PredictBias

		>HTHFIS#FIS bacterial regulatory protein HTH signature.

		          Length = 484

		

		 Score = 73.7 bits (181), Expect = 1e-15

		 Identities = 25/105 (23%), Positives = 51/105 (48%), Gaps = 4/105 (3%)

		

		Query: 669 KLLIIEDNRELSEFLGTKL-KNNYELLL-SDGTDAIEKALTYIPDLLICDVNLPQKNGFE 726

		            +L+ +D+  +   L   L +  Y++ + S+             DL++ DV +P +N F+

		Sbjct: 5   TILVADDDAAIRTVLNQALSRAGYDVRITSNAATLWRWIAAGDGDLVVTDVVMPDENAFD 64

		

		Query: 727 ICKILRNDLRTSHIPIIILTALSDKESYIKGLEAGADTYLTKPFS 771

		           +   ++       +P+++++A +   + IK  E GA  YL KPF 

		Sbjct: 65  LLPRIKK--ARPDLPVLVMSAQNTFMTAIKASEKGAYDYLPKPFD 107

		

		

		

		 Score = 30.2 bits (68), Expect = 0.038

		 Identities = 14/66 (21%), Positives = 31/66 (46%), Gaps = 3/66 (4%)

		

		Query: 786 RERLRYYYSNNLDKIENSNSFGTMEQEFVQRLNELINVNLDNSDFSVEELAESLGVSRVQ 845

		            E +R Y+++  D +  S  +       ++    LI   L  +  +  + A+ LG++R  

		Sbjct: 409 EENMRQYFASFGDALPPSGLYD-RVLAEMEY--PLILAALTATRGNQIKAADLLGLNRNT 465

		

		Query: 846 LYRKVK 851

		           L +K++

		Sbjct: 466 LRKKIR 471

		

		

		>RTXTOXINA#Gram-negative bacterial RTX toxin determinant A family

		            signature.

		          Length = 1024

		

		 Score = 29.5 bits (66), Expect = 0.033

		 Identities = 17/69 (24%), Positives = 31/69 (44%), Gaps = 4/69 (5%)

		

		Query: 102  KVHIQSPSINYHPKKQDSSSASETNSSSPRITIEKLIVENGSFLMKDTTNQR-SARLEDM 160

		            +   ++   +Y       +  S+ + +     I K+I   GSF   D   +R +A L  +

		Sbjct: 948  EYQQRNNKASYVYGNDALAYGSQGDLNPLINEISKIISAAGSF---DVKEERTAASLLQL 1004

		

		Query: 161  AINISDFTY 169

		            + N SDF+Y

		Sbjct: 1005 SGNASDFSY 1013

		

		

		>SYCDCHAPRONE#Gram-negative bacterial type III secretion SycD

		           chaperone signature.

		          Length = 168

		

		 Score = 28.4 bits (63), Expect = 0.011

		 Identities = 9/52 (17%), Positives = 17/52 (32%)

		

		Query: 100 RYSEAITIIKRSVSAYPFDVGLMNFLATIYEKNDNVDSAIETYKKAILTSKK 151

		           +Y +A  + +       +D      L    +     D AI +Y    +   K

		Sbjct: 51  KYEDAHKVFQALCVLDHYDSRFFLGLGACRQAMGQYDLAIHSYSYGAIMDIK 102

		

		

		>PF06580#Sensor histidine kinase

		          Length = 349

		

		 Score =  169 bits (430), Expect = 4e-52

		 Identities = 74/317 (23%), Positives = 143/317 (45%), Gaps = 12/317 (3%)

		

		Query: 11  FHLIVFLAVFLLELLISWSTFSNYGNIYDYFIWQFAYASMVVLVVGINHFFLIPYLLDNK 70

		             +I  +A+ L+ L+++ + + ++     +         + VL   +    +        

		Sbjct: 40  HSMIFNIAISLMGLVLTHA-YRSFIKRQGWLKLNMGQIILRVLPACVVIGMVW------- 91

		

		Query: 71  RYVFYSILLLVTIYLGIQLKSYGKDFGYSIKVFLIFTYITGTGLAFFLLKRSIVFEKE-- 128

		            +V  + +  +  ++  +  ++      SI   ++      + L F         + E  

		Sbjct: 92  -FVANTSIWRLLAFINTKPVAFTLPLALSIIFNVVVVTFMWSLLYFGWHFFKNYKQAEID 150

		

		Query: 129 NAQKNKLQKEMELNYLREQVNPHFLFNSLNSIYALAKSRSLEAPDLVMQLSELMRYQLES 188

		             +   + +E +L  L+ Q+NPHF+FN+LN+I AL      +A +++  LSELMRY L  

		Sbjct: 151 QWKMASMAQEAQLMALKAQINPHFMFNALNNIRALILEDPTKAREMLTSLSELMRYSLRY 210

		

		Query: 189 AKKDKVSLREELEFIENYLLLEEKRLSERCNIELYISEIERELYIAPMLLIPFVENAVKH 248

		           +   +VSL +EL  +++YL L   +  +R   E  I+    ++ + PML+   VEN +KH

		Sbjct: 211 SNARQVSLADELTVVDSYLQLASIQFEDRLQFENQINPAIMDVQVPPMLVQTLVENGIKH 270

		

		Query: 249 GAQATNEKSKIEVRADVNGNRFDFSVSNTKPKTIKEDNR-KGIGLDNVKKRLKLLYANVH 307

		           G     +  KI ++   +       V NT    +K      G GL NV++RL++LY    

		Sbjct: 271 GIAQLPQGGKILLKGTKDNGTVTLEVENTGSLALKNTKESTGTGLQNVRERLQMLYGTEA 330

		

		Query: 308 VLEILEKEEHYMIHLSI 324

		            +++ EK+      + I

		Sbjct: 331 QIKLSEKQGKVNAMVLI 347

		

		

		>HTHFIS#FIS bacterial regulatory protein HTH signature.

		          Length = 484

		

		 Score = 57.1 bits (138), Expect = 8e-12

		 Identities = 27/144 (18%), Positives = 54/144 (37%), Gaps = 14/144 (9%)

		

		Query: 2   IKVGIVDDEILARNIIEDYCAKIDNLKL-VISTGNPIEFINFLQQNELDLIFLDIEMPEL 60

		             + + DD+     I       +      V  T N      ++   + DL+  D+ MP+ 

		Sbjct: 4   ATILVADDD---AAIRTVLNQALSRAGYDVRITSNAATLWRWIAAGDGDLVVTDVVMPDE 60

		

		Query: 61  SGMEILRSMVN---SPKVILTTAYS--EYAVESYNYDVVDYLLKPIKLSRFLKAIHKVSH 115

		           +  ++L  +        V++ +A +    A+++      DYL KP  L+  +  I +   

		Sbjct: 61  NAFDLLPRIKKARPDLPVLVMSAQNTFMTAIKASEKGAYDYLPKPFDLTELIGIIGRALA 120

		

		Query: 116 TLTASTKTVDTHKALQLKQDGMPI 139

		                   ++        QDGMP+

		Sbjct: 121 EPKRRPSKLEDD-----SQDGMPL 139

		

		

		>HTHFIS#FIS bacterial regulatory protein HTH signature.

		          Length = 484

		

		 Score = 27.9 bits (62), Expect = 0.005

		 Identities = 15/89 (16%), Positives = 31/89 (34%), Gaps = 7/89 (7%)

		

		Query: 5   QEEESIAEVLHLPEPVVENPVVVSQPQEDRYHFAEEIEEEETLSLQEKEIELIKKSLER- 63

		           ++  + +  L + + V EN         D    +   +      L E E  LI  +L   

		Sbjct: 393 EKAAARSGSLSISQAVEENMRQYFASFGDALPPSGLYDR----VLAEMEYPLILAALTAT 448

		

		Query: 64  KSRKTQGRRSTNWAFRNRTLYRKIKQYDL 92

		           +  + +            TL +KI++  +

		Sbjct: 449 RGNQIKAADLLGLNRN--TLRKKIRELGV 475

		

		

		>RTXTOXIND#Gram-negative bacterial RTX secretion protein D

		           signature.

		          Length = 478

		

		 Score = 42.9 bits (101), Expect = 7e-07

		 Identities = 38/186 (20%), Positives = 68/186 (36%), Gaps = 47/186 (25%)

		

		Query: 12  VRNKLAFWKLSENQID-EIESSGKVRENFPVYANVSGVVSEIMV-EEGDYVSTGSPLVKV 69

		           + +KL     +   +  E+  + + ++   + A VS  V ++ V  EG  V+T   L+ +

		Sbjct: 300 ILDKLRQTTDNIGLLTLELAKNEERQQASVIRAPVSVKVQQLKVHTEGGVVTTAETLMVI 359

		

		Query: 70  ANLNSVWAVFDAYENQLSLLKK-------GQNLEVLIKSYPNETF---NAKISFV----- 114

		              +      D  E    +  K       GQN  + ++++P   +     K+  +     

		Sbjct: 360 VPED------DTLEVTALVQNKDIGFINVGQNAIIKVEAFPYTRYGYLVGKVKNINLDAI 413

		

		Query: 115 -DPLLNSS---TRTLEVRANLDNRKGL-LKPGMFVTAEIQLENDTETETLTVPESAVLWT 169

		            D  L        ++E        K + L  GM VTAEI+                   T

		Sbjct: 414 EDQRLGLVFNVIISIEENCLSTGNKNIPLSSGMAVTAEIK-------------------T 454

		

		Query: 170 GERSVV 175

		           G RSV+

		Sbjct: 455 GMRSVI 460

		

		

		

		 Score = 35.2 bits (81), Expect = 2e-04

		 Identities = 20/58 (34%), Positives = 32/58 (55%), Gaps = 6/58 (10%)

		

		Query: 32  SGKVRENFPVYANVSGVVSEIMVEEGDYVSTGSPLVKVANLNSVWAVFDAYENQLSLL 89

		           SG+ +E   +    + +V EI+V+EG+ V  G  L+K   L ++ A  D  + Q SLL

		Sbjct: 93  SGRSKE---IKPIENSIVKEIIVKEGESVRKGDVLLK---LTALGAEADTLKTQSSLL 144

		

		

		>PF03309#Bvg accessory factor

		          Length = 271

		

		 Score =  151 bits (383), Expect = 4e-47

		 Identities = 62/261 (23%), Positives = 106/261 (40%), Gaps = 21/261 (8%)

		

		Query: 1   MNLVIDIGNTLIKYAVFKNDS----------IVHDQSSESGLFLSKIKELFEQ-YPQINN 49

		           M L ID+ NT     +               I  +    +      I  L      ++  

		Sbjct: 1   MLLAIDVRNTHTVVGLISGSGDHAKVVQQWRIRTEPEVTADELALTIDGLIGDDAERLTG 60

		

		Query: 50  AILSS-VGKLDRKERDVVALF--CKVHVLTSAS-KVPFKNSYATPHTLGVDRLALAAAAY 105

		           A   S V  +  + R ++  +     HVL     +         P  +G DR+    AAY

		Sbjct: 61  ASGLSTVPSVLHEVRVMLEQYWPNVPHVLIEPGVRTGIPLLVDNPKEVGADRIVNCLAAY 120

		

		Query: 106 HQNPRGNTLVIDAGTCITYDMVNNAGEYVGGAISPGIRMRYNAMHNQTAGLPLLQPGELL 165

		           H+      +V+D G+ I  D+V+  GE++GGAI+PG+++  +A   ++A L  ++     

		Sbjct: 121 HKYG-TAAIVVDFGSSICVDVVSAKGEFLGGAIAPGVQVSSDAAAARSAALRRVELTRPR 179

		

		Query: 166 DFVGNSTESCMHSGVINGVAQEVDGVIGQYRSRF-----QDLTVILTGGDYHFFAKRLKN 220

		             +G +T  CM +G + G A  VDG++ + R         D+ V+ TG         L+ 

		Sbjct: 180 SVIGKNTVECMQAGAVFGFAGLVDGLVNRIRDDVDGFSGADVAVVATGHTAPLVLPDLRT 239

		

		Query: 221 TIFANSKFLLEGLNCLLEYNT 241

		               +    L+GL  + E N 

		Sbjct: 240 VEHYDRHLTLDGLRLVFERNR 260

		

		

		>ARGDEIMINASE#Bacterial arginine deiminase signature.

		          Length = 409

		

		 Score = 30.6 bits (69), Expect = 0.006

		 Identities = 25/159 (15%), Positives = 60/159 (37%), Gaps = 22/159 (13%)

		

		Query: 29  FLTKRNTKSIQEFEKYGIVTVTSDNQEAVKNSDILIFAVQPG----QFVSILKE---TKD 81

		           F +      ++      +++    +  A++N  I  F ++        +++LK+   +  

		Sbjct: 58  FASILKNNLVEIEYIEDLISEVLVSSVALENKFISQFILEAEIKTDFTINLLKDYFSSLT 117

		

		Query: 82  LLTEKHVIISTITGFRIPK-----IEEIIGSDKFIIRSMPNT------AISVGKSMTCIC 130

		           +      +IS +    +        + + G++ FII  MPN         S+G  +T   

		Sbjct: 118 IDNMISKMISGVVTEELKNYTSSLDDLVNGANLFIIDPMPNVLFTRDPFASIGNGVTINK 177

		

		Query: 131 SNELGKKR-IDLAKAIFN---RMGHTMEIPEDQMQAATV 165

		                ++R    A+ IF         + I  ++ + A++

		Sbjct: 178 MFTKVRQRETIFAEYIFKYHPVYKENVPIWLNRWEEASL 216

		

		

		>DHBDHDRGNASE#2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase

		           signature.

		          Length = 261

		

		 Score =  120 bits (302), Expect = 3e-35

		 Identities = 78/251 (31%), Positives = 122/251 (48%), Gaps = 9/251 (3%)

		

		Query: 3   LKDKVCIVTGATSGMGKAIAQGLSSEGARLVLSGRNKESGQALENSLD----HAVFVPGD 58

		           ++ K+  +TGA  G+G+A+A+ L+S+GA +     N E  + + +SL     HA   P D

		Sbjct: 6   IEGKIAFITGAAQGIGEAVARTLASQGAHIAAVDYNPEKLEKVVSSLKAEARHAEAFPAD 65

		

		Query: 59  VTEPSYNKKLVDTALETYGQLDILSLNAGVLGLGNVMELPIETWQNAINTNLSSLFYLCK 118

		           V + +   ++        G +DIL   AGVL  G +  L  E W+   + N + +F   +

		Sbjct: 66  VRDSAAIDEITARIEREMGPIDILVNVAGVLRPGLIHSLSDEEWEATFSVNSTGVFNASR 125

		

		Query: 119 YALPILQRQPQGNILINASIAAFKSFPNHPAYCASKAGAVALMKQMAVDYAP-NIRVNAI 177

		                +  +  G+I+   S  A     +  AY +SKA AV   K + ++ A  NIR N +

		Sbjct: 126 SVSKYMMDRRSGSIVTVGSNPAGVPRTSMAAYASSKAAAVMFTKCLGLELAEYNIRCNIV 185

		

		Query: 178 CPGPVDTPL---LWESAKAFEQP-ETAVEHAKRTTLLKRLGTPQDITKLVLFLVSDDSSW 233

		            PG  +T +   LW      EQ  + ++E  K    LK+L  P DI   VLFLVS  +  

		Sbjct: 186 SPGSTETDMQWSLWADENGAEQVIKGSLETFKTGIPLKKLAKPSDIADAVLFLVSGQAGH 245

		

		Query: 234 ITGTTVTIDGG 244

		           IT   + +DGG

		Sbjct: 246 ITMHNLCVDGG 256

		

		

		>MICOLLPTASE#Microbial collagenase metalloprotease (M9) signature.

		          Length = 1104

		

		 Score = 30.8 bits (69), Expect = 0.018

		 Identities = 19/69 (27%), Positives = 22/69 (31%), Gaps = 10/69 (14%)

		

		Query: 277 LENAGT-IAYFENSVTGNQTVEPLIAHEIAHQWFGNSATEKSWNH---------VWLSEG 326

		           +EN GT   Y         T+E L  HE  H   G       W            W  EG

		Sbjct: 476 IENIGTFFTYERTPEESIYTLEELFRHEFTHYLQGRYVVPGMWGQGEFYQEGVLTWYEEG 535

		

		Query: 327 FATYFAILY 335

		            A +FA   

		Sbjct: 536 TAEFFAGST 544

		

		

		>DHBDHDRGNASE#2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase

		           signature.

		          Length = 261

		

		 Score = 87.8 bits (217), Expect = 6e-23

		 Identities = 51/187 (27%), Positives = 86/187 (45%), Gaps = 8/187 (4%)

		

		Query: 3   LEGKVAYITGGTKGIGYGIAESLLEQGMKVAISGRSQESADAAVKGLD----HPDHVLGL 58

		           +EGK+A+ITG  +GIG  +A +L  QG  +A    + E  +  V  L     H +     

		Sbjct: 6   IEGKIAFITGAAQGIGEAVARTLASQGAHIAAVDYNPEKLEKVVSSLKAEARHAEA---F 62

		

		Query: 59  VSDVSQLEDEQKAVAAILDKWGQLDVVMANAGVGHFAPVDELGDDKWHQMINTNLNGVYH 118

		            +DV       +  A I  + G +D+++  AGV     +  L D++W    + N  GV++

		Sbjct: 63  PADVRDSAAIDEITARIEREMGPIDILVNVAGVLRPGLIHSLSDEEWEATFSVNSTGVFN 122

		

		Query: 119 TLKASVDALK-KSEGYYMTLASLAGTNFFAQGAGYNATKFGVVGFTQAAMLDLRPYNIKV 177

		             ++    +  +  G  +T+ S          A Y ++K   V FT+   L+L  YNI+ 

		Sbjct: 123 ASRSVSKYMMDRRSGSIVTVGSNPAGVPRTSMAAYASSKAAAVMFTKCLGLELAEYNIRC 182

		

		Query: 178 TTIMPGS 184

		             + PGS

		Sbjct: 183 NIVSPGS 189

		

		

		>SACTRNSFRASE#Streptothricin acetyltransferase signature.

		          Length = 173

		

		 Score = 38.8 bits (90), Expect = 3e-06

		 Identities = 28/125 (22%), Positives = 53/125 (42%), Gaps = 5/125 (4%)

		

		Query: 26  ENGIFQWNEHYPSKEAFQKDIERGELFVVEEKNTVQGTIVISTFMDEEYKPIQWLTSNGN 85

		           ENG++ + E   SK  F K  E  ++ V   +    G      +++        + SN N

		Sbjct: 31  ENGVWTYTEERFSKPYF-KQYEDDDMDVSYVEEE--GKAAFLYYLENNCIGRIKIRSNWN 87

		

		Query: 86  S-VYIHRLSVHPNLQGKGLAQQMMDFAENHAREHRFVSVRLDTFSQNKRNQRFYEQRGYQ 144

		               I  ++V  + + KG+   ++  A   A+E+ F  + L+T   N     FY +  + 

		Sbjct: 88  GYALIEDIAVAKDYRKKGVGTALLHKAIEWAKENHFCGLMLETQDINISACHFYAKHHF- 146

		

		Query: 145 KLGDI 149

		            +G +

		Sbjct: 147 IIGAV 151

		

		

		>SECA#SecA protein signature.

		          Length = 901

		

		 Score = 25.2 bits (55), Expect = 0.037

		 Identities = 14/61 (22%), Positives = 31/61 (50%), Gaps = 9/61 (14%)

		

		Query: 3  VKYLKSLEKDLRKVNDKKTKQKLKQIILQMKEAKSLDELTSVKKLSGHPNAFRI-RVGSY 61

		          V  + ++E ++ K++D++ K K  +   ++++ + L+ L         P AF + R  S 

		Sbjct: 25 VNIINAMEPEMEKLSDEELKGKTAEFRARLEKGEVLENLI--------PEAFAVVREASK 76

		

		Query: 62 R 62

		          R

		Sbjct: 77 R 77

		

		

		>TCRTETA#Tetracycline resistance protein signature.

		          Length = 399

		

		 Score = 34.4 bits (79), Expect = 6e-04

		 Identities = 58/324 (17%), Positives = 118/324 (36%), Gaps = 27/324 (8%)

		

		Query: 51  GLMEVIPAVSMALFA---GHIVDQKEKRNLLVTCIAGFSVISLGLFLLSWPGLEASWESK 107

		           G++  + A+     A   G + D+  +R +L+  +AG +V      +++         + 

		Sbjct: 46  GILLALYALMQFACAPVLGALSDRFGRRPVLLVSLAGAAV---DYAIMA---------TA 93

		

		Query: 108 TILYSIYALVFLGGFVRSFLGPTIFSLIALIVPKKIYPNAATWSSSTWQLASVLGPALAG 167

		             L+ +Y    + G +    G    + IA I           + S+ +    V GP L G

		Sbjct: 94  PFLWVLYIGRIVAG-ITGATGAVAGAYIADITDGDERARHFGFMSACFGFGMVAGPVLGG 152

		

		Query: 168 FSISWIGVHWSMCVIFGFSLVAL---MFLFQIPKKPIMNPKLGEPVFQSLRDGLKFVFGN 224

		             +     H         + +      FL     K    P   E +  +     ++  G 

		Sbjct: 153 L-MGGFSPHAPFFAAAALNGLNFLTGCFLLPESHKGERRPLRREAL--NPLASFRWARGM 209

		

		Query: 225 KAIFGALTLDMIAVLFGGAVALLPV-YAQDILHVGSEGFGILRAAPAVGASITMLGSTRF 283

		             +   + +  I  L G   A L V + +D  H  +   GI  AA  +  S+     T  

		Sbjct: 210 TVVAALMAVFFIMQLVGQVPAALWVIFGEDRFHWDATTIGISLAAFGILHSLAQAMITG- 268

		

		Query: 284 PLHKNAGKK--LLWAVFAFGVCIIVFGLSELFWLSVIALFLSGAVDGVSMIIRQTILQLK 341

		           P+    G++  L+  + A G   I+   +   W++   + L  +  G+ M   Q +L  +

		Sbjct: 269 PVAARLGERRALMLGMIADGTGYILLAFATRGWMAFPIMVLLASG-GIGMPALQAMLSRQ 327

		

		Query: 342 TPDNMRGRVASVNSMFVGSSNELG 365

		             +  +G++    +     ++ +G

		Sbjct: 328 VDEERQGQLQGSLAALTSLTSIVG 351

		

		

		>INTIMIN#Intimin signature.

		          Length = 939

		

		 Score = 34.7 bits (79), Expect = 0.012

		 Identities = 54/310 (17%), Positives = 91/310 (29%), Gaps = 39/310 (12%)

		

		Query: 1101 FEYSTISAPSFALDADAVLTQDYTCLQEGIIEVQNVTGGTAPYEYSIDGVNFGSASTFNN 1160

		            F     SA +   D    +T   T  + G+ +              + G    SA++ N 

		Sbjct: 563  FTADKTSAKA---DGTEAITYTATVKKNGVAQANVPVSFN-----IVSGTAVLSANSANT 614

		

		Query: 1161 LTDGTYTVTVR-DAVGCVFTATPIT--IDPLDPPTDIDFAATNPLCPTFTSDVTLTVTGG 1217

		               G  TVT++ D  G V  +         L+    I    T        +D T  V  G

		Sbjct: 615  NGSGKATVTLKSDKPGQVVVSAKTAEMTSALNANAVIFVDQTKASITEIKADKTTAVANG 674

		

		Query: 1218 EPNLVYEIVSPAGSAVNNSNNNTFTGLAPGTYLFRVTDNAGCTYDESYTIAPVTEISVTG 1277

		            +  + Y +    G    ++   TFT             +       + T     +  V+ 

		Sbjct: 675  QDAITYTVKVMKGDKPVSNQEVTFTTTLGKLSNSTEKTDTNGYAKVTLTSTTPGKSLVSA 734

		

		Query: 1278 QLISNITCLGDSDGEIQYTVNNFNTDYNYSVTGPASFSGTGETSGTVSLNGLAEGTYTIT 1337

		            ++        D   +++     F T       G     GTG   G +    L  G   + 

		Sbjct: 735  RV-------SDVAVDVKAPEVEFFTTLTID-DGNIEIVGTG-VKGKLPTVWLQYGQVNLK 785

		

		Query: 1338 VTDNFTNCTDTASVTVAAPTAAITAPVTITQPTCLANGSVSIAAAGGWGSYTYEITSG-- 1395

		             +      T  ++    A   A +  VT+                   G+ T  + S   

		Sbjct: 786  ASGGNGKYTWRSANPAIASVDASSGQVTLK----------------EKGTTTISVISSDN 829

		

		Query: 1396 -PAGYTLPAP 1404

		              A YT+  P

		Sbjct: 830  QTATYTIATP 839

		

		

		>PF03944#delta endotoxin

		          Length = 633

		

		 Score = 26.6 bits (58), Expect = 0.008

		 Identities = 14/36 (38%), Positives = 20/36 (55%)

		

		Query: 35 QNTKNELYPTNILGGLAPLLQKVAISLVAKKILKKL 70

		          +   + LY   I+G +A  L K   SLV K+IL +L

		Sbjct: 42 KKNNHSLYLDPIVGTVASFLLKKVGSLVGKRILSEL 77

		

		

		>GPOSANCHOR#Gram-positive coccus surface protein anchor signature.

		          Length = 539

		

		 Score = 56.6 bits (136), Expect = 3e-10

		 Identities = 44/292 (15%), Positives = 93/292 (31%), Gaps = 29/292 (9%)

		

		Query: 485 LYDDNELNNKELEFQNTTLNKLGESLKNMQEQEEKLSE---INQLQKEEKALNFEEKSQI 541

		              +N     +    +     L +    + E+     E    N     EKA   +E    

		Sbjct: 62  FEIENNTLKLKNSDLSFNNKALKDHNDELTEELSNAKEKLRKNDKSLSEKASKIQELEAR 121

		

		Query: 542 KSFLQQQQMQEQLMEKFSQDLNKSIDKNEEDSEMKRMIQERLERQEAEARKNAKLLEELE 601

		           K+ L++                K+++  +     ++        +  E   N    +  +

		Sbjct: 122 KADLEKALEGAMNFSTADSAKIKTLEAEKAALAARK----ADLEKALEGAMNFSTADSAK 177

		

		Query: 602 KIAEKIDKEELQQRLEELGKNQGKNTRNLEQILELTKRYYVTEKASQIAKELEELARKQE 661

		               + +K  L+ R  EL K                     + K   +  E   LA ++ 

		Sbjct: 178 IKTLEAEKAALEARQAELEKALEGAMNFSTA---------DSAKIKTLEAEKAALAARKA 228

		

		Query: 662 TLSELKLGEDFSDKEQKKLNEEFESLEKEIRDLENDNQELKKPIE---------LDTDET 712

		            L +     + +       + + ++LE E   LE    EL+K +E             +T

		Sbjct: 229 DLEKAL---EGAMNFSTADSAKIKTLEAEKAALEARQAELEKALEGAMNFSTADSAKIKT 285

		

		Query: 713 KTGAIKQDQQDALEEINKHQGMEESSQA-KEKEDAGNNATKKQKSAAQKMRE 763

		                   + +  +  ++ Q +  + Q+ +   DA   A K+ ++  QK+ E

		Sbjct: 286 LEAEKAALEAEKADLEHQSQVLNANRQSLRRDLDASREAKKQLEAEHQKLEE 337

		

		

		

		 Score = 39.3 bits (91), Expect = 9e-05

		 Identities = 49/299 (16%), Positives = 102/299 (34%), Gaps = 39/299 (13%)

		

		Query: 488 DNELNNKELEFQNTTLNK--LGESLKNMQEQEEKLSEINQLQKEEKALNFEEKSQIKSFL 545

		             ++   E E       K  L ++L+         S   +  + EKA     +++++  L

		Sbjct: 140 SAKIKTLEAEKAALAARKADLEKALEGAMNFSTADSAKIKTLEAEKAALEARQAELEKAL 199

		

		Query: 546 QQQQMQEQLMEKFSQDLNKSIDKNEEDSEMKRMIQERLERQEAEARKNAKLLEELEK-IA 604

		           +             + L             K  +++ LE     +  ++  ++ LE   A

		Sbjct: 200 EGAMNFSTADSAKIKTLEAEKAALAAR---KADLEKALEGAMNFSTADSAKIKTLEAEKA 256

		

		Query: 605 EKIDKEELQQRLEELGKNQGKNTRNLEQILELTKRYYVTEKAS----------------- 647

		               ++   ++  E   N         + LE  K     EKA                  

		Sbjct: 257 ALEARQAELEKALEGAMNFSTADSAKIKTLEAEKAALEAEKADLEHQSQVLNANRQSLRR 316

		

		Query: 648 QIAKELEELARKQETLSELKLGEDFSDKEQKKLNEEFESLEKEIRDLENDNQELKKPIE- 706

		            +    E   + +    +L+     S+  ++ L  + ++  +  + LE ++Q+L++  + 

		Sbjct: 317 DLDASREAKKQLEAEHQKLEEQNKISEASRQSLRRDLDASREAKKQLEAEHQKLEEQNKI 376

		

		Query: 707 -------LDTDETKTGAIKQDQQDALEEINK--------HQGMEESSQAKEKEDAGNNA 750

		                  L  D   +   K+  + ALEE N         ++ +EES +  EKE A   A

		Sbjct: 377 SEASRQSLRRDLDASREAKKQVEKALEEANSKLAALEKLNKELEESKKLTEKEKAELQA 435

		

		

		>NUCEPIMERASE#Nucleotide sugar epimerase signature.

		          Length = 334

		

		 Score = 45.5 bits (108), Expect = 7e-08

		 Identities = 20/110 (18%), Positives = 47/110 (42%), Gaps = 3/110 (2%)

		

		Query: 30  DFKPMDALDITQREQIVEVFEKGKCDFCINCAAFTNVEAAESNAEEAFKVNAEAVKDLAQ 89

		            F+     D+  RE + ++F  G  +          V  +  N       N     ++ +

		Sbjct: 53  GFQFHKI-DLADREGMTDLFASGHFERVFISPHRLAVRYSLENPHAYADSNLTGFLNILE 111

		

		Query: 90  ICKQHGVV-LIHVSTDYVFDGEKKDAYTVEDNPN-PINEYGKSKLAGEKL 137

		            C+ + +  L++ S+  V+   +K  ++ +D+ + P++ Y  +K A E +

		Sbjct: 112 GCRHNKIQHLLYASSSSVYGLNRKMPFSTDDSVDHPVSLYAATKKANELM 161

		

		

		>NUCEPIMERASE#Nucleotide sugar epimerase signature.

		          Length = 334

		

		 Score =  114 bits (288), Expect = 2e-33

		 Identities = 43/158 (27%), Positives = 72/158 (45%), Gaps = 13/158 (8%)

		

		Query: 1   MKILITGGAGFIGSHVVRRFVLNYPNYNIYNIDALT--YAGNLENLR-DIENNPNYFFIK 57

		           MK L+TG AGFIG HV +R +     + +  ID L   Y  +L+  R ++   P + F K

		Sbjct: 1   MKYLVTGAAGFIGFHVSKRLLEA--GHQVVGIDNLNDYYDVSLKQARLELLAQPGFQFHK 58

		

		Query: 58  GDINNAEFIADLFDKYRFDGIIHLAAESHVDRSISDPLAFAKTNILGTMNLLNAFKQIWS 117

		            D+ + E + DLF    F+ +        V  S+ +P A+A +N+ G +N+L   +    

		Sbjct: 59  IDLADREGMTDLFASGHFERVFISPHRLAVRYSLENPHAYADSNLTGFLNILEGCRHN-- 116

		

		Query: 118 GNWEGKRFYHVSTDEVYGSLGTTGFFYRNESLPTKLPI 155

		              + +   + S+  VYG      F   +       P+

		Sbjct: 117 ---KIQHLLYASSSSVYGLNRKMPF---STDDSVDHPV 148

		

		

		>NUCEPIMERASE#Nucleotide sugar epimerase signature.

		          Length = 334

		

		 Score = 64.0 bits (156), Expect = 4e-15

		 Identities = 28/137 (20%), Positives = 53/137 (38%), Gaps = 27/137 (19%)

		

		Query: 2   PVYGDGNYTRDWLYVEDHAGAI------------DLVFHQGTIN------ETYNIGGFNE 43

		            VY  G   RD+ Y++D A AI                  GT          YNIG  + 

		Sbjct: 206 DVYNYGKMKRDFTYIDDIAEAIIRLQDVIPHADTQWTVETGTPAASIAPYRVYNIGNSSP 265

		

		Query: 44  WKNIDLVRELCKQMDNKLNRSTGSSEELITFVKDRPGHDLRYAIDASKINNELGWSPSVT 103

		            + +D ++ L   +  +  ++          +  +PG  L  + D   +   +G++P  T

		Sbjct: 266 VELMDYIQALEDALGIEAKKN---------MLPLQPGDVLETSADTKALYEVIGFTPETT 316

		

		Query: 104 FEEGLSKTIDWYLENQN 120

		            ++G+   ++WY +   

		Sbjct: 317 VKDGVKNFVNWYRDFYK 333

		

		

		>GPOSANCHOR#Gram-positive coccus surface protein anchor signature.

		          Length = 539

		

		 Score = 33.9 bits (77), Expect = 0.001

		 Identities = 24/201 (11%), Positives = 56/201 (27%), Gaps = 8/201 (3%)

		

		Query: 28  EQKVLEAKRERLQEEIKEINRLLFAERKEKGTVLDQMEALDNKINVRQELIRVTNQQSNL 87

		           + K LEA++  L     ++ + L            +++ L+ +    +       +    

		Sbjct: 142 KIKTLEAEKAALAARKADLEKALEGAMNFSTADSAKIKTLEAEKAALEARQAELEKALEG 201

		

		Query: 88  LSRQINVNIRSISKLREDLEVLKEDYAELIQKTYQNKSQNNRLMFLLSAENFFQAFKRLQ 147

		                  +   I  L  +   L    A+L +      + +      +             

		Sbjct: 202 AMNFSTADSAKIKTLEAEKAALAARKADLEKALEGAMNFSTADSAKIKTLE--------A 253

		

		Query: 148 YMQQYAKHRKKQGEGIVQKTEELKALNQDLVRQRKEKDQLVAENQKAKEELSKEIEAQRS 207

		                   + +  + +        A +  +     EK  L AE    + +       ++S

		Sbjct: 254 EKAALEARQAELEKALEGAMNFSTADSAKIKTLEAEKAALEAEKADLEHQSQVLNANRQS 313

		

		Query: 208 LLTSIKQNEAKYTAAIAEKQK 228

		           L   +  +        AE QK

		Sbjct: 314 LRRDLDASREAKKQLEAEHQK 334

		

		

		>DNABINDINGHU#Prokaryotic integration host factor signature.

		          Length = 91

		

		 Score = 28.1 bits (63), Expect = 0.014

		 Identities = 12/45 (26%), Positives = 24/45 (53%)

		

		Query: 52 LVSHIAKEKQLGYEELLKEVENVAQDWKERLAQGERIELFGIGTL 96

		          L++ +A+  +L  ++    V+ V       LA+GE+++L G G  

		Sbjct: 7  LIAKVAEATELTKKDSAAAVDAVFSAVSSYLAKGEKVQLIGFGNF 51

		

		

		>FLAGELLIN#Flagellin signature.

		          Length = 507

		

		 Score = 26.9 bits (59), Expect = 0.007

		 Identities = 7/21 (33%), Positives = 10/21 (47%)

		

		Query: 3   GSFQMRVKPQLQNVNNTSLNT 23

		           G+ Q R    + N+ NT  N 

		Sbjct: 439 GAIQNRFDSAITNLGNTVTNL 459

		

		

		>BACYPHPHTASE#Salmonella/Yersinia modular tyrosine phosphatase

		           signature.

		          Length = 468

		

		 Score = 30.2 bits (67), Expect = 0.033

		 Identities = 17/67 (25%), Positives = 31/67 (46%)

		

		Query: 263 TFALVTDESELFQVAENGEITLAEGKNLDFEIATEHSLTLSVSDGSNEPVEFTVTVTVTD 322

		           T+  +T ES++ Q    G+  +A+   L    A + ++++ V    N P +  V+  VT 

		Sbjct: 307 TYGSITVESKMTQQVGLGDGIMADMYTLTIREAGQKTISVPVVHVGNWPDQTAVSSEVTK 366

		

		Query: 323 VADGLAD 329

		               L D

		Sbjct: 367 ALASLVD 373

		

		

		>HTHFIS#FIS bacterial regulatory protein HTH signature.

		          Length = 484

		

		 Score = 48.3 bits (115), Expect = 1e-09

		 Identities = 26/124 (20%), Positives = 47/124 (37%), Gaps = 15/124 (12%)

		

		Query: 7   IIDDDLVSQFATRYCIQQSHGNFDIVTCSSGEEGIQACFGYVEEHDRLPDIIFLDLVMDG 66

		           + DDD   +      + ++   +D+   S+     +     +   D   D++  D+VM  

		Sbjct: 8   VADDDAAIRTVLNQALSRA--GYDVRITSNAATLWRW----IAAGD--GDLVVTDVVMPD 59

		

		Query: 67  MNGWDFLENLKNLFKEHKLPSVYVLSAFTNASDRAIAKKNGMISGYVDKPLSRSYLEKIL 126

		            N +D L  +K       LP V V+SA         A + G    Y+ KP     L +++

		Sbjct: 60  ENAFDLLPRIKKA--RPDLP-VLVMSAQNTFMTAIKASEKG-AYDYLPKPFD---LTELI 112

		

		Query: 127 KEEE 130

		               

		Sbjct: 113 GIIG 116

		

		

		>BACTRLTOXIN#Bacterial toxin signature.

		          Length = 266

		

		 Score = 28.3 bits (63), Expect = 0.050

		 Identities = 10/60 (16%), Positives = 22/60 (36%), Gaps = 3/60 (5%)

		

		Query: 15  SSRSKNGKAPIYARISV-NGKKLNISLKRRIPINEWDSNKQRVKNSSIHAKS--TNQYLD 71

		             +   GK  +Y  I+   G   +    + + +  +++ +  +       K   T Q LD

		Sbjct: 128 VGKVTGGKTCMYGGITKHEGNHFDNGNLQNVLVRVYENKRNTISFEVQTDKKSVTAQELD 187

		

		

		>CHLAMIDIAOM6#Chlamydia cysteine-rich outer membrane protein 6

		           signature.

		          Length = 547

		

		 Score = 42.8 bits (100), Expect = 1e-05

		 Identities = 84/324 (25%), Positives = 131/324 (40%), Gaps = 40/324 (12%)

		

		Query: 285 ISFEISISNAGPHDATNVRVVDQLLSGFNFVSYAATTGTYSPVSGFWEVGTLPNGATETL 344

		           + ++I+I N G   A NV V + +  G     YA ++G    V  F  +G +  G   T+

		Sbjct: 227 VVYKINIVNQGTATARNVVVENPVPDG-----YAHSSG--QRVLTF-TLGDMQPGEHRTI 278

		

		Query: 345 TIDVMVNPSGNYTNTTQVIASDAYDIDSTPSNGVSSEDDQSDVVVAPAPLIDLSLTKTID 404

		           T++      G  TN    IA+ +Y      +  V++        V   P + +S+    D

		Sbjct: 279 TVEFCPLKRGRATN----IATVSYCGGHKNTASVTT--------VINEPCVQVSIAGA-D 325

		

		Query: 405 KSPPLVSDNVRFTLTVSNDGPSDATSVEVTDLLPSGYTYVSDNGGGAYDDISGVWDIGTV 464

		            S   V   V + ++VSN G      V V D L  G T V +  G        VW +  +

		Sbjct: 326 WS--YVCKPVEYVISVSNPGDLVLRDVVVEDTLSPGVT-VLEAAGAQISCNKVVWTVKEL 382

		

		Query: 465 ANGSSATLSILATVNASGDY-NNIAEITAHDQNDVDSSPNNNIPGEDDQDGVSVVPEPLV 523

		             G S    +L      G + NN+   +  D     S        +    GV+     +V

		Sbjct: 383 NPGESLQYKVLVRAQTPGQFTNNVVVKSCSDCGTCTSCAEATTYWK----GVAATHMCVV 438

		

		Query: 524 DIFVTKTVDELIPEVGQEIVFTVTVGNDGPSDATNVVVTDILASGYQLVNAV-PSTGTYN 582

		           D     T D +   VG+  V+ + V N G ++ TNV +    +   Q V+   P+ GT  

		Sbjct: 439 D-----TCDPVC--VGENTVYRICVTNRGSAEDTNVSLMLKFSKELQPVSFSGPTKGT-- 489

		

		Query: 583 ATNGSWVVGSLPN-GSPETLAITV 605

		            T  + V  SLP  GS ET+  +V

		Sbjct: 490 ITGNTVVFDSLPRLGSKETVEFSV 513

		

		

		

		 Score = 33.5 bits (76), Expect = 0.007

		 Identities = 54/239 (22%), Positives = 85/239 (35%), Gaps = 48/239 (20%)

		

		Query: 525 IFVTKTVDELIPEVGQEIVFTVTVGND--------GPSDATNVVVTDILASGYQLVNAVP 576

		           ++  K  D+   E+ Q +    TVG+         G  D  +V++T  L    + V + P

		Sbjct: 92  MYTVKVNDDRNVEITQAVPEYATVGSPYPIEITATGKRDCVDVIITQQLPCEAEFVRSDP 151

		

		Query: 577 STGTYNATNGSWVVGSLPNGSPETLAITVDVLQTGNYINTAELTNVAENDVDSSPNNNNE 636

		           +T         W +  L  G    + + V  L+ G     A         V + P   + 

		Sbjct: 152 ATTPTADGKLVWKIDRLGQGEKSKITVWVKPLKEGCCFTAAT--------VCACPEIRSV 203

		

		Query: 637 AEDDQQTVEPIVVPVADLLLRKSVNQLSP---FVGQDVIFTINITNLGPSDATGVEVLDL 693

		            +  Q  +               V Q  P    +   V++ INI N G + A  V V + 

		Sbjct: 204 TKCGQPAI--------------CVKQEGPENACLRCPVVYKINIVNQGTATARNVVVENP 249

		

		Query: 694 LPDGYSYVSHGTTAGLYSASSGMWTLNGTLAD---GSTETLTIVASVNNAGDYFNVTEV 749

		           +PDGY++            SSG   L  TL D   G   T+T+       G   N+  V

		Sbjct: 250 VPDGYAH------------SSGQRVLTFTLGDMQPGEHRTITVEFCPLKRGRATNIATV 296

		

		

		>HTHFIS#FIS bacterial regulatory protein HTH signature.

		          Length = 484

		

		 Score = 67.2 bits (164), Expect = 5e-15

		 Identities = 32/117 (27%), Positives = 53/117 (45%), Gaps = 7/117 (5%)

		

		Query: 4   KAIIIEDEKHSRETLKSMLEEFCKGVEVIAMAGTVDEAVRVLSVYSPDIVFLDIELQSGV 63

		             ++ +D+   R  L   L     G +V           R ++    D+V  D+ +    

		Sbjct: 5   TILVADDDAAIRTVLNQALSR--AGYDVRI-TSNAATLWRWIAAGDGDLVVTDVVMPDEN 61

		

		Query: 64  GFDVLERIKE--PNFEIIFTTAFE--KYAIKAIKFSSLDYLLKPIDLSELQQAVNKA 116

		            FD+L RIK+  P+  ++  +A      AIKA +  + DYL KP DL+EL   + +A

		Sbjct: 62  AFDLLPRIKKARPDLPVLVMSAQNTFMTAIKASEKGAYDYLPKPFDLTELIGIIGRA 118

		

		

		>PF06580#Sensor histidine kinase

		          Length = 349

		

		 Score =  138 bits (349), Expect = 3e-38

		 Identities = 78/368 (21%), Positives = 156/368 (42%), Gaps = 33/368 (8%)

		

		Query: 271 DSELGFWAL-TISQVLINLFYILFAKFYLNTEKQYPLLDIIIKIIVLVLILIVLAHGTAY 329

		            +   +W    I   +  L    FA  Y +     P L  +I  I + L+ +VL H  AY

		Sbjct: 7   QANKYYWYCQGIGWGVYTLTGFGFASLYGS-----PKLHSMIFNIAISLMGLVLTH--AY 59

		

		Query: 330 FSEHYQLQSNILNFQRLLMTLFGLFAMVYLLLLRKDILACFIVAGSFCYMLGALAFWLMY 389

		            S   +     LN  ++++ +     ++ ++    +     ++A    ++      + + 

		Sbjct: 60  RSFIKRQGWLKLNMGQIILRVLPACVVIGMVWFVANTSIWRLLA----FINTKPVAFTLP 115

		

		Query: 390 SKHYMILGSMLEIMIFS-LGLAYKIKLEYEGKVI--LQREVSLKD--ISAKRAQINPHFF 444

		               +I   ++   ++S L   +     Y+   I   +     ++  + A +AQINPHF 

		Sbjct: 116 LALSIIFNVVVVTFMWSLLYFGWHFFKNYKQAEIDQWKMASMAQEAQLMALKAQINPHFM 175

		

		Query: 445 FNSLGSIQHLILHDKKNAALNYLNKFSKLARSVLESSYETTVTLTEEIELLRSYLELESL 504

		           FN+L +I+ LIL D   A    L   S+L R  L  S    V+L +E+ ++ SYL+L S+

		Sbjct: 176 FNALNNIRALILEDPTKAR-EMLTSLSELMRYSLRYSNARQVSLADELTVVDSYLQLASI 234

		

		Query: 505 RFDKAFSYTITVADSVDTDAVEIPLMLIQPFAENAIIHGLMGKKTGEKKLEFRFFMETEY 564

		           +F+    +   +  ++    V++P ML+Q   EN I HG+     G  K+  +   +   

		Sbjct: 235 QFEDRLQFENQINPAI--MDVQVPPMLVQTLVENGIKHGIAQLPQG-GKILLKGTKDNGT 291

		

		Query: 565 LVIEIEDNGVGRYYEKTNKNRKKSRGMEITKKRLKMRDTSDLNKNSIEIIDKYDTQSQPS 624

		           + +E+E+ G        N       G++  ++RL+M   ++     I++        +  

		Sbjct: 292 VTLEVENTGSL---ALKNTKESTGTGLQNVRERLQMLYGTEA---QIKL------SEKQG 339

		

		Query: 625 GTKVIIRL 632

		               ++ +

		Sbjct: 340 KVNAMVLI 347

		

		

		>IGASERPTASE#IgA-specific serine endopeptidase (S6) signature.

		          Length = 1541

		

		 Score = 37.4 bits (86), Expect = 8e-05

		 Identities = 39/200 (19%), Positives = 77/200 (38%), Gaps = 22/200 (11%)

		

		Query: 68   QSLSADVRLGNRSGIGLLMYNDSNGETKQRGAKIAFAHHLTLDKYEGN---YLSLALSFN 124

		            Q++S +V+LG     G+  Y  ++    +  +K   A      KY  +   YL + L + 

		Sbjct: 1328 QTISNNVQLG-----GVFTYVRNSNNFDKATSKNTLAQVNFYSKYYADNHWYLGIDLGYG 1382

		

		Query: 125  LNQFRIDIENFEDNTDLAVTDDRASSNPNFDLGALYRRGEF----YLGLNVSNIFNKDFN 180

		              Q ++   +   N   A    R ++      G  +  G F     +G+  S + N DF 

		Sbjct: 1383 KFQSKLQTNH---NAKFA----RHTAQFGLTAGKAFNLGNFGITPIVGVRYSYLSNADFA 1435

		

		Query: 181  KFNPILEPNTLRNYYLYSGYSFRKS-KRADFEIEPSVFFQYFESDGRSVTDVNTKFKWYD 239

		                 ++ N +     ++      +    +F + P +  +Y  + G    +VN     Y+

		Sbjct: 1436 LDQARIKVNPISVKTAFAQVDLSYTYHLGEFSVTPILSARYDANQGSGKINVNGYDFAYN 1495

		

		Query: 240  FLDY--YYAGFTYRFLNDQL 257

		              +   Y AG   ++ N +L

		Sbjct: 1496 VENQQQYNAGLKLKYHNVKL 1515

		

		

		>BCTERIALGSPD#Bacterial general secretion pathway protein D

		           signature.

		          Length = 660

		

		 Score = 26.4 bits (58), Expect = 0.041

		 Identities = 11/61 (18%), Positives = 25/61 (40%), Gaps = 1/61 (1%)

		

		Query: 39  TEKTKEAKAPVVVPKISIDSRIQKFEKLRGLATNRERLNQTLGELTKFNYNQDGSSSFYI 98

		            + +K A    +V  +  D R      + G   +R+R+   + +L +    Q  +   Y+

		Sbjct: 216 KDTSKSALPGSMVANVVADERTNAVL-VSGEPNSRQRIIAMIKQLDRQQATQGNTKVIYL 274

		

		Query: 99  R 99

		           +

		Sbjct: 275 K 275

		

		

		>ACRIFLAVINRP#Acriflavin resistance protein family signature.

		          Length = 1034

		

		 Score =  315 bits (809), Expect = 1e-92

		 Identities = 115/538 (21%), Positives = 218/538 (40%), Gaps = 44/538 (8%)

		

		Query: 7   KFLIENKLVAVLLLALFVGWGVVNAPFNWETGFLPTDPVAVDAIPDIGENQQIVFTKWQG 66

		            F I   + A +L  + +  G            LP     V   P I      V   + G

		Sbjct: 3   NFFIRRPIFAWVLAIILMMAGA------LAILQLP-----VAQYPTIAPPAVSVSANYPG 51

		

		Query: 67  RSPQDIEDQITYPLTTSLLGIPGVKTIRSSSM-FGFSSIYIIFEEDIEFYWSRSRILEKL 125

		              Q ++D +T  +  ++ GI  +  + S+S   G  +I + F+   +   ++ ++  KL

		Sbjct: 52  ADAQTVQDTVTQVIEQNMNGIDNLMYMSSTSDSAGSVTITLTFQSGTDPDIAQVQVQNKL 111

		

		Query: 126 NSLPANLLPDGVNPSLGPDATGLGQIFWYTLEGRDKDGNVTGGWDLQELRSIQDYYVKYG 185

		                 LLP  V                      D       G    ++       VK  

		Sbjct: 112 QLAT-PLLPQEVQQQGISVEKSSSSYLMVAGFVSDN-----PGTTQDDISDYVASNVKDT 165

		

		Query: 186 LSSASGVSEVASIGGYVQEYQVDIDPEKMRQYNVSMGDVVKAVKQSNQDIGA------QT 239

		           LS  +GV +V   G      ++ +D + + +Y ++  DV+  +K  N  I A        

		Sbjct: 166 LSRLNGVGDVQLFGAQYA-MRIWLDADLLNKYKLTPVDVINQLKVQNDQIAAGQLGGTPA 224

		

		Query: 240 LEINQAEYLVRGLGYVKSIADIESAVVD-SENFTSIRIKDVANVHLGPAARRGILDKEGA 298

		           L   Q    +      K+  +     +  + + + +R+KDVA V LG      I    G 

		Sbjct: 225 LPGQQLNASIIAQTRFKNPEEFGKVTLRVNSDGSVVRLKDVARVELGGENYNVIARINGK 284

		

		Query: 299 EVVGGVVVARYGANPLEVINNVKAQIAEISSGLPTKTLSDGRTSQVTIVPFYDRTELIQE 358

		              G  +    GAN L+    +KA++AE+    P           + ++  YD T  +Q 

		Sbjct: 285 PAAGLGIKLATGANALDTAKAIKAKLAELQPFFP---------QGMKVLYPYDTTPFVQL 335

		

		Query: 359 TLGTLNEALTLEILITILVIIIMVFNLRASILISGLLPVAVLMVFITMKLFNVDANIVAL 418

		           ++  + + L   I++  LV+ + + N+RA+++ +  +PV +L  F  +  F    N + +

		Sbjct: 336 SIHEVVKTLFEAIMLVFLVMYLFLQNMRATLIPTIAVPVVLLGTFAILAAFGYSINTLTM 395

		

		Query: 419 SGIAIAIGTMVDVGVILAENMIRHLEDEKLRLNENGKEYTTNEIIYNATAEVSGAILTAV 478

		            G+ +AIG +VD  +++ EN+ R + ++KL            E    + +++ GA++   

		Sbjct: 396 FGMVLAIGLLVDDAIVVVENVERVMMEDKLP---------PKEATEKSMSQIQGALVGIA 446

		

		Query: 479 LTTIISFLPVFTMIGAEGKLFRPLAFTKTMALTASLIIALFLIPPIAAFLFRKTSVRE 536

		           +     F+P+    G+ G ++R  + T   A+  S+++AL L P + A L +  S   

		Sbjct: 447 MVLSAVFIPMAFFGGSTGAIYRQFSITIVSAMALSVLVALILTPALCATLLKPVSAEH 504

		

		

		

		 Score =  228 bits (583), Expect = 2e-63

		 Identities = 73/382 (19%), Positives = 149/382 (39%), Gaps = 44/382 (11%)

		

		Query: 866  GPDLKSIESFGLELEDILKQAEGVKEQA---------VFADRIVGKPYLLIDIKRDQLAR 916

		            G D + I+  GL  + + +    +   A         V  + +       +++ +++   

		Sbjct: 678  GFDFELIDQAGLGHDALTQARNQLLGMAAQHPASLVSVRPNGLEDTAQFKLEVDQEKAQA 737

		

		Query: 917  YGVSIMEVQEILQVAVGGMPLTQTVEGRERYAVRVRYPRELRADPDDLKNIYVPVEKGSP 976

		             GVS+ ++ + +  A+GG  +   ++      + V+   + R  P+D+  +YV    G  

		Sbjct: 738  LGVSLSDINQTISTALGGTYVNDFIDRGRVKKLYVQADAKFRMLPEDVDKLYVRSANGEM 797

		

		Query: 977  VPLGELVKIRYEQGPQVIKSEDTFLIGYVLFDKLDGFAEVDVVENAQALIQQNIDKGSLV 1036

		            VP        +  G   ++  +      +  +   G        +A AL++    K    

		Sbjct: 798  VPFSAFTTSHWVYGSPRLERYNGLPSMEIQGEAAPGT----SSGDAMALMENLASK---- 849

		

		Query: 1037 VPQGVSYRFTGTYENQLRAEKTLSVVVPLCLLVIFLILYFQFRSVSTSLMVFTAIAVAFA 1096

		            +P G+ Y +TG    +  +      +V +  +V+FL L   + S S  + V   + +   

		Sbjct: 850  LPAGIGYDWTGMSYQERLSGNQAPALVAISFVVVFLCLAALYESWSIPVSVMLVVPLGIV 909

		

		Query: 1097 GGFIMIWLYGQDWFFNFGFFGENLRDLFNMKTINLSVAVWVGFIALFGIATDDGVVMATY 1156

		            G  +   L+ Q                         V   VG +   G++  + +++  +

		Sbjct: 910  GVLLAATLFNQ----------------------KNDVYFMVGLLTTIGLSAKNAILIVEF 947

		

		Query: 1157 LDQSFKSNEPDNKKGIRLAALEAAGKRIRPCLMTTVTTVLALLPVLTSTGKGSDIMIPMA 1216

		                 +       KG+  A L A   R+RP LMT++  +L +LP+  S G GS     + 

		Sbjct: 948  AKDLMEK----EGKGVVEATLMAVRMRLRPILMTSLAFILGVLPLAISNGAGSGAQNAVG 1003

		

		Query: 1217 IPIFGGMIID-VTSYFLLPVLY 1237

		            I + GGM+   + + F +PV +

		Sbjct: 1004 IGVMGGMVSATLLAIFFVPVFF 1025

		

		

		

		 Score = 70.6 bits (173), Expect = 3e-14

		 Identities = 50/336 (14%), Positives = 115/336 (34%), Gaps = 37/336 (11%)

		

		Query: 204  EYQVDIDPEKMRQYNVSMGDVVKAVKQS-NQDIGAQTLEINQAEYLVRGL--GYVKSIAD 260

		            ++++++D EK +   VS+ D+ + +  +         ++  + + L       +     D

		Sbjct: 725  QFKLEVDQEKAQALGVSLSDINQTISTALGGTYVNDFIDRGRVKKLYVQADAKFRMLPED 784

		

		Query: 261  IESAVVDSENFTSIRIKDVANVHLGPAARRGILDKEGAEVVGGVVVARYGANPLE--VIN 318

		            ++   V S N   +        H    +    L++       G+                

		Sbjct: 785  VDKLYVRSANGEMVPFSAFTTSHWVYGS--PRLERYN-----GLPSMEIQGEAAPGTSSG 837

		

		Query: 319  NVKAQIAEISSGLPTKTLSDGRTSQVTIVPFYDRTELIQETLGTLNEALTLEILITILVI 378

		            +  A +  ++S LP                 YD T +  +   + N+A  L  +  ++V 

		Sbjct: 838  DAMALMENLASKLPAGI-------------GYDWTGMSYQERLSGNQAPALVAISFVVVF 884

		

		Query: 379  IIMVF---NLRASILISGLLPVAVLMVFITMKLFNVDANIVALSGIAIAIGTMVDVGVIL 435

		            + +     +    + +  ++P+ ++ V +   LFN   ++  + G+   IG      +++

		Sbjct: 885  LCLAALYESWSIPVSVMLVVPLGIVGVLLAATLFNQKNDVYFMVGLLTTIGLSAKNAILI 944

		

		Query: 436  AENMIRHLEDEKLRLNENGKEYTTNEIIYNATAEVSGAILTAVLTTIISFLPVFTMIGAE 495

		             E     +E E              E    A       IL   L  I+  LP+    GA 

		Sbjct: 945  VEFAKDLMEKEG---------KGVVEATLMAVRMRLRPILMTSLAFILGVLPLAISNGAG 995

		

		Query: 496  GKLFRPLAFTKTMALTASLIIALFLIPPIAAFLFRK 531

		                  +       + ++ ++A+F +P     + R 

		Sbjct: 996  SGAQNAVGIGVMGGMVSATLLAIFFVPVFFVVIRRC 1031

		

		

		

		 Score = 67.2 bits (164), Expect = 3e-13

		 Identities = 64/377 (16%), Positives = 143/377 (37%), Gaps = 59/377 (15%)

		

		Query: 879  LEDILKQAEGVKEQAVFADRIVGKPY-LLIDIKRDQLARYGVSIMEVQEIL-----QVAV 932

		            ++D L +  GV +  +F     G  Y + I +  D L +Y ++ ++V   L     Q+A 

		Sbjct: 162  VKDTLSRLNGVGDVQLF-----GAQYAMRIWLDADLLNKYKLTPVDVINQLKVQNDQIAA 216

		

		Query: 933  GGMPLTQTVEGRER-YAVRVRYPRELRADPDDLKNIYVPVEK-GSPVPLGELVKIRYEQG 990

		            G +  T  + G++   ++  +       +P++   + + V   GS V L ++ ++  E G

		Sbjct: 217  GQLGGTPALPGQQLNASIIAQ---TRFKNPEEFGKVTLRVNSDGSVVRLKDVARV--ELG 271

		

		Query: 991  PQVIKSEDTF----LIGYVLFDKLDGFAEVDVVENAQALIQQNIDKGSLVVPQGVSYRFT 1046

		             +              G  +     G   +D  +     I+  + +     PQG+     

		Sbjct: 272  GENYNVIARINGKPAAGLGIK-LATGANALDTAK----AIKAKLAELQPFFPQGMKV--L 324

		

		Query: 1047 GTYENQLRAEKTLSVVVPLCL---LVIFLILYFQFRSVSTSLMVFTAIAVAFAGGFIMIW 1103

		              Y+     + ++  VV       +++FL++Y   +++  +L+   A+ V   G F ++ 

		Sbjct: 325  YPYDTTPFVQLSIHEVVKTLFEAIMLVFLVMYLFLQNMRATLIPTIAVPVVLLGTFAILA 384

		

		Query: 1104 LYGQDWFFNFGFFGENLRDLFNMKTINLSVAVWVGFIALFGIATDDGVVMATYLDQSFKS 1163

		             +G         +  N   +F M      +A+        G+  DD +V+   +++    

		Sbjct: 385  AFG---------YSINTLTMFGM-----VLAI--------GLLVDDAIVVVENVERVMME 422

		

		Query: 1164 NEPDNKKGIRLAALEAAGKRIRPCLMTTVTTVLALLPVLTSTGKGSDIMIPMAIPIFGGM 1223

		            ++   K+    +  +  G      +   +      +P+    G    I    +I I   M

		Sbjct: 423  DKLPPKEATEKSMSQIQG----ALVGIAMVLSAVFIPMAFFGGSTGAIYRQFSITIVSAM 478

		

		Query: 1224 IID-VTSYFLLPVLYSW 1239

		             +  + +  L P L + 

		Sbjct: 479  ALSVLVALILTPALCAT 495

		

		

		

		 Score = 49.8 bits (119), Expect = 6e-08

		 Identities = 18/93 (19%), Positives = 38/93 (40%), Gaps = 2/93 (2%)

		

		Query: 637 YYERILRWALQNRYLFLIVPLTVLTLGIIIMRNTGKEFMPALNEGSFLLMPTSLPHAGVE 696

		           +Y   +   L +   +L++   ++   +++       F+P  ++G FL M      A  E

		Sbjct: 525 HYTNSVGKILGSTGRYLLIYALIVAGMVVLFLRLPSSFLPEEDQGVFLTMIQLPAGATQE 584

		

		Query: 697 ENKRVLQQL--DMAVASIPEIETVVGKAGRTES 727

		             ++VL Q+           +E+V    G + S

		Sbjct: 585 RTQKVLDQVTDYYLKNEKANVESVFTVNGFSFS 617

		

		

		>FbpA_PF05833#Fibronectin-binding protein

		          Length = 577

		

		 Score = 29.8 bits (67), Expect = 0.019

		 Identities = 21/77 (27%), Positives = 37/77 (48%), Gaps = 2/77 (2%)

		

		Query: 105 DAEYVDITIAKRKLALSVAQSYYRLFAIRAKQAVLDENIQLLETYERLA-LTSVEVGKAS 163

		           + + V IT+ + K      QSYY+ +  + K++    N QLL+  E L  L SV     +

		Sbjct: 365 NYDTVKITLDENKTPSQNVQSYYKKYN-KLKKSEEAANEQLLQNEEELNYLYSVLTNINN 423

		

		Query: 164 AVDVLRLQIRQNELQQQ 180

		           A +   ++  + EL + 

		Sbjct: 424 ADNYDEIEEIKKELIET 440

		

		

		>SECA#SecA protein signature.

		          Length = 901

		

		 Score = 36.0 bits (83), Expect = 6e-04

		 Identities = 11/48 (22%), Positives = 17/48 (35%), Gaps = 5/48 (10%)

		

		Query: 391 KMENEMNMEMKKDATPMNHKM-----STMQKDTASFNYDTRKTYFNYD 433

		           ++   M     K    + H       +  Q+   S N+D RK    YD

		Sbjct: 602 RVSGMMRKLGMKPGEAIEHPWVTKAIANAQRKVESRNFDIRKQLLEYD 649

		

		

		>RTXTOXIND#Gram-negative bacterial RTX secretion protein D

		           signature.

		          Length = 478

		

		 Score = 32.9 bits (75), Expect = 0.003

		 Identities = 19/99 (19%), Positives = 44/99 (44%), Gaps = 7/99 (7%)

		

		Query: 118 DGMISLSGKIAANDENNTVQSSYFKGRIEQLNVNYKGQQVKRGQLLATIYAP----DLVA 173

		           + + + +GK+  +  +  ++       ++++ V  +G+ V++G +L  + A     D + 

		Sbjct: 81  EIVATANGKLTHSGRSKEIKPIE-NSIVKEIIVK-EGESVRKGDVLLKLTALGAEADTLK 138

		

		Query: 174 AQQELITAASLKESQPALYKAV-RNKLKNWKLSDTQINA 211

		            Q  L+ A   +     L +++  NKL   KL D     

		Sbjct: 139 TQSSLLQARLEQTRYQILSRSIELNKLPELKLPDEPYFQ 177

		

		

		

		 Score = 31.0 bits (70), Expect = 0.015

		 Identities = 10/44 (22%), Positives = 25/44 (56%), Gaps = 1/44 (2%)

		

		Query: 228 VSGTVSEVMAAQGDYVNQGEPIVKLSNLNSVWSEFDAYENQLAQ 271

		            +  V E++  +G+ V +G+ ++KL+ L +  ++    ++ L Q

		Sbjct: 103 ENSIVKEIIVKEGESVRKGDVLLKLTALGAE-ADTLKTQSSLLQ 145

		

		

		>ACRIFLAVINRP#Acriflavin resistance protein family signature.

		          Length = 1034

		

		 Score =  693 bits (1789), Expect = 0.0

		 Identities = 202/1057 (19%), Positives = 420/1057 (39%), Gaps = 40/1057 (3%)

		

		Query: 5    IIDFSINNKFIIGLFTLTLIGVGIWSMATVNLGSVPDITNNQVQVITQSPNLGTEDIEQF 64

		            + +F I       +  + L+  G  ++  + +   P I    V V    P    + ++  

		Sbjct: 1    MANFFIRRPIFAWVLAIILMMAGALAILQLPVAQYPTIAPPAVSVSANYPGADAQTVQDT 60

		

		Query: 65   VTYPVELSMGNLPGVTEIRSIS-RFGLSVVTIVFEDDMGTYLPRQLVQEKLNELGESIPE 123

		            VT  +E +M  +  +  + S S   G   +T+ F+      + +  VQ KL      +P+

		Sbjct: 61   VTQVIEQNMNGIDNLMYMSSTSDSAGSVTITLTFQSGTDPDIAQVQVQNKLQLATPLLPQ 120

		

		Query: 124  KFGSPSMGPISTGLGQIYEYTIKPEEGFENKYSPMELRTVQDWVIKRQLTLLEGVVEVNS 183

		            +     +    +    +       +       +  ++       +K  L+ L GV +V  

		Sbjct: 121  EVQQQGISVEKSSSSYLMVAGFVSDNP---GTTQDDISDYVASNVKDTLSRLNGVGDVQL 177

		

		Query: 184  YGGSIKQYEVAVNPDKLNSLGISISQVYEALARNNVNTGG------AYIEKNKMSNFIRG 237

		            +G       + ++ D LN   ++   V   L   N             +   +++  I  

		Sbjct: 178  FGAQ-YAMRIWLDADLLNKYKLTPVDVINQLKVQNDQIAAGQLGGTPALPGQQLNASIIA 236

		

		Query: 238  EGLIRSLEDIKDISI-INEGNIPVTIGDVATRVHFGNQVRYGAFTQDGKEAVGGIIMMLK 296

		            +   ++ E+   +++ +N     V + DVA RV  G +        +GK A G  I +  

		Sbjct: 237  QTRFKNPEEFGKVTLRVNSDGSVVRLKDVA-RVELGGENYNVIARINGKPAAGLGIKLAT 295

		

		Query: 297  GSNPNAVIQNVKNRMAEIEKSLPEGLTIAPIIDRSELIARTTDTVKTNLLEGALIVIFAL 356

		            G+N     + +K ++AE++   P+G+ +    D +  +  +   V   L E  ++V   +

		Sbjct: 296  GANALDTAKAIKAKLAELQPFFPQGMKVLYPYDTTPFVQLSIHEVVKTLFEAIMLVFLVM 355

		

		Query: 357  VLLLGSLRGGIITATTIPLSLLFAFILMKQFNVWANLMSLG--AIDFGIIIDGAVIIIEG 414

		             L L ++R  +I    +P+ LL  F ++  F    N +++    +  G+++D A++++E 

		Sbjct: 356  YLFLQNMRATLIPTIAVPVVLLGTFAILAAFGYSINTLTMFGMVLAIGLLVDDAIVVVE- 414

		

		Query: 415  TVYEIQKRIRSGKLKFNQGVMDKVAYDAGTTMMGSAFFGQIIILIVFTPILFLTGVEGKM 474

		                +++ +   KL   +         + + + G+     +++  VF P+ F  G  G +

		Sbjct: 415  ---NVERVMMEDKLPPKEAT-----EKSMSQIQGALVGIAMVLSAVFIPMAFFGGSTGAI 466

		

		Query: 475  FKPMAYTFGFAMIGAIILCLTYVPMMSALFMKPVQNTKSWF-GKFERWLEKISDKIIGAI 533

		            ++  + T   AM  ++++ L   P + A  +KPV        G F  W     D  +   

		Sbjct: 467  YRQFSITIVSAMALSVLVALILTPALCATLLKPVSAEHHENKGGFFGWFNTTFDHSV--- 523

		

		Query: 534  HSAYKPLLKGALRLKLIVLSSSAVLLIIAGFIFSNMGGEFVPQLDEGDIAMQAFIRPGSS 593

		             + Y   +   L      L   A+++     +F  +   F+P+ D+G       +  G++

		Sbjct: 524  -NHYTNSVGKILGSTGRYLLIYALIVAGMVVLFLRLPSSFLPEEDQGVFLTMIQLPAGAT 582

		

		Query: 594  LTESIEVSKKIETILLENFPEIKTVTARIGVADIPTDPMPMDIADMYIILNKDMDEWTTA 653

		               + +V  ++    L+N  E   V +   V          +    ++ L K  +E    

		Sbjct: 583  QERTQKVLDQVTDYYLKN--EKANVESVFTVNGFSFSGQAQNAGMAFVSL-KPWEERNG- 638

		

		Query: 654  STKEGLIEAIRDKLDDELVGVNLSFTQPVEL-RFNELLEGVREDIA-VKLYGEDLEVLSD 711

		               E   EA+  +   EL  +   F  P  +    EL      D   +   G   + L+ 

		Sbjct: 639  --DENSAEAVIHRAKMELGKIRDGFVIPFNMPAIVELGTATGFDFELIDQAGLGHDALTQ 696

		

		Query: 712  KVQEMAAIIKTVPGA-GDVSAERTAGLPQMTVKFRRDKMAQYGLDIQKVNDYISTAFAGG 770

		               ++  +    P +   V         Q  ++  ++K    G+ +  +N  ISTA  G 

		Sbjct: 697  ARNQLLGMAAQHPASLVSVRPNGLEDTAQFKLEVDQEKAQALGVSLSDINQTISTALGGT 756

		

		Query: 771  TAGVIFEGEKRFDLVVRFDESHRKSIDDLRTMYIDLKDGSQVPIIEIAEIEYVPGPMQIS 830

		                  +  +   L V+ D   R   +D+  +Y+   +G  VP        +V G  ++ 

		Sbjct: 757  YVNDFIDRGRVKKLYVQADAKFRMLPEDVDKLYVRSANGEMVPFSAFTTSHWVYGSPRLE 816

		

		Query: 831  RDNTYRRTYVGVNARGRDVESVVKDIQQKLDEELDLPSGYYITYGGEFENLQSAKDRLTI 890

		            R N      +   A           + + L  +L  P+G    + G     + + ++   

		Sbjct: 817  RYNGLPSMEIQGEAAPGTSSGDAMALMENLASKL--PAGIGYDWTGMSYQERLSGNQAPA 874

		

		Query: 891  VVPIALFLIFVLLYFALKSFSQSLMIYIAIPLAAIGGVFALWLRDMPFSISAGVGFIVLF 950

		            +V I+  ++F+ L    +S+S  + + + +PL  +G + A  L +    +   VG +   

		Sbjct: 875  LVAISFVVVFLCLAALYESWSIPVSVMLVVPLGIVGVLLAATLFNQKNDVYFMVGLLTTI 934

		

		Query: 951  GVAVLNGLVLINRFNSLKEEGVTSIKDRIFQGTKERIRPIMLTATTDIFGFLPMAFSTSA 1010

		            G++  N ++++     L E+    + +      + R+RPI++T+   I G LP+A S  A

		Sbjct: 935  GLSAKNAILIVEFAKDLMEKEGKGVVEATLMAVRMRLRPILMTSLAFILGVLPLAISNGA 994

		

		Query: 1011 GAEVQQPLATVVIGGMLTATLLTLIVLPVLYIFIEKR 1047

		            G+  Q  +   V+GGM++ATLL +  +PV ++ I + 

		Sbjct: 995  GSGAQNAVGIGVMGGMVSATLLAIFFVPVFFVVIRRC 1031

		

		

		

		 Score = 93.0 bits (231), Expect = 5e-21

		 Identities = 67/354 (18%), Positives = 142/354 (40%), Gaps = 19/354 (5%)

		

		Query: 720  IKTVPGAGDVS---AERTAGLPQMTVKFRRDKMAQYGLDIQKVNDYISTA----FAGGTA 772

		            +  + G GDV    A+       M +    D + +Y L    V + +        AG   

		Sbjct: 166  LSRLNGVGDVQLFGAQY-----AMRIWLDADLLNKYKLTPVDVINQLKVQNDQIAAGQLG 220

		

		Query: 773  GVIFEGEKRFDLVVRFDESHRKSIDDLRTMYIDL-KDGSQVPIIEIAEIEY-VPGPMQIS 830

		            G      ++ +  +   ++  K+ ++   + + +  DGS V + ++A +E        I+

		Sbjct: 221  GTPALPGQQLNASII-AQTRFKNPEEFGKVTLRVNSDGSVVRLKDVARVELGGENYNVIA 279

		

		Query: 831  RDNTYRRTYVGVNAR-GRDVESVVKDIQQKLDE-ELDLPSGYYITYGGEF-ENLQSAKDR 887

		            R N      +G+    G +     K I+ KL E +   P G  + Y  +    +Q +   

		Sbjct: 280  RINGKPAAGLGIKLATGANALDTAKAIKAKLAELQPFFPQGMKVLYPYDTTPFVQLSIHE 339

		

		Query: 888  LTIVVPIALFLIFVLLYFALKSFSQSLMIYIAIPLAAIGGVFALWLRDMPFSISAGVGFI 947

		            +   +  A+ L+F+++Y  L++   +L+  IA+P+  +G    L       +     G +

		Sbjct: 340  VVKTLFEAIMLVFLVMYLFLQNMRATLIPTIAVPVVLLGTFAILAAFGYSINTLTMFGMV 399

		

		Query: 948  VLFGVAVLNGLVLINRFNSLKEEGVTSIKDRIFQGTKERIRPIMLTATTDIFGFLPMAFS 1007

		            +  G+ V + +V++     +  E     K+   +   +    ++  A      F+PMAF 

		Sbjct: 400  LAIGLLVDDAIVVVENVERVMMEDKLPPKEATEKSMSQIQGALVGIAMVLSAVFIPMAFF 459

		

		Query: 1008 TSAGAEVQQPLATVVIGGMLTATLLTLIVLPVL-YIFIEKRRERKDQNKIGSFN 1060

		              +   + +  +  ++  M  + L+ LI+ P L    ++       +NK G F 

		Sbjct: 460  GGSTGAIYRQFSITIVSAMALSVLVALILTPALCATLLKPVSAEHHENKGGFFG 513

		

		

		>RTXTOXIND#Gram-negative bacterial RTX secretion protein D

		           signature.

		          Length = 478

		

		 Score = 59.8 bits (145), Expect = 7e-12

		 Identities = 59/333 (17%), Positives = 110/333 (33%), Gaps = 46/333 (13%)

		

		Query: 10  TTMLMALTLFSCGESKTEDGHDEATHSETEENHSEGEDEEDNMEGEAKEVMLTAQQFEAL 69

		              L          S   +   E    +     +  E+E        +   L  +QF   

		Sbjct: 145 QARLEQTRYQILSRSIELNKLPELKLPDEPYFQNVSEEEV------LRLTSLIKEQFSTW 198

		

		Query: 70  QMEIDTLSQRYMSGYVETNGTLEVPPQNEASITAITGANVASIEVIEGDEVKKNQAVAYL 129

		           Q +             E    L       A I        + +E    D+         +

		Sbjct: 199 QNQKYQKELNLDKKRAERLTVL-------ARINRYENL--SRVEKSRLDDFSSLLHKQAI 249

		

		Query: 130 SHPSIIQIQSDYLNAHSNSRFLKQEYERQKRLYEAGVA-SGMNFQKATADYQSSTAMVNG 188

		           +  ++++ ++ Y+ A +  R     Y+ Q    E+ +  +   +Q  T  +++       

		Sbjct: 250 AKHAVLEQENKYVEAVNELR----VYKSQLEQIESEILSAKEEYQLVTQLFKNEIL---- 301

		

		Query: 189 LEAQLRQYNINVNGVR-----NGTIYQRVALRSPIAGVVEKVFIKT-GQYVEPQTNLMEI 242

		              +LRQ   N+  +      N    Q   +R+P++  V+++ + T G  V     LM I

		Sbjct: 302 --DKLRQTTDNIGLLTLELAKNEERQQASVIRAPVSVKVQQLKVHTEGGVVTTAETLMVI 359

		

		Query: 243 VDTDHV-HADLMVFEKDVDRVKKGQQVRFSVQSRPGTE---LVAEIYSVGKTFEQDPKAV 298

		           V  D       +V  KD+  +  GQ     V++ P T    LV ++ ++     +D +  

		Sbjct: 360 VPEDDTLEVTALVQNKDIGFINVGQNAIIKVEAFPYTRYGYLVGKVKNINLDAIEDQRLG 419

		

		Query: 299 HV----------HAEIENKGGGLISGMYIKGRI 321

		            V               NK   L SGM +   I

		Sbjct: 420 LVFNVIISIEENCLSTGNKNIPLSSGMAVTAEI 452

		

		

		

		 Score = 30.6 bits (69), Expect = 0.013

		 Identities = 20/94 (21%), Positives = 34/94 (36%), Gaps = 4/94 (4%)

		

		Query: 85  VETNGTLEVPPQNEASITAITGANVASIEVIEGDEVKKNQAVAYLSHPSIIQIQSDYLNA 144

		              NG L         I  I  + V  I V EG+ V+K   +  L+       ++D L  

		Sbjct: 84  ATANGKL-THSGRSKEIKPIENSIVKEIIVKEGESVRKGDVLLKLTAL---GAEADTLKT 139

		

		Query: 145 HSNSRFLKQEYERQKRLYEAGVASGMNFQKATAD 178

		            S+    + E  R + L  +   + +   K   +

		Sbjct: 140 QSSLLQARLEQTRYQILSRSIELNKLPELKLPDE 173

		

		

		>BINARYTOXINB#Binary toxin B family signature.

		          Length = 764

		

		 Score = 34.3 bits (78), Expect = 0.003

		 Identities = 38/171 (22%), Positives = 66/171 (38%), Gaps = 37/171 (21%)

		

		Query: 221 GSGTYTSFDVDALQNQEDPGDNNTF-SIRYSGFIQIDTPGTYTFFTTSDDGSKLFINGTE 279

		           G  +  S +++ +     P +N  F S  +SGFI++     YTF T++D+   ++++  E

		Sbjct: 70  GDLSIPSSELENI-----PSENQYFQSAIWSGFIKVKKSDEYTFATSADNHVTMWVDDQE 124

		

		Query: 280 VVDNDGLHGSQERSGTISLTAG-LHDITV---------------LFFENSGGETLTVQYQ 323

		           V++          S  I L  G L+ I +               L++ +S  +   +   

		Sbjct: 125 VIN------KASNSNKIRLEKGRLYQIKIQYQRENPTEKGLDFKLYWTDSQNKKEVI--- 175

		

		Query: 324 GPSISKQNIPFSKLYSTCSVGSADLDGDGVDDVADVDDDNDGILDIDECGG 374

		             S + Q     +  S      +   G         D DNDGI D  E  G

		Sbjct: 176 -SSDNLQLPELKQKSSNSRKKRSTSAGP-----TVPDRDNDGIPDSLEVEG 220

		

		

		>TCRTETOQM#Tetracycline resistance protein TetO/TetQ/TetM family

		           signature.

		          Length = 639

		

		 Score = 64.9 bits (158), Expect = 9e-13

		 Identities = 40/134 (29%), Positives = 61/134 (45%), Gaps = 19/134 (14%)

		

		Query: 405 VMGHVDHGKTSLLDYI------------------RQENVIAGESGGITQHIGAYGVSLED 446

		           V+ HVD GKT+L + +                  R +N +     GIT   G      E+

		Sbjct: 8   VLAHVDAGKTTLTESLLYNSGAITELGSVDKGTTRTDNTLLERQRGITIQTGITSFQWEN 67

		

		Query: 447 GQKITFLDTPGHEAFTAMRARGAQVTDIAIIVIAADDDIMPQTKEAISHAQAAGVPIVFA 506

		             K+  +DTPGH  F A   R   V D AI++I+A D +  QT+      +  G+P +F 

		Sbjct: 68  -TKVNIIDTPGHMDFLAEVYRSLSVLDGAILLISAKDGVQAQTRILFHALRKMGIPTIFF 126

		

		Query: 507 INKVDKPTANPDKI 520

		           INK+D+   +   +

		Sbjct: 127 INKIDQNGIDLSTV 140

		

		

		>ACRIFLAVINRP#Acriflavin resistance protein family signature.

		          Length = 1034

		

		 Score = 33.3 bits (76), Expect = 0.002

		 Identities = 18/90 (20%), Positives = 38/90 (42%), Gaps = 12/90 (13%)

		

		Query: 167 ASGIS-NEMILGALALVFGLLVVMLILVNKTLRRIAEANGV-----VLEKEKEKRLPLWK 220

		           A G S N + +  + L  GLLV   I+V + + R+   + +       +   + +  L  

		Sbjct: 385 AFGYSINTLTMFGMVLAIGLLVDDAIVVVENVERVMMEDKLPPKEATEKSMSQIQGALVG 444

		

		Query: 221 AFVQNQFLVLVSVVFLLLASAYFAYGWMMQ 250

		                   +++S VF+ +A    + G + +

		Sbjct: 445 I------AMVLSAVFIPMAFFGGSTGAIYR 468

		

		

		>PF06580#Sensor histidine kinase

		          Length = 349

		

		 Score =  166 bits (422), Expect = 8e-48

		 Identities = 57/231 (24%), Positives = 116/231 (50%), Gaps = 22/231 (9%)

		

		Query: 504 WIIYSLIFGIAFMAL-TAFLYYRSNRQQKLANNLLA-------LKSLRTQMNPHFIFNAL 555

		            I   ++    +  L   + ++++ +Q ++    +A       L +L+ Q+NPHF+FNAL

		Sbjct: 120 IIFNVVVVTFMWSLLYFGWHFFKNYKQAEIDQWKMASMAQEAQLMALKAQINPHFMFNAL 179

		

		Query: 556 NSVNTYIAKSDERSANRFLSEFSVLMRSVLENSEEDFIPLSKELELLRLYVKLEHSRFAD 615

		           N++   I +   + A   L+  S LMR  L  S    + L+ EL ++  Y++L   +F D

		Sbjct: 180 NNIRALILEDPTK-AREMLTSLSELMRYSLRYSNARQVSLADELTVVDSYLQLASIQFED 238

		

		Query: 616 KFDYDIEVDKEVDVDAFQIPPMLLQPYIENAIWHGLRYKEEKGSLTIKVKQVTSDMLEIC 675

		           +  ++ +++    +   Q+PPML+Q  +EN I HG+    + G + +K  +  +  + + 

		Sbjct: 239 RLQFENQINPA--IMDVQVPPMLVQTLVENGIKHGIAQLPQGGKILLKGTK-DNGTVTLE 295

		

		Query: 676 IEDDGIGRKKSAELKTSNQKKQNSKGMGNIKKRIQILNDMYKNRVEVSISD 726

		           +E+ G        L   N K+    G+ N+++R+Q+L   Y    ++ +S+

		Sbjct: 296 VENTG-------SLALKNTKESTGTGLQNVRERLQML---YGTEAQIKLSE 336

		

		

		>HTHFIS#FIS bacterial regulatory protein HTH signature.

		          Length = 484

		

		 Score = 61.0 bits (148), Expect = 7e-13

		 Identities = 36/142 (25%), Positives = 61/142 (42%), Gaps = 9/142 (6%)

		

		Query: 1   MMELKAVIVEDEANSREILRSYLAKYCENVTLLGEGATIEEGLAQIKKHRPDLVFLDVEM 60

		           M     ++ +D+A  R +L   L++   +V +             I     DLV  DV M

		Sbjct: 1   MTGATILVADDDAAIRTVLNQALSRAGYDVRITS---NAATLWRWIAAGDGDLVVTDVVM 57

		

		Query: 61  PFGNAFDLLDQLPERSFET--VFVTAYNQY--AMDALNHHAAYYLMKPINIDELIKAVDY 116

		           P  NAFDLL ++ +   +   + ++A N +  A+ A    A  YL KP ++ ELI  +  

		Sbjct: 58  PDENAFDLLPRIKKARPDLPVLVMSAQNTFMTAIKASEKGAYDYLPKPFDLTELIGIIG- 116

		

		Query: 117 VRAIKEKENALEGQVLQARSVR 138

		            RA+ E +         ++   

		Sbjct: 117 -RALAEPKRRPSKLEDDSQDGM 137

		

		

		>SHAPEPROTEIN#Bacterial cell shape determinant MreB/Mbl protein

		           signature.

		          Length = 347

		

		 Score = 72.9 bits (179), Expect = 3e-16

		 Identities = 53/190 (27%), Positives = 91/190 (47%), Gaps = 12/190 (6%)

		

		Query: 175 KSAGLDLGNITLEPLASADAVLSQEEKEAGVALIDIGGGTTDLAIFKDGIIRHTSVIPFG 234

		           + AG     +  EP+A+A        +  G  ++DIGGGTT++A+     + ++S +  G

		Sbjct: 131 QGAGAREVFLIEEPMAAAIGAGLPVSEATGSMVVDIGGGTTEVAVISLNGVVYSSSVRIG 190

		

		Query: 235 GNVITEDI------KEGCSIIEKQAELLKIKFGSAWPGENKDNEIVSIPG--LRGREPKE 286

		           G+   E I        G  I E  AE +K + GSA+PG+  +   + + G  L    P+ 

		Sbjct: 191 GDRFDEAIINYVRRNYGSLIGEATAERIKHEIGSAYPGD--EVREIEVRGRNLAEGVPRG 248

		

		Query: 287 ITLKN--LSKIIHARVVEIVEQVYVEIKNYGHEEQKKKLIAGIVLTGGGSQLKHLKQLVE 344

		            TL +  + + +   +  IV  V V ++    E        G+VLTGGG+ L++L +L+ 

		Sbjct: 249 FTLNSNEILEALQEPLTGIVSAVMVALEQCPPELASDISERGMVLTGGGALLRNLDRLLM 308

		

		Query: 345 YITGMDTRIG 354

		             TG+   + 

		Sbjct: 309 EETGIPVVVA 318

		

		

		>TONBPROTEIN#Gram-negative bacterial tonB protein signature.

		          Length = 239

		

		 Score = 34.6 bits (79), Expect = 9e-04

		 Identities = 15/62 (24%), Positives = 23/62 (37%), Gaps = 5/62 (8%)

		

		Query: 345 LEDEQIAEQDLTPESTSVQEVQTEKVPAPQPEPTPQPEPKVVKHTLDMEMEEEKVAPKIP 404

		           +    +   DL P        +    P P+PEP P+P  +         +E+ K  PK  

		Sbjct: 45  ISVTMVTPADLEPPQAVQPPPEPVVEPEPEPEPIPEPPKEAPVV-----IEKPKPKPKPK 99

		

		Query: 405 SK 406

		            K

		Sbjct: 100 PK 101

		

		

		>RTXTOXIND#Gram-negative bacterial RTX secretion protein D

		           signature.

		          Length = 478

		

		 Score =  104 bits (261), Expect = 2e-26

		 Identities = 73/435 (16%), Positives = 166/435 (38%), Gaps = 35/435 (8%)

		

		Query: 18  QEILGNPPAWIIRWGLSLVFMFTMIIFALTFIIEYPDYVSAKVIVTTEKPTERIVARYSG 77

		            E++  P +   R     +  F +I F L+ + +     +A   +T    ++ I    + 

		Sbjct: 46  LELIETPVSRRPRLVAYFIMGFLVIAFILSVLGQVEIVATANGKLTHSGRSKEIKPIENS 105

		

		Query: 78  NMERIYIENGDTVSSGQ---RLAVFRNTANV-----------NDVFKLKFILDTVEQSSQ 123

		            ++ I ++ G++V  G    +L      A+             +  + + +  ++E +  

		Sbjct: 106 IVKEIIVKEGESVRKGDVLLKLTALGAEADTLKTQSSLLQARLEQTRYQILSRSIELNKL 165

		

		Query: 124 N-LDFPLEAISHYVL-GDIETAYINFEKSYIDYRLLRDLDPYTSKLYTNIQSVEEIKLQL 181

		             L  P E     V   ++       ++ +  ++           L         +  ++

		Sbjct: 166 PELKLPDEPYFQNVSEEEVLRLTSLIKEQFSTWQ--NQKYQKELNLDKKRAERLTVLARI 223

		

		Query: 182 KNHLEQRTVFEQLYELEKKDYERYEKLSEKGVISEQELESKKQELLQMERNLNDMTISIS 241

		             +       E L  +EK   + +  L  K  I++  +  ++ + ++    L      + 

		Sbjct: 224 NRY-------ENLSRVEKSRLDDFSSLLHKQAIAKHAVLEQENKYVEAVNELRVYKSQLE 276

		

		Query: 242 KMRASISTAGQIVKATEVNRQED----NTRVLTNLSQSFNALKKAIREWEHNYVLYSSID 297

		           ++ + I +A +  +      + +      +   N+      L K   E +   V+ + + 

		Sbjct: 277 QIESEILSAKEEYQLVTQLFKNEILDKLRQTTDNIGLLTLELAKN-EERQQASVIRAPVS 335

		

		Query: 298 GVVGFQEFWGENQYIVSGEVVFTILPIGSGKLVGKLVLPSQNAGKVVSGQKVLVKLDNFP 357

		             V   +   E   + + E +  I+P      V  LV      G +  GQ  ++K++ FP

		Sbjct: 336 VKVQQLKVHTEGGVVTTAETLMVIVPEDDTLEVTALVQNKD-IGFINVGQNAIIKVEAFP 394

		

		Query: 358 YQQYGMLLGRVENIS---VSPTKEGNYF-VYISLPQGTVTSYNKKLPFEQELLGNAEIIT 413

		           Y +YG L+G+V+NI+   +   + G  F V IS+ +  +++ NK +P    +   AEI T

		Sbjct: 395 YTRYGYLVGKVKNINLDAIEDQRLGLVFNVIISIEENCLSTGNKNIPLSSGMAVTAEIKT 454

		

		Query: 414 EKLSLADRIFYRLKD 428

		              S+   +   L++

		Sbjct: 455 GMRSVISYLLSPLEE 469

		

		

		>HTHTETR#TetR bacterial regulatory protein HTH signature.

		          Length = 215

		

		 Score = 32.7 bits (74), Expect = 0.001

		 Identities = 9/26 (34%), Positives = 16/26 (61%)

		

		Query: 222 ESISLDDIANVANMSKNAFCRYFKNR 247

		            S SL +IA  A +++ A   +FK++

		Sbjct: 30  SSTSLGEIAKAAGVTRGAIYWHFKDK 55

		

		

		>PF04183#IucA / IucC family

		          Length = 580

		

		 Score = 29.8 bits (67), Expect = 0.029

		 Identities = 18/92 (19%), Positives = 29/92 (31%), Gaps = 9/92 (9%)

		

		Query: 56  VYRKVSGA--KRSAFLNAIADEILALDQSLIDMYMSESGLPEGRAIGERGRTIFQLRSFA 113

		            YR + G         +    ++ A D +L+       G P    +   G         A

		Sbjct: 283 CYRGIPGRYIAAGPLASRWLQQVFATDATLVQSGAVILGEPAAGYVSHEGYAALAR---A 339

		

		Query: 114 DLIQNED----WRDNVFDQAQPNREPLPKADL 141

		                E     WR+N     +P+  P+  A L

		Sbjct: 340 PYRYQEMLGVIWRENPCRWLKPDESPVLMATL 371

		

		

		>NUCEPIMERASE#Nucleotide sugar epimerase signature.

		          Length = 334

		

		 Score =  174 bits (442), Expect = 6e-54

		 Identities = 86/349 (24%), Positives = 148/349 (42%), Gaps = 35/349 (10%)

		

		Query: 1   MKILVTGGLGFIGSHTVVELQNEGYEVVVVDNLSNASLDVL---DGIEAITGKRPIFEEF 57

		           MK LVTG  GFIG H    L   G++VV +DNL N   DV      +E +      F + 

		Sbjct: 1   MKYLVTGAAGFIGFHVSKRLLEAGHQVVGIDNL-NDYYDVSLKQARLELLAQPGFQFHKI 59

		

		Query: 58  DMREKARVQSFFQKYSDIEGVIHFAASKAVGESVNEPLLYYENNLVGLINILKELKKMEK 117

		           D+ ++  +   F      E V       AV  S+  P  Y ++NL G +NIL+  +  + 

		Sbjct: 60  DLADREGMTDLFASG-HFERVFISPHRLAVRYSLENPHAYADSNLTGFLNILEGCRHNKI 118

		

		Query: 118 GSFIFSSSCTVYGQADEMPISEAAPVKPSESPYGNTKQVGEEIIRDTCKVNPMIKAIALR 177

		              +++SS +VYG   +MP S    V    S Y  TK+  E +      +   + A  LR

		Sbjct: 119 QHLLYASSSSVYGLNRKMPFSTDDSVDHPVSLYAATKKANELMAHTYSHLYG-LPATGLR 177

		

		Query: 178 YFNPIGAHPSGNIGELPIGVPQNLVPFITQTGLGQRDYLSVFGNDYPTKDGTCIRDYIYV 237

		           +F   G          P G P ++  F     + +   + V+        G   RD+ Y+

		Sbjct: 178 FFTVYG----------PWGRP-DMALFKFTKAMLEGKSIDVYN------YGKMKRDFTYI 220

		

		Query: 238 IDLAQAHVAALVRLLKGKNDGN------------YEVFNLGTGKGSSVLEVIQSFERVSG 285

		            D+A+A +     +                    Y V+N+G      +++ IQ+ E   G

		Sbjct: 221 DDIAEAIIRLQDVIPHADTQWTVETGTPAASIAPYRVYNIGNSSPVELMDYIQALEDALG 280

		

		Query: 286 KKLNYKIVGRRSGDVVQAYADTTKANEILGWKAKHSLDEAIRSAWLWEK 334

		            +    ++  + GDV++  ADT    E++G+  + ++ + +++   W +

		Sbjct: 281 IEAKKNMLPLQPGDVLETSADTKALYEVIGFTPETTVKDGVKNFVNWYR 329

		

		

		>BINARYTOXINA#Clostridial binary toxin A signature.

		          Length = 454

		

		 Score = 32.7 bits (74), Expect = 0.009

		 Identities = 42/189 (22%), Positives = 67/189 (35%), Gaps = 27/189 (14%)

		

		Query: 535 IGILFLVYNLIKS--PSKRLATGIGIIVCMTIAAFSNSQYLENYIPKKKKEQQI----AE 588

		           I +  ++Y ++ S  PS   A  + I     I   +  +  E+++  K+   Q     AE

		Sbjct: 8   ISVFLILYLILTSSFPSYTYAQDLQI-ASNYITDRAFIERPEDFLKDKENAIQWEKKEAE 66

		

		Query: 589 RVSYEKKYRKYQRIHQPTIKKVDTKIDLYPNER----SYTIQG-----------EYLLKN 633

		           RV  EK     ++      KK   +I  Y   R     Y I+              + KN

		Sbjct: 67  RV--EKNLDTLEKEALELYKKDSEQISNYSQTRQYFYDYQIESNPREKEYKNLRNAISKN 124

		

		Query: 634 TYEKPIDSVLIHVPEDFEIKSLVYQYKNETIRMDEPISELYLNQAITPNDSAKLSFKISY 693

		             +KPI+      PE F     +       I   E  +E  L + I      +  FK   

		Sbjct: 125 KIDKPINVYYFESPEKFAFNKEIRTENQNEIS-LEKFNE--LKETIQDKLFKQDGFKDVS 181

		

		Query: 694 QWYPINGHD 702

		            + P NG +

		Sbjct: 182 LYEPGNGDE 190

		

		

		>PF05272#Virulence-associated E family protein

		          Length = 892

		

		 Score = 32.7 bits (74), Expect = 0.002

		 Identities = 19/62 (30%), Positives = 28/62 (45%), Gaps = 10/62 (16%)

		

		Query: 9   VSLVYSSGYKALTALNLEIQNGIFGLLGPNGAGKSSLMKTIVGLQKPSEGNISF-NGADV 67

		           V+ V   G K   ++ LE         G  G GKS+L+ T+VGL   S+ +     G D 

		Sbjct: 585 VARVMEPGCKFDYSVVLE---------GTGGIGKSTLINTLVGLDFFSDTHFDIGTGKDS 635

		

		Query: 68  VQ 69

		            +

		Sbjct: 636 YE 637

		

		

		>DHBDHDRGNASE#2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase

		           signature.

		          Length = 261

		

		 Score = 71.2 bits (174), Expect = 5e-17

		 Identities = 47/191 (24%), Positives = 78/191 (40%), Gaps = 16/191 (8%)

		

		Query: 2   KYGIVTGSSRGIGLATVSLLAED-------DCLQLFGSSTSGSHSLNLPNFQCLKLDLSE 54

		           K   +TG+++GIG A    LA         D           S      + +    D+ +

		Sbjct: 9   KIAFITGAAQGIGEAVARTLASQGAHIAAVDYNPEKLEKVVSSLKAEARHAEAFPADVRD 68

		

		Query: 55  SQSIAEFVEQIGK--FKIDFLINNAAILIDDRTDCEINLERLKKTFDVNVFGTIELTEKL 112

		           S +I E   +I +    ID L+N A +L        ++ E  + TF VN  G    +  +

		Sbjct: 69  SAAIDEITARIEREMGPIDILVNVAGVLRPGLIH-SLSDEEWEATFSVNSTGVFNASRSV 127

		

		Query: 113 LPNL--NENAHIINITSDWGSFSEQNFDAFQPHYKMSKAALNMYSKLLSRRLETQHIKVS 170

		              +    +  I+ + S+       +  A    Y  SKAA  M++K L   L   +I+ +

		Sbjct: 128 SKYMMDRRSGSIVTVGSNPAGVPRTSMAA----YASSKAAAVMFTKCLGLELAEYNIRCN 183

		

		Query: 171 SLDPGWTKTDM 181

		            + PG T+TDM

		Sbjct: 184 IVSPGSTETDM 194

		

		

		>PF06580#Sensor histidine kinase

		          Length = 349

		

		 Score = 56.4 bits (136), Expect = 5e-11

		 Identities = 25/131 (19%), Positives = 49/131 (37%), Gaps = 25/131 (19%)

		

		Query: 268 IRLDIDINQKEDHQKFPRRKLLPIVGNLIANAIKFTPSQGTIGVDLDISGKDGKRALLIK 327

		           ++ +  IN      + P   +  +V N I + I   P  G I     + G      + ++

		Sbjct: 240 LQFENQINPAIMDVQVPPMLVQTLVENGIKHGIAQLPQGGKI----LLKGTKDNGTVTLE 295

		

		Query: 328 VSDNGKGIPKERLENIKKLAWFEDHGTDYEKGYGLGLQLVTEMVEDIHG---TLHIDSEE 384

		           V + G    K                   ++  G GLQ V E ++ ++G    + +  ++

		Sbjct: 296 VENTGSLALKNT-----------------KESTGTGLQNVRERLQMLYGTEAQIKLSEKQ 338

		

		Query: 385 GKGTSVRIVIP 395

		           GK     ++IP

		Sbjct: 339 GKVN-AMVLIP 348

		

		

		>FLAGELLIN#Flagellin signature.

		          Length = 507

		

		 Score = 40.8 bits (95), Expect = 4e-05

		 Identities = 38/300 (12%), Positives = 84/300 (28%), Gaps = 8/300 (2%)

		

		Query: 957  TYEHNGDESATDSFTYNFEDAVSFSQTVTATLNITNVNDVPSGADSTVEVIQDAAYTFTA 1016

		              + NG +  +       +   +  +T+T  L   +V  +     +     +       +

		Sbjct: 128  QTQFNGVKVLSQDNQMKIQVGANDGETITIDLQKIDVKSLGLDGFNVNGPKEATVGDLKS 187

		

		Query: 1017 ADFTFTDVDPSDSFNGIQVISLPAKGTLEYNGSAVQINDMIDDISLLTYTTANGEYGDGY 1076

		            +    T  D          + + +   +    +    + +  + +    TT + E     

		Sbjct: 188  SFKNVTGYDTYAVGANKYRVDVNSGAVVTDTTAPTVPDKVYVNAANGQLTTDDAENNTAV 247

		

		Query: 1077 SSFAFKVKDNDDAVSASSYTASINASQDTDGDGIPDDLDDDDDNDGTPDSEDAFPKDASE 1136

		                    D      +++ TA   A       G   D  D      T D++     +   

		Sbjct: 248  --------DLFKTTKSTAGTAEAKAIAGAIKGGKEGDTFDYKGVTFTIDTKTGNDGNGKV 299

		

		Query: 1137 DTDTDGDGTGDNADDDDDNDGTPDSEDAFPKDSSEDTDTDGDGTGDNADDDDDNDGTPDS 1196

		             T  +G+       D        D+       +   +  +G  T D+   ++    +   

		Sbjct: 300  STTINGEKVTLTVADITAGAANVDAATLQSSKNVYTSVVNGQFTFDDKTKNESAKLSDLE 359

		

		Query: 1197 EDVFPKDSSEDTDTDGDGTGDNADDDDDNDGTPDSEDAFPKDASEDTDTDGDGTGDNTDD 1256

		             +   K  S+ T    + T + A D     G     D      S   + D      +T +

		Sbjct: 360  ANNAVKGESKITVNGAEYTANAAGDKVTLAGKTMFIDKTASGVSTLINEDAAAAKKSTAN 419

		

		

		

		 Score = 36.9 bits (85), Expect = 8e-04

		 Identities = 38/300 (12%), Positives = 68/300 (22%), Gaps = 15/300 (5%)

		

		Query: 1248 DGTGDNTDDDDDNDGTPDSEDAFPKDSSEDTDTDGDGTGDNADDDDDNDGTPDSEDAFPK 1307

		                        NDG   + D    D         +  G       D   +  +   +  

		Sbjct: 138  SQDNQMKIQVGANDGETITIDLQKIDVKSLGLDGFNVNGPKEATVGDLKSSFKNVTGYDT 197

		

		Query: 1308 DASEDTDTDGDGTGDNTDDDDDNDGTPDSEDAFPKDASEDTDTDGDETGDNTDDDDDNDG 1367

		             A        D        D      PD       +    TD   + T  +      +  

		Sbjct: 198  YAVGANKYRVDVNSGAVVTDTTAPTVPDKVYVNAANGQLTTDDAENNTAVDLFKTTKS-- 255

		

		Query: 1368 TPDSEDAFPKDASEDTDTDGDGTGDNTDDDDDNDGTPDSEDAFPKDASEDTDTDGDGTGD 1427

		                  A   +A         G   +T D      T D++     +    T  +G+    

		Sbjct: 256  -----TAGTAEAKAIAGAIKGGKEGDTFDYKGVTFTIDTKTGNDGNGKVSTTINGEKVTL 310

		

		Query: 1428 NTDDDDDNDGTPDSEDAFPKDAFEDTDTDGDGTGDNTDDDDDNDGTPDTEDAFPKDASED 1487

		               D        D+           +  +   +  N     D+    ++      +A+  

		Sbjct: 311  TVADITAGAANVDAATL-------QSSKNVYTSVVNGQFTFDDKTKNESAKLSDLEANNA 363

		

		Query: 1488 TDTDGDGTGDNADDDADNDGVPDTEDA-FPNDPNETSDVDGDGVGDNADTDDDNDGVTDT 1546

		               +   T + A+  A+  G   T            S V      D A           +

		Sbjct: 364  VKGESKITVNGAEYTANAAGDKVTLAGKTMFIDKTASGVSTLINEDAAAAKKSTANPLAS 423

		

		

		

		 Score = 33.9 bits (77), Expect = 0.007

		 Identities = 29/220 (13%), Positives = 52/220 (23%), Gaps = 5/220 (2%)

		

		Query: 1388 DGTGDNTDDDDDNDGTPDSEDAFPKDASEDTDTDGDGTGDNTDDDDDNDGTPDSEDAFPK 1447

		                        NDG   + D    D         +  G       D   +  +   +  

		Sbjct: 138  SQDNQMKIQVGANDGETITIDLQKIDVKSLGLDGFNVNGPKEATVGDLKSSFKNVTGYDT 197

		

		Query: 1448 DAFEDTDTDGDGTGDNTDDDDDNDGTPDTEDAFPKDASEDTDTDGDGTGDNADDDADNDG 1507

		             A        D        D      PD       +    TD   + T  +      +  

		Sbjct: 198  YAVGANKYRVDVNSGAVVTDTTAPTVPDKVYVNAANGQLTTDDAENNTAVDLFKTTKSTA 257

		

		Query: 1508 VPDTEDAFPNDPN-----ETSDVDGDGVGDNADTDDDNDGVTDTDNDGDGLGDNVDNDDD 1562

		                  A           +T D  G     +  T +D +G   T  +G+ +   V +   

		Sbjct: 258  GTAEAKAIAGAIKGGKEGDTFDYKGVTFTIDTKTGNDGNGKVSTTINGEKVTLTVADITA 317

		

		Query: 1563 NDGIPDSEDAFPTDASETVDTDGDGIGDNADTDDDGDGYS 1602

		                 D+     +    T   +G    D+   ++      

		Sbjct: 318  GAANVDAATLQSSKNVYTSVVNGQFTFDDKTKNESAKLSD 357

		

		

		>NUCEPIMERASE#Nucleotide sugar epimerase signature.

		          Length = 334

		

		 Score = 32.1 bits (73), Expect = 0.003

		 Identities = 26/113 (23%), Positives = 41/113 (36%), Gaps = 28/113 (24%)

		

		Query: 1  MKIAIVCYPTFGGSGVVATELGIALAERGHEV----HFITYRQPV----RLELLGN-NIH 51

		          MK  +      G +G +   +   L E GH+V    +   Y        RLELL      

		Sbjct: 1  MKYLVT-----GAAGFIGFHVSKRLLEAGHQVVGIDNLNDYYDVSLKQARLELLAQPGFQ 55

		

		Query: 52 FHEVHVPEYPLFHYQPYELALSSKLVDTIKLYDIELFH---VHYAI--PHAYA 99

		          FH++ + +             +S   + +        H   V Y++  PHAYA

		Sbjct: 56 FHKIDLADREGM-----TDLFASGHFERV----FISPHRLAVRYSLENPHAYA 99

		

		

		>OMPADOMAIN#OMPA domain signature.

		          Length = 346

		

		 Score = 88.8 bits (220), Expect = 8e-22

		 Identities = 41/117 (35%), Positives = 63/117 (53%), Gaps = 6/117 (5%)

		

		Query: 270 NVYFKLNSSYLTSNDKELLDQLVAIM--NDEPGLAIKITAHTDSRGTEKYNQWLSERRAE 327

		           +V F  N + L    +  LDQL + +   D    ++ +  +TD  G++ YNQ LSERRA+

		Sbjct: 220 DVLFNFNKATLKPEGQAALDQLYSQLSNLDPKDGSVVVLGYTDRIGSDAYNQGLSERRAQ 279

		

		Query: 328 RTVEYLLSKGIAADRISHEAFGETRLV--NECSD--GVRCTEEQHSQNRRSDFEIVG 380

		             V+YL+SKGI AD+IS    GE+  V  N C +        +  + +RR + E+ G

		Sbjct: 280 SVVDYLISKGIPADKISARGMGESNPVTGNTCDNVKQRAALIDCLAPDRRVEIEVKG 336

		

		

		>NUCEPIMERASE#Nucleotide sugar epimerase signature.

		          Length = 334

		

		 Score =  502 bits (1294), Expect = 0.0

		 Identities = 193/351 (54%), Positives = 241/351 (68%), Gaps = 27/351 (7%)

		

		Query: 1   MKILVTGAAGFIGFHVSKKLTSLGHTVVGLDNINDYYDVNLKYARLNELGIDKQAASKYN 60

		           MK LVTGAAGFIGFHVSK+L   GH VVG+DN+NDYYDV+LK ARL  L           

		Sbjct: 1   MKYLVTGAAGFIGFHVSKRLLEAGHQVVGIDNLNDYYDVSLKQARLELLAQ--------- 51

		

		Query: 61  SLSKSTTIPTFSFVRMDLANSDQMAGLFNQEQFQVVCNLAAQAGVRYSLENPAAYMDSNI 120

		                   P F F ++DLA+ + M  LF    F+ V     +  VRYSLENP AY DSN+

		Sbjct: 52  --------PGFQFHKIDLADREGMTDLFASGHFERVFISPHRLAVRYSLENPHAYADSNL 103

		

		Query: 121 VGFLNVLEGCRHNHVKHLVYASSSSVYGLNKKIPFETSDSVDHPISLYAASKKSNELMAH 180

		            GFLN+LEGCRHN ++HL+YASSSSVYGLN+K+PF T DSVDHP+SLYAA+KK+NELMAH

		Sbjct: 104 TGFLNILEGCRHNKIQHLLYASSSSVYGLNRKMPFSTDDSVDHPVSLYAATKKANELMAH 163

		

		Query: 181 TYSHLYGFNTTGLRFFTVYGPWGRPDMALFLFTKAILNGEPIKVFNHGHLERDFTYIDDI 240

		           TYSHLYG   TGLRFFTVYGPWGRPDMALF FTKA+L G+ I V+N+G ++RDFTYIDDI

		Sbjct: 164 TYSHLYGLPATGLRFFTVYGPWGRPDMALFKFTKAMLEGKSIDVYNYGKMKRDFTYIDDI 223

		

		Query: 241 TEGVVRIIEKDTTEREKNDQL----------YKLYNIGNNKSVKLLDFIEQIEKSLGMQA 290

		            E ++R+ +       +              Y++YNIGN+  V+L+D+I+ +E +LG++A

		Sbjct: 224 AEAIIRLQDVIPHADTQWTVETGTPAASIAPYRVYNIGNSSPVELMDYIQALEDALGIEA 283

		

		Query: 291 IKNHLPMQPGDVERTWANVDELIKDYDYKPNTPIAMGIAKFTEWYRDFYNV 341

		            KN LP+QPGDV  T A+   L +   + P T +  G+  F  WYRDFY V

		Sbjct: 284 KKNMLPLQPGDVLETSADTKALYEVIGFTPETTVKDGVKNFVNWYRDFYKV 334

		

		

		>TYPE3IMSPROT#Type III secretion system inner membrane S protein

		           family signature.

		          Length = 354

		

		 Score = 28.2 bits (63), Expect = 0.037

		 Identities = 8/27 (29%), Positives = 13/27 (48%)

		

		Query: 68  VHLYGVPYKVDQVHAIAEEFDIPVIED 94

		           V       +V  V  IAEE  +P+++ 

		Sbjct: 283 VTFKYTDAQVQTVRKIAEEEGVPILQR 309

		

		

		>NUCEPIMERASE#Nucleotide sugar epimerase signature.

		          Length = 334

		

		 Score = 88.3 bits (219), Expect = 4e-21

		 Identities = 55/298 (18%), Positives = 110/298 (36%), Gaps = 46/298 (15%)

		

		Query: 296 IMVTGGAGSIGSELVRQICKYNYRALIVIDQAESALYDL---QQELKQTGFFNFVPIVGD 352

		            +VTG AG IG  + +++ +  ++ ++ ID   +  YD+   Q  L+      F     D

		Sbjct: 3   YLVTGAAGFIGFHVSKRLLEAGHQ-VVGID-NLNDYYDVSLKQARLELLAQPGFQFHKID 60

		

		Query: 353 IRDKNKMRVLFDQYKPDRIFHAAAYKHVPLMEQNPYEAIKINVAGTKTIADLALEYEVEK 412

		           + D+  M  LF     +R+F +     V    +NP+     N+ G   I +     +++ 

		Sbjct: 61  LADREGMTDLFASGHFERVFISPHRLAVRYSLENPHAYADSNLTGFLNILEGCRHNKIQH 120

		

		Query: 413 FVFVST---------------DKAVNPTNIMGATKRIAEMYISCKQQDGRTKFITTRFGN 457

		            ++ S+               D   +P ++  ATK+  E+                RF  

		Sbjct: 121 LLYASSSSVYGLNRKMPFSTDDSVDHPVSLYAATKKANELMAHTYSHLYGLPATGLRFFT 180

		

		Query: 458 VLGSNGS---VIPLFRKQIEKGGPLTV-THKDITRYFMTIPEASQLVL------------ 501

		           V G  G     +  F K + +G  + V  +  + R F  I + ++ ++            

		Sbjct: 181 VYGPWGRPDMALFKFTKAMLEGKSIDVYNYGKMKRDFTYIDDIAEAIIRLQDVIPHADTQ 240

		

		Query: 502 ---EAGAMGKG---GEIFIFDMGESVKIMDLAKNMIRLSGLSYPDDIDIKITGLRPGE 553

		              E G          ++       V++MD  + +    G+    +    +  L+PG+

		Sbjct: 241 WTVETGTPAASIAPYRVYNIGNSSPVELMDYIQALEDALGI----EAKKNMLPLQPGD 294

		

		

		>HTHFIS#FIS bacterial regulatory protein HTH signature.

		          Length = 484

		

		 Score = 85.3 bits (211), Expect = 2e-21

		 Identities = 36/137 (26%), Positives = 68/137 (49%), Gaps = 1/137 (0%)

		

		Query: 6   KLILVEDDNSLGYLLSEYLGMKGFAVTWAKDASEAIQKTKTSVFDLAILDVMLPDMDGFE 65

		            +++ +DD ++  +L++ L   G+ V    +A+   +       DL + DV++PD + F+

		Sbjct: 5   TILVADDDAAIRTVLNQALSRAGYDVRITSNAATLWRWIAAGDGDLVVTDVVMPDENAFD 64

		

		Query: 66  LSQKIKGINPELPFIFLTARSMKIDVLKGFSLGAVDYLKKPIDEEELVVRINALLARLVN 125

		           L  +IK   P+LP + ++A++  +  +K    GA DYL KP D  EL+  I   LA    

		Sbjct: 65  LLPRIKKARPDLPVLVMSAQNTFMTAIKASEKGAYDYLPKPFDLTELIGIIGRALAEP-K 123

		

		Query: 126 TEEEEVQVAQYEIGDYV 142

		               +++    +    V

		Sbjct: 124 RRPSKLEDDSQDGMPLV 140

		

		

		>ANTHRAXTOXNA#Anthrax toxin LF subunit signature.

		          Length = 800

		

		 Score = 29.7 bits (66), Expect = 0.030

		 Identities = 29/136 (21%), Positives = 58/136 (42%), Gaps = 3/136 (2%)

		

		Query: 314 DKKELQQIQEKYPNKRLLPICNKTDLLNPEQIEKITSEIP-DVLFLSAKLKTGIPELEQK 372

		           +K E ++ ++   N       N+T L   +Q + +  +IP DVL + ++L   I   +  

		Sbjct: 52  NKTEKEKFKDSINNLVKTEFTNET-LDKIQQTQDLLKKIPKDVLEIYSELGGEIYFTDID 110

		

		Query: 373 LLSLVDSGALSGDKTIITNSRHYDALLKALEEIQKVKEGLDIELSSDLMAIDIRQALYHL 432

		           L+   +   LS ++    NSR       +    +K +E   + ++    AI+  Q+    

		Sbjct: 111 LVEHKELQDLSEEEKNSMNSRGEKVPFASRFVFEKKRETPKLIINIKDYAINSEQSKEVY 170

		

		Query: 433 GEITGSVTTDDLLGNI 448

		            EI G   + D++   

		Sbjct: 171 YEI-GKGISLDIISKD 185

		

		

		>IGASERPTASE#IgA-specific serine endopeptidase (S6) signature.

		          Length = 1541

		

		 Score = 30.0 bits (67), Expect = 0.019

		 Identities = 27/143 (18%), Positives = 55/143 (38%), Gaps = 10/143 (6%)

		

		Query: 262  SSNSVQRQRVESRNDRSNSYRKSNNNVNRPGRATASNNRANRSSYERSSNSRKVSPAATG 321

		            S  S ++++ E+   ++   R+++  VN     + +N  A+     + ++S    P    

		Sbjct: 1127 SQVSPKQEQSETVQPQAEPARENDPTVNIKEPQSQTNTTADTEQPAKETSSNVEQPVTES 1186

		

		Query: 322  RTIKR---------SEQSTYRKPKTVSRTTNRSAVKRDNSSRREVARSSRPSTRKSTASR 372

		             T+           +      +P   S ++N+    R   S R V  +  P+T  S    

		Sbjct: 1187 TTVNTGNSVVENPENTTPATTQPTVNSESSNKPKN-RHRRSVRSVPHNVEPATTSSNDRS 1245

		

		Query: 373  KESSRATVSRSSNARKSSARTSS 395

		              +     S ++NA  S AR  +

		Sbjct: 1246 TVALCDLTSTNTNAVLSDARAKA 1268