PredictBias

		>SSBTLNINHBTR#Streptomyces subtilisin inhibitor signature.

		          Length = 144

		

		 Score = 34.0 bits (77), Expect = 5e-04

		 Identities = 29/116 (25%), Positives = 48/116 (41%), Gaps = 15/116 (12%)

		

		Query: 90  AGAAPAAP-RAPLAPTGPAATVAAIAANLAANASAAPTAPADVPMTPSAAAAHHLNADDA 148

		           AGA+ A+P  AP +   P+A V  +    +A A+AAP     +   P+A+  H   A   

		Sbjct: 23  AGASLASPATAPASLYAPSALVLTVGHGESA-ATAAPLRAVTLTCAPTASGTHPAAAAAC 81

		

		Query: 149 DI------DLPSLPAHEAAAGRRTWRPGPGAAPAAGGEADSMYERSKLNPVLTFDN 198

		                   D  +L A ++    R + P            D +++  +L+   TF N

		Sbjct: 82  AELRAAHGDPSALAAEDSVMCTREYAP-------VVVTVDGVWQGRRLSYERTFAN 130

		

		

		>TYPE3IMRPROT#Type III secretion system inner membrane R protein

		           family signature.

		          Length = 261

		

		 Score =  160 bits (407), Expect = 1e-50

		 Identities = 115/256 (44%), Positives = 166/256 (64%), Gaps = 1/256 (0%)

		

		Query: 1   MFSVTYEQLNGWLTAFLWPFVRMLALVATAPVVGHAAVPVRVKIGLAAFMALVVAPTLGA 60

		           M  VT EQ   WL  + WP +R+LAL++TAP++   +VP RVK+GLA  +   +AP+L A

		Sbjct: 1   MLQVTSEQWLSWLNLYFWPLLRVLALISTAPILSERSVPKRVKLGLAMMITFAIAPSLPA 60

		

		Query: 61  MPDVTVFSAQGIWILVTQFLIGAAMGFTMQIVFAAVEAAGDFIGLSMGLGFATFFDPHTS 120

		             DV VFS   +W+ V Q LIG A+GFTMQ  FAAV  AG+ IGL MGL FATF DP + 

		Sbjct: 61  -NDVPVFSFFALWLAVQQILIGIALGFTMQFAFAAVRTAGEIIGLQMGLSFATFVDPASH 119

		

		Query: 121 GATPVMGRFLNAVAMLAFLAVDGHLQVFAALTASFQSLPVSADLLHAPGWRTLAGFGTTV 180

		              PV+ R ++ +A+L FL  +GHL + + L  +F +LP+  + L++  +  L   G+ +

		Sbjct: 120 LNMPVLARIMDMLALLLFLTFNGHLWLISLLVDTFHTLPIGGEPLNSNAFLALTKAGSLI 179

		

		Query: 181 FEMGLLLALPVVAALLIANLALGILNRAAPQIGVFQIGFPVTMLVGLLLVQLMIPNLVPF 240

		           F  GL+LALP++  LL  NLALG+LNR APQ+ +F IGFP+T+ VG+ L+  ++P + PF

		Sbjct: 180 FLNGLMLALPLITLLLTLNLALGLLNRMAPQLSIFVIGFPLTLTVGISLMAALMPLIAPF 239

		

		Query: 241 VAHLFDMGLDAMGRVL 256

		             HLF    + +  ++

		Sbjct: 240 CEHLFSEIFNLLADII 255

		

		

		>TYPE3IMQPROT#Type III secretion system inner membrane Q protein

		          family signature.

		          Length = 86

		

		 Score = 64.8 bits (158), Expect = 9e-18

		 Identities = 28/85 (32%), Positives = 46/85 (54%)

		

		Query: 4  EQVMTLAHQAMMVGLLLAAPLLLVALVVGLVVSLFQAATQINESTLSFIPKLLAVAVTLV 63

		          + ++   ++A+ + L+L+    +VA ++GL+V LFQ  TQ+ E TL F  KLL V + L 

		Sbjct: 2  DDLVFAGNKALYLVLILSGWPTIVATIIGLLVGLFQTVTQLQEQTLPFGIKLLGVCLCLF 61

		

		Query: 64 IAGPWMMTTMLDYLRQTLLHVATLG 88

		          +   W    +L Y RQ +      G

		Sbjct: 62 LLSGWYGEVLLSYGRQVIFLALAKG 86

		

		

		>FLGBIOSNFLIP#Escherichia coli: Flagellar biosynthetic protein FliP

		           signature.

		          Length = 245

		

		 Score =  286 bits (734), Expect = e-100

		 Identities = 146/238 (61%), Positives = 190/238 (79%)

		

		Query: 15  VLILCLAPALAFAQANGLPAFNASPGPHGGTTYSLSVQTMLLLTMLSFLPAMLLMMTSFT 74

		            +   L   +       LP   + P P GG ++SL VQT++ +T L+F+PA+LLMMTSFT

		Sbjct: 6   SVAPVLLWLITPLAFAQLPGITSQPLPGGGQSWSLPVQTLVFITSLTFIPAILLMMTSFT 65

		

		Query: 75  RIIIVLSLLRQALGTATTPPNQVLVGLAMFLTFFVMSPVLDRAYNDGYKPFSDGSMPMEQ 134

		           RIIIV  LLR ALGT + PPNQVL+GLA+FLTFF+MSPV+D+ Y D Y+PFS+  + M++

		Sbjct: 66  RIIIVFGLLRNALGTPSAPPNQVLLGLALFLTFFIMSPVIDKIYVDAYQPFSEEKISMQE 125

		

		Query: 135 AVQRGVAPFKTFMLKQTRETDLALFAKISKAAPMQGPEDVPLSLLVPAFVTSELKTGFQI 194

		           A+++G  P + FML+QTRE DL LFA+++   P+QGPE VP+ +L+PA+VTSELKT FQI

		Sbjct: 126 ALEKGAQPLREFMLRQTREADLGLFARLANTGPLQGPEAVPMRILLPAYVTSELKTAFQI 185

		

		Query: 195 GFTVFIPFLIIDMVVASVLMSMGMMMVSPSTVSLPFKLMLFVLVDGWQLLIGSLAQSF 252

		           GFT+FIPFLIID+V+ASVLM++GMMMV P+T++LPFKLMLFVLVDGWQLL+GSLAQSF

		Sbjct: 186 GFTIFIPFLIIDLVIASVLMALGMMMVPPATIALPFKLMLFVLVDGWQLLVGSLAQSF 243

		

		

		>FLGMOTORFLIN#Flagellar motor switch protein FliN signature.

		          Length = 137

		

		 Score =  135 bits (341), Expect = 1e-43

		 Identities = 75/132 (56%), Positives = 98/132 (74%), Gaps = 3/132 (2%)

		

		Query: 33  AAEEDPGMDD-WAAALAEQNQQPVQAGATGAGVFQPLSKAAASSTHNDIEMILDIPVKMT 91

		           + E    +DD WA AL EQ     ++ A    VFQ L     S    DI++I+DIPVK+T

		Sbjct: 8   SDENTGALDDLWADALNEQKATTTKSAADA--VFQQLGGGDVSGAMQDIDLIMDIPVKLT 65

		

		Query: 92  VELGRTKIAIRNLLQLAQGSVVELDGMAGEPMDVLVNGCLIAQGEVVVVNDKFGIRLTDI 151

		           VELGRT++ I+ LL+L QGSVV LDG+AGEP+D+L+NG LIAQGEVVVV DK+G+R+TDI

		Sbjct: 66  VELGRTRMTIKELLRLTQGSVVALDGLAGEPLDILINGYLIAQGEVVVVADKYGVRITDI 125

		

		Query: 152 ITPAERIRKLNR 163

		           ITP+ER+R+L+R

		Sbjct: 126 ITPSERMRRLSR 137

		

		

		>FLGMOTORFLIM#Flagellar motor switch protein FliM signature.

		          Length = 344

		

		 Score =  272 bits (698), Expect = 3e-92

		 Identities = 82/324 (25%), Positives = 159/324 (49%), Gaps = 10/324 (3%)

		

		Query: 5   EFMSQEEVDALLKGV-TGEADSVDEQ--RDTSGVRPYNIATQERIVRGRMPGLEIINDRF 61

		           E +SQ+E+D LL  + +G+A   D +   DT  +  Y+    ++  + +M  L ++++ F

		Sbjct: 3   EVLSQDEIDQLLTAISSGDASIEDARPISDTRKITLYDFRRPDKFSKEQMRTLSLMHETF 62

		

		Query: 62  ARLLRIGIFNFMRRTAEISVSQVKVQKYSEFTRNLPIPTNLNLVHVKPLRGTSLFVFDPN 121

		           ARL    +   +R    + V+ V    Y EF R++P P+ L ++ + PL+G ++   DP+

		Sbjct: 63  ARLTTTSLSAQLRSMVHVHVASVDQLTYEEFIRSIPTPSTLAVITMDPLKGNAVLEVDPS 122

		

		Query: 122 LVFFVVDNLFGGDGRFHTRVEGRDFTATEQRIIGKLLNLVFEHYTTAWKSVRPLQFEFVR 181

		           + F ++D LFGG G+       RD T  E  ++  ++  +  +   +W  V  L+    +

		Sbjct: 123 ITFSIIDRLFGGTGQAAKVQ--RDLTDIENSVMEGVIVRILANVRESWTQVIDLRPRLGQ 180

		

		Query: 182 SEMHTQFANVATPNEIVIVTQFSIEFGPTGGTLHICMPYSMIEPIRDVLSSPIQGEAL-- 239

		            E + QFA +  P+E+V++     + G   G ++ C+PY  IEPI   LSS     ++  

		Sbjct: 181 IETNPQFAQIVPPSEMVVLVTLETKVGEEEGMMNFCIPYITIEPIISKLSSQFWFSSVRR 240

		

		Query: 240 EVDRRWVRVLSQQVQAAEVELTANLAEISSNFEKILNLRAGDVLPLE---IEDTITAKVD 296

		               +++ VL  ++   ++++ A +  +  +   IL LR GD++ L    + D     + 

		Sbjct: 241 SSTTQYMGVLRDKLSTVDMDVVAEVGSLRLSVRDILGLRVGDIIRLHDTHVGDPFVLSIG 300

		

		Query: 297 GVPVMECGYGIFNGQYALRVQKMI 320

		                 C  G+   + A ++ + I

		Sbjct: 301 NRKKFLCQPGVVGKKIAAQILERI 324

		

		

		>TCRTETB#Tetracycline resistance protein TetB signature.

		          Length = 458

		

		 Score =  120 bits (302), Expect = 1e-31

		 Identities = 83/398 (20%), Positives = 160/398 (40%), Gaps = 16/398 (4%)

		

		Query: 30  LALGTFMEVLDTSIANVAVPTISGSLGVATSEGTWVISSYSVASAIAVPLTGWLARRVGE 89

		           L + +F  VL+  + NV++P I+       +   WV +++ +  +I   + G L+ ++G 

		Sbjct: 19  LCILSFFSVLNEMVLNVSLPDIANDFNKPPASTNWVNTAFMLTFSIGTAVYGKLSDQLGI 78

		

		Query: 90  VRLFTLSVLAFTVASALCGLA-TNFETLIAFRLLQGLVSGPMVPLSQTILMRSYPPAKRG 148

		            RL    ++     S +  +  + F  LI  R +QG  +     L   ++ R  P   RG

		Sbjct: 79  KRLLLFGIIINCFGSVIGFVGHSFFSLLIMARFIQGAGAAAFPALVMVVVARYIPKENRG 138

		

		Query: 149 LALGLWAMTVIVAPIFGPLLGGWISDNYTWPWIFYINLPIGIFSATCAYFLLRGRETKTS 208

		            A GL    V +    GP +GG I+    W ++  I +   I        L   ++    

		Sbjct: 139 KAFGLIGSIVAMGEGVGPAIGGMIAHYIHWSYLLLIPMITIITVPFLMKLL---KKEVRI 195

		

		Query: 209 KQRIDAIGLALLVIGVSCLQMMLDLGKDRDWFNSTFIVALALIAVVSLAFMLVWEATEKE 268

		           K   D  G+ L+ +G+    +          F +++ ++  +++V+S    +       +

		Sbjct: 196 KGHFDIKGIILMSVGIVFFML----------FTTSYSISFLIVSVLSFLIFVKHIRKVTD 245

		

		Query: 269 PVVDLSLFKDRNFALGAMIISFGFMAFFGSVVIFPLWLQTVMGYTAGKAGLATA-PVGLL 327

		           P VD  L K+  F +G +     F    G V + P  ++ V   +  + G     P  + 

		Sbjct: 246 PFVDPGLGKNIPFMIGVLCGGIIFGTVAGFVSMVPYMMKDVHQLSTAEIGSVIIFPGTMS 305

		

		Query: 328 ALVLSPLIGRNMHRLDLRMVASFAFIVFAGVSIWNSTFTLDVPFNHVILPRLVQGIGVAC 387

		            ++   + G  + R     V +   + F  VS   ++F L+     + +  +    G++ 

		Sbjct: 306 VIIFGYIGGILVDRRGPLYVLNIG-VTFLSVSFLTASFLLETTSWFMTIIIVFVLGGLSF 364

		

		Query: 388 FFVPMTTITLSSISDDRLASASGLSNFLRTLSGAIGTA 425

		               ++TI  SS+      +   L NF   LS   G A

		Sbjct: 365 TKTVISTIVSSSLKQQEAGAGMSLLNFTSFLSEGTGIA 402

		

		

		>PRTACTNFAMLY#Pertactin virulence factor family signature.

		          Length = 910

		

		 Score = 30.0 bits (67), Expect = 0.024

		 Identities = 41/153 (26%), Positives = 51/153 (33%), Gaps = 26/153 (16%)

		

		Query: 147 PHVAAPPADSEVDAAAVAADAVETPPARPATVAAVLGLAASVEQVLVEAGAQPAAAGAPR 206

		           P   AP A S + A+ +  D       R A VAA+ G    +++  +  G  PA    P 

		Sbjct: 212 PASGAPAAVSVLGASELTLDGGHITGGRAAGVAAMQGAVVHLQRATIRRGDAPAGGAVP- 270

		

		Query: 207 LELAVARGALGEGFAAPASRAAGTLAA--LAGGGDVEL----YELGEPGAEPRLASVGR- 259

		              AV  GA+  GF                  G  VEL     E  E GA  R+    R 

		Sbjct: 271 -GGAVPGGAVPGGFGPGGFGPVLDGWYGVDVSGSSVELAQSIVEAPELGAAIRVGRGARV 329

		

		Query: 260 ---------------TDGGPL--LPGAAPLSFD 275

		                            GG     P AAPLS  

		Sbjct: 330 TVSGGSLSAPHGNVIETGGARRFAPQAAPLSIT 362

		

		

		>BCTERIALGSPG#Bacterial general secretion pathway protein G

		          signature.

		          Length = 145

		

		 Score = 36.8 bits (85), Expect = 2e-05

		 Identities = 20/67 (29%), Positives = 32/67 (47%), Gaps = 7/67 (10%)

		

		Query: 11 MRRPLARPARGFTLIELMIAIAILAVVAILAWRGLDQIMRGRDKVAA--AMEDERVFAQM 68

		          MR       RGFTL+E+M+ I I+ V+A L    +  +M  ++K     A+ D       

		Sbjct: 1  MRA--TDKQRGFTLLEIMVVIVIIGVLASLV---VPNLMGNKEKADKQKAVSDIVALENA 55

		

		Query: 69 FDQMRID 75

		           D  ++D

		Sbjct: 56 LDMYKLD 62

		

		

		>BCTERIALGSPG#Bacterial general secretion pathway protein G

		          signature.

		          Length = 145

		

		 Score = 28.7 bits (64), Expect = 0.005

		 Identities = 9/20 (45%), Positives = 15/20 (75%)

		

		Query: 13 RGFTMIEVLVALAIIAVALA 32

		          RGFT++E++V + II V  +

		Sbjct: 8  RGFTLLEIMVVIVIIGVLAS 27

		

		

		>RTXTOXIND#Gram-negative bacterial RTX secretion protein D

		           signature.

		          Length = 478

		

		 Score = 27.1 bits (60), Expect = 0.030

		 Identities = 15/88 (17%), Positives = 28/88 (31%), Gaps = 4/88 (4%)

		

		Query: 53  ELDAAHKRVDQELAQAR---NDGQQRIADAEKRAQAVAEEIKSNAQAEAARIIAQAKAEA 109

		           E +  +     EL   +      +  I  A++  Q V +  K+    +  +         

		Sbjct: 256 EQENKYVEAVNELRVYKSQLEQIESEILSAKEEYQLVTQLFKNEILDKLRQTTDNI-GLL 314

		

		Query: 110 EQQIVKAREALRGEVATLAVKGAEQILK 137

		             ++ K  E  +  V    V    Q LK

		Sbjct: 315 TLELAKNEERQQASVIRAPVSVKVQQLK 342

		

		

		>HTHTETR#TetR bacterial regulatory protein HTH signature.

		          Length = 215

		

		 Score = 63.5 bits (154), Expect = 2e-14

		 Identities = 26/140 (18%), Positives = 53/140 (37%), Gaps = 2/140 (1%)

		

		Query: 26  RPRQSRAQASSDALQQAFVQLLLERGYAKATIREIAAVAGVSIGTFYEYFGDKQSLAALC 85

		           R  +  AQ +   +    ++L  ++G +  ++ EIA  AGV+ G  Y +F DK  L +  

		Sbjct: 3   RKTKQEAQETRQHILDVALRLFSQQGVSSTSLGEIAKAAGVTRGAIYWHFKDKSDLFSEI 62

		

		Query: 86  IHRHVLALADRLRDTVARLRGAPRAELAAVLVDLQVDAI--GADAALWGALFALERQVSP 143

		                  + +   +  A+  G P + L  +L+ +    +       L   +F     V  

		Sbjct: 63  WELSESNIGELELEYQAKFPGDPLSVLREILIHVLESTVTEERRRLLMEIIFHKCEFVGE 122

		

		Query: 144 LTAYRRHYDAYVALWRDALA 163

		           +   ++          D + 

		Sbjct: 123 MAVVQQAQRNLCLESYDRIE 142

		

		

		>V8PROTEASE#V8 serine protease family signature.

		          Length = 336

		

		 Score = 68.1 bits (166), Expect = 8e-15

		 Identities = 33/183 (18%), Positives = 63/183 (34%), Gaps = 38/183 (20%)

		

		Query: 116 NLGSGVIVSPEGYILTNQHVVDGADQIEVALA------------DGRTATAKVIGSDPET 163

		            + SGV+V     +LTN+HVVD       AL             +G     ++     E 

		Sbjct: 102 FIASGVVVGK-DTLLTNKHVVDATHGDPHALKAFPSAINQDNYPNGGFTAEQITKYSGEG 160

		

		Query: 164 DLAVLKIN--------MTNLPTITLGRSDQSRVGDVVLAIGNPFGVGQTVTMGIISALGR 215

		           DLA++K +           +   T+  + +++V   +   G P           ++ +  

		Sbjct: 161 DLAIVKFSPNEQNKHIGEVVKPATMSNNAETQVNQNITVTGYPGD-------KPVATMWE 213

		

		Query: 216 NHLGINTFEN-FIQTDAPINPGNSGGALVDVNGNLLGINTAIYSRSGGSLGIGFAIPVST 274

		           +   I   +   +Q D     GNSG  + +    ++GI+           G+      + 

		Sbjct: 214 SKGKITYLKGEAMQYDLSTTGGNSGSPVFNEKNEVIGIHWG---------GVPNEFNGAV 264

		

		Query: 275 ART 277

		              

		Sbjct: 265 FIN 267

		

		

		>OMPADOMAIN#OMPA domain signature.

		          Length = 346

		

		 Score = 88.1 bits (218), Expect = 7e-22

		 Identities = 35/112 (31%), Positives = 60/112 (53%), Gaps = 11/112 (9%)

		

		Query: 218 FETGSATLTPQGRLILDQMAAALAKM--QNRTVDIIGHTDNSGNRTSNIALSQARADAVK 275

		           F    ATL P+G+  LDQ+ + L+ +  ++ +V ++G+TD  G+   N  LS+ RA +V 

		Sbjct: 223 FNFNKATLKPEGQAALDQLYSQLSNLDPKDGSVVVLGYTDRIGSDAYNQGLSERRAQSVV 282

		

		Query: 276 GYLITKSILPQQMTTTGVGPDQPIAPNDTADGRAR---------NRRIEFRV 318

		            YLI+K I   +++  G+G   P+  N   + + R         +RR+E  V

		Sbjct: 283 DYLISKGIPADKISARGMGESNPVTGNTCDNVKQRAALIDCLAPDRRVEIEV 334

		

		

		>DHBDHDRGNASE#2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase

		           signature.

		          Length = 261

		

		 Score =  135 bits (340), Expect = 1e-40

		 Identities = 79/250 (31%), Positives = 127/250 (50%), Gaps = 6/250 (2%)

		

		Query: 8   KVAMVTGAGRGIGAAIARAFVREGAAVALVDLDFPQAQRTAAEIAQEIAGARVLPLQADV 67

		           K+A +TGA +GIG A+AR    +GA +A VD +  + ++  + +  E   A   P   DV

		Sbjct: 9   KIAFITGAAQGIGEAVARTLASQGAHIAAVDYNPEKLEKVVSSLKAEARHAEAFPA--DV 66

		

		Query: 68  ARQDAVREALARTEAAFGPLDVLVNNAGINVFADPLTMTDDDWRRCFAVDLDGVWHGCRA 127

		               A+ E  AR E   GP+D+LVN AG+       +++D++W   F+V+  GV++  R+

		Sbjct: 67  RDSAAIDEITARIEREMGPIDILVNVAGVLRPGLIHSLSDEEWEATFSVNSTGVFNASRS 126

		

		Query: 128 ALEGMVERGRGSIVNIASTHAFRIIPGCFPYPVAKHGVLGLTRALGIEYAARNVRVNAIA 187

		             + M++R  GSIV + S  A         Y  +K   +  T+ LG+E A  N+R N ++

		Sbjct: 127 VSKYMMDRRSGSIVTVGSNPAGVPRTSMAAYASSKAAAVMFTKCLGLELAEYNIRCNIVS 186

		

		Query: 188 PGYIETQLTRDWW---DAQPDPAAARAETLALQ-PMKRIGRPEEVAMTAVFLASDEAPFI 243

		           PG  ET +    W   +          ET     P+K++ +P ++A   +FL S +A  I

		Sbjct: 187 PGSTETDMQWSLWADENGAEQVIKGSLETFKTGIPLKKLAKPSDIADAVLFLVSGQAGHI 246

		

		Query: 244 NAACITVDGG 253

		               + VDGG

		Sbjct: 247 TMHNLCVDGG 256

		

		

		>PF05272#Virulence-associated E family protein

		          Length = 892

		

		 Score = 29.7 bits (66), Expect = 0.038

		 Identities = 14/38 (36%), Positives = 17/38 (44%), Gaps = 5/38 (13%)

		

		Query: 18  RALD-GISFDVHAGEVHGLMGENGAGKSTLLKILGGEY 54

		           R ++ G  FD        L G  G GKSTL+  L G  

		Sbjct: 587 RVMEPGCKFDY----SVVLEGTGGIGKSTLINTLVGLD 620

		

		

		>DHBDHDRGNASE#2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase

		           signature.

		          Length = 261

		

		 Score =  150 bits (379), Expect = 2e-46

		 Identities = 81/256 (31%), Positives = 131/256 (51%), Gaps = 8/256 (3%)

		

		Query: 22  LDGRRALITGSGRGIGLTLARGLAEAGAAIVINDRNEEKAATLVRHLREEGFTADYAVFD 81

		           ++G+ A ITG+ +GIG  +AR LA  GA I   D N EK   +V  L+ E   A+    D

		Sbjct: 6   IEGKIAFITGAAQGIGEAVARTLASQGAHIAAVDYNPEKLEKVVSSLKAEARHAEAFPAD 65

		

		Query: 82  VAEHAQVRAAIDDFEARVGAIDILVNNAGIQRRAPLDAFEPDDWHALMRVNLDGVFNVAQ 141

		           V + A +       E  +G IDILVN AG+ R   + +   ++W A   VN  GVFN ++

		Sbjct: 66  VRDSAAIDEITARIEREMGPIDILVNVAGVLRPGLIHSLSDEEWEATFSVNSTGVFNASR 125

		

		Query: 142 AVARHMIARGRGKIINICSVQSELARPTIAPYAATKGAVRMLTKGMCADWARHGIQANGL 201

		           +V+++M+ R  G I+ + S  + + R ++A YA++K A  M TK +  + A + I+ N +

		Sbjct: 126 SVSKYMMDRRSGSIVTVGSNPAGVPRTSMAAYASSKAAAVMFTKCLGLELAEYNIRCNIV 185

		

		Query: 202 APGYFETELNRAL-VDD-------AAFSDWLCKRTPAGRWGRVDELCGAAIFLASAASDF 253

		           +PG  ET++  +L  D+           +      P  +  +  ++  A +FL S  +  

		Sbjct: 186 SPGSTETDMQWSLWADENGAEQVIKGSLETFKTGIPLKKLAKPSDIADAVLFLVSGQAGH 245

		

		Query: 254 VNGQTLFVDGGLTSAV 269

		           +    L VDGG T  V

		Sbjct: 246 ITMHNLCVDGGATLGV 261

		

		

		>TCRTETB#Tetracycline resistance protein TetB signature.

		          Length = 458

		

		 Score = 41.0 bits (96), Expect = 8e-06

		 Identities = 29/106 (27%), Positives = 49/106 (46%), Gaps = 11/106 (10%)

		

		Query: 91  LGGVVFGILGDRIGRKFVLTATVLLMGIASTLIGVLPTFATAGYWAPALLILLRILQGLG 150

		           +G  V+G L D++G K +L   +++    S +  V  +F +       LLI+ R +QG G

		Sbjct: 64  IGTAVYGKLSDQLGIKRLLLFGIIINCFGSVIGFVGHSFFS-------LLIMARFIQGAG 116

		

		Query: 151 AGAEQAGAAVLMTEYAPPGKR----GFYASLPFLGIQLGTVLAAAV 192

		           A A  A   V++  Y P   R    G   S+  +G  +G  +   +

		Sbjct: 117 AAAFPALVMVVVARYIPKENRGKAFGLIGSIVAMGEGVGPAIGGMI 162

		

		

		>TCRTETB#Tetracycline resistance protein TetB signature.

		          Length = 458

		

		 Score = 40.6 bits (95), Expect = 7e-06

		 Identities = 38/182 (20%), Positives = 68/182 (37%), Gaps = 14/182 (7%)

		

		Query: 37  LAAIARSFGRAPTELGYLVTLTQLGYAASLLLIVPLGDAVNRHTLIVRLLMLNVVALVAV 96

		           L  IA  F + P    ++ T   L ++    +   L D +    L++  +++N    V  

		Sbjct: 37  LPDIANDFNKPPASTNWVNTAFMLTFSIGTAVYGKLSDQLGIKRLLLFGIIINCFGSVIG 96

		

		Query: 97  TFSTN------FTMFVVANIAVGFVTCSTQLLVPFAASLADARSRGRAVGTVMSGLLLGI 150

		               +         F+    A  F      L++   A      +RG+A G + S + +G 

		Sbjct: 97  FVGHSFFSLLIMARFIQGAGAAAFPA----LVMVVVARYIPKENRGKAFGLIGSIVAMGE 152

		

		Query: 151 LLARVAAGAIADGFGWRAVYGIAAVMVAVLTVVLAVKLPKD--RRDARLDYAALMKSLVA 208

		            +     G IA    W   Y +   M+ ++TV   +KL K   R     D   ++   V 

		Sbjct: 153 GVGPAIGGMIAHYIHWS--YLLLIPMITIITVPFLMKLLKKEVRIKGHFDIKGIILMSVG 210

		

		Query: 209 LV 210

		           +V

		Sbjct: 211 IV 212

		

		

		>ACRIFLAVINRP#Acriflavin resistance protein family signature.

		          Length = 1034

		

		 Score = 29.4 bits (66), Expect = 0.033

		 Identities = 13/47 (27%), Positives = 21/47 (44%), Gaps = 4/47 (8%)

		

		Query: 145  KAVLVAAALYPRFFPMLMTAAGTVKAARVLIL--GAGVAGLQAIATA 189

		            +A L+A  +  R  P+LMT+   +     L +  GAG     A+   

		Sbjct: 961  EATLMAVRM--RLRPILMTSLAFILGVLPLAISNGAGSGAQNAVGIG 1005

		

		

		>TCRTETA#Tetracycline resistance protein signature.

		          Length = 399

		

		 Score = 29.4 bits (66), Expect = 0.033

		 Identities = 18/67 (26%), Positives = 27/67 (40%), Gaps = 10/67 (14%)

		

		Query: 184 HLLNLMLALAMLGFGILFFVTQSWLPFIIMTAIAFALGVLIIIPIGGADMPVVVSMLNSY 243

		             L L +     G+ +L F T+ W+ F IM  +A           GG  MP + +ML+  

		Sbjct: 278 RALMLGMIADGTGYILLAFATRGWMAFPIMVLLAS----------GGIGMPALQAMLSRQ 327

		

		Query: 244 SGWAAAG 250

		                 G

		Sbjct: 328 VDEERQG 334

		

		

		>ARGREPRESSOR#Bacterial arginine repressor signature.

		          Length = 149

		

		 Score = 36.4 bits (84), Expect = 2e-05

		 Identities = 20/75 (26%), Positives = 34/75 (45%), Gaps = 6/75 (8%)

		

		Query: 3  RRADRLFQIAELLRGRRLTTAQQLADWL-----SVSPRTVYRDVRDLQLSGVPIEGEAGI 57

		           +  R  +I E++    + T  +L D L     +V+  TV RD+++L L  VP    +  

		Sbjct: 2  NKGQRHIKIREIITANEIETQDELVDILKKDGYNVTQATVSRDIKELHLVKVPTNNGSYK 61

		

		Query: 58 GYRLNRNASLPPLTF 72

		           Y L  +    PL+ 

		Sbjct: 62 -YSLPADQRFNPLSK 75

		

		

		>TYPE4SSCAGX#Type IV secretion system CagX conjugation protein

		           signature.

		          Length = 522

		

		 Score = 30.1 bits (67), Expect = 0.017

		 Identities = 24/81 (29%), Positives = 44/81 (54%), Gaps = 4/81 (4%)

		

		Query: 177 KRVNEMNARAMQDTIR-VAQIEVNRAEESVQRAAKSILAFRQNKSVFDPEKQS-ELQLQR 234

		           +R+ +M  +A  + ++ + ++   +AEE+V++ AK  ++ + +KS   PE  S EL    

		Sbjct: 215 ERLEDMQEQAQANALKQIEELNKKQAEEAVRQRAKDKISIKTDKSQKSPEDNSIELSPSD 274

		

		Query: 235 AALLQNELVSNRTQLAQVQLI 255

		           +A   N +V  RT  A  Q I

		Sbjct: 275 SAWRTNLVV--RTNKALYQFI 293

		

		

		>OMPADOMAIN#OMPA domain signature.

		          Length = 346

		

		 Score = 94.6 bits (235), Expect = 9e-26

		 Identities = 25/105 (23%), Positives = 48/105 (45%), Gaps = 5/105 (4%)

		

		Query: 65  SIYFDFDSYSVKDEYQPLMQQHAQYLKSHPQRH--VLIQGNTDERGTSEYNLALGQKRAE 122

		            + F+F+  ++K E Q  + Q    L +   +   V++ G TD  G+  YN  L ++RA+

		Sbjct: 220 DVLFNFNKATLKPEGQAALDQLYSQLSNLDPKDGSVVVLGYTDRIGSDAYNQGLSERRAQ 279

		

		Query: 123 AVRRAMALLGVNDSQMEAVSLGKEKPQAAGHDEASWAQNRRADLV 167

		           +V   +   G+   ++ A  +G+  P             +RA L+

		Sbjct: 280 SVVDYLISKGIPADKISARGMGESNPVT---GNTCDNVKQRAALI 321

		

		

		>IGASERPTASE#IgA-specific serine endopeptidase (S6) signature.

		          Length = 1541

		

		 Score = 58.5 bits (141), Expect = 2e-11

		 Identities = 30/184 (16%), Positives = 67/184 (36%), Gaps = 4/184 (2%)

		

		Query: 49   STPAGAEAELWTEVPDVPAPRPVVTPTPPVKVAPPPPPVRDEQADIALQQKKRQQEAAAR 108

		            +T       +  +VP VP+    +       V PP P    E  +   +  K++ +   +

		Sbjct: 994  TTNITTPNNIQADVPSVPSNNEEIARVDEAPVPPPAPATPSETTETVAENSKQESKTVEK 1053

		

		Query: 109  EALLEQQRRAQQLKAQQEDEARRAQLAAQQAAALAAQKAAERDKQKQADKLKQQQLAEQQ 168

		                  +  AQ    +   EA+    A  Q   +A   +  ++ Q    K       +++

		Sbjct: 1054 NEQDATETTAQN--REVAKEAKSNVKANTQTNEVAQSGSETKETQTTETKETATV-EKEE 1110

		

		Query: 169  KLEQQKLQQQKQAQLEAQQAAKAKADAAAKAKAEAQAKAKAEATARAKANAAANAKLDRE 228

		            K + +  + Q+  ++ +Q + K +     + +AE   +         +  +  N   D E

		Sbjct: 1111 KAKVETEKTQEVPKVTSQVSPKQEQSETVQPQAEPARE-NDPTVNIKEPQSQTNTTADTE 1169

		

		Query: 229  RSAR 232

		            + A+

		Sbjct: 1170 QPAK 1173

		

		

		

		 Score = 52.0 bits (124), Expect = 2e-09

		 Identities = 30/202 (14%), Positives = 65/202 (32%), Gaps = 14/202 (6%)

		

		Query: 81   APPPPPVRDEQADIALQQKKRQQEAAAREALLEQQRRAQQLKAQQEDEARRAQLAAQQAA 140

		                    + QAD+       ++ A   EA +     A          +   +  A+ + 

		Sbjct: 994  TTNITTPNNIQADVPSVPSNNEEIARVDEAPVPPPAPAT--------PSETTETVAENSK 1045

		

		Query: 141  ALAAQKAAERDKQKQADKLKQQ-QLAEQQKLE-QQKLQQQKQAQLEAQQAAKAKADAAAK 198

		                 K  E+++Q   +   Q  ++A++ K   +   Q  + AQ  ++       +    

		Sbjct: 1046 Q--ESKTVEKNEQDATETTAQNREVAKEAKSNVKANTQTNEVAQSGSETKETQTTETKET 1103

		

		Query: 199  AKAEAQAKAKAEATARAKANAAANAKLDRERSARLAQMQGLSGAGEGGGEGLAKSGTGTG 258

		            A  E + KAK E     +     +    ++  +   Q Q            + +  + T 

		Sbjct: 1104 ATVEKEEKAKVETEKTQEVPKVTSQVSPKQEQSETVQPQAEPARENDPTVNIKEPQSQTN 1163

		

		Query: 259  SGGNAATPGYADKVRRRVKPNI 280

		            +   A T   A +    V+  +

		Sbjct: 1164 T--TADTEQPAKETSSNVEQPV 1183

		

		

		

		 Score = 34.7 bits (79), Expect = 7e-04

		 Identities = 22/143 (15%), Positives = 41/143 (28%), Gaps = 2/143 (1%)

		

		Query: 95   ALQQKKRQQEAAAREALLEQQRRAQQLKAQQEDEARRAQLAAQQAAALAAQKAAERDKQK 154

		            A + K R           E ++R Q +           Q       +   + A   D+  

		Sbjct: 966  AWKYKLRNVNGRYDLYNPEVEKRNQTVDTTNITTPNNIQADVPSVPSNNEEIARV-DEAP 1024

		

		Query: 155  QADKLKQQQLAEQQKLEQQKLQQQKQAQLEAQQAAKAKADAAAKAKAEAQAKAKAEATAR 214

		                         + + +   Q+ K  +   Q A +  A     AK EA++  KA     

		Sbjct: 1025 VPPPAPATPSETTETVAENSKQESKTVEKNEQDATETTAQNREVAK-EAKSNVKANTQTN 1083

		

		Query: 215  AKANAAANAKLDRERSARLAQMQ 237

		              A + +  K  +    +     

		Sbjct: 1084 EVAQSGSETKETQTTETKETATV 1106

		

		

		>DHBDHDRGNASE#2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase

		           signature.

		          Length = 261

		

		 Score = 87.0 bits (215), Expect = 1e-22

		 Identities = 61/244 (25%), Positives = 107/244 (43%), Gaps = 16/244 (6%)

		

		Query: 2   IVFVTGASAGFGAAIARAFVKGGHRVVATARRKDRLDALAAEL---GDSLLPLELDVRDR 58

		           I F+TGA+ G G A+AR     G  + A     ++L+ + + L            DVRD 

		Sbjct: 10  IAFITGAAQGIGEAVARTLASQGAHIAAVDYNPEKLEKVVSSLKAEARHAEAFPADVRDS 69

		

		Query: 59  AAVEAVPAALPAEFAALDVLVNNAGLALGVEPAQKASLDEWHTMIDTNCTGLVTVTHALL 118

		           AA++ + A +  E   +D+LVN AG+ L        S +EW      N TG+   + ++ 

		Sbjct: 70  AAIDEITARIEREMGPIDILVNVAGV-LRPGLIHSLSDEEWEATFSVNSTGVFNASRSVS 128

		

		Query: 119 PGMIDRGRGHVFNIGSVAGSYPYAGGNVYGATKAFVRQFSLNLRADLLGTPLRVTDIEPG 178

		             M+DR  G +  +GS     P      Y ++KA    F+  L  +L    +R   + PG

		Sbjct: 129 KYMMDRRSGSIVTVGSNPAGVPRTSMAAYASSKAAAVMFTKCLGLELAEYNIRCNIVSPG 188

		

		Query: 179 LCGGTEFSNIRYRGDDAKAANVYNNVQ------PL----MPEDIADTIYWIATRPA-HVN 227

		               T+     +  ++     +  +++      PL     P DIAD + ++ +  A H+ 

		Sbjct: 189 -STETDMQWSLWADENGAEQVIKGSLETFKTGIPLKKLAKPSDIADAVLFLVSGQAGHIT 247

		

		Query: 228 VNTI 231

		           ++ +

		Sbjct: 248 MHNL 251

		

		

		>BCTERIALGSPH#Bacterial general secretion pathway protein H

		          signature.

		          Length = 170

		

		 Score = 28.8 bits (64), Expect = 0.009

		 Identities = 17/65 (26%), Positives = 26/65 (40%), Gaps = 3/65 (4%)

		

		Query: 14 RSGGFTLVELMVA---ISLAAGLALYAAPAFDQWRMRERVDARSRALLGALSFARTEATR 70

		          R  GFTL+E+M+    + ++AG+ L A PA       + +      L             

		Sbjct: 2  RQRGFTLLEMMLILLLMGVSAGMVLLAFPASRDDSAAQTLARFEAQLRFVQQRGLQTGQF 61

		

		Query: 71 LGVRV 75

		           GV V

		Sbjct: 62 FGVSV 66

		

		

		>BCTERIALGSPG#Bacterial general secretion pathway protein G

		           signature.

		          Length = 145

		

		 Score = 40.3 bits (94), Expect = 5e-07

		 Identities = 29/136 (21%), Positives = 55/136 (40%), Gaps = 17/136 (12%)

		

		Query: 9   RSAGFTLIELMIVLAIVAVLAGWGIPSYREHVVRVHRASAVAALYRAAQYLET--LDGGP 66

		           +  GFTL+E+M+V+ I+ VLA   +P+   +  +  +  AV+ +      L+   LD   

		Sbjct: 6   KQRGFTLLEIMVVIVIIGVLASLVVPNLMGNKEKADKQKAVSDIVALENALDMYKLDNH- 64

		

		Query: 67  PSALPMALTQAPPDGRAIYRLALRRPEGDDSPVSYALEAIPLDTGPMHDDACGAFTLRSD 126

		                           ++       P   +      ++ +P D  P  +D    + L + 

		Sbjct: 65  ------HYPTTNQGLESLVEAPTLPPLAANYNKEGYIKRLPAD--PWGND----YVLVNP 112

		

		Query: 127 GTKG--NVRSDGADGQ 140

		           G  G  ++ S G DG+

		Sbjct: 113 GEHGAYDLLSAGPDGE 128

		

		

		>TCRTETB#Tetracycline resistance protein TetB signature.

		          Length = 458

		

		 Score =  131 bits (331), Expect = 1e-35

		 Identities = 76/409 (18%), Positives = 174/409 (42%), Gaps = 20/409 (4%)

		

		Query: 14  LIVLCLGVLMIVLDSTIVNVALPSISTDLHFTETALVWVVNAYLLTFGGCLLLGGRLGDL 73

		           LI LC+     VL+  ++NV+LP I+ D +    +  WV  A++LTF     + G+L D 

		Sbjct: 16  LIWLCILSFFSVLNEMVLNVSLPDIANDFNKPPASTNWVNTAFMLTFSIGTAVYGKLSDQ 75

		

		Query: 74  YGQRRMFLAGLVVFTLASLACGLAQSQ-TMLIAARAVQGIGGAVVSAVALSLIMNLFTEP 132

		            G +R+ L G+++    S+   +  S  ++LI AR +QG G A   A+ + +++  +   

		Sbjct: 76  LGIKRLLLFGIIINCFGSVIGFVGHSFFSLLIMARFIQGAGAAAFPAL-VMVVVARYIPK 134

		

		Query: 133 GERARAMGVYGFVCAGGGSIGVLLGGLLTSSLSWHWIFLVNLPIGIAVYAMCVALLPRLR 192

		             R +A G+ G + A G  +G  +GG++   +  HW +L+ +P+   +    +  L + +

		Sbjct: 135 ENRGKAFGLIGSIVAMGEGVGPAIGGMIAHYI--HWSYLLLIPMITIITVPFLMKLLK-K 191

		

		Query: 193 APAGTARLDVAGAITVTASLMLAVYGIVGGNEAGWLSTQTVSLIGAAVVLLALFIAIEAR 252

		                   D+ G I ++  ++  +            ++ ++S +  +V+   +F+    +

		Sbjct: 192 EVRIKGHFDIKGIILMSVGIVFFMLFT---------TSYSISFLIVSVLSFLIFVKHIRK 242

		

		Query: 253 AAHPLMPLSLFASRNVALANVIAVLWAAAMFAWFFLSALYMQRVLGYGPLQVGLAFLPAN 312

		              P +   L  +    +  +   +    +  +  +    M+ V      ++G   +   

		Sbjct: 243 VTDPFVDPGLGKNIPFMIGVLCGGIIFGTVAGFVSMVPYMMKDVHQLSTAEIGSVIIFPG 302

		

		Query: 313 LIMAVFSLGLSARIVMRFGIRGPIAAGLLIAACGLALFSRAPVDGGFVWHVLPGMTLLGI 372

		            +  +    +   +V R G    +  G+   +      S    +    +  +  + +LG 

		Sbjct: 303 TMSVIIFGYIGGILVDRRGPLYVLNIGVTFLSVSFLTASFLL-ETTSWFMTIIIVFVLG- 360

		

		Query: 373 GAGVAFNPMLLA--AMSDVDPADSGLASGIVNTAFMMGGALGLAVLASL 419

		             G++F   +++    S +   ++G    ++N    +    G+A++  L

		Sbjct: 361 --GLSFTKTVISTIVSSSLKQQEAGAGMSLLNFTSFLSEGTGIAIVGGL 407

		

		

		>NUCEPIMERASE#Nucleotide sugar epimerase signature.

		          Length = 334

		

		 Score =  174 bits (443), Expect = 6e-54

		 Identities = 88/351 (25%), Positives = 141/351 (40%), Gaps = 45/351 (12%)

		

		Query: 2   ILVTGGAGFIGANFVIDWLCQSDEAVLNVDKLT--YAGNLRTL-QSLNGSPKHVFARVDI 58

		            LVTG AGFIG + V   L ++   V+ +D L   Y  +L+     L   P   F ++D+

		Sbjct: 3   YLVTGAAGFIGFH-VSKRLLEAGHQVVGIDNLNDYYDVSLKQARLELLAQPGFQFHKIDL 61

		

		Query: 59  CDRAALDALLAEHRPRAILHFAAESHVDRSIHGPAEFVQTNVVGTFTLLEAARQYWSALP 118

		            DR  +  L A      +        V  S+  P  +  +N+ G   +LE  R       

		Sbjct: 62  ADREGMTDLFASGHFERVFISPHRLAVRYSLENPHAYADSNLTGFLNILEGCRHN----- 116

		

		Query: 119 DAEQAGFRFLHVSTDEVFGSLSATDPQFSETTPYA-PNSPYSATKAGSDHLVRAYHHTYG 177

		             +      L+ S+  V+G L+   P FS       P S Y+ATK  ++ +   Y H YG

		Sbjct: 117 KIQ----HLLYASSSSVYG-LNRKMP-FSTDDSVDHPVSLYAATKKANELMAHTYSHLYG 170

		

		Query: 178 LPTLTTNCSNNYGPYQFPEKLIPLMIANALAGKPLPVYGDGQNVRDWLYVGD---HCSAI 234

		           LP         YGP+  P+  +       L GK + VY  G+  RD+ Y+ D       +

		Sbjct: 171 LPATGLRFFTVYGPWGRPDMALFKFTKAMLEGKSIDVYNYGKMKRDFTYIDDIAEAIIRL 230

		

		Query: 235 REVLARGT---------------PGETYNVGGWNEMTNLDVVHTLCDLLD-DARPRAQGT 278

		           ++V+                   P   YN+G  + +  +D +  L D L  +A+      

		Sbjct: 231 QDVIPHADTQWTVETGTPAASIAPYRVYNIGNSSPVELMDYIQALEDALGIEAKKN---- 286

		

		Query: 279 YRDQITYVKDRPGHDRRYAIDARKLERELGWKPDETFATGLAKTVSWYLDN 329

		                  +  +PG     + D + L   +G+ P+ T   G+   V+WY D 

		Sbjct: 287 ------MLPLQPGDVLETSADTKALYEVIGFTPETTVKDGVKNFVNWYRDF 331

		

		

		>CHANLCOLICIN#Channel forming colicin signature.

		          Length = 522

		

		 Score = 30.4 bits (68), Expect = 0.049

		 Identities = 46/204 (22%), Positives = 75/204 (36%), Gaps = 13/204 (6%)

		

		Query: 500 SQVHAAQTTTLKDSAQKVAEEQADKISSLKATIRQFEQGHAESEALTQ---PNVAAAAIH 556

		           S+  AA   T K S  ++ + QA++ +  KA      +  A  +ALTQ     V  A  H

		Sbjct: 45  SESSAAIHATAKWSTAQLKKTQAEQAARAKAAAEAQAKAKANRDALTQRLKDIVNEALRH 104

		

		Query: 557 STSGSPMLFRRYMSAPLTYMSRAAYILR--NGGVRALVSAARRHYRYQQAQQQIQQAAIE 614

		           + S +P        A    M      LR      +A   A      +Q+A+Q+ ++   E

		Sbjct: 105 NASRTPSATELAH-ANNAAMQAEDERLRLAKAEEKARKEAEAAEKAFQEAEQRRKEIERE 163

		

		Query: 615 VASGTPTAEDQRLLFRAAAKLQREEIIVIAAHAYDWAGSGHRYAQLTTTALAAGHRVVYL 674

		                  AE +R L  A A+ +R   +   A A + A      AQ     +    + +  

		Sbjct: 164 ------KAETERQLKLAEAEEKRLAALSEEAKAVEIAQKKLSAAQSEVVKMDGEIKTLNS 217

		

		Query: 675 VAPSDTGSTPAPLTPRIPGLIHEY 698

		              S   +  A +     G  +E 

		Sbjct: 218 RLSSSIHARDAEMKTL-AGKRNEL 240

		

		

		>ABC2TRNSPORT#ABC-2 type transport system membrane protein

		           signature.

		          Length = 262

		

		 Score = 29.9 bits (67), Expect = 0.011

		 Identities = 25/91 (27%), Positives = 45/91 (49%), Gaps = 6/91 (6%)

		

		Query: 176 PWTAILF--PVVMLP-LIIGSLGLAWFLSALGVYIRDIAQITGVITSVLMFLSPVFYPVS 232

		            W ++L+  PV+ L  L   SLG+   ++AL            ++ + ++FLS   +PV 

		Sbjct: 143 QWLSLLYALPVIALTGLAFASLGM--VVTALAPSYDYFIFYQTLVITPILFLSGAVFPVD 200

		

		Query: 233 NLPPQYRSWIELNPLTFIIEEGRNTLIFGHP 263

		            LP  +++     PL+  I+  R  ++ GHP

		Sbjct: 201 QLPIVFQTAARFLPLSHSIDLIRP-IMLGHP 230

		

		

		>NUCEPIMERASE#Nucleotide sugar epimerase signature.

		          Length = 334

		

		 Score = 89.5 bits (222), Expect = 2e-22

		 Identities = 75/339 (22%), Positives = 127/339 (37%), Gaps = 36/339 (10%)

		

		Query: 3   RIVVTGANGFVGHAVCRLALAAGYTVTAL-------------VRRPGGCIEGVREWVHDA 49

		           + +VTGA GF+G  V +  L AG+ V  +              R       G +    D 

		Sbjct: 2   KYLVTGAAGFIGFHVSKRLLEAGHQVVGIDNLNDYYDVSLKQARLELLAQPGFQFHKIDL 61

		

		Query: 50  PDFEGVAGAWPEDLQADCVIHLAARVHVMHDESPDPDAAFDATNVAGTLRVADAARMHGV 109

		            D EG+   +      + V     R+ V +  S +   A+  +N+ G L + +  R + +

		Sbjct: 62  ADREGMTDLF-ASGHFERVFISPHRLAVRY--SLENPHAYADSNLTGFLNILEGCRHNKI 118

		

		Query: 110 RRFVFASSIKVVGEGDAGVPLAE-DAVPDPQDAYGRSKLRAEQQLARLGEA-GLEVVVVR 167

		           +  ++ASS  V G  +  +P +  D+V  P   Y  +K   E          GL    +R

		Sbjct: 119 QHLLYASSSSVYG-LNRKMPFSTDDSVDHPVSLYAATKKANELMAHTYSHLYGLPATGLR 177

		

		Query: 168 PPLVYGPGVRAN--FLRMMDAVFRGAPLPLA-AIPARRSVVYVDNLADALLHCAIDPRAA 224

		              VYGP  R +    +   A+  G  + +      +R   Y+D++A+A++        A

		Sbjct: 178 FFTVYGPWGRPDMALFKFTKAMLEGKSIDVYNYGKMKRDFTYIDDIAEAIIRLQDVIPHA 237

		

		Query: 225 GECFHVADDDAPSVAGLLRMVGDALGKPARLFPVPAGALRALGRLTGRSAVVDRLTGSLQ 284

		              + V      +     R+       P  L       ++AL    G  A   +    LQ

		Sbjct: 238 DTQWTVETGTPAASIAPYRVYNIGNSSPVELMDY----IQALEDALGIEA--KKNMLPLQ 291

		

		Query: 285 L--------DTGRLRRVLNWHPPYTTRQGLEATAAWYRS 315

		                    DT  L  V+ + P  T + G++    WYR 

		Sbjct: 292 PGDVLETSADTKALYEVIGFTPETTVKDGVKNFVNWYRD 330

		

		

		>NUCEPIMERASE#Nucleotide sugar epimerase signature.

		          Length = 334

		

		 Score = 71.0 bits (174), Expect = 2e-15

		 Identities = 54/298 (18%), Positives = 108/298 (36%), Gaps = 44/298 (14%)

		

		Query: 285 VMVTGAGGSIGSELCRQILRFAPAQLVAFD-LSEYAMYRLTEELRERFPDQPVVPIIGDA 343

		            +VTGA G IG  + +++L  A  Q+V  D L++Y    L +   E            D 

		Sbjct: 3   YLVTGAAGFIGFHVSKRLLE-AGHQVVGIDNLNDYYDVSLKQARLELLAQPGFQFHKIDL 61

		

		Query: 344 KDSLLLDQVMSRHVPHIVFHAAAYKHVPLMEEHNAWQALRNNVLGTYRVARAAIRHDVRH 403

		            D   +  + +      VF +     V    E N      +N+ G   +      + ++H

		Sbjct: 62  ADREGMTDLFASGHFERVFISPHRLAVRYSLE-NPHAYADSNLTGFLNILEGCRHNKIQH 120

		

		Query: 404 FVLIST---------------DKAVNPTNVMGASKRLAEMACQALQQTSGRTQFETVRFG 448

		            +  S+               D   +P ++  A+K+  E+         G      +RF 

		Sbjct: 121 LLYASSSSVYGLNRKMPFSTDDSVDHPVSLYAATKKANELMAHTYSHLYG-LPATGLRFF 179

		

		Query: 449 NVLGSAGS---VIPKFQQQIAKGGPVTV-THPQITRFFMTIPEASQLVLQAS-------- 496

		            V G  G     + KF + + +G  + V  + ++ R F  I + ++ +++          

		Sbjct: 180 TVYGPWGRPDMALFKFTKAMLEGKSIDVYNYGKMKRDFTYIDDIAEAIIRLQDVIPHADT 239

		

		Query: 497 --SMGHGG--------EIFILDMGEPVKIVDLACDLIRLYGFSEDQIQIEFTGLRPGE 544

		             ++  G          ++ +    PV+++D    L    G    + +     L+PG+

		Sbjct: 240 QWTVETGTPAASIAPYRVYNIGNSSPVELMDYIQALEDALGI---EAKKNMLPLQPGD 294

		

		

		>60KDINNERMP#60kDa inner membrane protein signature.

		          Length = 548

		

		 Score = 29.9 bits (67), Expect = 0.020

		 Identities = 14/50 (28%), Positives = 20/50 (40%), Gaps = 3/50 (6%)

		

		Query: 164 LASMVSFMMFASLAYVAFQVGDPVVMSASII-MMGAVLGFFLWNFPAGLI 212

		           L  ++   MF         V DP  M   I+  M  +   F   FP+GL+

		Sbjct: 467 LPILMGVTMFFIQKMSPTTVTDP--MQQKIMTFMPVIFTVFFLWFPSGLV 514

		

		

		>NUCEPIMERASE#Nucleotide sugar epimerase signature.

		          Length = 334

		

		 Score =  168 bits (426), Expect = 2e-51

		 Identities = 80/353 (22%), Positives = 149/353 (42%), Gaps = 54/353 (15%)

		

		Query: 6   TILVTGGAGYIGSHTAVELLDNGYDVVIVDNLVNSKAESVR--RIERITGKTPAFHQVDV 63

		             LVTG AG+IG H +  LL+ G+ VV +DNL +    S++  R+E +      FH++D+

		Sbjct: 2   KYLVTGAAGFIGFHVSKRLLEAGHQVVGIDNLNDYYDVSLKQARLELLAQPGFQFHKIDL 61

		

		Query: 64  CDEAALAKVFDAHPITGTIHFAALKAVGESVAKPLEYYQNNIGGLLAVLKVMRERNVRQF 123

		            D   +  +F +             AV  S+  P  Y  +N+ G L +L+  R   ++  

		Sbjct: 62  ADREGMTDLFASGHFERVFISPHRLAVRYSLENPHAYADSNLTGFLNILEGCRHNKIQHL 121

		

		Query: 124 VFSSSATVYGVPERSPIDES----FPLSATNPYGQSKLIAEQI------LRDLEVSDPSW 173

		           +++SS++VYG+  + P         P+S    Y  +K   E +      L  L       

		Sbjct: 122 LYASSSSVYGLNRKMPFSTDDSVDHPVS---LYAATKKANELMAHTYSHLYGL------- 171

		

		Query: 174 RIATLRYFNPVGAHASGLIGEDPAGIPNNLMPYVAQVAVGKLERLRVFGSDYATPDGTGV 233

		               LR+F   G          P G P ++  +    A+ + + + V+        G   

		Sbjct: 172 PATGLRFFTVYG----------PWGRP-DMALFKFTKAMLEGKSIDVYN------YGKMK 214

		

		Query: 234 RDYIHVVDLAKGHIAALDALAKRDASF---------------IVNLGTGQGYSVLEVVRA 278

		           RD+ ++ D+A+  I   D +   D  +               + N+G      +++ ++A

		Sbjct: 215 RDFTYIDDIAEAIIRLQDVIPHADTQWTVETGTPAASIAPYRVYNIGNSSPVELMDYIQA 274

		

		Query: 279 FEKASGRPVPYELVARRPGDIAECYANPQAAADIIGWRATLGIEEMCADHWRW 331

		            E A G      ++  +PGD+ E  A+ +A  ++IG+     +++   +   W

		Sbjct: 275 LEDALGIEAKKNMLPLQPGDVLETSADTKALYEVIGFTPETTVKDGVKNFVNW 327

		

		

		>UREASE#Urea amidohydrolase (urease) protein signature.

		          Length = 570

		

		 Score = 1102 bits (2851), Expect = 0.0

		 Identities = 424/570 (74%), Positives = 480/570 (84%), Gaps = 2/570 (0%)

		

		Query: 1   MTLRLSRRAYAEMFGPTTGDRVRLADTELLIEIERDFTTYGEEVKFGGGKVIRDGMGQSQ 60

		           M+ R+SR AYA MFGPT GD+VRLADTEL IE+E+DFTT+GEEVKFGGGKVIRDGMGQSQ

		Sbjct: 1   MSYRMSRAAYANMFGPTVGDKVRLADTELFIEVEKDFTTHGEEVKFGGGKVIRDGMGQSQ 60

		

		Query: 61  RV-AADVPDTIITNAVILDHWGIVKADIAIKHGRIAAIGKAGNPDIQPGVTIAIGAATEV 119

		                   DT+ITNA+ILDHWGIVKADI +K GRIAAIGKAGNPD+QPGVTI +G  TEV

		Sbjct: 61  VTREGGAVDTVITNALILDHWGIVKADIGLKDGRIAAIGKAGNPDMQPGVTIIVGPGTEV 120

		

		Query: 120 IAGEGLIVTAGGIDTHIHFISPQQIDEALASGVTTMLGGGTGPATGTNATTCTPGPWHME 179

		           IAGEG IVTAGG+D+HIHFI PQQI+EAL SG+T MLGGGTGPA GT ATTCTPGPWH+ 

		Sbjct: 121 IAGEGKIVTAGGMDSHIHFICPQQIEEALMSGLTCMLGGGTGPAHGTLATTCTPGPWHIA 180

		

		Query: 180 RMLQAADGWPINLGFLGKGNASLPQPLVEQIAAGAIGLKLHEDWGTTPAAIDNCLSVADD 239

		           RM++AAD +P+NL F GKGNASLP  LVE +  GA  LKLHEDWGTTPAAID CLSVAD+

		Sbjct: 181 RMIEAADAFPMNLAFAGKGNASLPGALVEMVLGGATSLKLHEDWGTTPAAIDCCLSVADE 240

		

		Query: 240 TDTQVAIHTDTLNEGGFVESTVAAFKGRTIHTYHTEGAGGGHAPDILKVCGESNVLPSST 299

		            D QV IHTDTLNE GFVE T+AA KGRTIH YHTEGAGGGHAPDI+++CG+ NV+PSST

		Sbjct: 241 YDVQVMIHTDTLNESGFVEDTIAAIKGRTIHAYHTEGAGGGHAPDIIRICGQPNVIPSST 300

		

		Query: 300 NPTRPYTINTLDEHLDMLMVCHHLDPSIAEDLAFAESRIRRETIAAEDILHDLGALSMLS 359

		           NPTRPYT+NTL EHLDMLMVCHHL P+I ED+AFAESRIR+ETIAAEDILHD+GA S++S

		Sbjct: 301 NPTRPYTVNTLAEHLDMLMVCHHLSPTIPEDIAFAESRIRKETIAAEDILHDIGAFSIIS 360

		

		Query: 360 SDSQAMGRVGEVIIRTWQTAHKMKVQRGALPEDNTRNDNFRAKRYVAKYTINPALTHGIA 419

		           SDSQAMGRVGEV IRTWQTA KMK QRG L E+   NDNFR KRY+AKYTINPA+ HG++

		Sbjct: 361 SDSQAMGRVGEVAIRTWQTADKMKRQRGRLKEETGDNDNFRVKRYIAKYTINPAIAHGLS 420

		

		Query: 420 HEVGSIEPGKWADLVLWEPAFFGIKPSMILKGGMIAMAQMGDPNASIPTPQPVHYREMFA 479

		           HE+GS+E GK ADLVLW PAFFG+KP M+L GG IA A MGDPNASIPTPQPVHYR MF 

		Sbjct: 421 HEIGSLEVGKRADLVLWNPAFFGVKPDMVLLGGTIAAAPMGDPNASIPTPQPVHYRPMFG 480

		

		Query: 480 TRGGALARTSLTFVSQMAADAGIAERYGLAKRIVPVRNCR-NVTKADMIHNAWRPSISVD 538

		             G +   +S+TFVSQ + DAG+A R G+AK +V V+N R  + KA MIHN+  P I VD

		Sbjct: 481 AYGRSRTNSSVTFVSQASLDAGLAGRLGVAKELVAVQNTRGGIGKASMIHNSLTPHIEVD 540

		

		Query: 539 PETYDVIADGQLLTCEPATVLPMAQRYFLF 568

		           PETY+V ADG+LLTCEPATVLPMAQRYFLF

		Sbjct: 541 PETYEVRADGELLTCEPATVLPMAQRYFLF 570

		

		

		>DHBDHDRGNASE#2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase

		           signature.

		          Length = 261

		

		 Score = 84.7 bits (209), Expect = 9e-22

		 Identities = 64/251 (25%), Positives = 105/251 (41%), Gaps = 6/251 (2%)

		

		Query: 4   RVAIVTGASQGIGRSTAVRLARDFDAITLVARNRANLEQTAIDVKAAGAACLVIDVDLAA 63

		           ++A +TGA+QGIG + A  LA     I  V  N   LE+    +KA          D+  

		Sbjct: 9   KIAFITGAAQGIGEAVARTLASQGAHIAAVDYNPEKLEKVVSSLKAEARHAEAFPADVRD 68

		

		Query: 64  PEAAQRVVDDTLGAFGRIDALLNIAGAVPQIDVFEMTDAQWEQGLALKLHGARRLTIAAW 123

		             A   +        G ID L+N+AG +    +  ++D +WE   ++   G    + +  

		Sbjct: 69  SAAIDEITARIEREMGPIDILVNVAGVLRPGLIHSLSDEEWEATFSVNSTGVFNASRSVS 128

		

		Query: 124 PSLKA-SAGSVVLMSGNSALFPKAPYAAVGTINAAIIALAKAFSDRGITDGVQVNSVLPG 182

		             +    +GS+V +  N A  P+   AA  +  AA +   K          ++ N V PG

		Sbjct: 129 KYMMDRRSGSIVTVGSNPAGVPRTSMAAYASSKAAAVMFTKCLGLELAEYNIRCNIVSPG 188

		

		Query: 183 PVMTGRRRSYLEHWAPLHGMS--VDEATARFPVDAGIARYGTPEEIAELIAFVVSPAAHW 240

		              T  + S    WA  +G    +  +   F     + +   P +IA+ + F+VS  A  

		Sbjct: 189 STETDMQWSL---WADENGAEQVIKGSLETFKTGIPLKKLAKPSDIADAVLFLVSGQAGH 245

		

		Query: 241 MTGSALRMDGG 251

		           +T   L +DGG

		Sbjct: 246 ITMHNLCVDGG 256

		

		

		>TCRTETA#Tetracycline resistance protein signature.

		          Length = 399

		

		 Score = 47.5 bits (113), Expect = 5e-08

		 Identities = 76/332 (22%), Positives = 118/332 (35%), Gaps = 26/332 (7%)

		

		Query: 35  VLDGVDSVIYALVLIPALTELLPASGIAATPANLGMYGSILFALFLIGWGLSFIWGPLAD 94

		            LD V   +   VL   L +L+ ++ + A       YG +L    L+ +  + + G L+D

		Sbjct: 15  ALDAVGIGLIMPVLPGLLRDLVHSNDVTAH------YGILLALYALMQFACAPVLGALSD 68

		

		Query: 95  RFGRVRTLAASILIYSVFTGAAAFVHDVWALAACRLIAGIGVGGEWALAGTYVAESWPED 154

		           RFGR   L  S+   +V     A    +W L   R++AGI  G   A+AG Y+A+    D

		Sbjct: 69  RFGRRPVLLVSLAGAAVDYAIMATAPFLWVLYIGRIVAGI-TGATGAVAGAYIADITDGD 127

		

		Query: 155 RRKMGAGYLQTGYYFGFFIAACLNYTIGATYGWRAMFLCGLAPALLAVFTVMRVKEPGQW 214

		            R    G++   + FG      L   +G        F       L  +     + E  + 

		Sbjct: 128 ERARHFGFMSACFGFGMVAGPVLGGLMGGFSPHAPFFAAAALNGLNFLTGCFLLPESHKG 187

		

		Query: 215 RRHDARDGDVADARRAHPMREIFAPAFLRRTVTSASLVGVAIVGLWAGSVYEASAVSTLA 274

		            R   R   +         R +   A L        LVG     LW   ++        A

		Sbjct: 188 ERRPLRREALNPLASFRWARGMTVVAALMAVFFIMQLVGQVPAALWV--IFGEDRFHWDA 245

		

		Query: 275 ARAGIDHIGAMRLASIGAAILSCATIAGCLVAPWLSERLGRRTALGVYFAGMAASIVFAF 334

		              GI       LA+ G       ++A  ++   ++ RLG R AL     GM A      

		Sbjct: 246 TTIGIS------LAAFGIL----HSLAQAMITGPVAARLGERRAL---MLGMIADGTGYI 292

		

		Query: 335 GWAFYQPNGLAAFMVSLAFLGFFGGNFAIFSL 366

		             AF        +M     +    G   + +L

		Sbjct: 293 LLAFAT----RGWMAFPIMVLLASGGIGMPAL 320

		

		

		>STREPTOPAIN#Streptopain (C10) cysteine protease family signature.

		          Length = 398

		

		 Score = 27.3 bits (60), Expect = 0.015

		 Identities = 11/31 (35%), Positives = 15/31 (48%)

		

		Query: 41  AGHRAGHAWVPDELTHDAFFHLRWRMLGLPD 71

		            G   GHA+V D      F+H+ W   G+ D

		Sbjct: 334 VGKVGGHAFVIDGADGRNFYHVNWGWGGVSD 364

		

		

		>TCRTETA#Tetracycline resistance protein signature.

		          Length = 399

		

		 Score = 32.5 bits (74), Expect = 0.003

		 Identities = 27/114 (23%), Positives = 45/114 (39%), Gaps = 8/114 (7%)

		

		Query: 289 LLCFAVVFMGLATPLSAWASDRFGRKPVLVVGAIAALLSGFAMEPLLGSGSMPLVALFLT 348

		           L  +A++    A  L A  SDRFGR+PVL+V    A +       ++ +     V     

		Sbjct: 49  LALYALMQFACAPVLGAL-SDRFGRRPVLLVSLAGAAVDYA----IMATAPFLWVLYIGR 103

		

		Query: 349 IELFLMGVTFAPMGALLPELFP--TNVRYTG-AGVAYNLGGILGASIAPYIAQL 399

		           I   + G T A  GA + ++       R+ G     +  G + G  +   +   

		Sbjct: 104 IVAGITGATGAVAGAYIADITDGDERARHFGFMSACFGFGMVAGPVLGGLMGGF 157

		

		

		>PF03544#Gram-negative bacterial tonB protein

		          Length = 243

		

		 Score = 31.9 bits (72), Expect = 9e-04

		 Identities = 12/47 (25%), Positives = 18/47 (38%)

		

		Query: 81  VVVAFTVDGSGRLVNASVYRSNGDSEAEALALASLRRSAPLPPPPSR 127

		           V V F V   GR+ N  +  +   +  E     ++RR    P  P  

		Sbjct: 180 VKVKFDVTPDGRVDNVQILSAKPANMFEREVKNAMRRWRYEPGKPGS 226

		

		

		>ECOLNEIPORIN#E.coli/Neisseria porin superfamily signature.

		          Length = 331

		

		 Score =  129 bits (326), Expect = 1e-36

		 Identities = 88/388 (22%), Positives = 134/388 (34%), Gaps = 64/388 (16%)

		

		Query: 1   MKKTLIVAALSGVFVTAAHAQSSVTLYGLIDAGITYTNNQGGHSAW-----QETSGSVNG 55

		           MKK+LI   L+ + V A    + VTLYG I AG+  + +   + A        T     G

		Sbjct: 1   MKKSLIALTLAALPVAAM---ADVTLYGTIKAGVETSRSVAHNGAQAASVETGTGIVDLG 57

		

		Query: 56  SRWGLRGTEDLGGGLKAIFTLENGFGINNGALKQNGREFGRQAFVGLAHDSYGSLTLGRQ 115

		           S+ G +G EDLG GLKAI+ +E    I       +     RQ+F+GL    +G L +GR 

		Sbjct: 58  SKIGFKGQEDLGNGLKAIWQVEQKASIAGT----DSGWGNRQSFIGLKGG-FGKLRVGRL 112

		

		Query: 116 YDSVVDYLG--PLSLTGTQYGGTQFAHPFDNDNLNNSFRINNSVKYQSANYGGLKFGALY 173

		              + D     P        G  + A P        +  I  SV+Y S  + GL     Y

		Sbjct: 113 NSVLKDTGDINPWDSKSDYLGVNKIAEP-------EARLI--SVRYDSPEFAGLSGSVQY 163

		

		Query: 174 GFSNSTAFANNRAYSGGVSYSYLGFNFAAAYLQLNSDVNALAQAASDPGAVTGDWTFASR 233

		             +++    N+ +Y  G +Y   GF                            +     +

		Sbjct: 164 ALNDNAGRHNSESYHAGFNYKNGGFFVQYGGAYKRHH-------------QVQENVNIEK 210

		

		Query: 234 VQRTWGAGLNYGFGPATVGFVFTQTRLTGIRAISASQSGVSGGITGLGGTARFSNYELNG 293

		            Q        Y    A    V  Q +     A    ++      T +  T  +     N 

		Sbjct: 211 YQ-IHRLVSGYDND-ALYASVAVQQQD----AKLVEENYSHNSQTEVAATLAYRF--GNV 262

		

		Query: 294 RYALTPALSLAGSYTYTQGRLAGDKPTWHQFNLQADYALSKRTDVYLQGEFQKVNNDGLD 353

		              ++ A    GS+             + Q  + A+Y  SKRT   +   + +       

		Sbjct: 263 TPRVSYAHGFKGSFDA-----TNYNNDYDQVVVGAEYDFSKRTSALVSAGWLQEG----- 312

		

		Query: 354 LGANINGLGAASSTNKQIAVTAGMRHRF 381

		                 G     ST    A   G+RH+F

		Sbjct: 313 -----KGESKFVST----AGGVGLRHKF 331

		

		

		>PF03544#Gram-negative bacterial tonB protein

		          Length = 243

		

		 Score = 33.4 bits (76), Expect = 0.001

		 Identities = 20/94 (21%), Positives = 32/94 (34%), Gaps = 4/94 (4%)

		

		Query: 321 AAAAAASTVEVASAAEQIAVPDAAPILAPSAVPLAVPTPAAVMDPAAVIDPAPAFAMPPS 380

		            A    ++V         A P +  ++AP+ +    P  A    P  V++P P     P 

		Sbjct: 29  VAGLLYTSVHQVIELPAPAQPISVTMVAPADLE---PPQAVQPPPEPVVEPEPEPEPIPE 85

		

		Query: 381 AEPEPAFAPPPVAEPVPAFAPPPAAEPAAPRADA 414

		              E         +P P   P P  +   P+ D 

		Sbjct: 86  PPKEAPVVIEK-PKPKPKPKPKPVKKVEQPKRDV 118

		

		

		

		 Score = 31.9 bits (72), Expect = 0.003

		 Identities = 17/129 (13%), Positives = 27/129 (20%), Gaps = 12/129 (9%)

		

		Query: 286 MATVVATVAILGSVGLSFVFDPARRPAARAAAASSAAAAAASTVEVASAAEQIAVPDAAP 345

		               + +V I G+V    ++             S              +   +A  D  P

		Sbjct: 15  PWPTLLSVCIHGAVVAGLLY------------TSVHQVIELPAPAQPISVTMVAPADLEP 62

		

		Query: 346 ILAPSAVPLAVPTPAAVMDPAAVIDPAPAFAMPPSAEPEPAFAPPPVAEPVPAFAPPPAA 405

		             A    P  V  P    +P           +            P      P     P  

		Sbjct: 63  PQAVQPPPEPVVEPEPEPEPIPEPPKEAPVVIEKPKPKPKPKPKPVKKVEQPKRDVKPVE 122

		

		Query: 406 EPAAPRADA 414

		              A   + 

		Sbjct: 123 SRPASPFEN 131

		

		

		>TCRTETB#Tetracycline resistance protein TetB signature.

		          Length = 458

		

		 Score = 50.6 bits (121), Expect = 5e-09

		 Identities = 57/361 (15%), Positives = 121/361 (33%), Gaps = 52/361 (14%)

		

		Query: 48  SAFPDGASWIGAVPTATQLGYAAGMFLLAPLGDRFDRRGLILMQIAGLSVALIVAATAPS 107

		           +  P   +W   V TA  L ++ G  +   L D+   + L+L  I       ++     S

		Sbjct: 45  NKPPASTNW---VNTAFMLTFSIGTAVYGKLSDQLGIKRLLLFGIIINCFGSVIGFVGHS 101

		

		Query: 108 LAVLAVAS---LAIGVLATIAQQAVPFAAEIAPPAERGHAVGTVMSGLLLGILLARTAAG 164

		              L + +      G  A  A   V  A  I P   RG A G + S + +G  +     G

		Sbjct: 102 FFSLLIMARFIQGAGAAAFPALVMVVVARYI-PKENRGKAFGLIGSIVAMGEGVGPAIGG 160

		

		Query: 165 FVAEYFGWRAVFAASVAALVALAAVIVLRLPRSSPTSTL--------------------S 204

		            +A Y  W  +    +  ++ +  ++ L                               S

		Sbjct: 161 MIAHYIHWSYLLLIPMITIITVPFLMKLLKKEVRIKGHFDIKGIILMSVGIVFFMLFTTS 220

		

		Query: 205 YGKLLGSMWHLAVEL--RGLREAS------------------LTGAALFAAFSAFWPVLT 244

		           Y      +  L+  +  + +R+ +                  L G  +F   + F  ++ 

		Sbjct: 221 YSISFLIVSVLSFLIFVKHIRKVTDPFVDPGLGKNIPFMIGVLCGGIIFGTVAGFVSMVP 280

		

		Query: 245 LLLAGAPFHLGPQAAG--LFGIVGAAGALAAPYAGRFADKRGPRAIISLAIALLALSFVI 302

		            ++      L     G  +      +  +     G   D+RGP  ++++ +  L++SF+ 

		Sbjct: 281 YMM-KDVHQLSTAEIGSVIIFPGTMSVIIFGYIGGILVDRRGPLYVLNIGVTFLSVSFLT 339

		

		Query: 303 FA-LSGSSLVGLVIGVIVLDVGVQAAQIS-NQSRIYALKPEARSRVNTVYMVCYFIGGAL 360

		            + L  ++   + I ++ +  G+   +   +     +LK +      ++     F+    

		Sbjct: 340 ASFLLETTSWFMTIIIVFVLGGLSFTKTVISTIVSSSLKQQEAGAGMSLLNFTSFLSEGT 399

		

		Query: 361 G 361

		           G

		Sbjct: 400 G 400

		

		

		>PF05272#Virulence-associated E family protein

		          Length = 892

		

		 Score = 28.9 bits (64), Expect = 0.033

		 Identities = 19/59 (32%), Positives = 26/59 (44%), Gaps = 10/59 (16%)

		

		Query: 21  RVLEPLDLSIGAGETLVLLGPSGCGKTTTLRLIAGL----DTPDAGGTIAFGNDDVTAL 75

		           RV+EP         ++VL G  G GK+T +  + GL    DT    GT   G D    +

		Sbjct: 587 RVMEP---GCKFDYSVVLEGTGGIGKSTLINTLVGLDFFSDTHFDIGT---GKDSYEQI 639

		

		

		>PF06580#Sensor histidine kinase

		          Length = 349

		

		 Score = 29.1 bits (65), Expect = 0.025

		 Identities = 25/181 (13%), Positives = 66/181 (36%), Gaps = 32/181 (17%)

		

		Query: 158 SERLRDDIDEMTQLLEATLSFLRNEEV-VEEFSPVDINALVDAIAEDAAEHGQKVTISGE 216

		             + R+ +  +++L+  +L +    +V + +    ++  +   +   + +   ++    +

		Sbjct: 190 PTKAREMLTSLSELMRYSLRYSNARQVSLAD----ELTVVDSYLQLASIQFEDRLQFENQ 245

		

		Query: 217 VPPISAQPLGLKRCLTNLVANAIRYG-----EDAHIRLI--DAPSCVRIQIADHGPGIPE 269

		           + P           +  LV N I++G     +   I L        V +++ + G    +

		Sbjct: 246 INPAIMDVQVPPMLVQTLVENGIKHGIAQLPQGGKILLKGTKDNGTVTLEVENTGSLALK 305

		

		Query: 270 AQLERALEPFYRVESSRNRNTGGTGLGLAIANDVVK-RHGGELVLR-NGPEGGLVAQVTL 327

		              E                   TG GL    + ++  +G E  ++ +  +G + A V +

		Sbjct: 306 NTKE------------------STGTGLQNVRERLQMLYGTEAQIKLSEKQGKVNAMVLI 347

		

		Query: 328 P 328

		           P

		Sbjct: 348 P 348

		

		

		>TCRTETA#Tetracycline resistance protein signature.

		          Length = 399

		

		 Score = 44.0 bits (104), Expect = 7e-07

		 Identities = 74/402 (18%), Positives = 125/402 (31%), Gaps = 40/402 (9%)

		

		Query: 31  LAILVIVAFFAFVDRQMLILLTEPIRHDFGLTDTQIGLMQGAGIALFA---GVASLPIGW 87

		           L +++       V   +++ +   +  D   ++       G  +AL+A      +  +G 

		Sbjct: 7   LIVILSTVALDAVGIGLIMPVLPGLLRDLVHSNDVTAHY-GILLALYALMQFACAPVLGA 65

		

		Query: 88  VADRVDRRVVLVACVLVWSAATAICGVTTHFWQLFIATVGLGIGEAGLVPVIYGLIPDLF 147

		           ++DR  RR VL+  +   +   AI       W L+I  +  GI  A    V    I D+ 

		Sbjct: 66  LSDRFGRRPVLLVSLAGAAVDYAIMATAPFLWVLYIGRIVAGITGA-TGAVAGAYIADIT 124

		

		Query: 148 PARQRVLANAIFALANLLGAGAGMALGGALMQGIAAVHGALPAGLADLAPWRLAFFAVAL 207

		              +R       +     G  AG  LGG +           P            F A AL

		Sbjct: 125 DGDERARHFGFMSACFGFGMVAGPVLGGLM----GGFSPHAP-----------FFAAAAL 169

		

		Query: 208 PAPVLAVLVLLIRPGKHRDTNASAARHRTAAPLPSAPVYFRREAIMMLKFFGAIGLVNLS 267

		                     L+      +                        A +M  FF    LV   

		Sbjct: 170 NGLNFLTGCFLLPESHKGERRPLRREALNPLASFRWARGMTVVAALMAVFFIMQ-LVGQV 228

		

		Query: 268 FGGVATWMPVVAVRTFGATPAEAGGGMGVAAMAGGIAGCVLSGLVAGRMRARFGVLAPLR 327

		               A    +     F          +G++  A GI   +   ++ G + AR G    L 

		Sbjct: 229 P---AALWVIFGEDRFHWDATT----IGISLAAFGILHSLAQAMITGPVAARLGERRALM 281

		

		Query: 328 VCECGALVAGGLSFLYLAVGSLTPVYALFGAQLACMVAGMVLFPTIMQNICPAH----LR 383

		           +     ++A G  ++ LA  +   +       LA    GM     ++           L+

		Sbjct: 282 L----GMIADGTGYILLAFATRGWMAFPIMVLLASGGIGMPALQAMLSRQVDEERQGQLQ 337

		

		Query: 384 SRVAAIGALTSIVVQSGSPVFIGFMSDRLHAFSEGLLWSIVC 425

		             +AA+ +LTSIV     P+    +         G  W    

		Sbjct: 338 GSLAALTSLTSIV----GPLLFTAIYAASITTWNGWAWIAGA 375

		

		

		>PF03544#Gram-negative bacterial tonB protein

		          Length = 243

		

		 Score = 64.2 bits (156), Expect = 1e-14

		 Identities = 42/176 (23%), Positives = 65/176 (36%), Gaps = 4/176 (2%)

		

		Query: 38  VVDVIRQPIETRIIEEIKPPPPPPPPPKQIAPPPPKHVAPPPPFVPPPEVRVAAPPSANA 97

		            V    +P+     E    P PP   P  I  P PK   P P   P  +V          

		Sbjct: 65  AVQPPPEPVVEPEPEPEPIPEPPKEAPVVIEKPKPK---PKPKPKPVKKVEQPKRDVKPV 121

		

		Query: 98  ITTQSTTPAPSAPVAPPAPPAAAAPVSTSVGVVCPNSTQVRAAIRYPREALKDNLTGDVV 157

		            +  ++    +AP  P +  A AA       V        R   +YP  A    + G V 

		Sbjct: 122 ESRPASPFENTAPARPTSSTATAATSKPVTSVASGPRALSRNQPQYPARAQALRIEGQVK 181

		

		Query: 158 VTFVVGTDGNVKDLSVTQSA-APVLDRAAENAVRQFHCVAQGEEVRVQVPFSFKLD 212

		           V F V  DG V ++ +  +  A + +R  +NA+R++          + V   FK++

		Sbjct: 182 VKFDVTPDGRVDNVQILSAKPANMFEREVKNAMRRWRYEPGKPGSGIVVNILFKIN 237

		

		

		>HTHFIS#FIS bacterial regulatory protein HTH signature.

		          Length = 484

		

		 Score = 93.7 bits (233), Expect = 4e-24

		 Identities = 37/135 (27%), Positives = 65/135 (48%), Gaps = 1/135 (0%)

		

		Query: 20  AIRILVVDDDSQIRSLLCDCLADFGMTTAQAGTGAEMHLALGEGGFDLVVLDLMLPDDDG 79

		              ILV DDD+ IR++L   L+  G         A +   +  G  DLVV D+++PD++ 

		Sbjct: 3   GATILVADDDAAIRTVLNQALSRAGYDVRITSNAATLWRWIAAGDGDLVVTDVVMPDENA 62

		

		Query: 80  LNLCREIRAT-SEIPLIILTARGEMTDRIVGLELGADDYIVKPFEPRELVARIQTILRRV 138

		            +L   I+    ++P+++++A+      I   E GA DY+ KPF+  EL+  I   L   

		Sbjct: 63  FDLLPRIKKARPDLPVLVMSAQNTFMTAIKASEKGAYDYLPKPFDLTELIGIIGRALAEP 122

		

		Query: 139 RAQTQGRTRAQEESR 153

		           + +        ++  

		Sbjct: 123 KRRPSKLEDDSQDGM 137

		

		

		>cloacin#Cloacin signature.

		          Length = 551

		

		 Score = 32.8 bits (74), Expect = 0.002

		 Identities = 29/105 (27%), Positives = 45/105 (42%), Gaps = 7/105 (6%)

		

		Query: 213 SGALAATGSITAQCTNGDAWKIALNGG-SSGSVTARHMQRSGGGGTIGYGLYTDAARSIA 271

		           +GA + +G+I     NG    + + GG S GS  +      GGG   G      +     

		Sbjct: 11  TGAHSTSGNI-----NGGPTGLGVGGGASDGSGWSSENNPWGGGSGSGIHWGGGSGHGNG 65

		

		Query: 272 WGDGTGGSSTVTGVGTGTSQVVTVYGAVPAQTTPAPGNYSDTITA 316

		            G+G  G  + TG G  ++    V    PA +TP  G  + +I+A

		Sbjct: 66  GGNGNSGGGSGTG-GNLSAVAAPVAFGFPALSTPGAGGLAVSISA 109

		

		

		>PF00577#Outer membrane usher protein FimD

		          Length = 878

		

		 Score =  402 bits (1035), Expect = e-130

		 Identities = 149/809 (18%), Positives = 259/809 (32%), Gaps = 91/809 (11%)

		

		Query: 64  LEVSVNGESTALL-AHFRERDGHLSA----SGADLRTIGFATDRL----GIADAATVDLD 114

		           +++ +N    A     F   D         + A L ++G  T  +     +AD A V L 

		Sbjct: 80  VDIYLNNGYMATRDVTFNTGDSEQGIVPCLTRAQLASMGLNTASVSGMNLLADDACVPLT 139

		

		Query: 115 T-IPGLHYRYDAAHQSVDLQMPDTLRRPYAVDSRALPATQEASASRGVAINYEAYAQT-- 171

		           + I     + D   Q ++L +P             +P            +NY     +  

		Sbjct: 140 SMIHDATAQLDVGQQRLNLTIPQAFMSN--RARGYIPPELWDPGINAGLLNYNFSGNSVQ 197

		

		Query: 172 --IGDRQFSLYTGVR--------YFDPNGVFNTTGTAYFYNGQRRYTRFDTSWSRSDPAR 221

		             IG      Y  ++            N  ++   +      + ++   +T   R     

		Sbjct: 198 NRIGGNSHYAYLNLQSGLNIGAWRLRDNTTWSYNSSDSSSGSKNKWQHINTWLERDIIPL 257

		

		Query: 222 PSTTQIGDAISGSLAWTRSVRLGGFQWRSNFALRPDLVTFPIPSLAGSAAVPSAVDLYIN 281

		            S   +GD  +    +   +   G Q  S+  + PD      P + G A   + V +  N

		Sbjct: 258 RSRLTLGDGYTQGDIFD-GINFRGAQLASDDNMLPDSQRGFAPVIHGIARGTAQVTIKQN 316

		

		Query: 282 NVRQYTGNVPSGPFIIHDVPGITGAGQATVITRDALGRTVATSVPLYVDTRMLSAGLSSY 341

		               Y   VP GPF I+D+     +G   V  ++A G T   +VP      +   G + Y

		Sbjct: 317 GYDIYNSTVPPGPFTINDIYAAGNSGDLQVTIKEADGSTQIFTVPYSSVPLLQREGHTRY 376

		

		Query: 342 SFEAGFLRRNYGVQSFDYDARPAVSGSMRRGITDALTVEGHAEATGGVVNAGVGALLRLG 401

		           S  AG  R     Q            ++  G+    T+ G  +          G    +G

		Sbjct: 377 SITAGEYRSGNAQQEKPRFF----QSTLLHGLPAGWTIYGGTQLADRYRAFNFGIGKNMG 432

		

		Query: 402 YAGVVSGAVAGSAGRYP---------------------GTQVS-VGYQVIEPRFSINAQT 439

		             G +S  +  +    P                     GT +  VGY+     +   A T

		Sbjct: 433 ALGALSVDMTQANSTLPDDSQHDGQSVRFLYNKSLNESGTNIQLVGYRYSTSGYFNFADT 492

		

		Query: 440 IRAFGRYGDLASRDGSPVPSATD--------------QATLALPFMHRQTLSLSYIGFRL 485

		             +     ++ ++DG                      Q T+        TL LS      

		Sbjct: 493 TYSRMNGYNIETQDGVIQVKPKFTDYYNLAYNKRGKLQLTVTQQLGRTSTLYLSGSHQTY 552

		

		Query: 486 PQGPSA-RIGTVSYTLSFGDLA-SVSVSAYRDFAQ-QGANGAFVSLNIGLGRNTSINATV 542

		               +           +F D+  ++S S  ++  Q        +++NI        ++  

		Sbjct: 553 WGTSNVDEQFQAGLNTAFEDINWTLSYSLTKNAWQKGRDQMLALNVNIPFSHWLRSDSKS 612

		

		Query: 543 GRQ------------RGQSNYTVDASRPPDYDGGWGWGVQTGGTG-----AVPYRQAQLR 585

		             +             G+             D    + VQTG  G     +     A L 

		Sbjct: 613 QWRHASASYSMSHDLNGRMTNLAGVYGTLLEDNNLSYSVQTGYAGGGDGNSGSTGYATLN 672

		

		Query: 586 YLGHAGEVIAAAQNIDRQTGASLDVSGALVFMDRSLQVSRRIDDGFALVSTDGVAGIPVL 645

		           Y G  G       + D        VSG ++     + + + ++D   LV   G     V 

		Sbjct: 673 YRGGYGNANIGYSHSDDIKQLYYGVSGGVLAHANGVTLGQPLNDTVVLVKAPGAKDAKV- 731

		

		Query: 646 HENRVIGTTDRAGHLLVPDLNAYQNNQIAIDSMKLPADARIARTSMTVVPQAQSGVVAHF 705

		            EN+    TD  G+ ++P    Y+ N++A+D+  L  +  +      VVP   + V A F

		Sbjct: 732 -ENQTGVRTDWRGYAVLPYATEYRENRVALDTNTLADNVDLDNAVANVVPTRGAIVRAEF 790

		

		Query: 706 GVSRYRAASVILRDADGRPLPAGAHVHHAESGANTIVGYDGLTFIDGLKEDNHLVIDYGT 765

		                    + L   + +PLP GA V    S ++ IV  +G  ++ G+     + + +G 

		Sbjct: 791 KARVGIKLLMTLTH-NNKPLPFGAMVTSESSQSSGIVADNGQVYLSGMPLAGKVQVKWGE 849

		

		Query: 766 ---QRCAAEFAFTAPGNGTLPTIGPLTCR 791

		                C A +         L T     CR

		Sbjct: 850 EENAHCVANYQLPPESQQQLLTQLSAECR 878

		

		

		>TCRTETA#Tetracycline resistance protein signature.

		          Length = 399

		

		 Score = 39.0 bits (91), Expect = 2e-05

		 Identities = 79/402 (19%), Positives = 135/402 (33%), Gaps = 31/402 (7%)

		

		Query: 10  RPGGSAALPLLALAAGAFGIGTTEFSPMGLLPVIADGVHVSIPQA---GMLISAYAIGVM 66

		           +P     + L  +A  A GIG      M +LP +   +  S       G+L++ YA+   

		Sbjct: 2   KPNRPLIVILSTVALDAVGIGLI----MPVLPGLLRDLVHSNDVTAHYGILLALYALMQF 57

		

		Query: 67  VGAPLMTLLLARWSRRSALIALMSIFTIGNLLSAFAPGYTTLLLARLVTSLNHGAFFGLG 126

		             AP++  L  R+ RR  L+  ++   +   + A AP    L + R+V  +        G

		Sbjct: 58  ACAPVLGALSDRFGRRPVLLVSLAGAAVDYAIMATAPFLWVLYIGRIVAGITGATGAVAG 117

		

		Query: 127 SVVAASLVPREKQASAVATMFMGLTIANVGGVPAATWLGQIIGWRMSFAATAGLGLVAIA 186

		           + + A +   +++A     M        V G      +G        F A A L  +   

		Sbjct: 118 AYI-ADITDGDERARHFGFMSACFGFGMVAGPVLGGLMGG-FSPHAPFFAAAALNGLNFL 175

		

		Query: 187 GLFAALPKGEAGKMPDLRAELSVLTRPVVLGALGTTVLGAGAMF-----------TLYTY 235

		                LP+   G+   LR E              T V    A+F            L+  

		Sbjct: 176 TGCFLLPESHKGERRPLRREALNPLASFRWARGMTVVAALMAVFFIMQLVGQVPAALWVI 235

		

		Query: 236 VAPTLEHVTGATPGFVTAMLVLIGVGFSIGNIAGGRLADRSLDGTLIGFLLLLIATMAAF 295

		                 H    T G   A   ++        +  G +A R  +   +  +L +IA    +

		Sbjct: 236 FGEDRFHWDATTIGISLAAFGILHSLAQA--MITGPVAARLGERRAL--MLGMIADGTGY 291

		

		Query: 296 PVLASTHVGAAVTLLVWGVATFAVVPPLQMRVM--RAAHEAPGLASAVNIGAFNLGNALG 353

		            +LA    G     ++  +A+  +  P    ++  +   E  G          +L + +G

		Sbjct: 292 ILLAFATRGWMAFPIMVLLASGGIGMPALQAMLSRQVDEERQGQLQGSLAALTSLTSIVG 351

		

		Query: 354 AAAGGAAISAGFGYAAVPLVGGLIAAAGLALVFLQIAQQRRA 395

		                A  +A           G    AG AL  L +   RR 

		Sbjct: 352 PLLFTAIYAASITTW-----NGWAWIAGAALYLLCLPALRRG 388

		

		

		>ARGDEIMINASE#Bacterial arginine deiminase signature.

		          Length = 409

		

		 Score = 30.2 bits (68), Expect = 0.021

		 Identities = 10/47 (21%), Positives = 19/47 (40%), Gaps = 6/47 (12%)

		

		Query: 182 QVDRIVDKVPRVDIPGDRVHFV--VEAGRPFYVEPL----FTRDPAA 222

		            + +++  V   ++          V     F ++P+    FTRDP A

		Sbjct: 121 MISKMISGVVTEELKNYTSSLDDLVNGANLFIIDPMPNVLFTRDPFA 167

		

		

		>FERRIBNDNGPP#Ferrichrome-binding periplasmic protein signature.

		          Length = 296

		

		 Score = 29.1 bits (65), Expect = 0.026

		 Identities = 48/297 (16%), Positives = 93/297 (31%), Gaps = 32/297 (10%)

		

		Query: 15  SALLPVSRRLLAAAVLGCAAAQAAAYPVTVRSCDRDVTFERAPTRAVSNDVNLTEMMLVL 74

		           S L  +SRR L           A A    +   +        P R V+ +    E++L L

		Sbjct: 2   SGLPLISRRRLL---------TAMALSPLLWQMNTAHAAAIDPNRIVALEWLPVELLLAL 52

		

		Query: 75  GLKDRLVGYTGIGGWKTGTARVRDALRGVPELASQYPSLEVLAAARADFYLAGWNYGMHV 134

		           G+     G      ++   +        +       P+LE+L   +  F +    YG   

		Sbjct: 53  GIVP--YGVADTINYRLWVSEPPLPDSVIDVGLRTEPNLELLTEMKPSFMVWSAGYGPSP 110

		

		Query: 135 GGAVTPATLAPFGIRTYELTESCSHVMKQSAASFDDVFRDLNNLGRIFGVDARAAQVVGA 194

		                 A +AP     +   +    + ++S          L  +  +  + + A   +  

		Sbjct: 111 E---MLARIAPGRGFNFSDGKQPLAMARKS----------LTEMADLLNLQSAAETHLAQ 157

		

		Query: 195 MRARL-AAVSRAIGHPAPLRVFVYDSGTDKPMTAGGLAMPTALLTAAGARNVMADLPRSW 253

		               + +   R +   A   +          +  G  ++   +L   G  N        W

		Sbjct: 158 YEDFIRSMKPRFVKRGARPLLLTTLIDPRHMLVFGPNSLFQEILDEYGIPNAWQGETNFW 217

		

		Query: 254 --TQVSWESVVA-RDPQVIVIVDYSAVTAAQKQQFLLSQPSLARVAAIRDRRFIVIP 307

		             T VS + + A +D  V+         +      L++ P    +  +R  RF  +P

		Sbjct: 218 GSTAVSIDRLAAYKDVDVLCF---DHDNSKDMDA-LMATPLWQAMPFVRAGRFQRVP 270

		

		

		>HTHFIS#FIS bacterial regulatory protein HTH signature.

		          Length = 484

		

		 Score = 74.5 bits (183), Expect = 2e-17

		 Identities = 28/136 (20%), Positives = 60/136 (44%), Gaps = 3/136 (2%)

		

		Query: 9   RVLLIEDDDRLAQLVREYLDGYEFAVTVVRRGDLAVAAVREHQPALVILDLMLPNLDGME 68

		            +L+ +DD  +  ++ + L    + V +          +      LV+ D+++P+ +  +

		Sbjct: 5   TILVADDDAAIRTVLNQALSRAGYDVRITSNAATLWRWIAAGDGDLVVTDVVMPDENAFD 64

		

		Query: 69  VCRRIRA-FTNVPVLILTARLDVYDQVAGLETGADDYVTKPIEPRVLVARARALL--RRA 125

		           +  RI+    ++PVL+++A+      +   E GA DY+ KP +   L+      L   + 

		Sbjct: 65  LLPRIKKARPDLPVLVMSAQNTFMTAIKASEKGAYDYLPKPFDLTELIGIIGRALAEPKR 124

		

		Query: 126 QPAVAEAPVATPEALV 141

		           +P+  E        LV

		Sbjct: 125 RPSKLEDDSQDGMPLV 140

		

		

		>TYPE4SSCAGX#Type IV secretion system CagX conjugation protein

		           signature.

		          Length = 522

		

		 Score = 33.6 bits (76), Expect = 0.002

		 Identities = 13/36 (36%), Positives = 21/36 (58%)

		

		Query: 227 PTQVFDDGARIYVQFSDMKHLPAIFTETSSGRVLMS 262

		           P+++FDDG   Y  F ++   PAIF     G++ M+

		Sbjct: 416 PSEIFDDGTFTYFGFKNITLQPAIFVVQPDGKLSMT 451

		

		

		>PERTACTIN#Pertactin signature.

		          Length = 922

		

		 Score = 29.7 bits (66), Expect = 0.040

		 Identities = 43/177 (24%), Positives = 67/177 (37%), Gaps = 19/177 (10%)

		

		Query: 322 LTRAGLKAGGALSDGIALGLRLGFDSGSTLDYVYRNRAQGRLGVGALIDRTY-LD-SPGW 379

		           L RA ++ G A + G   G  +   +                G G L+D  Y +D S   

		Sbjct: 253 LQRATIRRGDAPAGGAVPGGAVPGGAVPG-------------GFGPLLDGWYGVDVSDST 299

		

		Query: 380 VGIRQRKVHLQELIGAAIGRLRGHGAPVRIVDIAAGHGRYVLDAIASAAERDGAAPDDIT 439

		           V + Q  V   +L GAAI   RG    V    ++A HG  +     +      A+P  IT

		Sbjct: 300 VDLAQSIVEAPQL-GAAIRAGRGARVTVSGGSLSAPHGNVIETGGGARRFPPPASPLSIT 358

		

		Query: 440 LRDYSPPNVEAGRVLIAQRGLDPIARFERGDAFDEASLATLEPRPTLAIVSGLYELF 496

		           L+  +      GR L+ +   +P+     G A  +  +   E  P     SG  ++ 

		Sbjct: 359 LQAGARAQ---GRALLYRVLPEPVKLTLAGGAQGQGDIVATELPPIPGASSGPLDVA 412

		

		

		>PYOCINKILLER#Pyocin S killer protein signature.

		          Length = 617

		

		 Score = 30.9 bits (69), Expect = 0.010

		 Identities = 29/141 (20%), Positives = 44/141 (31%), Gaps = 17/141 (12%)

		

		Query: 202 AVAPAQAVPAGGAASHAAAATATMPAETRRHHADAAWLVVLYGMPGFGYIITATFLPVIA 261

		           A   +    A   A   AAA A   AE +     A      Y MP  G ++         

		Sbjct: 209 AAKASIEAAAANKAREQAAAEAKRKAEEQARQQAAIRAANTYAMPANGSVVA----TAAG 264

		

		Query: 262 RAALPAGSPWPDLFWPMFGAALIVGAITAARLPGHWDNRLLLAAGCATQALGIAAGIVWP 321

		           R  +        L   +  A  ++G +  A  P       ++A G A+          W 

		Sbjct: 265 RGLIQVAQGAASLAQAISDAIAVLGRV-LASAPS------VMAVGFASLTYSSRTAEQWQ 317

		

		Query: 322 NA------AGFSIGSALLGLP 336

		           +           + +A LGLP

		Sbjct: 318 DQTPDSVRYALGMDAAKLGLP 338

		

		

		>RTXTOXINA#Gram-negative bacterial RTX toxin determinant A family

		           signature.

		          Length = 1024

		

		 Score = 30.7 bits (69), Expect = 0.011

		 Identities = 24/66 (36%), Positives = 33/66 (50%), Gaps = 3/66 (4%)

		

		Query: 250 LIAAVIGGTGAFFGPAAGAAVLTALSIVVAGVSRAWALYLGVLFVVIVVAAPRG-IAGIA 308

		           L+AA    TGA    A+   + T L+ V +G+S A    L    V  +V A  G I+GI 

		Sbjct: 353 LLAAFHKETGAI--DASLTTISTVLASVSSGISAAATTSLVGAPVSALVGAVTGIISGIL 410

		

		Query: 309 QALAQA 314

		           +A  QA

		Sbjct: 411 EASKQA 416

		

		

		>DHBDHDRGNASE#2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase

		           signature.

		          Length = 261

		

		 Score =  103 bits (258), Expect = 8e-29

		 Identities = 78/251 (31%), Positives = 122/251 (48%), Gaps = 14/251 (5%)

		

		Query: 7   KVAIVTGGSKGIGAAIAKALAAEGASVV-VNYASSKAGADAVVSAIVEAGGRAVAVGGDV 65

		           K+A +TG ++GIG A+A+ LA++GA +  V+Y   K   + VVS++      A A   DV

		Sbjct: 9   KIAFITGAAQGIGEAVARTLASQGAHIAAVDYNPEKL--EKVVSSLKAEARHAEAFPADV 66

		

		Query: 66  SKAADAQRIVDTAIDTYGRLDVLVNNSGVYEFGAIEAITEEHYRRQFDTNVFGVLLMTQA 125

		             +A    I        G +D+LVN +GV   G I ++++E +   F  N  GV   +++

		Sbjct: 67  RDSAAIDEITARIEREMGPIDILVNVAGVLRPGLIHSLSDEEWEATFSVNSTGVFNASRS 126

		

		Query: 126 AVKHL--GEGASIVNISSVVTSITPPASAVYSGTKGAVDAITGVLALELGPRKIRVNAIN 183

		             K++      SIV + S    +   + A Y+ +K A    T  L LEL    IR N ++

		Sbjct: 127 VSKYMMDRRSGSIVTVGSNPAGVPRTSMAAYASSKAAAVMFTKCLGLELAEYNIRCNIVS 186

		

		Query: 184 PGMIVTEGTHS--------AGIIGSDLDKQVRSETPLGRLGEPDDIASVAVFLASDDARW 235

		           PG   T+   S          +I   L+   ++  PL +L +P DIA   +FL S  A  

		Sbjct: 187 PGSTETDMQWSLWADENGAEQVIKGSLE-TFKTGIPLKKLAKPSDIADAVLFLVSGQAGH 245

		

		Query: 236 MTGEHLVVSGG 246

		           +T  +L V GG

		Sbjct: 246 ITMHNLCVDGG 256

		

		

		>SOPEPROTEIN#Salmonella type III secretion SopE effector protein

		           signature.

		          Length = 239

		

		 Score = 30.9 bits (69), Expect = 0.006

		 Identities = 19/52 (36%), Positives = 26/52 (50%), Gaps = 8/52 (15%)

		

		Query: 148 IPPFIATLGTMVAARGFAKWFTNGMPVSMLTDQFAAIGAGANPVIIFLVIAA 199

		           I PF+  +G   AA+        G+P +   D F   GAGANP I  L+ +A

		Sbjct: 136 IAPFLQEIGE--AAK------NAGLPGTTKNDVFTPSGAGANPFITPLISSA 179

		

		

		>DNABINDINGHU#Prokaryotic integration host factor signature.

		          Length = 91

		

		 Score =  118 bits (297), Expect = 4e-38

		 Identities = 35/89 (39%), Positives = 53/89 (59%)

		

		Query: 39  TKAELAELLFDSVGLNKREAKDMVEAFFEVIRDALENGESVKLSGFGNFQLRDKPQRPGR 98

		            K +L   + ++  L K+++   V+A F  +   L  GE V+L GFGNF++R++  R GR

		Sbjct: 3   NKQDLIAKVAEATELTKKDSAAAVDAVFSAVSSYLAKGEKVQLIGFGNFEVRERAARKGR 62

		

		Query: 99  NPKTGEAIPIAARRVVTFHASQKLKALVE 127

		           NP+TGE I I A +V  F A + LK  V+

		Sbjct: 63  NPQTGEEIKIKASKVPAFKAGKALKDAVK 91

		

		

		>TCRTETOQM#Tetracycline resistance protein TetO/TetQ/TetM family

		           signature.

		          Length = 639

		

		 Score =  167 bits (425), Expect = 1e-46

		 Identities = 98/435 (22%), Positives = 171/435 (39%), Gaps = 62/435 (14%)

		

		Query: 5   LRNIAIIAHVDHGKTTLVDQLLRQSGTFRENQQIAE--RVMDSNDIEKERGITILAKNCA 62

		           + NI ++AHVD GKTTL + LL  SG   E   + +     D+  +E++RGITI     +

		Sbjct: 3   IINIGVLAHVDAGKTTLTESLLYNSGAITELGSVDKGTTRTDNTLLERQRGITIQTGITS 62

		

		Query: 63  VEYEGTHINIVDTPGHADFGGEVERVLSMVDSVLLLVDAVEGPMPQTRFVTKKALALGLK 122

		            ++E T +NI+DTPGH DF  EV R LS++D  +LL+ A +G   QTR +      +G+ 

		Sbjct: 63  FQWENTKVNIIDTPGHMDFLAEVYRSLSVLDGAILLISAKDGVQAQTRILFHALRKMGIP 122

		

		Query: 123 PIVIVNKIDRPGARIDWV-------------INQTFDLFDKLGATE----EQLDFPIV-- 163

		            I  +NKID+ G  +  V             I Q  +L+  +  T     EQ D  I   

		Sbjct: 123 TIFFINKIDQNGIDLSTVYQDIKEKLSAEIVIKQKVELYPNMCVTNFTESEQWDTVIEGN 182

		

		Query: 164 -----------------YASGLNGY---ASLDP-----AAREGDMRPLFEAVLEHVPVRP 198

		                                 +      SL P     A     +  L E +        

		Sbjct: 183 DDLLEKYMSGKSLEALELEQEESIRFHNCSLFPVYHGSAKNNIGIDNLIEVITNKFYSST 242

		

		Query: 199 ADPEAPLQLQITSLDYSTYVGRIGVGRITRGRIKPGQPVAMRFGPEGDVLNRKINQVLSF 258

		              ++ L  ++  ++YS    R+   R+  G +     V  R   +  +   KI ++ + 

		Sbjct: 243 HRGQSELCGKVFKIEYSEKRQRLAYIRLYSGVLHLRDSV--RISEKEKI---KITEMYTS 297

		

		Query: 259 TGLERVQVESAEAGDIVLINGIEDVGIGATICAVDTPEALPMITVDEPTLTMNFLVNSSP 318

		              E  +++ A +G+IV++   E + + + +           I    P L      +   

		Sbjct: 298 INGELCKIDKAYSGEIVILQN-EFLKLNSVLGDTKLLPQRERIENPLPLLQTTVEPSKPQ 356

		

		Query: 319 LAGREGKFVTSRQIRDRLMKELNHNVALRVKDTGDETVFEVSGRGELHLTILVENMRRE- 377

		                   +      D L++         V     E +  +S  G++ + +    ++ + 

		Sbjct: 357 QREMLLDALLEISDSDPLLR-------YYVDSATHEII--LSFLGKVQMEVTCALLQEKY 407

		

		Query: 378 GYELAVSRPRVVMQE 392

		             E+ +  P V+  E

		Sbjct: 408 HVEIEIKEPTVIYME 422

		

		

		

		 Score = 34.4 bits (79), Expect = 0.002

		 Identities = 16/100 (16%), Positives = 32/100 (32%), Gaps = 1/100 (1%)

		

		Query: 387 RVVMQEIDGVRHEPYELLTVDVEDEHQGGVMEELGRRKGEMLDMASDGRGRTRLEYKISA 446

		             V+++      EPY    +    E+      +  +    ++D          L  +I A

		Sbjct: 525 EQVLKKAGTELLEPYLSFKIYAPQEYLSRAYTDAPKYCANIVD-TQLKNNEVILSGEIPA 583

		

		Query: 447 RGLIGFQSEFLTLTRGTGLMSHIFDSYAPVKDGSVFERRN 486

		           R +  ++S+    T G  +       Y       V + R 

		Sbjct: 584 RCIQEYRSDLTFFTNGRSVCLTELKGYHVTTGEPVCQPRR 623

		

		

		>RTXTOXIND#Gram-negative bacterial RTX secretion protein D

		           signature.

		          Length = 478

		

		 Score = 31.7 bits (72), Expect = 0.005

		 Identities = 9/91 (9%), Positives = 31/91 (34%), Gaps = 4/91 (4%)

		

		Query: 48  EVPAPAAGVLAQVLQNDGDTVVADQIIATID---TEAKAGAAEAAAGAAEVKPAAAPAAA 104

		           E+      ++ +++  +G++V    ++  +     EA     +++   A ++        

		Sbjct: 98  EIKPIENSIVKEIIVKEGESVRKGDVLLKLTALGAEADTLKTQSSLLQARLE-QTRYQIL 156

		

		Query: 105 APAAQPVAAAASSTTASPAASKLLAEKGLSA 135

		           + + +            P    +  E+ L  

		Sbjct: 157 SRSIELNKLPELKLPDEPYFQNVSEEEVLRL 187

		

		

		>PF06776#Invasion associated locus B

		          Length = 214

		

		 Score = 27.6 bits (61), Expect = 0.020

		 Identities = 17/90 (18%), Positives = 31/90 (34%), Gaps = 4/90 (4%)

		

		Query: 6   RPFRAIAIAGVLLACAAPTFAQADNPIGMWQTIDDNTHQPKALVQIAEDGDGALTGKVVK 65

		           R    + +AG      A +F  +D      Q    + H    +      G  A    +++

		Sbjct: 47  RNGARLMLAGA--MAIALSFGWSDRADA--QGAVRSVHGDWQIRCDTPPGAKAEQCALIQ 102

		

		Query: 66  GLGANDTPDRRCTACTDERKDQLIKGMTII 95

		            + A D  +   T    +  DQ  K M ++

		Sbjct: 103 SVVAEDRSNAGLTVIILKTADQKSKLMRVV 132

		

		

		>cloacin#Cloacin signature.

		          Length = 551

		

		 Score = 29.3 bits (65), Expect = 0.046

		 Identities = 18/61 (29%), Positives = 28/61 (45%)

		

		Query: 33 GSISQGLGGGSSSGGGDTISTSGTSGTSGTSGTSGTSGTSGTSGTSGTSGTSGTSGTSGT 92

		          G    G+GGG+S G G +   +   G SG+    G     G  G +G SG    +G + +

		Sbjct: 23 GPTGLGVGGGASDGSGWSSENNPWGGGSGSGIHWGGGSGHGNGGGNGNSGGGSGTGGNLS 82

		

		Query: 93 S 93

		          +

		Sbjct: 83 A 83

		

		

		>SACTRNSFRASE#Streptothricin acetyltransferase signature.

		          Length = 173

		

		 Score = 39.2 bits (91), Expect = 2e-06

		 Identities = 17/95 (17%), Positives = 35/95 (36%), Gaps = 2/95 (2%)

		

		Query: 60  EKEWGLVLIAEADGEPVGFVSAERPVDPALGVLLDCLHVHPSYRGSGTGKRMIEAVRAWA 119

		           E+E     +   +   +G +      +     L++ + V   YR  G G  ++     WA

		Sbjct: 61  EEEGKAAFLYYLENNCIGRIKIRSNWNGYA--LIEDIAVAKDYRKKGVGTALLHKAIEWA 118

		

		Query: 120 RTLGVDTVHLRVLADNERAIGFYEHNSWQLAGIET 154

		           +      + L     N  A  FY  + + +  ++T

		Sbjct: 119 KENHFCGLMLETQDINISACHFYAKHHFIIGAVDT 153

		

		

		>PF00577#Outer membrane usher protein FimD

		          Length = 878

		

		 Score =  688 bits (1776), Expect = 0.0

		 Identities = 232/845 (27%), Positives = 359/845 (42%), Gaps = 63/845 (7%)

		

		Query: 2   RIRHSFLCVSVLVVGSQSHATEFNSSFLDIDGTSNVDLSQFSQADFTLPGEYMLDVQVND 61

		            +R    C         S    FN  FL  D  +  DLS+F       PG Y +D+ +N+

		Sbjct: 27  FVRLFVACAFAAQAPLSSAELYFNPRFLADDPQAVADLSRFENGQELPPGTYRVDIYLNN 86

		

		Query: 62  LFLGLQAIEFVAVDTSGAGKPCLRPELVARFGLKPSLAKDLPRFQGGSCVDLT-AIEGAT 120

		            ++  + + F   D+     PCL    +A  GL  +    +      +CV LT  I  AT

		Sbjct: 87  GYMATRDVTFNTGDSEQGIVPCLTRAQLASMGLNTASVSGMNLLADDACVPLTSMIHDAT 146

		

		Query: 121 VRYLKSDGRLKITIPQAALEFTDSTYLPPENWSEGIPGAMLDYRVIANTNRSFGADGGQN 180

		            +      RL +TIPQA +      Y+PPE W  GI   +L+Y    N+ ++    GG +

		Sbjct: 147 AQLDVGQQRLNLTIPQAFMSNRARGYIPPELWDPGINAGLLNYNFSGNSVQNRI--GGNS 204

		

		Query: 181 NSIQAYGTIGANWDAWRFRGDYQAQSNSGNKAYADRT-FRFSRLYAFRALPSIQSTATFG 239

		           +        G N  AWR R +     NS + +   +  ++    +  R +  ++S  T G

		Sbjct: 205 HYAYLNLQSGLNIGAWRLRDNTTWSYNSSDSSSGSKNKWQHINTWLERDIIPLRSRLTLG 264

		

		Query: 240 EDYLSSDIFDTFALTGASIRSDDRMLPPSLRGYAPLISGVARTNATVTVSQAGRVLYVTR 299

		           + Y   DIFD     GA + SDD MLP S RG+AP+I G+AR  A VT+ Q G  +Y + 

		Sbjct: 265 DGYTQGDIFDGINFRGAQLASDDNMLPDSQRGFAPVIHGIARGTAQVTIKQNGYDIYNST 324

		

		Query: 300 VSPGAFALQNIN-TSVQGTLDVAVEEEDGSVQRFQVTTAAVPFLARAGQLRYKMALGKPR 358

		           V PG F + +I      G L V ++E DGS Q F V  ++VP L R G  RY +  G+ R

		Sbjct: 325 VPPGPFTINDIYAAGNSGDLQVTIKEADGSTQIFTVPYSSVPLLQREGHTRYSITAGEYR 384

		

		Query: 359 QFGGAGITPFFGFGEVAYGLPLDFTVYGGFIAASGYTSIALGVGRDFGTFGALSADVTHA 418

		                   P F    + +GLP  +T+YGG   A  Y +   G+G++ G  GALS D+T A

		Sbjct: 385 SGNAQQEKPRFFQSTLLHGLPAGWTIYGGTQLADRYRAFNFGIGKNMGALGALSVDMTQA 444

		

		Query: 419 RARLWWNGATRNGNSYRVNYSKHFDGLDADVRFFGYRFSERDYTNFAQFTGDPTSYGL-- 476

		            + L  + +  +G S R  Y+K  +    +++  GYR+S   Y NFA  T    +     

		Sbjct: 445 NSTL-PDDSQHDGQSVRFLYNKSLNESGTNIQLVGYRYSTSGYFNFADTTYSRMNGYNIE 503

		

		Query: 477 -------------------ANSKQRYSASMSKRFGDTST-YFSYDQTTYW-ARESEQRVG 515

		                               N + +   +++++ G TST Y S    TYW     +++  

		Sbjct: 504 TQDGVIQVKPKFTDYYNLAYNKRGKLQLTVTQQLGRTSTLYLSGSHQTYWGTSNVDEQFQ 563

		

		Query: 516 ITLTRSFSIGALRNLSVNLSAFRTQSAGGSGNQFSINATLPIGVKHTLTSNVTTGSGSTS 575

		             L  +F      +++  LS   T++A   G    +   + I   H L S+  +     S

		Sbjct: 564 AGLNTAF-----EDINWTLSYSLTKNAWQKGRDQMLALNVNIPFSHWLRSDSKSQWRHAS 618

		

		Query: 576 VNAGYIYD----------------DSDGRTYQINTGATDGRASANASFRQRSSTYQ---- 615

		            +    +D                + +  +Y + TG   G    + S    +  Y+    

		Sbjct: 619 ASYSMSHDLNGRMTNLAGVYGTLLEDNNLSYSVQTGYAGGGDGNSGSTGYATLNYRGGYG 678

		

		Query: 616 -LNAQASTLANSYAAASLEVDGSFVATQYGISAHANGNAGDTRLLVSTDGVPDVPLS-GS 673

		             N   S  ++        V G  +A   G++        DT +LV   G  D  +   +

		Sbjct: 679 NANIGYSH-SDDIKQLYYGVSGGVLAHANGVTLGQPL--NDTVVLVKAPGAKDAKVENQT 735

		

		Query: 674 LTHTDSRGYGVLDGISPYNVYDATVNVEKLPLEVQVTNPIQRMVLTDGAIGFVKFTAARG 733

		              TD RGY VL   + Y      ++   L   V + N +  +V T GAI   +F A  G

		Sbjct: 736 GVRTDWRGYAVLPYATEYRENRVALDTNTLADNVDLDNAVANVVPTRGAIVRAEFKARVG 795

		

		Query: 734 SNLYLTLTDAAGKPLPFGASVQDAANGKELGIVGEGGAAFLTQVQPKSTLAVRAGERT-- 791

		             L +TLT    KPLPFGA V    + +  GIV + G  +L+ +     + V+ GE    

		Sbjct: 796 IKLLMTLTH-NNKPLPFGAMVTS-ESSQSSGIVADNGQVYLSGMPLAGKVQVKWGEEENA 853

		

		Query: 792 LCTVD 796

		            C  +

		Sbjct: 854 HCVAN 858

		

		

		>PF05272#Virulence-associated E family protein

		          Length = 892

		

		 Score = 28.9 bits (64), Expect = 0.028

		 Identities = 12/23 (52%), Positives = 13/23 (56%)

		

		Query: 35  VTALCGPNGCGKSTLLRTLAGLQ 57

		              L G  G GKSTL+ TL GL 

		Sbjct: 598 SVVLEGTGGIGKSTLINTLVGLD 620

		

		

		>2FE2SRDCTASE#Ferric iron reductase signature.

		          Length = 262

		

		 Score = 81.2 bits (200), Expect = 2e-20

		 Identities = 65/212 (30%), Positives = 95/212 (44%), Gaps = 20/212 (9%)

		

		Query: 49  TLPDHRSAILDAMVGHYGGDPAQHAR---ALMSQWSKYYFGRAAPAGVVAALTLGRPLDM 105

		           + P+  S++L     H   +     R    L+S W+++Y G   P  ++A LT  + LD+

		Sbjct: 61  SSPNVLSSLLAVYSDHIYRNQPMMIRENKPLISLWAQWYIGLMVPPLMLALLTQEKALDV 120

		

		Query: 106 SPERTFVAL-DDGMPAALYF--PHDALGAPCDDPAPRYAGLIAH-LGAVIDLLAAMGRVT 161

		           SPE       + G  A  +     D    P   P  R   LI+  L  V+  L A G + 

		Sbjct: 121 SPEHFHAEFHETGRVACFWVDVCEDKNATP-HSPQHRMETLISQALVPVVQALEATGEIN 179

		

		Query: 162 PRVLWSNAGNLLDYLLDTYRSLPCAA--DPVRDADWLFGSSCVHGEPNPLRVPVRDAVPR 219

		            +++WSN G L+++ L   + L   A  + +R A   F  +  +GE NPL    R  V R

		Sbjct: 180 GKLIWSNTGYLINWYLTEMKQLLGEATVESLRHA-LFFEKTLTNGEDNPL---WRTVVLR 235

		

		Query: 220 SALLPTPFRARRVCCLRYEIPGETQLCGSCPL 251

		             LL      RR CC RY +P   Q CG C L

		Sbjct: 236 DGLL-----VRRTCCQRYRLPD-VQQCGDCTL 261

		

		

		>FERRIBNDNGPP#Ferrichrome-binding periplasmic protein signature.

		          Length = 296

		

		 Score =  121 bits (304), Expect = 4e-34

		 Identities = 68/272 (25%), Positives = 119/272 (43%), Gaps = 15/272 (5%)

		

		Query: 68  PQRVVALDFMFAESVIALDIVPVGMADTAFYPGWLGYQSERLANVTDIGSRQEPGLEAIA 127

		           P R+VAL+++  E ++AL IVP G+ADT  Y  W+  +     +V D+G R EP LE + 

		Sbjct: 35  PNRIVALEWLPVELLLALGIVPYGVADTINYRLWVS-EPPLPDSVIDVGLRTEPNLELLT 93

		

		Query: 128 AVKPDLIIGVGFRHAPIFDALDRIAPTILFQFSPNVSDGGVPVTQLDWMRQIFRTIGAVT 187

		            +KP  ++     + P  + L RIAP   F FS            L   R+    +  + 

		Sbjct: 94  EMKPSFMVW-SAGYGPSPEMLARIAPGRGFNFSDGKQ-------PLAMARKSLTEMADLL 145

		

		Query: 188 GRDARAQAVDAQLDAGIARNAARLAAAGRKGERVALLQDLGLPDRYWAYTGNSTSAGLAR 247

		              + A+   AQ +  I     R     ++G R  LL  L  P     +  NS    +  

		Sbjct: 146 NLQSAAETHLAQYEDFIRSMKPRFV---KRGARPLLLTTLIDPRHMLVFGPNSLFQEILD 202

		

		Query: 248 ALGL-DPWPKKPTREGTLYVTSADLLKQRELAVLFVTASGMDVPLSAKLDSPVWRYVPAM 306

		             G+ + W  +    G+  V+   L   +++ VL          + A + +P+W+ +P +

		Sbjct: 203 EYGIPNAWQGETNFWGSTAVSIDRLAAYKDVDVLCFDHDNSKD-MDALMATPLWQAMPFV 261

		

		Query: 307 KDHRIALIERNIWGFGGPMSALKLADVMTDTM 338

		           +  R   +   +W +G  +SA+    V+ + +

		Sbjct: 262 RAGRFQRVP-AVWFYGATLSAMHFVRVLDNAI 292