

		

		

		>TCRTETA#Tetracycline resistance protein signature.

		          Length = 399

		

		 Score = 35.6 bits (82), Expect = 3e-04

		 Identities = 44/192 (22%), Positives = 72/192 (37%), Gaps = 22/192 (11%)

		

		Query: 4   LKNTNFWMFGLFFFFYFFI-MGAYFPFFPIWLHDINHISK--SDTGIIFAAISLFSLLFQ 60

		           +K     +  L       + +G   P  P  L D+ H +   +  GI+ A  +L      

		Sbjct: 1   MKPNRPLIVILSTVALDAVGIGLIMPVLPGLLRDLVHSNDVTAHYGILLALYALMQFACA 60

		

		Query: 61  PLFGLLSDKLGLRKYLLWIITGMLVMFAPFFIFIFGPLLQYNILVGSIVGGIYLGFCFNA 120

		           P+ G LSD+ G R  LL     +      + I    P L + + +G IV GI       A

		Sbjct: 61  PVLGALSDRFGRRPVLL---VSLAGAAVDYAIMATAPFL-WVLYIGRIVAGIT-----GA 111

		

		Query: 121 GAPAVEAFIEKVSRRSNFEFGRARMFG----CVGWALCAS--IVGIMFTINNQFVFWLGS 174

		                 A+I  ++        RAR FG    C G+ + A   + G+M   +    F+  +

		Sbjct: 112 TGAVAGAYIADITDGDE----RARHFGFMSACFGFGMVAGPVLGGLMGGFSPHAPFFAAA 167

		

		Query: 175 GCALILAVLLFF 186

		               +  +   F

		Sbjct: 168 ALNGLNFLTGCF 179

		

		

		>BINARYTOXINB#Binary toxin B family signature.

		          Length = 764

		

		 Score = 30.0 bits (67), Expect = 0.015

		 Identities = 19/69 (27%), Positives = 30/69 (43%)

		

		Query: 254 DIVRELRERTELPIGAYQVSGEYAMIKFAALAGAIDEEKVVLESLGSIKRAGADLIFSYF 313

		           +   EL +  +L +   QV G  A   F      +D      E L  I+   A +IF+  

		Sbjct: 466 NQFLELEKTKQLRLDTDQVYGNIATYNFENGRVRVDTGSNWSEVLPQIQETTARIIFNGK 525

		

		Query: 314 ALDLAEKKI 322

		            L+L E++I

		Sbjct: 526 DLNLVERRI 534

		

		

		>PRTACTNFAMLY#Pertactin virulence factor family signature.

		          Length = 910

		

		 Score =  122 bits (307), Expect = 2e-30

		 Identities = 103/442 (23%), Positives = 169/442 (38%), Gaps = 59/442 (13%)

		

		Query: 572 TVNGNNDINNGDEVDNSSVDNVVA---ATGNYKVRIDNSTGAGAIADYAGKQLIYIDDTK 628

		           T+ G+         D    D +V    A+G +++ + NS   G+    A   L+      

		Sbjct: 477 TLAGSGLFRMNVFADLGLSDKLVVMQDASGQHRLWVRNS---GSEPASANTLLLVQTPLG 533

		

		Query: 629 TNATFSAAN---KADLGAYTYQAEQRGNTV------------------------------ 655

		           + ATF+ AN   K D+G Y Y+    GN                                

		Sbjct: 534 SAATFTLANKDGKVDIGTYRYRLAANGNGQWSLVGAKAPPAPKPAPQPGPQPPQPPQPQP 593

		

		Query: 656 ------VLQQMELTDYANMALSIP--SANTNIWNLEQDTVGTRLTNSRHGLADNGGAWVS 707

		                      EL+  AN A++       + +W  E + +  RL   R    D GGAW  

		Sbjct: 594 EAPAPQPPAGRELSAAANAAVNTGGVGLASTLWYAESNALSKRLGELRL-NPDAGGAWGR 652

		

		Query: 708 YFGGNFNGDNGTIN-YDQDVNGIMVGVDTKIDGNNAKWIVGAAAGFAKGDMN---DRSGQ 763

		            F      DN     +DQ V G  +G D  +     +W +G  AG+ +GD     D  G 

		Sbjct: 653 GFAQRQQLDNRAGRRFDQKVAGFELGADHAVAVAGGRWHLGGLAGYTRGDRGFTGDGGGH 712

		

		Query: 764 VDQDSQTAYIYSSAHFANNVF-VDGSLSYSHFNNDLSATMSNGTYVDGSTNSDAWGFGLK 822

		            D      Y   + + A++ F +D +L  S   ND     S+G  V G   +   G  L+

		Sbjct: 713 TDSVHVGGY---ATYIADSGFYLDATLRASRLENDFKVAGSDGYAVKGKYRTHGVGASLE 769

		

		Query: 823 AGYDFKLGDAGYVTPYGSISGLFQSGDDYQLSNDMKVDGQSYDSMRYELGVDAGYTFTYS 882

		           AG  F   D  ++ P   ++     G  Y+ +N ++V  +   S+   LG++ G     +

		Sbjct: 770 AGRRFTHADGWFLEPQAELAVFRAGGGAYRAANGLRVRDEGGSSVLGRLGLEVGKRIELA 829

		

		Query: 883 EDQALTPYFKLAYVYDDSNNDNDVNGDSIDNGTEGSAVRV--GLGTQFSFTKNFSAYTDA 940

		             + + PY K + +  + +    V+ + I + TE    R   GLG   +  +  S Y   

		Sbjct: 830 GGRQVQPYIKASVL-QEFDGAGTVHTNGIAHRTELRGTRAELGLGMAAALGRGHSLYASY 888

		

		Query: 941 NYLGGGDVDQDWSANVGVKYTW 962

		            Y  G  +   W+ + G +Y+W

		Sbjct: 889 EYSKGPKLAMPWTFHAGYRYSW 910

		

		

		>BCTERIALGSPF#Bacterial general secretion pathway protein F

		           signature.

		          Length = 408

		

		 Score = 29.8 bits (67), Expect = 0.028

		 Identities = 31/137 (22%), Positives = 54/137 (39%), Gaps = 24/137 (17%)

		

		Query: 245 IWLPLGLVIGLLAAMFVLRILRRIQSPHHRLQDAIENRDICVHYQPIVSLANGKIVGAEA 304

		            W+ L L+ G +A   +LR          R+          + + P++    G+I     

		Sbjct: 228 PWMLLALLAGFMAFRVMLR------QEKRRVS-----FHRRLLHLPLI----GRIARGLN 272

		

		Query: 305 LARWPQTDGSWLSPDSFIPLAQQTGLS-EPLTLLIIRSVFEDMGDWLRQHPQQHISINLE 363

		            AR+ +T     +  S +PL Q   +S + ++    R       D +R+    H +  LE

		Sbjct: 273 TARYARTLSILNA--SAVPLLQAMRISGDVMSNDYARHRLSLATDAVREGVSLHKA--LE 328

		

		Query: 364 STVLTSEKIPQLLREMI 380

		            T L     P ++R MI

		Sbjct: 329 QTAL----FPPMMRHMI 341

		

		

		>ACRIFLAVINRP#Acriflavin resistance protein family signature.

		          Length = 1034

		

		 Score = 1369 bits (3546), Expect = 0.0

		 Identities = 802/1033 (77%), Positives = 915/1033 (88%), Gaps = 1/1033 (0%)

		

		Query: 1    MPNFFIDRPIFAWVIAIIIMLAGGLAILKLPVAQYPTIAPPAVTISASYPGADAKTVQDT 60

		            M NFFI RPIFAWV+AII+M+AG LAIL+LPVAQYPTIAPPAV++SA+YPGADA+TVQDT

		Sbjct: 1    MANFFIRRPIFAWVLAIILMMAGALAILQLPVAQYPTIAPPAVSVSANYPGADAQTVQDT 60

		

		Query: 61   VTQVIEQNMNGIDNLMYMSSNSDSTGTVQITLTFESGTDADIAQVQVQNKLQLAMPLLPQ 120

		            VTQVIEQNMNGIDNLMYMSS SDS G+V ITLTF+SGTD DIAQVQVQNKLQLA PLLPQ

		Sbjct: 61   VTQVIEQNMNGIDNLMYMSSTSDSAGSVTITLTFQSGTDPDIAQVQVQNKLQLATPLLPQ 120

		

		Query: 121  EVQQQGVSVEKSSSSFLMVVGVINTDGTMTQEDISDYVAANMKDAISRTSGVGDVQLFGS 180

		            EVQQQG+SVEKSSSS+LMV G ++ +   TQ+DISDYVA+N+KD +SR +GVGDVQLFG+

		Sbjct: 121  EVQQQGISVEKSSSSYLMVAGFVSDNPGTTQDDISDYVASNVKDTLSRLNGVGDVQLFGA 180

		

		Query: 181  QYAMRIWMNPNELNKFQLTPVDVITAIKAQNAQVAAGQLGGTPPVKGQQLNASIIAQTRL 240

		            QYAMRIW++ + LNK++LTPVDVI  +K QN Q+AAGQLGGTP + GQQLNASIIAQTR 

		Sbjct: 181  QYAMRIWLDADLLNKYKLTPVDVINQLKVQNDQIAAGQLGGTPALPGQQLNASIIAQTRF 240

		

		Query: 241  TSTEEFGKILLKVNQDGSRVLLRDVAKIELGGENYDIIAEFNGQPASGLGIKLATGANAL 300

		             + EEFGK+ L+VN DGS V L+DVA++ELGGENY++IA  NG+PA+GLGIKLATGANAL

		Sbjct: 241  KNPEEFGKVTLRVNSDGSVVRLKDVARVELGGENYNVIARINGKPAAGLGIKLATGANAL 300

		

		Query: 301  DTAAAIRAELAKMEPFFPSGLKIVYPYDTTPFVKISIHEVVKTLVEAIILVFLVMYLFLQ 360

		            DTA AI+A+LA+++PFFP G+K++YPYDTTPFV++SIHEVVKTL EAI+LVFLVMYLFLQ

		Sbjct: 301  DTAKAIKAKLAELQPFFPQGMKVLYPYDTTPFVQLSIHEVVKTLFEAIMLVFLVMYLFLQ 360

		

		Query: 361  NFRATLIPTIAVPVVLLGTFAVLAAFGFSINTLTMFGMVLAIGLLVDDAIVVVENVERVM 420

		            N RATLIPTIAVPVVLLGTFA+LAAFG+SINTLTMFGMVLAIGLLVDDAIVVVENVERVM

		Sbjct: 361  NMRATLIPTIAVPVVLLGTFAILAAFGYSINTLTMFGMVLAIGLLVDDAIVVVENVERVM 420

		

		Query: 421  AEEGLPPKEATRKSMGQIQGALVGIAMVLSAVFVPMAFFGGSTGAIYRQFSITIVSAMAL 480

		             E+ LPPKEAT KSM QIQGALVGIAMVLSAVF+PMAFFGGSTGAIYRQFSITIVSAMAL

		Sbjct: 421  MEDKLPPKEATEKSMSQIQGALVGIAMVLSAVFIPMAFFGGSTGAIYRQFSITIVSAMAL 480

		

		Query: 481  SVLVALILTPALCATMLKPIAKGDHGEGKKGFFGWFNRMFEKSTHHYTDSVGGILRSTGR 540

		            SVLVALILTPALCAT+LKP++   H E K GFFGWFN  F+ S +HYT+SVG IL STGR

		Sbjct: 481  SVLVALILTPALCATLLKPVSAE-HHENKGGFFGWFNTTFDHSVNHYTNSVGKILGSTGR 539

		

		Query: 541  YLVLYLIIVVGMAYLFVRLPSSFLPDEDQGVFMTMVQLPAGATQERTQKVLNEVTHYYLT 600

		            YL++Y +IV GM  LF+RLPSSFLP+EDQGVF+TM+QLPAGATQERTQKVL++VT YYL 

		Sbjct: 540  YLLIYALIVAGMVVLFLRLPSSFLPEEDQGVFLTMIQLPAGATQERTQKVLDQVTDYYLK 599

		

		Query: 601  KEKNNVESVFAVNGFGFAGRGQNTGIAFVSLKDWADRPGEENKVEAITMRATRAFSQIKD 660

		             EK NVESVF VNGF F+G+ QN G+AFVSLK W +R G+EN  EA+  RA     +I+D

		Sbjct: 600  NEKANVESVFTVNGFSFSGQAQNAGMAFVSLKPWEERNGDENSAEAVIHRAKMELGKIRD 659

		

		Query: 661  AMVFAFNLPAIVELGTATGFDFELIDQAGLGHEKLTQARNQLLAEAAKHPDMLTSVRPNG 720

		              V  FN+PAIVELGTATGFDFELIDQAGLGH+ LTQARNQLL  AA+HP  L SVRPNG

		Sbjct: 660  GFVIPFNMPAIVELGTATGFDFELIDQAGLGHDALTQARNQLLGMAAQHPASLVSVRPNG 719

		

		Query: 721  LEDTPQFKIDIDQEKAQALGVSINDINTTLGAAWGGSYVNDFIDRGRVKKVYVMSEAKYR 780

		            LEDT QFK+++DQEKAQALGVS++DIN T+  A GG+YVNDFIDRGRVKK+YV ++AK+R

		Sbjct: 720  LEDTAQFKLEVDQEKAQALGVSLSDINQTISTALGGTYVNDFIDRGRVKKLYVQADAKFR 779

		

		Query: 781  MLPDDIGDWYVRAADGQMVPFSAFSSSRWEYGSPRLERYNGLPSMEILGQAAPGKSTGEA 840

		            MLP+D+   YVR+A+G+MVPFSAF++S W YGSPRLERYNGLPSMEI G+AAPG S+G+A

		Sbjct: 780  MLPEDVDKLYVRSANGEMVPFSAFTTSHWVYGSPRLERYNGLPSMEIQGEAAPGTSSGDA 839

		

		Query: 841  MELMEQLASKLPTGVGYDWTGMSYQERLSGNQAPSLYAISLIVVFLCLAALYESWSIPFS 900

		            M LME LASKLP G+GYDWTGMSYQERLSGNQAP+L AIS +VVFLCLAALYESWSIP S

		Sbjct: 840  MALMENLASKLPAGIGYDWTGMSYQERLSGNQAPALVAISFVVVFLCLAALYESWSIPVS 899

		

		Query: 901  VMLVVPLGVIGALLAATFRGLTNDVYFQVGLLTTIGLSAKNAILIVEFAKDLMDKEGKGL 960

		            VMLVVPLG++G LLAAT     NDVYF VGLLTTIGLSAKNAILIVEFAKDLM+KEGKG+

		Sbjct: 900  VMLVVPLGIVGVLLAATLFNQKNDVYFMVGLLTTIGLSAKNAILIVEFAKDLMEKEGKGV 959

		

		Query: 961  IEATLDAVRMRLRPILMTSLAFILGVMPLVISTGAGSGAQNAVGTGVMGGMVTATVLAIF 1020

		            +EATL AVRMRLRPILMTSLAFILGV+PL IS GAGSGAQNAVG GVMGGMV+AT+LAIF

		Sbjct: 960  VEATLMAVRMRLRPILMTSLAFILGVLPLAISNGAGSGAQNAVGIGVMGGMVSATLLAIF 1019

		

		Query: 1021 FVPVFFVVVRRRF 1033

		            FVPVFFVV+RR F

		Sbjct: 1020 FVPVFFVVIRRCF 1032

		

		

		>RTXTOXIND#Gram-negative bacterial RTX secretion protein D

		           signature.

		          Length = 478

		

		 Score = 44.0 bits (104), Expect = 6e-07

		 Identities = 33/212 (15%), Positives = 71/212 (33%), Gaps = 23/212 (10%)

		

		Query: 100 TYQATYDSAKGDLAKAQAAANIAQLTVNRYQKLLGTQYISKQEYDQALADAQQANAAVTA 159

		             +  Y  A  +L      + + Q+           Q +++   ++ L   +Q    +  

		Sbjct: 256 EQENKYVEAVNELR--VYKSQLEQIESEILSAKEEYQLVTQLFKNEILDKLRQTTDNIGL 313

		

		Query: 160 AKAAVETARINLAYTKVTSPISGRIGKSNV-TEGALVQNGQATALATVQQLDPIYVDVTQ 218

		               +         + + +P+S ++ +  V TEG +V   + T +  V + D + V    

		Sbjct: 314 LTLELAKNEERQQASVIRAPVSVKVQQLKVHTEGGVVTTAE-TLMVIVPEDDTLEVTALV 372

		

		Query: 219 SSNDFLRLKQELA----------NGTLKQENGKAKVSLITSDGIKFPQDGTLEFSDVTVD 268

		            + D   +                          KV  I  D I+  + G +    ++++

		Sbjct: 373 QNKDIGFINVGQNAIIKVEAFPYTRYGYLV---GKVKNINLDAIEDQRLGLVFNVIISIE 429

		

		Query: 269 QTTGSITLRAIFPNPDHTLLPGMFVRARLEEG 300

		           +   S   + I       L  GM V A ++ G

		Sbjct: 430 ENCLSTGNKNIP------LSSGMAVTAEIKTG 455

		

		

		

		 Score = 34.4 bits (79), Expect = 8e-04

		 Identities = 24/125 (19%), Positives = 43/125 (34%), Gaps = 13/125 (10%)

		

		Query: 49  PLQITTELPGR-TSAYRIAEVRPQVSGIILKRNFKEGSDIEAGVSLYQIDPATYQATYDS 107

		            ++I     G+ T + R  E++P  + I+ +   KEG  +  G  L ++     +A    

		Sbjct: 79  QVEIVATANGKLTHSGRSKEIKPIENSIVKEIIVKEGESVRKGDVLLKLTALGAEA---- 134

		

		Query: 108 AKGDLAKAQAAANIAQLTVNRYQKLLGTQYISKQEYDQALADAQQANAAVTAAKAAVETA 167

		              D  K Q++   A+L   RYQ L         E ++                      

		Sbjct: 135 ---DTLKTQSSLLQARLEQTRYQILS-----RSIELNKLPELKLPDEPYFQNVSEEEVLR 186

		

		Query: 168 RINLA 172

		             +L 

		Sbjct: 187 LTSLI 191

		

		

		>HTHTETR#TetR bacterial regulatory protein HTH signature.

		          Length = 215

		

		 Score =  222 bits (567), Expect = 5e-76

		 Identities = 215/215 (100%), Positives = 215/215 (100%)

		

		Query: 1   MARKTKQEAQETRQHILDVALRLFSQQGVSSTSLGEIAKAAGVTRGAIYWHFKDKSDLFS 60

		           MARKTKQEAQETRQHILDVALRLFSQQGVSSTSLGEIAKAAGVTRGAIYWHFKDKSDLFS

		Sbjct: 1   MARKTKQEAQETRQHILDVALRLFSQQGVSSTSLGEIAKAAGVTRGAIYWHFKDKSDLFS 60

		

		Query: 61  EIWELSESNIGELELEYQAKFPGDPLSVLREILIHVLESTVTEERRRLLMEIIFHKCEFV 120

		           EIWELSESNIGELELEYQAKFPGDPLSVLREILIHVLESTVTEERRRLLMEIIFHKCEFV

		Sbjct: 61  EIWELSESNIGELELEYQAKFPGDPLSVLREILIHVLESTVTEERRRLLMEIIFHKCEFV 120

		

		Query: 121 GEMAVVQQAQRNLCLESYDRIEQTLKHCIEAKMLPADLMTRRAAIIMRGYISGLMENWLF 180

		           GEMAVVQQAQRNLCLESYDRIEQTLKHCIEAKMLPADLMTRRAAIIMRGYISGLMENWLF

		Sbjct: 121 GEMAVVQQAQRNLCLESYDRIEQTLKHCIEAKMLPADLMTRRAAIIMRGYISGLMENWLF 180

		

		Query: 181 APQSFDLKKEARDYVAILLEMYLLCPTLRNPATNE 215

		           APQSFDLKKEARDYVAILLEMYLLCPTLRNPATNE

		Sbjct: 181 APQSFDLKKEARDYVAILLEMYLLCPTLRNPATNE 215

		

		

		>RTXTOXIND#Gram-negative bacterial RTX secretion protein D

		           signature.

		          Length = 478

		

		 Score = 32.1 bits (73), Expect = 0.014

		 Identities = 18/125 (14%), Positives = 40/125 (32%), Gaps = 6/125 (4%)

		

		Query: 28  QNTAFARASSNGDLPTKADLQAQLDSLNKQKDLSAQDKLVQQDLTDTLATLDKIDRIKEE 87

		            N    RA     L      +        +  L     L+ +      A L++ ++  E 

		Sbjct: 207 LNLDKKRAERLTVLARINRYENLSRVEKSR--LDDFSSLLHKQAIAKHAVLEQENKYVEA 264

		

		Query: 88  TVQLRQKVAEAPEKMRQATAALTALSDIDND--EETRKIL--STLSLRQLETRVAQALDD 143

		             +LR   ++  +   +  +A      +      E    L  +T ++  L   +A+  + 

		Sbjct: 265 VNELRVYKSQLEQIESEILSAKEEYQLVTQLFKNEILDKLRQTTDNIGLLTLELAKNEER 324

		

		Query: 144 LQNAQ 148

		            Q + 

		Sbjct: 325 QQASV 329

		

		

		>IGASERPTASE#IgA-specific serine endopeptidase (S6) signature.

		          Length = 1541

		

		 Score = 39.7 bits (92), Expect = 4e-05

		 Identities = 40/251 (15%), Positives = 78/251 (31%), Gaps = 31/251 (12%)

		

		Query: 404  PLPETTSQVLAARQQLQRVQGATKAKKSEPAA----ATRARPVNNAALERLASVTDRVQA 459

		            P  E  +Q +        +      +   P+        AR  + A +   A  T     

		Sbjct: 983  PEVEKRNQTVDTTN----ITTPNNIQADVPSVPSNNEEIARV-DEAPVPPPAPATPSETT 1037

		

		Query: 460  RPVPSALEKAPAKKEAYRWKATTPVMQQKE--------VVATPKALKKA---LEHEKTPE 508

		              V    ++     E     AT    Q +E        V A  +  + A    E ++T  

		Sbjct: 1038 ETVAENSKQESKTVEKNEQDATETTAQNREVAKEAKSNVKANTQTNEVAQSGSETKETQT 1097

		

		Query: 509  LAAKLAA---------EAIERDAWAAQVSQLSLPKLVEQVALNAWKE-ESDNAVCLHLRS 558

		               K  A            E+     +V+    PK  +   +    E   +N   ++++ 

		Sbjct: 1098 TETKETATVEKEEKAKVETEKTQEVPKVTSQVSPKQEQSETVQPQAEPARENDPTVNIKE 1157

		

		Query: 559  SQRHLNNRGAQQKLAEALST-LKGSTVELTIVEDDNPAVRTPLEWRQAIYEEKLAQARES 617

		             Q   N     ++ A+  S+ ++    E T V   N  V  P     A  +  +     +

		Sbjct: 1158 PQSQTNTTADTEQPAKETSSNVEQPVTESTTVNTGNSVVENPENTTPATTQPTVNSESSN 1217

		

		Query: 618  IIADNNIQTLR 628

		               + + +++R

		Sbjct: 1218 KPKNRHRRSVR 1228