PredictBias

		>RTXTOXIND#Gram-negative bacterial RTX secretion protein D

		           signature.

		          Length = 478

		

		 Score = 50.2 bits (120), Expect = 4e-09

		 Identities = 22/159 (13%), Positives = 55/159 (34%), Gaps = 12/159 (7%)

		

		Query: 8   IIRVGITVLVVVLAVIAIFNVWAFYT--ESPWTRDAKFTAD--VVAIAPDVSGLLTEVPV 63

		           + R    V   ++  + I  + +     E   T + K T       I P  + ++ E+ V

		Sbjct: 53  VSRRPRLVAYFIMGFLVIAFILSVLGQVEIVATANGKLTHSGRSKEIKPIENSIVKEIIV 112

		

		Query: 64  KDNQLVQKGQILFVIDQPRYQQALAEAEADVAYYQTLAAEKQRESSRRHRLGIQALS--- 120

		           K+ + V+KG +L  +     +    + ++ +   +      Q  S       +  L    

		Sbjct: 113 KEGESVRKGDVLLKLTALGAEADTLKTQSSLLQARLEQTRYQILSRSIELNKLPELKLPD 172

		

		Query: 121 -----QEEIDQASNVLQTVQHQLAKAIAVRDLARLDLER 154

		                    ++   +   ++ Q +     +    L+L++

		Sbjct: 173 EPYFQNVSEEEVLRLTSLIKEQFSTWQNQKYQKELNLDK 211

		

		

		

		 Score = 46.7 bits (111), Expect = 6e-08

		 Identities = 33/178 (18%), Positives = 60/178 (33%), Gaps = 17/178 (9%)

		

		Query: 62  PVKDNQLVQKGQILFVIDQPRYQQALAEAEADVAYY--QTLAAEKQRESSRRHRLGIQAL 119

		            +   Q + K  +L        +    EA  ++  Y  Q    E +  S++     +  L

		Sbjct: 242 SLLHKQAIAKHAVL------EQENKYVEAVNELRVYKSQLEQIESEILSAKEEYQLVTQL 295

		

		Query: 120 SQEEIDQASNVLQTVQHQLAKAIAVRDLARLDLERTTVRAPAEGWVTNLNVHA-GEFINR 178

		            + EI      L+     +              + + +RAP    V  L VH  G  +  

		Sbjct: 296 FKNEILDK---LRQTTDNIGLLTLELAKNEERQQASVIRAPVSVKVQQLKVHTEGGVVTT 352

		

		Query: 179 GATAVALVKKDTFYIL-AYLEETKLEGVKPGYRAEIT----PLGSNRILHGTVDSISA 231

		             T + +V +D    + A ++   +  +  G  A I     P      L G V +I+ 

		Sbjct: 353 AETLMVIVPEDDTLEVTALVQNKDIGFINVGQNAIIKVEAFPYTRYGYLVGKVKNINL 410

		

		

		>PF05272#Virulence-associated E family protein

		          Length = 892

		

		 Score = 30.8 bits (69), Expect = 0.006

		 Identities = 13/30 (43%), Positives = 15/30 (50%)

		

		Query: 44  VGRSGCGKSTLLRLLAGLEAASDGTLLSGN 73

		            G  G GKSTL+  L GL+  SD     G 

		Sbjct: 602 EGTGGIGKSTLINTLVGLDFFSDTHFDIGT 631

		

		

		>adhesinmafb#Neisseria meningitidis: adhesin MafB signature.

		          Length = 467

		

		 Score = 36.6 bits (84), Expect = 2e-04

		 Identities = 14/32 (43%), Positives = 18/32 (56%)

		

		Query: 118 NPLHKRRFAQQILKRFDSASSSFSQRADEAQR 149

		           NP   R   Q+I   + +  S+FS RADEA R

		Sbjct: 178 NPTDTRSIRQRISDNYSNLGSNFSDRADEANR 209

		

		

		>HTHFIS#FIS bacterial regulatory protein HTH signature.

		          Length = 484

		

		 Score = 34.8 bits (80), Expect = 3e-04

		 Identities = 7/47 (14%), Positives = 16/47 (34%)

		

		Query: 215 DSLTTAVETFECAVLTQRQRLYGNDKSRIAASLGLSLRALTYKLAKY 261

		                 +   E  ++         ++ + A  LGL+   L  K+ + 

		Sbjct: 427 GLYDRVLAEMEYPLILAALTATRGNQIKAADLLGLNRNTLRKKIREL 473

		

		

		>HTHTETR#TetR bacterial regulatory protein HTH signature.

		          Length = 215

		

		 Score = 28.1 bits (62), Expect = 0.047

		 Identities = 12/106 (11%), Positives = 31/106 (29%), Gaps = 14/106 (13%)

		

		Query: 16  QGMSSRAIARELGISRNTVKRYLQAKSEPPKYTPRPAVASLLDEYRDYIRQRIAD----- 70

		              S   IA+  G++R  +  + + KS+          + + +     I +   +     

		Sbjct: 30  SSTSLGEIAKAAGVTRGAIYWHFKDKSD--------LFSEIWELSESNIGELELEYQAKF 81

		

		Query: 71  -AHPYKIPATVIAREIRDQGYRGGMTILRAFIRSLSVPQEQEPAVR 115

		              P  +   ++   +          +L   I        +   V+

		Sbjct: 82  PGDPLSVLREILIHVLESTVTEERRRLLMEIIFHKCEFVGEMAVVQ 127

		

		

		>TYPE3IMQPROT#Type III secretion system inner membrane Q protein

		           family signature.

		          Length = 86

		

		 Score = 27.8 bits (62), Expect = 0.034

		 Identities = 11/32 (34%), Positives = 17/32 (53%)

		

		Query: 302 IGVFIMMFLYGGWLVWVVLGFTAMYMILRLAT 333

		           +GV + +FL  GW   V+L +    + L LA 

		Sbjct: 54  LGVCLCLFLLSGWYGEVLLSYGRQVIFLALAK 85

		

		

		>RTXTOXIND#Gram-negative bacterial RTX secretion protein D

		           signature.

		          Length = 478

		

		 Score =  108 bits (272), Expect = 7e-28

		 Identities = 83/430 (19%), Positives = 163/430 (37%), Gaps = 62/430 (14%)

		

		Query: 41  FIAALCAIFLVLLITLIIYGTYTRRINVNGEVISQPHPINIFSPQQGFITKKWVEVGDIV 100

		            +A     FLV+   L + G        NG++        I   +   + +  V+ G+ V

		Sbjct: 59  LVAYFIMGFLVIAFILSVLGQVEIVATANGKLTHSGRSKEIKPIENSIVKEIIVKEGESV 118

		

		Query: 101 RKGQHLYQIDV--SRTTFSGNVSLNSLEAINNQLSQIDSIINNTQKNKELTLLN------ 152

		           RKG  L ++    +        S      +     QI S      K  EL L +      

		Sbjct: 119 RKGDVLLKLTALGAEADTLKTQSSLLQARLEQTRYQILSRSIELNKLPELKLPDEPYFQN 178

		

		Query: 153 ------------LRQQLAQYQKAHKKSQELVDNAGKGMDDMRRTMASYGTYQRQGLITKD 200

		                       +++Q + +Q    + +  +D        +   +  Y   +    + K 

		Sbjct: 179 VSEEEVLRLTSLIKEQFSTWQNQKYQKELNLDKKRAERLTVLARINRY---ENLSRVEKS 235

		

		Query: 201 QLTNQRSLF----------YQQQNAFQSLNTQLIQESLQIAKLESEIS-------TRASD 243

		           +L +  SL            +Q+N +     +L     Q+ ++ESEI             

		Sbjct: 236 RLDDFSSLLHKQAIAKHAVLEQENKYVEAVNELRVYKSQLEQIESEILSAKEEYQLVTQL 295

		

		Query: 244 FDNDISQYLFQKGD----LKRQLAEVDA-SGMLLINSPSDGKIENMSV-TQGQMVNVNDS 297

		           F N+I   L Q  D    L  +LA+ +      +I +P   K++ + V T+G +V   ++

		Sbjct: 296 FKNEILDKLRQTTDNIGLLTLELAKNEERQQASVIRAPVSVKVQQLKVHTEGGVVTTAET 355

		

		Query: 298 LVQLTPSDNPYYCLVLWVPNNSVPYINTGDKVNIRYDAFPFEKFGQFPGRIISISNVPVS 357

		           L+ + P D+      L V N  + +IN G    I+ +AFP+ ++G   G++ +I+   + 

		Sbjct: 356 LMVIVPEDDTLEVTAL-VQNKDIGFINVGQNAIIKVEAFPYTRYGYLVGKVKNINLDAIE 414

		

		Query: 358 QQEIASYNIAPRLPNGGLIEPYYKVIVALDDIHFRYQSKPLMLSNGLKANVTLFLEKRPL 417

		            Q +                  + VI+++++      +K + LS+G+     +    R +

		Sbjct: 415 DQRLG---------------LVFNVIISIEENCLSTGNKNIPLSSGMAVTAEIKTGMRSV 459

		

		Query: 418 YQWMLSPFYD 427

		             ++LSP  +

		Sbjct: 460 ISYLLSPLEE 469

		

		

		>HTHFIS#FIS bacterial regulatory protein HTH signature.

		          Length = 484

		

		 Score = 43.7 bits (103), Expect = 1e-06

		 Identities = 42/185 (22%), Positives = 66/185 (35%), Gaps = 47/185 (25%)

		

		Query: 187 EPAPSPDNHLDLHDIIGQSQA----KRALEIAAAGGHNLLLLGPPGTGKTMLATRLTGLL 242

		            P+   D+  D   ++G+S A     R L         L++ G  GTGK ++A R     

		Sbjct: 125 RPSKLEDDSQDGMPLVGRSAAMQEIYRVLARLMQTDLTLMITGESGTGKELVA-RALHDY 183

		

		Query: 243 PPLTDQE--ALEAAAIT-GLLHSNALPTQWRCRAFRAPHHSASMAALIG-------GGSI 292

		               +    A+  AAI   L+ S                       L G       G   

		Sbjct: 184 GKRRNGPFVAINMAAIPRDLIES----------------------ELFGHEKGAFTGAQT 221

		

		Query: 293 PRPGEISLAHNGVLFLDEL----PEFERRVLDSLREPLESGEIIISRAAAKICFPAKVQL 348

		              G    A  G LFLDE+     + + R+L  L++    GE   +    +    + V++

		Sbjct: 222 RSTGRFEQAEGGTLFLDEIGDMPMDAQTRLLRVLQQ----GE--YTTVGGRTPIRSDVRI 275

		

		Query: 349 IAAMN 353

		           +AA N

		Sbjct: 276 VAATN 280

		

		

		>RTXTOXIND#Gram-negative bacterial RTX secretion protein D

		          signature.

		          Length = 478

		

		 Score = 28.6 bits (64), Expect = 0.011

		 Identities = 11/45 (24%), Positives = 16/45 (35%), Gaps = 3/45 (6%)

		

		Query: 2  RLPGA---VMKAKSKKIICALLLLGSILLGYFFWLSLRPVEIVAI 43

		           LP     +    S++       +   L+  F    L  VEIVA 

		Sbjct: 41 FLPAHLELIETPVSRRPRLVAYFIMGFLVIAFILSVLGQVEIVAT 85

		

		

		>RTXTOXIND#Gram-negative bacterial RTX secretion protein D

		          signature.

		          Length = 478

		

		 Score = 30.2 bits (68), Expect = 0.003

		 Identities = 10/36 (27%), Positives = 13/36 (36%)

		

		Query: 1  MKAKSKKTLYALLLIGSVLLGYFFWLSLRPVEIVAV 36

		              S++       I   L+  F    L  VEIVA 

		Sbjct: 50 ETPVSRRPRLVAYFIMGFLVIAFILSVLGQVEIVAT 85

		

		

		>PYOCINKILLER#Pyocin S killer protein signature.

		          Length = 617

		

		 Score = 94.5 bits (234), Expect = 1e-22

		 Identities = 96/354 (27%), Positives = 143/354 (40%), Gaps = 55/354 (15%)

		

		Query: 6   QQQRVNADLETAKITEPQRVENARLTAEAAEKAARDRRISEEIAATEAKRQRMENERLAE 65

		                N  L T  I+  Q   N    A+A+ +AA   +  E+ AA EAKR+  E  R   

		Sbjct: 184 LTAAYNVKLFTEAISSLQIRMNTLTAAKASIEAAAANKAREQAAA-EAKRKAEEQARQQA 242

		

		Query: 66  QERQRVEGTKQQVSEASCAQQASAWQNRFTLPALQPSGSAQYSFAASGMSAVGE-AAELH 124

		             R                       N + +PA   +GS   + A  G+  V + AA L 

		Sbjct: 243 AIRA---------------------ANTYAMPA---NGSVVATAAGRGLIQVAQGAASLA 278

		

		Query: 125 NSFLAAQEQLSAIATISASGSVAAMIALGIYQTKVGESSERPPGWNVSPKFVGSISLSAM 184

		            +   A   L  +   SA   +A   A   Y ++   + +       S ++   +  + +

		Sbjct: 279 QAISDAIAVLGRVLA-SAPSVMAVGFASLTYSSRT--AEQWQDQTPDSVRYALGMDAAKL 335

		

		Query: 185 GLPATESL----ASQGEMALPVRMRIIDAKDWIGCTEIYAVKTGVAGVLPK-VKVGAAQY 239

		           GLP + +L     + G + LP  MR+ +     G T   +V +     +PK V V  A Y

		Sbjct: 336 GLPPSVNLNAVAKASGTVDLP--MRLTNEAR--GNTTTLSVVSTDGVSVPKAVPVRMAAY 391

		

		Query: 240 DESTGVYTFTTDST----PPRTLIFTPAQPPGAETRPILAPPGSTPATLQHTGEM---II 292

		           + +TG+Y  T  ST    PP  L +TPA PPG +      P  +TP   +         +

		Sbjct: 392 NATTGLYEVTVPSTTAEAPPLILTWTPASPPGNQN-----PSSTTPVVPKPVPVYEGATL 446

		

		Query: 293 KPVITPTILPLPQLYARDFHDYIIWFPADSGLEPVYVYLNSPY---GKTTAKGK 343

		            PV   T    P +      D II FPADSG++P+YV    P    G  T KG+

		Sbjct: 447 TPV-KATPETYPGVITLP-EDLIIGFPADSGIKPIYVMFRDPRDVPGAATGKGQ 498

		

		

		>PF00577#Outer membrane usher protein FimD

		          Length = 878

		

		 Score =  762 bits (1970), Expect = 0.0

		 Identities = 252/900 (28%), Positives = 399/900 (44%), Gaps = 79/900 (8%)

		

		Query: 15  RRKALTLCITLILHIDTAFGQEEP---QNFEFDESLFLGTKYASG-LTQLNKKNSITAGN 70

		            RK       + L +  AF  + P       F+         A   L++      +  G 

		Sbjct: 18  IRKHRLAGFFVRLFVACAFAAQAPLSSAELYFNPRFLADDPQAVADLSRFENGQELPPGT 77

		

		Query: 71  YDAVDVLVNNKLFKRMSVQFIKDANSSEVYPCLSDELLTAAGVELGRENSTPPKEPHVTE 130

		           Y  VD+ +NN       V F    +   + PCL+   L + G+     +           

		Sbjct: 78  Y-RVDIYLNNGYMATRDVTFNTGDSEQGIVPCLTRAQLASMGLNTASVSG---------- 126

		

		Query: 131 ANTPITETHAPTNQCLPLSTRVKGASFRFDQAKLRLELSIPQALLQKRPRGYIERAEWQE 190

		                       + C+PL++ +  A+ + D  + RL L+IPQA +  R RGYI    W  

		Sbjct: 127 ------MNLLADDACVPLTSMIHDATAQLDVGQQRLNLTIPQAFMSNRARGYIPPELWDP 180

		

		Query: 191 GEKLAFINYSANAYRSDTRGQQKRTSDFGFIGLKSGINLGLWQVRQQSNVRYASN--DSG 248

		           G     +NY+ +      R      S + ++ L+SG+N+G W++R  +   Y S+   SG

		Sbjct: 181 GINAGLLNYNFSGNSVQNRIGG--NSHYAYLNLQSGLNIGAWRLRDNTTWSYNSSDSSSG 238

		

		Query: 249 SDTQWNSIRTYVQRPIPQLDSQLTLGETFTDSTLFGSMSFLGAKMATDQRMWPVSMRGFS 308

		           S  +W  I T+++R I  L S+LTLG+ +T   +F  ++F GA++A+D  M P S RGF+

		Sbjct: 239 SKNKWQHINTWLERDIIPLRSRLTLGDGYTQGDIFDGINFRGAQLASDDNMLPDSQRGFA 298

		

		Query: 309 PEVRGVASTNARVIIRQNGREIYETNVAPGPFVINDLFSTSSQGDLNVEVIEANGSRSTF 368

		           P + G+A   A+V I+QNG +IY + V PGPF IND+++  + GDL V + EA+GS   F

		Sbjct: 299 PVIHGIARGTAQVTIKQNGYDIYNSTVPPGPFTINDIYAAGNSGDLQVTIKEADGSTQIF 358

		

		Query: 369 TVPFSAVPDSMRPGVSRYNAVIGESRDFTN--IDNYFTDFTYERGLTNQLTANSGVRLAK 426

		           TVP+S+VP   R G +RY+   GE R          F   T   GL    T   G +LA 

		Sbjct: 359 TVPYSSVPLLQREGHTRYSITAGEYRSGNAQQEKPRFFQSTLLHGLPAGWTIYGGTQLAD 418

		

		Query: 427 DYTALLAGGVLGT-PVGALGLNATYSHAKVENDKTQDGWRMQATYSQTFNQTGTTFSLAG 485

		            Y A   G       +GAL ++ T +++ + +D   DG  ++  Y+++ N++GT   L G

		Sbjct: 419 RYRAFNFGIGKNMGALGALSVDMTQANSTLPDDSQHDGQSVRFLYNKSLNESGTNIQLVG 478

		

		Query: 486 YRYSTKGYRDLNDVFGVRSMQKNGGTWD-------------SSTYKQRSQFTTTINQDLG 532

		           YRYST GY +  D    R    N  T D             +  Y +R +   T+ Q LG

		Sbjct: 479 YRYSTSGYFNFADTTYSRMNGYNIETQDGVIQVKPKFTDYYNLAYNKRGKLQLTVTQQLG 538

		

		Query: 533 NWGQLYASASTSDYYNDTARDTQLQLGYSNSYQQISYNLAVSRQRSVYTSTLYNWDSPDT 592

		               LY S S   Y+  +  D Q Q G + +++ I++ L+ S  ++ +            

		Sbjct: 539 RTSTLYLSGSHQTYWGTSNVDEQFQAGLNTAFEDINWTLSYSLTKNAWQ----------- 587

		

		Query: 593 DETATTTRYGNTENIATFTVSIPL--------NIGSNNQYLSMSASRNPKSGNNYQTSLS 644

		                       + +    V+IP              +   S S S +          + 

		Sbjct: 588 ---------KGRDQMLALNVNIPFSHWLRSDSKSQWRHASASYSMSHDLNGRMTNLAGVY 638

		

		Query: 645 GTAGERNSFNYALNAGYDDSNFGSSSNNWGANVQKQFPNATVNGSYSRGNNYTQYGAGAR 704

		           GT  E N+ +Y++  GY     G+S +   A +  +      N  YS  ++  Q   G  

		Sbjct: 639 GTLLEDNNLSYSVQTGYAGGGDGNSGSTGYATLNYRGGYGNANIGYSHSDDIKQLYYGVS 698

		

		Query: 705 GAAVIHRQGVTLGPYLGETFGLIEANGAQGARI--------DSNGFALVPALTPYNYNTI 756

		           G  + H  GVTLG  L +T  L++A GA+ A++        D  G+A++P  T Y  N +

		Sbjct: 699 GGVLAHANGVTLGQPLNDTVVLVKAPGAKDAKVENQTGVRTDWRGYAVLPYATEYRENRV 758

		

		Query: 757 GLDTKGINRNTELKENQGRVVPYAGAAVKVKFETLTGYAVLI--QAEGEGLPLGADVYNS 814

		            LDT  +  N +L      VVP  GA V+ +F+   G  +L+      + LP GA V + 

		Sbjct: 759 ALDTNTLADNVDLDNAVANVVPTRGAIVRAEFKARVGIKLLMTLTHNNKPLPFGAMVTSE 818

		

		Query: 815 KDELVGMVGQGNQIYARIADNKGTLDVRWGESSGDQCQLPYAFNRQDTEQDIIHITASCR 874

		             +  G+V    Q+Y       G + V+WGE     C   Y    +  +Q +  ++A CR

		Sbjct: 819 SSQSSGIVADNGQVYLSGMPLAGKVQVKWGEEENAHCVANYQLPPESQQQLLTQLSAECR 878

		

		

		>MALTOSEBP#Maltose binding protein signature.

		          Length = 396

		

		 Score = 26.2 bits (57), Expect = 0.031

		 Identities = 13/38 (34%), Positives = 18/38 (47%)

		

		Query: 43  LTFENGSKIVINRQEPLHQVWLATKAGGYHFNYRDGHW 80

		           L  +  S ++ N QEP     L    GGY F Y +G +

		Sbjct: 165 LKAKGKSALMFNLQEPYFTWPLIAADGGYAFKYENGKY 202

		

		

		>V8PROTEASE#V8 serine protease family signature.

		          Length = 336

		

		 Score = 31.1 bits (70), Expect = 0.008

		 Identities = 7/43 (16%), Positives = 18/43 (41%)

		

		Query: 293 AYGAPKAITSFVVPTGYSFNLDGSTLYQSIAAIFIAQLYGIEL 335

		           +  A   +   +  TGY  +   +T+++S   I   +   ++ 

		Sbjct: 186 SNNAETQVNQNITVTGYPGDKPVATMWESKGKITYLKGEAMQY 228

		

		

		>HTHFIS#FIS bacterial regulatory protein HTH signature.

		          Length = 484

		

		 Score = 59.1 bits (143), Expect = 2e-12

		 Identities = 26/127 (20%), Positives = 53/127 (41%), Gaps = 3/127 (2%)

		

		Query: 3   TKLLIVDDHELIIHGIKNMLAAYPRYLIVGQADNGLEVYNLCRQTEPDMVILDLGLPGMD 62

		             +L+ DD   I   +   L+       V    N   ++      + D+V+ D+ +P  +

		Sbjct: 4   ATILVADDDAAIRTVLNQALS--RAGYDVRITSNAATLWRWIAAGDGDLVVTDVVMPDEN 61

		

		Query: 63  GLDVIIQLLRRWPALKILTLTARNEEHYASRTFNSGALGYVLKKSPQQILMAAIQTVAIG 122

		             D++ ++ +  P L +L ++A+N    A +    GA  Y+ K      L+  I   A+ 

		Sbjct: 62  AFDLLPRIKKARPDLPVLVMSAQNTFMTAIKASEKGAYDYLPKPFDLTELIGIIGR-ALA 120

		

		Query: 123 KRYIDPA 129

		           +    P+

		Sbjct: 121 EPKRRPS 127

		

		

		>HTHFIS#FIS bacterial regulatory protein HTH signature.

		          Length = 484

		

		 Score = 79.1 bits (195), Expect = 2e-17

		 Identities = 36/173 (20%), Positives = 64/173 (36%), Gaps = 14/173 (8%)

		

		Query: 685 HILLVDDSETNRDITGMMLQQLGHQVTRADSGTTALAIGRQHRFDLVLMDIRMPVLDGLA 744

		            IL+ DD    R +    L + G+ V    +  T          DLV+ D+ MP  +   

		Sbjct: 5   TILVADDDAAIRTVLNQALSRAGYDVRITSNAATLWRWIAAGDGDLVVTDVVMPDENAFD 64

		

		Query: 745 TTARWRHDPANIDSHCMITALSANASPDEQIKTSQAGMNHYLSKPVTLGQLAEMLDLTAQ 804

		              R +           +  +SA  +    IK S+ G   YL KP     L E++ +  +

		Sbjct: 65  LLPRIK----KARPDLPVLVMSAQNTFMTAIKASEKGAYDYLPKPF---DLTELIGIIGR 117

		

		Query: 805 FQLERGVDLSPQLSEPQPLLDL-ADSALSLKLYQSLQVLIQQAKDAIENLPVL 856

		              E     S    + Q  + L   SA   ++Y+    ++ +      +L ++

		Sbjct: 118 ALAEPKRRPSKLEDDSQDGMPLVGRSAAMQEIYR----VLARLMQT--DLTLM 164

		

		

		>TYPE3OMGPROT#Type III secretion system outer membrane G protein

		           family signature.

		          Length = 607

		

		 Score =  479 bits (1233), Expect = e-166

		 Identities = 160/514 (31%), Positives = 269/514 (52%), Gaps = 21/514 (4%)

		

		Query: 22  IYIMRKITGLILLFFATLLPYGKFSYVKAIPWQGEPFFIYSRGMTVSELLKDLGMNYGIP 81

		            +  R +TG +LL  +        S+ + + W   P+   ++G ++ +LL D G NY   

		Sbjct: 7   SFFKRVLTGTLLLLSSY-------SWAQELDWLPIPYVYVAKGESLRDLLTDFGANYDAT 59

		

		Query: 82  VVISSEINEHFTGKIRDKTPEKILSELAGRYNITWYYDGETLYFYPVQSIKREFISPDGL 141

		           VV+S +IN+  +G+     P+  L  +A  YN+ WYYDG  LY +    +    I     

		Sbjct: 60  VVVSDKINDKVSGQFEHDNPQDFLQHIASLYNLVWYYDGNVLYIFKNSEVASRLIRLQES 119

		

		Query: 142 AANTLVKYLQRGDVLAGKNCAIKAIPHLDTLEVKGVPICIERVKSVSKMLS--EQVRHQN 199

		            A  L + LQR  +        +       + V G P  +E V+  +  L    Q+R + 

		Sbjct: 120 EAAELKQALQRSGIWE-PRFGWRPDASNRLVYVSGPPRYLELVEQTAAALEQQTQIRSEK 178

		

		Query: 200 QNKETVKVFPLKYASAADSDYQYRDQNVRLPGLVSVLRELNQGNNLPLAGGNQPDGNQAS 259

		                +++FPLKYASA+D    YRD  V  PG+ ++L+ +     +     +     QA+

		Sbjct: 179 TGALAIEIFPLKYASASDRTIHYRDDEVAAPGVATILQRVLSDATIQQVTVDNQRIPQAA 238

		

		Query: 260 S-----PVFSADPRQNAVIIRDRQANMPIYRSLITQLDQRPIQIEISVTIIDVDAGDISQ 314

		           +         ADP  NA+I+RD    MP+Y+ LI  LD+   +IE++++I+D++A  +++

		Sbjct: 239 TRASAQARVEADPSLNAIIVRDSPERMPMYQRLIHALDKPSARIEVALSIVDINADQLTE 298

		

		Query: 315 LGVDWSASASIGGTGV------SFNSTFAKNNAEGFSTVIGDTGNFMVRLNALQKNSRAR 368

		           LGVDW      G             S  A N A G           + R+N L+    A+

		Sbjct: 299 LGVDWRVGIRTGNNHQVVIKTTGDQSNIASNGALGSLVDARGLDYLLARVNLLENEGSAQ 358

		

		Query: 369 ILSQPSVVTLNNIQAVLDKNVTFYTKLQGEKVAKLESVTSGSLLRVTPRMIETEGVQEVL 428

		           ++S+P+++T  N QAV+D + T+Y K+ G++VA+L+ +T G++LR+TPR++      E+ 

		Sbjct: 359 VVSRPTLLTQENAQAVIDHSETYYVKVTGKEVAELKGITYGTMLRMTPRVLTQGDKSEIS 418

		

		Query: 429 LNLNIQDGQQQASTNSNEPLPEIRNSDISTQATLQVGQSLLLGGFIQDTQIESQNKIPLL 488

		           LNL+I+DG Q+ +++  E +P I  + + T A +  GQSL++GG  +D    + +K+PLL

		Sbjct: 419 LNLHIEDGNQKPNSSGIEGIPTISRTVVDTVARVGHGQSLIIGGIYRDELSVALSKVPLL 478

		

		Query: 489 GDIPLLGGLFRSTDKQSHSVVRLFLIKAVPVNAG 522

		           GDIP +G LFR   + +   VRLF+I+   ++ G

		Sbjct: 479 GDIPYIGALFRRKSELTRRTVRLFIIEPRIIDEG 512

		

		

		>RTXTOXIND#Gram-negative bacterial RTX secretion protein D

		           signature.

		          Length = 478

		

		 Score = 32.1 bits (73), Expect = 5e-04

		 Identities = 15/118 (12%), Positives = 38/118 (32%), Gaps = 11/118 (9%)

		

		Query: 5   QQRTLQRLLALRQRQERRLRQQLGQLRREQQQQEQQLENGRRRHQQLCQQLQQLAQWCGM 64

		               ++   +  Q Q+ +    L + R E+     ++       +    +L   +     

		Sbjct: 187 LTSLIKEQFSTWQNQKYQKELNLDKKRAERLTVLARINRYENLSRVEKSRLDDFSSL--- 243

		

		Query: 65  LTPREADEQKVLRQAVYQAERQAKKQLNAWVAQGRQQVSAIERQ--QARLRRNQREQE 120

		                  +Q + + AV + E +   +    +   + Q+  IE +   A+       Q 

		Sbjct: 244 -----LHKQAIAKHAVLEQENKY-VEAVNELRVYKSQLEQIESEILSAKEEYQLVTQL 295

		

		

		>TYPE3OMOPROT#Type III secretion system outer membrane O protein

		           family signature.

		          Length = 303

		

		 Score = 51.5 bits (123), Expect = 1e-09

		 Identities = 22/81 (27%), Positives = 37/81 (45%)

		

		Query: 235 PPLAAVQLEDLPQTLVMEIGRLTLPLGEIKQLAVGQTLACQTHCYGEVNICLNGQSVGRG 294

		                  L  LP  L   + R  + L E++ +   Q L+  T+    V I  NG  +G G

		Sbjct: 220 TAETLPGLNQLPVKLEFVLYRKNVTLAELEAMGQQQLLSLPTNAELNVEIMANGVLLGNG 279

		

		Query: 295 SLLRCDEKLVVRIAQWGLQNG 315

		            L++ ++ L V I +W  ++G

		Sbjct: 280 ELVQMNDTLGVEIHEWLSESG 300

		

		

		>TYPE3IMPPROT#Type III secretion system inner membrane P protein

		           family signature.

		          Length = 224

		

		 Score =  227 bits (581), Expect = 1e-77

		 Identities = 86/220 (39%), Positives = 143/220 (65%), Gaps = 7/220 (3%)

		

		Query: 24  LNSSYQLIALLFMLSVLPLLVVMGTAFLKLSVVFSLLRNALGVQQVPPNIAIYGLALVLT 83

		           + +   LIALL   ++LP ++  GT F+K S+VF ++RNALG+QQ+P N+ + G+AL+L+

		Sbjct: 1   MGNDISLIALLAFSTLLPFIIASGTCFVKFSIVFVMVRNALGLQQIPSNMTLNGVALLLS 60

		

		Query: 84  IFIMAPVGLDVQARLQNEELSNDIGALAHQIDQNALVPYRDFLQRNTDIEQVTFFNDIVQ 143

		           +F+M P+  D     ++E+++ +  +   +     L  YRD+L + +D E V FF +   

		Sbjct: 61  MFVMWPIMHDAYVYFEDEDVTFNDISSLSKHVDEGLDGYRDYLIKYSDRELVQFFENAQL 120

		

		Query: 144 NKWPE-------RYRDSVKPDSLLILMPAFTLSQLNEAFKIGLLLFLPFVAIDLIVSNIL 196

		            +          R +D ++  S+  L+PA+ LS++  AFKIG  L+LPFV +DL+VS++L

		Sbjct: 121 KRQYGEETETVKRDKDEIEKPSIFALLPAYALSEIKSAFKIGFYLYLPFVVVDLVVSSVL 180

		

		Query: 197 LAMGMMMVSPMTLSLPFKLLVFVLVDGWSLVLGQLVGSYL 236

		           LA+GMMM+SP+T+S P KL++FV +DGW+L+   L+  Y+

		Sbjct: 181 LALGMMMMSPVTISTPIKLVLFVALDGWTLLSKGLILQYM 220

		

		

		>TYPE3IMQPROT#Type III secretion system inner membrane Q protein

		          family signature.

		          Length = 86

		

		 Score = 68.6 bits (168), Expect = 3e-19

		 Identities = 32/79 (40%), Positives = 47/79 (59%)

		

		Query: 10 IVHLATELLWLVLLLSLPVVVVASTVGLVISLVQALTQIQDQTLQFLIKLLAVSATLLMT 69

		          +V    + L+LVL+LS    +VA+ +GL++ L Q +TQ+Q+QTL F IKLL V   L + 

		Sbjct: 4  LVFAGNKALYLVLILSGWPTIVATIIGLLVGLFQTVTQLQEQTLPFGIKLLGVCLCLFLL 63

		

		Query: 70 YHWMGATLLNYTQQSFLQI 88

		            W G  LL+Y +Q     

		Sbjct: 64 SGWYGEVLLSYGRQVIFLA 82

		

		

		>TYPE3IMRPROT#Type III secretion system inner membrane R protein

		           family signature.

		          Length = 261

		

		 Score =  141 bits (356), Expect = 5e-43

		 Identities = 52/230 (22%), Positives = 105/230 (45%), Gaps = 4/230 (1%)

		

		Query: 5   LPGLTALALAMMRPYGILLILPLFTARSLGSSLLRNGLIVAIALPVTPLFLSAPIITNSS 64

		           L  L      ++R   ++   P+ + RS+   + + GL + I   + P   +  +   S 

		Sbjct: 10  LSWLNLYFWPLLRVLALISTAPILSERSVPKRV-KLGLAMMITFAIAPSLPANDVPVFS- 67

		

		Query: 65  PVTWIGVLCTELLIGVVMGFVAALPFWAMNMAGFLIDTLRGATMSTLFNPGMGVESSLFG 124

		               + +   ++LIG+ +GF     F A+  AG +I    G + +T  +P   +   +  

		Sbjct: 68  -FFALWLAVQQILIGIALGFTMQFAFAAVRTAGEIIGLQMGLSFATFVDPASHLNMPVLA 126

		

		Query: 125 VLFTQILTVLFLISGGFNQVLAALYGSYDSLPIGQGIQPAADLLLFLQTEWQMMFELCLC 184

		            +   +  +LFL   G   +++ L  ++ +LPIG     +   L   +     +F   L 

		Sbjct: 127 RIMDMLALLLFLTFNGHLWLISLLVDTFHTLPIGGEPLNSNAFLALTKAGSL-IFLNGLM 185

		

		Query: 185 FALPALLVMVLADLSLGLINRSARQLNVFFLAMPIKSALALFLLLISLPY 234

		            ALP + +++  +L+LGL+NR A QL++F +  P+   + + L+   +P 

		Sbjct: 186 LALPLITLLLTLNLALGLLNRMAPQLSIFVIGFPLTLTVGISLMAALMPL 235

		

		

		>TYPE3IMSPROT#Type III secretion system inner membrane S protein

		           family signature.

		          Length = 354

		

		 Score =  347 bits (891), Expect = e-121

		 Identities = 125/351 (35%), Positives = 199/351 (56%), Gaps = 2/351 (0%)

		

		Query: 2   MSTEKNEKPTPKRLKEAKEKGQVVKSVEITSGVQLVALVIYFLLTGYSLVEQAKALIRSS 61

		           MS EK E+PTPK++++A++KGQV KS E+ S   +VAL    +       E    L+   

		Sbjct: 1   MSGEKTEQPTPKKIRDARKKGQVAKSKEVVSTALIVALSAMLMGLSDYYFEHFSKLMLIP 60

		

		Query: 62  IIQLQQPLTLALARIGAECMTVLMHIVVVLGGALIVVTIIAGIAQVGPLLATKAVSFKGE 121

		             Q   P + AL+ +    +    ++   L     ++ I + + Q G L++ +A+    +

		Sbjct: 61  AEQSYLPFSQALSYVVDNVLLEFFYLCFPLLTVAALMAIASHVVQYGFLISGEAIKPDIK 120

		

		Query: 122 RINPIQNAKQLFSLRSVFELMKSLLKVGVLTLIFGYLLMQYAPSFGYLTHCGSRCALPVF 181

		           +INPI+ AK++FS++S+ E +KS+LKV +L+++   ++     +   L  CG  C  P+ 

		Sbjct: 121 KINPIEGAKRIFSIKSLVEFLKSILKVVLLSILIWIIIKGNLVTLLQLPTCGIECITPLL 180

		

		Query: 182 STLMGWLLGSLIACYLVFSLMDYAFQRYTIMKQLKMSHDEVKREYKDSNGDPHIKQKRRQ 241

		             ++  L+      ++V S+ DYAF+ Y  +K+LKMS DE+KREYK+  G P IK KRRQ

		Sbjct: 181 GQILRQLMVICTVGFVVISIADYAFEYYQYIKELKMSKDEIKREYKEMEGSPEIKSKRRQ 240

		

		Query: 242 LQHEVQSGSFATNVRRSTAVVRNPTHFAVCLIYHPEETPLPIVIEKGHDEQAALIVSLAE 301

		              E+QS +   NV+RS+ VV NPTH A+ ++Y   ETPLP+V  K  D Q   +  +AE

		Sbjct: 241 FHQEIQSRNMRENVKRSSVVVANPTHIAIGILYKRGETPLPLVTFKYTDAQVQTVRKIAE 300

		

		Query: 302 QSGIPVVENIALARALHRDVACGDTIPEQFFEPVAALLRM--ALELDYQPS 350

		           + G+P+++ I LARAL+ D      IP +  E  A +LR      ++ Q S

		Sbjct: 301 EEGVPILQRIPLARALYWDALVDHYIPAEQIEATAEVLRWLERQNIEKQHS 351

		

		

		>PF01206#SirA family protein

		          Length = 76

		

		 Score = 92.1 bits (229), Expect = 1e-28

		 Identities = 17/71 (23%), Positives = 37/71 (52%)

		

		Query: 19 DYRLDMVGEPCPYPAVATLEAMPQLKPGEILEVISDCPQSINNIPLDARNYGYTVLDIQQ 78

		          D  LD  G  CP P +   + +  +  GE+L V++  P S+ +    ++  G+ +L+ ++

		Sbjct: 5  DQSLDATGLNCPLPILKAKKTLATMNAGEVLYVMATDPGSVKDFESFSKQTGHELLEQKE 64

		

		Query: 79 DGPTIRYLIQR 89

		          +  T  + ++R

		Sbjct: 65 EDGTYHFRLKR 75

		

		

		>PF05272#Virulence-associated E family protein

		          Length = 892

		

		 Score = 28.1 bits (62), Expect = 0.049

		 Identities = 10/21 (47%), Positives = 12/21 (57%)

		

		Query: 39  MVAIIGPNGAGKSTLLRLLTG 59

		            V + G  G GKSTL+  L G

		Sbjct: 598 SVVLEGTGGIGKSTLINTLVG 618

		

		

		>ALARACEMASE#Alanine racemase signature.

		          Length = 356

		

		 Score =  449 bits (1156), Expect = e-161

		 Identities = 147/357 (41%), Positives = 217/357 (60%), Gaps = 4/357 (1%)

		

		Query: 2   KAATAVIDRHALRHNLQQIRRLAPQSRLVAVVKANAYGHGLLAAAHTLQDADCYGVARIS 61

		           +   A +D  AL+ NL  +R+ A  +R+ +VVKANAYGHG+      +   D + +  + 

		Sbjct: 3   RPIQASLDLQALKQNLSIVRQAATHARVWSVVKANAYGHGIERIWSAIGATDGFALLNLE 62

		

		Query: 62  EALMLRAGGIVKPILLLEGFFDAEDLPVLVANHIETAVHSLEQLVALEAATLSAPINVWM 121

		           EA+ LR  G   PIL+LEGFF A+DL +   + + T VHS  QL AL+ A L AP+++++

		Sbjct: 63  EAITLRERGWKGPILMLEGFFHAQDLEIYDQHRLTTCVHSNWQLKALQNARLKAPLDIYL 122

		

		Query: 122 KLDTGMHRLGVRPDQAEAFYQRLSACRNVIQPVNIMSHFSRADEPEVAATQQQLACFDAF 181

		           K+++GM+RLG +PD+    +Q+L A  NV + + +MSHF+ A+ P+       +A  +  

		Sbjct: 123 KVNSGMNRLGFQPDRVLTVWQQLRAMANVGE-MTLMSHFAEAEHPD--GISGAMARIEQA 179

		

		Query: 182 AAGKPGKQSIAASGGILRWPQAHRDWVRPGIVLYGVSPF-DAPYGRDFGLLPAMTLKSSL 240

		           A G   ++S++ S   L  P+AH DWVRPGI+LYG SP        + GL P MTL S +

		Sbjct: 180 AEGLECRRSLSNSAATLWHPEAHFDWVRPGIILYGASPSGQWRDIANTGLRPVMTLSSEI 239

		

		Query: 241 IAVREHKAGESVGYGGTWVSERDTRLGVIAIGYGDGYPRSAPSGTPVWLNGREVSIVGRV 300

		           I V+  KAGE VGYGG + +  + R+G++A GY DGYPR AP+GTPV ++G     VG V

		Sbjct: 240 IGVQTLKAGERVGYGGRYTARDEQRIGIVAAGYADGYPRHAPTGTPVLVDGVRTMTVGTV 299

		

		Query: 301 SMDMISIDLGPESTDKVGDEALMWGAELPVERVAACTGISAYELITNLTSRVAMEYL 357

		           SMDM+++DL P     +G    +WG E+ ++ VAA  G   YEL+  L  RV +  +

		Sbjct: 300 SMDMLAVDLTPCPQAGIGTPVELWGKEIKIDDVAAAAGTVGYELMCALALRVPVVTV 356

		

		

		>PF07520#Virulence protein SrfB

		          Length = 1041

		

		 Score = 29.6 bits (66), Expect = 0.027

		 Identities = 16/83 (19%), Positives = 31/83 (37%), Gaps = 5/83 (6%)

		

		Query: 282 ILLPVIEEYNRP---QATRRFARIAQAMGVDTQDMSDE-QASHQAIAAIRQLSLQVGIPA 337

		           ++  VI     P    +  +      A  +      D      Q +   RQ S++V +P 

		Sbjct: 639 LVHRVISAIVLPRLQDSIAQAGGQFVAERMRELFGGDIGGQEQQTVQRRRQFSIRVLVPL 698

		

		Query: 338 GFSAL-GIEESDIEGWLDKALAD 359

		             + L   E+++    +D  +AD

		Sbjct: 699 AEAILSACEDAEEADRIDIPVAD 721

		

		

		>HTHTETR#TetR bacterial regulatory protein HTH signature.

		          Length = 215

		

		 Score = 48.9 bits (116), Expect = 2e-09

		 Identities = 35/179 (19%), Positives = 63/179 (35%), Gaps = 11/179 (6%)

		

		Query: 2   EESNVQREQVLSNALNLLEQQGLANTTLEMLAKALSVEVSDLTRFWPDREALLYDCLRYH 61

		           +E+   R+ +L  AL L  QQG+++T+L  +AKA  V    +   + D+  L  +     

		Sbjct: 7   QEAQETRQHILDVALRLFSQQGVSSTSLGEIAKAAGVTRGAIYWHFKDKSDLFSEIWELS 66

		

		Query: 62  SQQIDTWRRQLQLDETLSPQQKLLARY-QTLSEQVQNQRYPGCLFIAACSFYPDTEH--- 117

		              I     + Q      P   L       L   V  +R      +    F+        

		Sbjct: 67  ESNIGELELEYQAKFPGDPLSVLREILIHVLESTVTEERRRL---LMEIIFHKCEFVGEM 123

		

		Query: 118 -PIHQLAEQQKQASLHYTKALLQEMDAD---DADMVAQQMELILEGCLSKLLIKRQLAD 172

		             + Q        S    +  L+         AD++ ++  +I+ G +S L+     A 

		Sbjct: 124 AVVQQAQRNLCLESYDRIEQTLKHCIEAKMLPADLMTRRAAIIMRGYISGLMENWLFAP 182

		

		

		>AUTOINDCRSYN#Autoinducer synthesis protein signature.

		          Length = 216

		

		 Score = 27.9 bits (62), Expect = 0.007

		 Identities = 15/46 (32%), Positives = 23/46 (50%), Gaps = 1/46 (2%)

		

		Query: 60  EGKLEQEYEVQLLFKSNTDH-QQALLTYIKQHHPYQTPELLVLPVR 104

		           +G  E+E  V L+F    D  Q+AL   I +   + + EL   P+R

		Sbjct: 163 QGLSEKEERVYLVFLPVDDENQEALARRINRSGTFMSNELKQWPLR 208

		

		

		>SECA#SecA protein signature.

		          Length = 901

		

		 Score = 29.8 bits (67), Expect = 0.022

		 Identities = 21/115 (18%), Positives = 42/115 (36%), Gaps = 3/115 (2%)

		

		Query: 282 HIIDAADPRVAENMAAVDTVLAEIEADEIPTLLVMNKIDLLDDFVPRIDRNED-NLPVRV 340

		            ++D +D     N    D   A I+A   P  L   ++  +     R+  + D +LP+  

		Sbjct: 665 ELLDVSDVSETINSIREDVFKATIDAYIPPQSL--EEMWDIPGLQERLKNDFDLDLPIAE 722

		

		Query: 341 WLSAQTGAGIPLLFQALTERLSGEIAHFELRLPPQAGRLRSRFYQLQAIEKEWID 395

		           WL  +       L + +  +        E  +  +  R   +   LQ ++  W +

		Sbjct: 723 WLDKEPELHEETLRERILAQSIEVYQRKEEVVGAEMMRHFEKGVMLQTLDSLWKE 777

		

		

		>SECYTRNLCASE#Preprotein translocase SecY subunit signature.

		          Length = 437

		

		 Score = 28.6 bits (64), Expect = 0.042

		 Identities = 15/49 (30%), Positives = 24/49 (48%), Gaps = 3/49 (6%)

		

		Query: 4   SFLLIVVVVLIALFASLFVVEEGQRGIVLRFGKVL--RDSDNKPLVYAP 50

		            F  ++ V LI +   +FV E+ QR I +++ K +  R S      Y P

		Sbjct: 221 EFGTVIAVGLIMVALVVFV-EQAQRRIPVQYAKRMIGRRSYGGTSTYIP 268

		

		

		>HTHTETR#TetR bacterial regulatory protein HTH signature.

		          Length = 215

		

		 Score = 28.1 bits (62), Expect = 0.047

		 Identities = 12/106 (11%), Positives = 31/106 (29%), Gaps = 14/106 (13%)

		

		Query: 16  QGMSSRAIARELGISRNTVKRYLQAKSEPPKYTPRPAVASLLDEYRDYIRQRIAD----- 70

		              S   IA+  G++R  +  + + KS+          + + +     I +   +     

		Sbjct: 30  SSTSLGEIAKAAGVTRGAIYWHFKDKSD--------LFSEIWELSESNIGELELEYQAKF 81

		

		Query: 71  -AHPYKIPATVIAREIRDQGYRGGMTILRAFIRSLSVPQEQEPAVR 115

		              P  +   ++   +          +L   I        +   V+

		Sbjct: 82  PGDPLSVLREILIHVLESTVTEERRRLLMEIIFHKCEFVGEMAVVQ 127

		

		

		>PF05272#Virulence-associated E family protein

		          Length = 892

		

		 Score = 36.6 bits (84), Expect = 1e-04

		 Identities = 18/78 (23%), Positives = 25/78 (32%), Gaps = 19/78 (24%)

		

		Query: 33  VLVGPSGCGKSTLLRMIAGLEEISGGTVGINDKDVTDVEPKMRDIAMVFQSYALYPQMTV 92

		           VL G  G GKSTL+  + GL+  S       D          +D          Y     

		Sbjct: 600 VLEGTGGIGKSTLINTLVGLDFFS-------DTHFDI--GTGKDSYEQIAGIVAY----- 645

		

		Query: 93  RENMGFALKMAKMSKADI 110

		              +    +M    +AD 

		Sbjct: 646 --ELS---EMTAFRRADA 658

		

		

		>UREASE#Urea amidohydrolase (urease) protein signature.

		          Length = 570

		

		 Score = 30.1 bits (68), Expect = 0.017

		 Identities = 25/87 (28%), Positives = 38/87 (43%), Gaps = 18/87 (20%)

		

		Query: 289 LASLGVLDILSSD--------------YYPASLMDAAF-RIAHDE--SNRFTLPQAVNLV 331

		           L  +G   I+SSD              +  A  M     R+  +   ++ F + + +   

		Sbjct: 350 LHDIGAFSIISSDSQAMGRVGEVAIRTWQTADKMKRQRGRLKEETGDNDNFRVKRYIAKY 409

		

		Query: 332 TRNPARALGLNDR-GVIAEGKRADLIL 357

		           T NPA A GL+   G +  GKRADL+L

		Sbjct: 410 TINPAIAHGLSHEIGSLEVGKRADLVL 436

		

		

		>PF05272#Virulence-associated E family protein

		          Length = 892

		

		 Score = 28.1 bits (62), Expect = 0.034

		 Identities = 13/47 (27%), Positives = 17/47 (36%), Gaps = 8/47 (17%)

		

		Query: 40  CVVLHGHSGSGKSTLLRSLYANYLPDSGHI--------WIKHQGEWI 78

		            VVL G  G GKSTL+ +L         H         + +  G   

		Sbjct: 598 SVVLEGTGGIGKSTLINTLVGLDFFSDTHFDIGTGKDSYEQIAGIVA 644

		

		

		>SACTRNSFRASE#Streptothricin acetyltransferase signature.

		          Length = 173

		

		 Score = 37.6 bits (87), Expect = 8e-06

		 Identities = 16/50 (32%), Positives = 23/50 (46%), Gaps = 1/50 (2%)

		

		Query: 100 RGKGLAKQLALQALAFARQQGFGRCYLETTASLTSAVGLYERLGFEHIGG 149

		           R KG+   L  +A+ +A++  F    LET     SA   Y +  F  IG 

		Sbjct: 102 RKKGVGTALLHKAIEWAKENHFCGLMLETQDINISACHFYAKHHFI-IGA 150

		

		

		>ABC2TRNSPORT#ABC-2 type transport system membrane protein

		           signature.

		          Length = 262

		

		 Score = 65.0 bits (158), Expect = 1e-14

		 Identities = 51/246 (20%), Positives = 109/246 (44%), Gaps = 4/246 (1%)

		

		Query: 6   WIALQSIWIKEITRFARIWIQTLVPPVITMSLYFVIFGNLIGARIGDMGGFDYMQFIVPG 65

		           WIA   +W +    + +  + +L+  +    +Y    G  +G  +G +GG  Y  F+  G

		Sbjct: 16  WIA---VWRRNYIAWKKAALASLLGHLAEPLIYLFGLGAGLGVMVGRVGGVSYTAFLAAG 72

		

		Query: 66  LIMMAVITNA-YSNVAASFYGAKFQRSIEELLVAPVPTHIVIIGYVGGGVARGICVGILV 124

		           ++  + +T A +  + A+F   + QR+ E +L   +    +++G +     +    G  +

		Sbjct: 73  MVATSAMTAATFETIYAAFGRMEGQRTWEAMLYTQLRLGDIVLGEMAWAATKAALAGAGI 132

		

		Query: 125 TIISLFFVPLHVHSWSMIALTLILTAILFSLGGLLNAVFAKTFDDISLVPTFVLTPLTYL 184

		            +++         S       + LT + F+  G++    A ++D      T V+TP+ +L

		Sbjct: 133 GVVAAALGYTQWLSLLYALPVIALTGLAFASLGMVVTALAPSYDYFIFYQTLVITPILFL 192

		

		Query: 185 GGVFYSLSLLPPFWQAVSKLNPIVYMISGFRYGFLGITDVSLAYTIGVLVVFIAVFYAWA 244

		            G  + +  LP  +Q  ++  P+ + I   R   LG   V +   +G L ++I + +  +

		Sbjct: 193 SGAVFPVDQLPIVFQTAARFLPLSHSIDLIRPIMLGHPVVDVCQHVGALCIYIVIPFFLS 252

		

		Query: 245 WYLIER 250

		             L+ R

		Sbjct: 253 TALLRR 258

		

		

		>FERRIBNDNGPP#Ferrichrome-binding periplasmic protein signature.

		          Length = 296

		

		 Score =  414 bits (1066), Expect = e-148

		 Identities = 157/305 (51%), Positives = 199/305 (65%), Gaps = 20/305 (6%)

		

		Query: 55  RRRLLMALTLSPLLLSLPSLVAAAPKSDQPLLNIDRVIDIQRDIDTKRVVALEWLPVELL 114

		           RRRLL A+ LSPLL  + +  AAA                   ID  R+VALEWLPVELL

		Sbjct: 9   RRRLLTAMALSPLLWQMNTAHAAA-------------------IDPNRIVALEWLPVELL 49

		

		Query: 115 LALGVTPFGVADIHNYRLWVGEPALPADVINVGQRTEPNLELLQQMAPSLILLSQGYGPS 174

		           LALG+ P+GVAD  NYRLWV EP LP  VI+VG RTEPNLELL +M PS ++ S GYGPS

		Sbjct: 50  LALGIVPYGVADTINYRLWVSEPPLPDSVIDVGLRTEPNLELLTEMKPSFMVWSAGYGPS 109

		

		Query: 175 PEKLAPIAPTMSFAFNEQGSSPLAVGKNSLQTLGQRLGLETAAQQHLADFDHFMLAARAR 234

		           PE LA IAP   F F++ G  PLA+ + SL  +   L L++AA+ HLA ++ F+ + + R

		Sbjct: 110 PEMLARIAPGRGFNFSD-GKQPLAMARKSLTEMADLLNLQSAAETHLAQYEDFIRSMKPR 168

		

		Query: 235 LSGDTQTPLLMFSLLDPRHALIIGNGSLFQDVLSTLNIENAWQGETNFWGSAVVGIERLA 294

		                  PLL+ +L+DPRH L+ G  SLFQ++L    I NAWQGETNFWGS  V I+RLA

		Sbjct: 169 FVKRGARPLLLTTLIDPRHMLVFGPNSLFQEILDEYGIPNAWQGETNFWGSTAVSIDRLA 228

		

		Query: 295 TIKTARAVCFGHGNNEMLQQVARTPLWQSLSFVRENQLRLLPPVWFYGATLSAMRFVRLL 354

		             K    +CF H N++ +  +  TPLWQ++ FVR  + + +P VWFYGATLSAM FVR+L

		Sbjct: 229 AYKDVDVLCFDHDNSKDMDALMATPLWQAMPFVRAGRFQRVPAVWFYGATLSAMHFVRVL 288

		

		Query: 355 EQAWG 359

		           + A G

		Sbjct: 289 DNAIG 293

		

		

		>SACTRNSFRASE#Streptothricin acetyltransferase signature.

		          Length = 173

		

		 Score = 36.8 bits (85), Expect = 1e-04

		 Identities = 16/54 (29%), Positives = 22/54 (40%)

		

		Query: 812 VLVRSDLKGLGLGRALLEKMIRYARSHGLSRLTAVTMPNNRGMIGLAQKLGFTI 865

		           + V  D +  G+G ALL K I +A+ +    L   T   N        K  F I

		Sbjct: 95  IAVAKDYRKKGVGTALLHKAIEWAKENHFCGLMLETQDINISACHFYAKHHFII 148

		

		

		>TCRTETB#Tetracycline resistance protein TetB signature.

		          Length = 458

		

		 Score =  140 bits (355), Expect = 1e-38

		 Identities = 94/404 (23%), Positives = 167/404 (41%), Gaps = 17/404 (4%)

		

		Query: 18  LSLATFMQVLDSTIANVAIPTIAGDLGSSNSQGTWVITSFGVANAISIPVTGWLAKRVGE 77

		           L + +F  VL+  + NV++P IA D     +   WV T+F +  +I   V G L+ ++G 

		Sbjct: 19  LCILSFFSVLNEMVLNVSLPDIANDFNKPPASTNWVNTAFMLTFSIGTAVYGKLSDQLGI 78

		

		Query: 78  VRLFLWSTGLFVLASWLCGMSNS-LGMLIFFRVIQGLVAGPLIPLSQSLLLNNYPPAKRS 136

		            RL L+   +    S +  + +S   +LI  R IQG  A     L   ++    P   R 

		Sbjct: 79  KRLLLFGIIINCFGSVIGFVGHSFFSLLIMARFIQGAGAAAFPALVMVVVARYIPKENRG 138

		

		Query: 137 MALALWSMTIVVAPIFGPILGGYISDNYHWGWIFFINIPIGLVVVLLAGSTLKGRETKTE 196

		            A  L    + +    GP +GG I+   HW   + + IP+  ++ +     L  +E + +

		Sbjct: 139 KAFGLIGSIVAMGEGVGPAIGGMIAHYIHWS--YLLLIPMITIITVPFLMKLLKKEVRIK 196

		

		Query: 197 IRPIDTIGLVLLVVGIGALQIMLDQGKELDWFNSTEIIVLTVVAVVAITFLIVWELTDDH 256

		               D  G++L+ VGI  +  ML        F ++  I   +V+V++    +        

		Sbjct: 197 -GHFDIKGIILMSVGI--VFFML--------FTTSYSISFLIVSVLSFLIFVKHIRKVTD 245

		

		Query: 257 PVIDLSLFKSRNFTIGCLCLSLAYMLYFGAIVLLPQLLQEVYGYTATWAGLASAPVGILP 316

		           P +D  L K+  F IG LC  + +    G + ++P ++++V+  +    G      G + 

		Sbjct: 246 PFVDPGLGKNIPFMIGVLCGGIIFGTVAGFVSMVPYMMKDVHQLSTAEIGSVIIFPGTMS 305

		

		Query: 317 VLLS-PLIGRFAHRIDMRQLVTFSFIMYAVCFYWRAYTFEPGMDFGASAWPQFFQGFAIA 375

		           V++   + G    R     ++       +V F   ++  E    F          G +  

		Sbjct: 306 VIIFGYIGGILVDRRGPLYVLNIGVTFLSVSFLTASFLLETTSWFMTIIIVFVLGGLSFT 365

		

		Query: 376 CFFMPLTTITLSGLPPERMAAASSLSNFMRTLAGSIGTSITTTL 419

		                ++TI  S L  +   A  SL NF   L+   G +I   L

		Sbjct: 366 K--TVISTIVSSSLKQQEAGAGMSLLNFTSFLSEGTGIAIVGGL 407

		

		

		>RTXTOXIND#Gram-negative bacterial RTX secretion protein D

		           signature.

		          Length = 478

		

		 Score = 68.7 bits (168), Expect = 9e-15

		 Identities = 63/410 (15%), Positives = 118/410 (28%), Gaps = 99/410 (24%)

		

		Query: 29  LLLTAIFIMIGVAYLIYWFLVLRHHQ---ETDNAYISGNQVQIMSQVPGSVVSVHFENTD 85

		             L A FIM  +       ++ +             SG   +I       V  +  +  +

		Sbjct: 57  PRLVAYFIMGFLVIAFILSVLGQVEIVATANGKLTHSGRSKEIKPIENSIVKEIIVKEGE 116

		

		Query: 86  FVKSGDVLVTLDPTD-------AEQAFEQAK----------------------------- 109

		            V+ GDVL+ L            + +  QA+                             

		Sbjct: 117 SVRKGDVLLKLTALGAEADTLKTQSSLLQARLEQTRYQILSRSIELNKLPELKLPDEPYF 176

		

		Query: 110 ----------------TALANSVRQTHQLIINSKQYQ-------ANIALKKTELSQAQND 146

		                              +    Q +Q  +N  + +       A I   +      ++ 

		Sbjct: 177 QNVSEEEVLRLTSLIKEQFSTWQNQKYQKELNLDKKRAERLTVLARINRYENLSRVEKSR 236

		

		Query: 147 LKRRVVLGAAAVIGREELQHARDAVEAAQASLDMAVQQYNANQALVLNTPLE-------- 198

		           L     L     I +  +    +    A   L +   Q    ++ +L+   E        

		Sbjct: 237 LDDFSSLLHKQAIAKHAVLEQENKYVEAVNELRVYKSQLEQIESEILSAKEEYQLVTQLF 296

		

		Query: 199 -KQPAIEQAAAKMRDAWLT---------LQRTKVVSPISGYVSRRSVQ-VGAEISSGTPL 247

		             +   +          LT          Q + + +P+S  V +  V   G  +++   L

		Sbjct: 297 KNEILDKLRQTTDNIGLLTLELAKNEERQQASVIRAPVSVKVQQLKVHTEGGVVTTAETL 356

		

		Query: 248 MAVVPADQ-LWIDANFKETQLANMRIGQPATI-VTDF----YGDDVVYQGKVVGLDMGTG 301

		           M +VP D  L + A  +   +  + +GQ A I V  F    YG      GKV  +     

		Sbjct: 357 MVIVPEDDTLEVTALVQNKDIGFINVGQNAIIKVEAFPYTRYGY---LVGKVKNI----- 408

		

		Query: 302 SAFSLLPAQNATGNWIKVVQRLPVRIALDEKQLKEHPLRIGLSSLVKVDT 351

		           +  ++       G    V+  +           K  PL  G++   ++ T

		Sbjct: 409 NLDAIE--DQRLGLVFNVIISIEENCLSTG--NKNIPLSSGMAVTAEIKT 454

		

		

		>PF05272#Virulence-associated E family protein

		          Length = 892

		

		 Score = 28.5 bits (63), Expect = 0.016

		 Identities = 23/105 (21%), Positives = 37/105 (35%), Gaps = 12/105 (11%)

		

		Query: 20  LNSRAKRQKDFPYQEILLTRLSMHMHSKLLENRNKMLKAQGINETLFMALITLDAQESRS 79

		            +   +     P QE+ L    +      L  R     A+G  +  +    T        

		Sbjct: 745 PSPEDEEIYFRPEQELRLVETGVQGRLWALLTREGAPAAEGAAQKGYSVNTTF------- 797

		

		Query: 80  IQPSELSAALG-----SSRTNATRIADELEKKGWIERRESHNDRR 119

		           +  ++L  ALG     SS     ++ D L + GW   RE+   RR

		Sbjct: 798 VTIADLVQALGADPGKSSPMLEGQVRDWLNENGWEYLRETSGQRR 842

		

		

		>TCRTETB#Tetracycline resistance protein TetB signature.

		          Length = 458

		

		 Score = 47.2 bits (112), Expect = 7e-08

		 Identities = 35/163 (21%), Positives = 65/163 (39%), Gaps = 5/163 (3%)

		

		Query: 35  LETIATNFNLSVNQAGFIVTAAQLGYAVGLMFLVPLGDMFE-RRGLIVGMTLLAAGGMLI 93

		           L  IA +FN       ++ TA  L +++G      L D    +R L+ G+ +   G  +I

		Sbjct: 37  LPDIANDFNKPPASTNWVNTAFMLTFSIGTAVYGKLSDQLGIKRLLLFGIIINCFGS-VI 95

		

		Query: 94  TAMSQNLTMMIIGTALTGLFSVVA--QLLVPLAATLAAPEKRGKVVGIIMSGLLLGILLA 151

		             +  +   ++I           A   L++ + A     E RGK  G+I S + +G  + 

		Sbjct: 96  GFVGHSFFSLLIMARFIQGAGAAAFPALVMVVVARYIPKENRGKAFGLIGSIVAMGEGVG 155

		

		Query: 152 RTVAGALATLGGWRTIYWVASALMFIMALVLWRCLPRYKQHTG 194

		             + G +A    W  +  +    + I    L + L +  +  G

		Sbjct: 156 PAIGGMIAHYIHWSYLLLIPMITI-ITVPFLMKLLKKEVRIKG 197

		

		

		>PF05272#Virulence-associated E family protein

		          Length = 892

		

		 Score = 30.4 bits (68), Expect = 0.007

		 Identities = 14/42 (33%), Positives = 22/42 (52%), Gaps = 4/42 (9%)

		

		Query: 31  VISIIGRSGSGKSTLLRCMNGLEDYQDGSIKLGGMTVTNRDS 72

		            + + G  G GKSTL+  + GL+ + D    +G    T +DS

		Sbjct: 598 SVVLEGTGGIGKSTLINTLVGLDFFSDTHFDIG----TGKDS 635

		

		

		>HTHTETR#TetR bacterial regulatory protein HTH signature.

		          Length = 215

		

		 Score = 28.1 bits (62), Expect = 0.047

		 Identities = 12/106 (11%), Positives = 31/106 (29%), Gaps = 14/106 (13%)

		

		Query: 16  QGMSSRAIARELGISRNTVKRYLQAKSEPPKYTPRPAVASLLDEYRDYIRQRIAD----- 70

		              S   IA+  G++R  +  + + KS+          + + +     I +   +     

		Sbjct: 30  SSTSLGEIAKAAGVTRGAIYWHFKDKSD--------LFSEIWELSESNIGELELEYQAKF 81

		

		Query: 71  -AHPYKIPATVIAREIRDQGYRGGMTILRAFIRSLSVPQEQEPAVR 115

		              P  +   ++   +          +L   I        +   V+

		Sbjct: 82  PGDPLSVLREILIHVLESTVTEERRRLLMEIIFHKCEFVGEMAVVQ 127

		

		

		>PF05860#haemagglutination activity domain.

		          Length = 117

		

		 Score = 81.8 bits (202), Expect = 4e-21

		 Identities = 27/115 (23%), Positives = 51/115 (44%), Gaps = 6/115 (5%)

		

		Query: 67  VLAHPVLPVNGHVVIGQGMLDQQSSTLTVTQQTDKLAINWDSFDIAHGHSVIYAQPGSQS 126

		           +     LP+N ++                TQ    L  ++  F +    +  +  P +  

		Sbjct: 3   ITPDTTLPINSNITTEGN----TRIIERGTQAGSNLFHSFQEFSVPTSGTAFFNNPTNIQ 58

		

		Query: 127 IALNQVQGQSASQIYGRLQANG--QVFLLNPRGILFGKEAQVNVGGLVASTKYMS 179

		             +++V G S S I G ++AN    +FL+NP GI+FG+ A++++GG    +    

		Sbjct: 59  NIISRVTGGSVSNIDGLIRANATANLFLINPNGIIFGQNARLDIGGSFVGSTANR 113

		

		

		>MICOLLPTASE#Microbial collagenase metalloprotease (M9) signature.

		          Length = 1104

		

		 Score = 45.5 bits (107), Expect = 6e-07

		 Identities = 29/123 (23%), Positives = 45/123 (36%), Gaps = 23/123 (18%)

		

		Query: 366 PVAQITAPSSVQDNETITLSASAST---GQIASYQWEFQHFEPKVATTQNVTVRAVATQQ 422

		           P A I + SSV   E I    + S    G+I +Y+W+F   E                 +

		Sbjct: 775 PKAVIKSDSSVIVEEEINFDGTESKDEDGEIKAYEWDFGDGEKSNEAKATHKYNKTGEYE 834

		

		Query: 423 PLAGKVTLTVTNNQGVQSRAEKTINIL------------PSGGIEQEHPLWDRNKVTTYG 470

		                V LTVT+N G  +   K I ++            P+   E+ + +    K     

		Sbjct: 835 -----VKLTVTDNNGGINTESKKIKVVEDKPVEVINESEPNNDFEKANQI---AKSNMLV 886

		

		Query: 471 EGT 473

		           +GT

		Sbjct: 887 KGT 889

		

		

		>CARBMTKINASE#Bacterial carbamate kinase signature.

		          Length = 314

		

		 Score = 39.8 bits (93), Expect = 1e-05

		 Identities = 32/146 (21%), Positives = 57/146 (39%), Gaps = 21/146 (14%)

		

		Query: 119 DTMNALLDNRI---------VPVINENDAVATAEIKVGDNDNLSALAAILASADKLLLLT 169

		           +T+  L++  +         VPVI E+  +   E  V D D      A   +AD  ++LT

		Sbjct: 177 ETIKKLVERGVIVIASGGGGVPVILEDGEIKGVE-AVIDKDLAGEKLAEEVNADIFMILT 235

		

		Query: 170 DQAGLYTADPRNNPEAELIREVHGIDDVLRGMAGDSVSGLGTGGMATKLQAA-DVACRAG 228

		           D  G          + + +REV  ++++ +            G M  K+ AA       G

		Sbjct: 236 DVNGAALY--YGTEKEQWLREVK-VEELRKYYEEG---HFKAGSMGPKVLAAIRFIEWGG 289

		

		Query: 229 IDVVIAAGSQVGVIADVIDGTPVGTR 254

		              +IA   +     + ++G   GT+

		Sbjct: 290 ERAIIAHLEK---AVEALEGK-TGTQ 311

		

		

		

		 Score = 30.6 bits (69), Expect = 0.009

		 Identities = 17/76 (22%), Positives = 34/76 (44%), Gaps = 13/76 (17%)

		

		Query: 4  SQTLVVKLGTSVLTGGSRRLNRAHIVELVRQCAQQ----HAKGHRIVIVTSG-------- 51

		           + +V+ LG + L    ++ +   +++ VR+ A+Q     A+G+ +VI            

		Sbjct: 2  GKRVVIALGGNALQQRGQKGSYEEMMDNVRKTARQIAEIIARGYEVVITHGNGPQVGSLL 61

		

		Query: 52 -AIAAGREHLGYPELP 66

		            + AG+   G P  P

		Sbjct: 62 LHMDAGQATYGIPAQP 77

		

		

		>PF05272#Virulence-associated E family protein

		          Length = 892

		

		 Score = 28.5 bits (63), Expect = 0.015

		 Identities = 16/68 (23%), Positives = 27/68 (39%), Gaps = 12/68 (17%)

		

		Query: 7   MVGARGAGKTTIGKALAQALGYRFVDTDL-------FMQQTSQMTVAEVVESEGWDGFRL 59

		           + G  G GK+T+   L       F DT           +Q + +   E+ E      FR 

		Sbjct: 601 LEGTGGIGKSTLINTLVGL--DFFSDTHFDIGTGKDSYEQIAGIVAYELSE---MTAFRR 655

		

		Query: 60  RESMALQA 67

		            ++ A++A

		Sbjct: 656 ADAEAVKA 663

		

		

		>BCTERIALGSPF#Bacterial general secretion pathway protein F

		           signature.

		          Length = 408

		

		 Score = 28.3 bits (63), Expect = 0.045

		 Identities = 11/37 (29%), Positives = 21/37 (56%)

		

		Query: 218 DVIAEQAMNNYERRFAKSLAHVINLFDPDVVVLGGGM 254

		           D + E+A +N +R F+  +   + LF+P +VV    +

		Sbjct: 351 DSMLERAADNQDREFSSQMTLALGLFEPLLVVSMAAV 387

		

		

		>RTXTOXIND#Gram-negative bacterial RTX secretion protein D

		           signature.

		          Length = 478

		

		 Score = 41.7 bits (98), Expect = 2e-05

		 Identities = 32/222 (14%), Positives = 74/222 (33%), Gaps = 8/222 (3%)

		

		Query: 321 QYLAQLTPLT--QAVEQATAARQQQQLNQHEQETLIEQRIVPLDNLITQQQQTLSQLAGQ 378

		             L +LT L       +  ++  Q +L Q   + L     +     +    +   Q   +

		Sbjct: 122 DVLLKLTALGAEADTLKTQSSLLQARLEQTRYQILSRSIELNKLPELKLPDEPYFQNVSE 181

		

		Query: 379 IQQLRAKEQQNSQQLALNEQKLLQTHQRLQQLADYANLHAHHQHWEKHLPLWHEQFRQLQ 438

		            + LR       Q      QK  +     ++ A+   + A    +E    +   +     

		Sbjct: 182 EEVLRLTSLIKEQFSTWQNQKYQKELNLDKKRAERLTVLARINRYENLSRVEKSRLDDFS 241

		

		Query: 439 LQQQQSAQSEQQLHQQTTLLATLQQQATTLSAQEKQQQVALAEARAQASYLQQKL--LVL 496

		               + A ++  + +Q         +     +Q +Q +  +  A+ +   + Q     +L

		Sbjct: 242 SLLHKQAIAKHAVLEQENKYVEAVNELRVYKSQLEQIESEILSAKEEYQLVTQLFKNEIL 301

		

		Query: 497 EQ----QQPSAQLRQQLNEFNEQRQICQQLAALSPLAQQIQA 534

		           ++          L  +L +  E++Q     A +S   QQ++ 

		Sbjct: 302 DKLRQTTDNIGLLTLELAKNEERQQASVIRAPVSVKVQQLKV 343

		

		

		

		 Score = 38.7 bits (90), Expect = 1e-04

		 Identities = 36/222 (16%), Positives = 72/222 (32%), Gaps = 30/222 (13%)

		

		Query: 458 LATLQQQATTLSAQEKQQQVALAEARAQASYLQQKLLVLEQQ----QPSAQLRQQLNEFN 513

		           L  L  +A TL  Q    Q  L + R Q      +L  L +     +P  Q   +     

		Sbjct: 127 LTALGAEADTLKTQSSLLQARLEQTRYQILSRSIELNKLPELKLPDEPYFQNVSEEEVLR 186

		

		Query: 514 EQRQICQQLAALSPLAQQIQALYDKQQQQFTAQQQQLKQLEQQ---LTEKRQLYQQ-QKQ 569

		               I +Q +       Q +   DK++ +      ++ + E        +   +     +

		Sbjct: 187 LTSLIKEQFSTWQNQKYQKELNLDKKRAERLTVLARINRYENLSRVEKSRLDDFSSLLHK 246

		

		Query: 570 HLVDLEALLEREKQIVTLEAERAKLQPGDACPLCGAVEHPAITAYQAVKPSETAVRVAKL 629

		             +   A+LE+E + V    E    +                     ++  E+ +  AK 

		Sbjct: 247 QAIAKHAVLEQENKYVEAVNELRVYK-------------------SQLEQIESEILSAKE 287

		

		Query: 630 RL-QVEQLYTEGTELRTQVASMQQHQQRIEQELQDHRQQLAA 670

		               V QL+    E+  ++     +   +  EL  + ++  A

		Sbjct: 288 EYQLVTQLFKN--EILDKLRQTTDNIGLLTLELAKNEERQQA 327

		

		

		

		 Score = 37.9 bits (88), Expect = 2e-04

		 Identities = 28/206 (13%), Positives = 71/206 (34%), Gaps = 19/206 (9%)

		

		Query: 658 EQELQDHRQQLAAYQQRWQTLAQPLSL----AFTLNEPDALALWLEQHEQQEQACQLKLV 713

		             + Q    Q    Q R+Q L++ + L       L +        E+   +  +      

		Sbjct: 136 TLKTQSSLLQARLEQTRYQILSRSIELNKLPELKLPDEPYFQNVSEEEVLRLTSL----- 190

		

		Query: 714 EYERLTQQYQQAKDILTQLEQRQQEHQQQLALITERQKNAQQTYQQLQSQYQHQQEALIA 773

		               + +Q+   ++   Q E    + + +   +  R    +   +  +S+      +L+ 

		Sbjct: 191 ----IKEQFSTWQNQKYQKELNLDKKRAERLTVLARINRYENLSRVEKSRLDDFS-SLLH 245

		

		Query: 774 QQQVLNHTLTELSLSVPDADQQQDWLAQREEECQRWQQHQQEQQRLTIEQKTLETRIENE 833

		           +Q +  H + E      +A  +      + E+ +      +E+ +L  +    E   +  

		Sbjct: 246 KQAIAKHAVLEQENKYVEAVNELRVYKSQLEQIESEILSAKEEYQLVTQLFKNEILDK-- 303

		

		Query: 834 RRHLQECIDQLSALSQQRQQAETLLQ 859

		              L++  D +  L+ +  + E   Q

		Sbjct: 304 ---LRQTTDNIGLLTLELAKNEERQQ 326

		

		

		

		 Score = 34.0 bits (78), Expect = 0.004

		 Identities = 26/180 (14%), Positives = 72/180 (40%), Gaps = 13/180 (7%)

		

		Query: 844  LSALSQQRQQAETLLQQQIQQRQALFGEDIVAE-------VRQRLRLQQQQAELAQQNAE 896

		             + L Q R Q  +   +  +  +    ++   +       +R    +++Q +    Q  +

		Sbjct: 145  QARLEQTRYQILSRSIELNKLPELKLPDEPYFQNVSEEEVLRLTSLIKEQFSTWQNQKYQ 204

		

		Query: 897  K--ALQQAQSQLNRLSGELTGLEQQCQQYQQRATTTQAEL-QQALSTSEFADETALTAAL 953

		            K   L + +++   +   +   E   +  + R     + L +QA++     ++       

		Sbjct: 205  KELNLDKKRAERLTVLARINRYENLSRVEKSRLDDFSSLLHKQAIAKHAVLEQENKYVEA 264

		

		Query: 954  LSE--EERQHLQQLQQQLNERRQQAQIRLQQAR-EILDQHLQLCPQGVDKSSELTLLQQQ 1010

		            ++E    +  L+Q++ ++   +++ Q+  Q  + EILD+  Q        + EL   +++

		Sbjct: 265  VNELRVYKSQLEQIESEILSAKEEYQLVTQLFKNEILDKLRQTTDNIGLLTLELAKNEER 324

		

		

		>SECFTRNLCASE#Bacterial translocase SecF protein signature.

		          Length = 333

		

		 Score = 70.3 bits (172), Expect = 3e-15

		 Identities = 52/277 (18%), Positives = 115/277 (41%), Gaps = 12/277 (4%)

		

		Query: 342 NISLDSAGGATM--SNFTKDNIGKPMATL-FVEYKDSGKKDANGRSILVKQEEVINVATI 398

		           N  +D  GG T+   + T  ++G   A L  +E  D    +    S   + + V  +   

		Sbjct: 44  NFGIDFKGGTTIRTESTTAIDVGVYRAALEPLELGDVIISEVRDPS-FREDQHVAMIRIQ 102

		

		Query: 399 QSRLGNSFRITGIDNPAEARQLSLLLRAGALIAPIQIVEERTIGPTLGSQNIAQGLEACL 458

		               G      G        ++   L   A+   ++I    ++GP +  + +   + + L

		Sbjct: 103 MQEDGQGAEGQGAQGQELVNKVETAL--TAVDPALKITSFESVGPKVSGELVWTAVWSLL 160

		

		Query: 459 WGLAVSILFMVVYYR-KFGVIASTALMANLVLIVGVMSLLPGATLTMPGIAGIVLTLAVA 517

		               V + ++ V +  +F + A  AL+ +++L VG+ ++L      +  +A ++     +

		Sbjct: 161 AATVVIMFYIWVRFEWQFALGAVVALVHDVLLTVGLFAVL-QLKFDLTTVAALLTITGYS 219

		

		Query: 518 VDANVLINERIKEEYR--NGRTIQQAIHEGYKGAFSSIVDANITTLITAIILYAVGTGSI 575

		           ++  V++ +R++E         ++  ++       S  V   +TTL+  + +   G   I

		Sbjct: 220 INDTVVVFDRLRENLIKYKTMPLRDVMNLSVNETLSRTVMTGMTTLLALVPMLIWGGDVI 279

		

		Query: 576 KGFAITTAIGVVTSMFTAIVGTRAIVNLLYGGKRINK 612

		           +GF      GV T  ++++   + I  +L+ G   NK

		Sbjct: 280 RGFVFAMVWGVFTGTYSSVYVAKNI--VLFIGLDRNK 314

		

		

		>SECFTRNLCASE#Bacterial translocase SecF protein signature.

		          Length = 333

		

		 Score =  347 bits (892), Expect = e-122

		 Identities = 108/310 (34%), Positives = 177/310 (57%), Gaps = 15/310 (4%)

		

		Query: 17  YDFMRWDYVAFGVSLLLLVASIVVMSTKGFNWGLDFTGGTVIEINLENPADLDQLRDTLQ 76

		           +DF RW +  FG ++++++AS+++    G N+G+DF GGT I        D+   R  L+

		Sbjct: 14  FDFFRWQWATFGAAIVMMIASVILPLVIGLNFGIDFKGGTTIRTESTTAIDVGVYRAALE 73

		

		Query: 77  NAGFESPILQNFGSSR------DVMVRMPPAT--------GTAGQELGNKIISVINESVD 122

		                  I+               M+R+            G  GQEL NK+ + +   VD

		Sbjct: 74  PLELGDVIISEVRDPSFREDQHVAMIRIQMQEDGQGAEGQGAQGQELVNKVETALTA-VD 132

		

		Query: 123 KNASVKRIEFVGPSVGSDLAQAGALALLVALLSILVYVGFRFEWRLALGAVISLAHDVVI 182

		               +   E VGP V  +L      +LL A + I+ Y+  RFEW+ ALGAV++L HDV++

		Sbjct: 133 PALKITSFESVGPKVSGELVWTAVWSLLAATVVIMFYIWVRFEWQFALGAVVALVHDVLL 192

		

		Query: 183 TMGILSLFHIEIDLTIIASLMSVIGYSLNDSIVVSDRIRENFRKIRRGTPYEIMNVSLTQ 242

		           T+G+ ++  ++ DLT +A+L+++ GYS+ND++VV DR+REN  K +     ++MN+S+ +

		Sbjct: 193 TVGLFAVLQLKFDLTTVAALLTITGYSINDTVVVFDRLRENLIKYKTMPLRDVMNLSVNE 252

		

		Query: 243 TLSRTIMTSATTLMVVLMLFIFGGAMLQGFSLTMLIGVTIGTVSSIYVASALALKLGMKR 302

		           TLSRT+MT  TTL+ ++ + I+GG +++GF   M+ GV  GT SS+YVA  + L +G+ R

		Sbjct: 253 TLSRTVMTGMTTLLALVPMLIWGGDVIRGFVFAMVWGVFTGTYSSVYVAKNIVLFIGLDR 312

		

		Query: 303 EHMLQPKVEK 312

		               +   +K

		Sbjct: 313 NKEKKDPSDK 322

		

		

		>HTHTETR#TetR bacterial regulatory protein HTH signature.

		          Length = 215

		

		 Score =  165 bits (420), Expect = 7e-54

		 Identities = 135/210 (64%), Positives = 164/210 (78%)

		

		Query: 1   MARKTKQKAEETRQQILDAAVREFSAHGVSRTSLTDIAIAAGVTRGAIYWHFKNKVDLFN 60

		           MARKTKQ+A+ETRQ ILD A+R FS  GVS TSL +IA AAGVTRGAIYWHFK+K DLF+

		Sbjct: 1   MARKTKQEAQETRQHILDVALRLFSQQGVSSTSLGEIAKAAGVTRGAIYWHFKDKSDLFS 60

		

		Query: 61  EVWELSESKIDQLEIEYQAKYPDNPLRILRELLIYILVSTREDRRRRALMEIVFHKCEFV 120

		           E+WELSES I +LE+EYQAK+P +PL +LRE+LI++L ST  + RRR LMEI+FHKCEFV

		Sbjct: 61  EIWELSESNIGELELEYQAKFPGDPLSVLREILIHVLESTVTEERRRLLMEIIFHKCEFV 120

		

		Query: 121 GEMTSVHDARKVLDLASYERIESVLQGCIDANQLPVNLNTHRAAIIMRAYITGLMENWLF 180

		           GEM  V  A++ L L SY+RIE  L+ CI+A  LP +L T RAAIIMR YI+GLMENWLF

		Sbjct: 121 GEMAVVQQAQRNLCLESYDRIEQTLKHCIEAKMLPADLMTRRAAIIMRGYISGLMENWLF 180

		

		Query: 181 MPESFDIKQEAPVLIDAYLEMLGQSFSLRN 210

		            P+SFD+K+EA   +   LEM     +LRN

		Sbjct: 181 APQSFDLKKEARDYVAILLEMYLLCPTLRN 210

		

		

		>ADHESNFAMILY#Adhesin family signature.

		          Length = 309

		

		 Score = 26.0 bits (57), Expect = 0.034

		 Identities = 9/71 (12%), Positives = 27/71 (38%)

		

		Query: 47  IAGLNGQQPREGYNLQQMLEILTAQNVPIKLCKTCADARGIAGLTLVDGVEIGTLVELAQ 106

		           I  +N ++      ++ ++E L    VP    ++  D R +  ++    + I   +    

		Sbjct: 222 IWEINTEEEGTPEQIKTLVEKLRQTKVPSLFVESSVDDRPMKTVSQDTNIPIYAQIFTDS 281

		

		Query: 107 WTLAAEKVLTF 117

		                ++  ++

		Sbjct: 282 IAEQGKEGDSY 292

		

		

		>GPOSANCHOR#Gram-positive coccus surface protein anchor signature.

		          Length = 539

		

		 Score = 40.8 bits (95), Expect = 3e-05

		 Identities = 28/235 (11%), Positives = 58/235 (24%), Gaps = 21/235 (8%)

		

		Query: 54  SEVQSQLDLLSKQKILSPAEKLAQQDLTQTLE-YLDTIERTKQEANQLKQQLAQAPAKLR 112

		           S  + +L    K      ++    +     LE  L+         +   + L    A L 

		Sbjct: 95  SNAKEKLRKNDKSLSEKASKIQELEARKADLEKALEGAMNFSTADSAKIKTLEAEKAALA 154

		

		Query: 113 QATEGLE-ALKSSSADTMTKESLANYSLRQLESRLNETLDNLQSAQEDLSAYNSQLIALQ 171

		                LE AL+ +   +               +++        + +   +     L    

		Sbjct: 155 ARKADLEKALEGAMNFS-----------TADSAKIKTLEAEKAALEARQAELEKALEGAM 203

		

		Query: 172 TQPERVQSAMYSASMRLMQIRNQLNGLTPNQESLRPTQQ--QELLAEQVMLNGQLDLERK 229

		                  + + +       +  +   L    E            +         L+  + 

		Sbjct: 204 NFSTADSAKIKTLEAEKAALAARKADLEKALEGAMNFSTADSAKIKTLEAEKAALEARQA 263

		

		Query: 230 NLEANTTLQDLLQKQRDYTTAHINQLERYVQLLQEVVSGKRLILSEKTVKEAQAQ 284

		            LE      +         +A I  LE     L+     K  +  +  V  A  Q

		Sbjct: 264 ELEK---ALEGAMNFSTADSAKIKTLEAEKAALEAE---KADLEHQSQVLNANRQ 312

		

		

		

		 Score = 32.3 bits (73), Expect = 0.013

		 Identities = 36/201 (17%), Positives = 72/201 (35%), Gaps = 33/201 (16%)

		

		Query: 56  VQSQLDLLSKQKILSPAEKLAQQDLTQTLEYLDTIERTKQEANQLKQQ------------ 103

		              +  L ++Q  L  A + A    T     + T+E  K      K              

		Sbjct: 252 EAEKAALEARQAELEKALEGAMNFSTADSAKIKTLEAEKAALEAEKADLEHQSQVLNANR 311

		

		Query: 104 --LAQAPAKLRQATEGLEA-----------LKSSSADTMTKESLANYSLRQLESRLNETL 150

		             L +     R+A + LEA            ++S          +  + +QLE+   +  

		Sbjct: 312 QSLRRDLDASREAKKQLEAEHQKLEEQNKISEASRQSLRRDLDASREAKKQLEAEHQKLE 371

		

		Query: 151 DNLQSAQEDLSAYNSQLIALQTQPERVQSAMYSASMRLMQIRNQLNGLTPNQESLRPTQQ 210

		           +  + ++    +    L A +   ++V+ A+  A+ +L  +      L   +ES + T++

		Sbjct: 372 EQNKISEASRQSLRRDLDASREAKKQVEKALEEANSKLAALEKLNKEL---EESKKLTEK 428

		

		Query: 211 QELLAEQVMLNGQLDLERKNL 231

		                E+  L  +L+ E K L

		Sbjct: 429 -----EKAELQAKLEAEAKAL 444

		

		

		>NUCEPIMERASE#Nucleotide sugar epimerase signature.

		          Length = 334

		

		 Score = 61.0 bits (148), Expect = 1e-12

		 Identities = 49/295 (16%), Positives = 99/295 (33%), Gaps = 44/295 (14%)

		

		Query: 19  GDIRDQNKLLESIREFQPEIVFHMAAQPLVRLSYSEPVETYSTNVMGTVYLLEAIRHVGG 78

		            D+ D+  + +       E VF    +  VR S   P     +N+ G + +LE  RH   

		Sbjct: 59  IDLADREGMTDLFASGHFERVFISPHRLAVRYSLENPHAYADSNLTGFLNILEGCRHN-K 117

		

		Query: 79  VKAVVNITSDKCYDNKEWIWGYRENEAMGGYDPYSNSKGCAELVTSSYRNSFFNPAN--- 135

		           ++ ++  +S   Y     +    ++        Y+ +K   EL+  +Y + +  PA    

		Sbjct: 118 IQHLLYASSSSVYGLNRKMPFSTDDSVDHPVSLYAATKKANELMAHTYSHLYGLPATGLR 177

		

		Query: 136 ----YGQHG----------TAVATVRAGNVIGGGDWA-----LDRIVPDILRAFEQSQPV 176

		               YG  G           A+   ++ +V   G        +D I   I+R  +     

		Sbjct: 178 FFTVYGPWGRPDMALFKFTKAMLEGKSIDVYNYGKMKRDFTYIDDIAEAIIRLQDVI--- 234

		

		Query: 177 IIRNPHAIRPWQHVLEPLSGYLLLAQKLYTDGAEYAEGWNFGPNDADATPVKNIVEQMVK 236

		               PHA   W               +  T  A  A    +   ++    + + ++ +  

		Sbjct: 235 ----PHADTQW-------------TVETGTPAASIAPYRVYNIGNSSPVELMDYIQALED 277

		

		Query: 237 YWGEGASWQLDGNAHPHEAHYLKLDCSKAKMQLGWHPRWNLNTTLEYIVGWHKNW 291

		             G  A   +     P +      D       +G+ P   +   ++  V W++++

		Sbjct: 278 ALGIEAKKNML-PLQPGDVLETSADTKALYEVIGFTPETTVKDGVKNFVNWYRDF 331

		

		

		>NUCEPIMERASE#Nucleotide sugar epimerase signature.

		          Length = 334

		

		 Score = 66.0 bits (161), Expect = 1e-14

		 Identities = 59/321 (18%), Positives = 115/321 (35%), Gaps = 70/321 (21%)

		

		Query: 1   MKILITGVSGYLGSQLANALMLE-HEVVGTVRAGSVCNRITDIGNVNL------------ 47

		           MK L+TG +G++G  ++  L+   H+VVG        + + D  +V+L            

		Sbjct: 1   MKYLVTGAAGFIGFHVSKRLLEAGHQVVGI-------DNLNDYYDVSLKQARLELLAQPG 53

		

		Query: 48  -----INVTDSGWIDKVL-SFSPDVVINTAALYGRKGELLS--ELVDANIQFPLRILE-- 97

		                I++ D   +  +  S   + V  +      +  L +     D+N+   L ILE  

		Sbjct: 54  FQFHKIDLADREGMTDLFASGHFERVFISPHRLAVRYSLENPHAYADSNLTGFLNILEGC 113

		

		Query: 98  --------MLVST----GKGLFFQCGTSLPAD--VSQYALTKNQFTELAREYCNKFSGKF 143

		                   +  S+    G        T    D  VS YA TK     +A  Y + +    

		Sbjct: 114 RHNKIQHLLYASSSSVYGLNRKMPFSTDDSVDHPVSLYAATKKANELMAHTYSHLYGLPA 173

		

		Query: 144 IELKLEHFFGPFDDST----KFTTYVINSCRSHSDLKL-TAGLQRRDFIYINDLINA--- 195

		             L+    +GP+        KFT     +      + +   G  +RDF YI+D+  A   

		Sbjct: 174 TGLRFFTVYGPWGRPDMALFKFT----KAMLEGKSIDVYNYGKMKRDFTYIDDIAEAIIR 229

		

		Query: 196 ------------FKIMISKSESLISGESISIGSGHAVTIKEFVETVAKMTSYQGNLQFGA 243

		                            + + S+      +IG+   V + ++++ +      +       

		Sbjct: 230 LQDVIPHADTQWTVETGTPAASIAPYRVYNIGNSSPVELMDYIQALEDALGIEAKKNM-- 287

		

		Query: 244 IPTRENELMYSCASLARIQEL 264

		           +P +  +++ + A    + E+

		Sbjct: 288 LPLQPGDVLETSADTKALYEV 308

		

		

		>BINARYTOXINB#Binary toxin B family signature.

		          Length = 764

		

		 Score = 23.5 bits (50), Expect = 0.020

		 Identities = 12/23 (52%), Positives = 16/23 (69%)

		

		Query: 2   DNNIISPPENNDTKTNGTLFLLV 24

		           +N II+P EN DT TNG   +L+

		Sbjct: 733 ENTIINPSENGDTSTNGIKKILI 755

		

		

		>NUCEPIMERASE#Nucleotide sugar epimerase signature.

		          Length = 334

		

		 Score = 82.5 bits (204), Expect = 4e-20

		 Identities = 59/352 (16%), Positives = 122/352 (34%), Gaps = 59/352 (16%)

		

		Query: 5   RVFIAGHRGMVGSAIVRQLENRND--------------------IELIIRDR---TELDL 41

		           +  + G  G +G  + ++L                         +EL+ +      ++DL

		Sbjct: 2   KYLVTGAAGFIGFHVSKRLLEAGHQVVGIDNLNDYYDVSLKQARLELLAQPGFQFHKIDL 61

		

		Query: 42  MSQSAVQKFFATEKIDEIYLAAAKVGGIQANNNYPAEFIYQNLMIECNIIHAAHLAGIQK 101

		             +  +   FA+   + ++++  ++    +  N P  +   NL    NI+       IQ 

		Sbjct: 62  ADREGMTDLFASGHFERVFISPHRLAVRYSLEN-PHAYADSNLTGFLNILEGCRHNKIQH 120

		

		Query: 102 LLFLGSSCIYPKLAAQPMTEEALLTGVLEPTNEP---YAIAKIAGIKLCESYNRQYGRDY 158

		           LL+  SS +Y      P + +       +  + P   YA  K A   +  +Y+  YG   

		Sbjct: 121 LLYASSSSVYGLNRKMPFSTD-------DSVDHPVSLYAATKKANELMAHTYSHLYGLPA 173

		

		Query: 159 RSVMPTNLYGENDNFHPENSHVIPALLRRFHEAKIRNDKEMVVWGTGKPMREFLHVDDMA 218

		             +    +YG             P +        +   K + V+  GK  R+F ++DD+A

		Sbjct: 174 TGLRFFTVYGPWGR---------PDMALFKFTKAMLEGKSIDVYNYGKMKRDFTYIDDIA 224

		

		Query: 219 AASVHVMELSDQIYQTNTQPMLSH------------INVGTGVDCTIRELAETMAKVVGF 266

		            A   ++ L D I   +TQ  +               N+G      + +  + +   +G 

		Sbjct: 225 EA---IIRLQDVIPHADTQWTVETGTPAASIAPYRVYNIGNSSPVELMDYIQALEDALGI 281

		

		Query: 267 TGNLVFDSTKPDGTPRKLMDVSRLAK-LGWCYQISLEVGLTMTYQWFLAHQN 317

		                    +P        D   L + +G+  + +++ G+     W+     

		Sbjct: 282 EAKKNMLPLQPGDVLETSADTKALYEVIGFTPETTVKDGVKNFVNWYRDFYK 333

		

		

		>CHANLCOLICIN#Channel forming colicin signature.

		          Length = 522

		

		 Score = 29.3 bits (65), Expect = 0.021

		 Identities = 33/153 (21%), Positives = 61/153 (39%), Gaps = 20/153 (13%)

		

		Query: 130 SQRDNINSRLLHIVDEATNPWGIKITRIEIRDVRPP--TELISAMNAQMKAERTKRADIL 187

		           + RD +  RL  IV+EA          +     R P  TEL  A NA M+AE  +     

		Sbjct: 85  ANRDALTQRLKDIVNEA----------LRHNASRTPSATELAHANNAAMQAEDERLRLAK 134

		

		Query: 188 EAEGVRQAAILRAEGEKQSQILKAEGERQSA-------FLQAEARERAAEAEAQATKMVS 240

		             E  R+ A    +  ++++  + E ER+ A         +AE +  AA +E      ++

		Sbjct: 135 AEEKARKEAEAAEKAFQEAEQRRKEIEREKAETERQLKLAEAEEKRLAALSEEAKAVEIA 194

		

		Query: 241 EAIAAGDIQAINYFVAQKYTDALQHIGSANNSK 273

		           +   +     +     +  T     + S+ +++

		Sbjct: 195 QKKLSAAQSEVVKMDGEIKT-LNSRLSSSIHAR 226

		

		

		>PF06057#Type IV secretory pathway VirJ component

		          Length = 243

		

		 Score = 29.4 bits (66), Expect = 0.013

		 Identities = 15/68 (22%), Positives = 25/68 (36%), Gaps = 12/68 (17%)

		

		Query: 20  QSMSVPV-----LFYFWSERSQHCLQLTPTLDKLAAEYAGQFILARVDCDAQPMVASQFG 74

		           Q    PV     L Y+W ++      +T     +  +Y  +F   +V      ++   FG

		Sbjct: 75  QQQGWPVVGWSSLKYYWKQKDPK--DVTQDTLAIIDKYQAEFGTQKV-----ILIGYSFG 127

		

		Query: 75  LRSIPAVY 82

		              IP V 

		Sbjct: 128 AEVIPFVL 135

		

		

		>DHBDHDRGNASE#2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase

		           signature.

		          Length = 261

		

		 Score = 80.9 bits (199), Expect = 3e-20

		 Identities = 51/191 (26%), Positives = 85/191 (44%), Gaps = 7/191 (3%)

		

		Query: 3   KAVLITGCSSGIGLVAAQDLKNRGYRVLAACRKPDDVAKMVQ-LGLEG-----IELDLDD 56

		           K   ITG + GIG   A+ L ++G  + A    P+ + K+V  L  E         D+ D

		Sbjct: 9   KIAFITGAAQGIGEAVARTLASQGAHIAAVDYNPEKLEKVVSSLKAEARHAEAFPADVRD 68

		

		Query: 57  SASVERAAAQVIELTGGRLYGLFNNGGFGLYGSLHTISRQQLEKQFSTNLFGTHQLTQLL 116

		           SA+++   A++    G  +  L N  G    G +H++S ++ E  FS N  G    ++ +

		Sbjct: 69  SAAIDEITARIEREMG-PIDILVNVAGVLRPGLIHSLSDEEWEATFSVNSTGVFNASRSV 127

		

		Query: 117 LPAMLPHGEGRIIQTSSVMGLVSTAGRGAYAASKYALEAWSDALRMELQSSGIHVSLIEP 176

		              M+    G I+   S    V      AYA+SK A   ++  L +EL    I  +++ P

		Sbjct: 128 SKYMMDRRSGSIVTVGSNPAGVPRTSMAAYASSKAAAVMFTKCLGLELAEYNIRCNIVSP 187

		

		Query: 177 GPISTHFTQNV 187

		           G   T    ++

		Sbjct: 188 GSTETDMQWSL 198

		

		

		>PRTACTNFAMLY#Pertactin virulence factor family signature.

		          Length = 910

		

		 Score =  205 bits (523), Expect = 1e-58

		 Identities = 138/521 (26%), Positives = 218/521 (41%), Gaps = 40/521 (7%)

		

		Query: 152 DVTTHNPALPANVMIENLNVAGLVEIGPSWKGTSIVPLPLSDVLGPVLVT---RINNVTL 208

		           D+            I  L+VA  +     W G +     LS      ++T    +  + L

		Sbjct: 396 DIVATELPSIPGTSIGPLDVA--LASQARWTGATRAVDSLSIDNATWVMTDNSNVGALRL 453

		

		Query: 209 QG-GDINLMAYSAGGQFNRLEIENLSGQGNFAMTTQLASNTGDFITVSQQATGQFGITVQ 267

		              G ++    +  G+F  L +  L+G G F M         D + V Q A+GQ  + V+

		Sbjct: 454 ASDGSVDFQQPAEAGRFKVLTVNTLAGSGLFRMNVFADLGLSDKLVVMQDASGQHRLWVR 513

		

		Query: 268 DSGKEPQSADNLALVHINRG-DAQFRLLNTGGVVDLGVYQYGLYSQESNGSTDWYL---- 322

		           +SG EP SA+ L LV    G  A F L N  G VD+G Y+Y L    +NG+  W L    

		Sbjct: 514 NSGSEPASANTLLLVQTPLGSAATFTLANKDGKVDIGTYRYRL---AANGNGQWSLVGAK 570

		

		Query: 323 ---ATSTEELPGTTPNVTAPM--------------LSSAAQGVLNMA--AAPRHILNAEL 363

		              A      PG  P                    LS+AA   +N         +  AE 

		Sbjct: 571 APPAPKPAPQPGPQPPQPPQPQPEAPAPQPPAGRELSAAANAAVNTGGVGLASTLWYAES 630

		

		Query: 364 STLRQRQGELKADAEGTVGVWARYLTDDSRLSDNKNIAFKNTLSGMEIGADKQLGLNRGN 423

		           + L +R GEL+ + +   G W R      +L +     F   ++G E+GAD  + +  G 

		Sbjct: 631 NALSKRLGELRLNPDAG-GAWGRGFAQRQQLDNRAGRRFDQKVAGFELGADHAVAVAGGR 689

		

		Query: 424 MLIGAFTSYSSSDVKSTHDANGDIRSYGGGLYLTYLDQSGFYVDTVLKANRFNNKMNTQE 483

		             +G    Y+  D   T D  G   S   G Y TY+  SGFY+D  L+A+R  N      

		Sbjct: 690 WHLGGLAGYTRGDRGFTGDGGGHTDSVHVGGYATYIADSGFYLDATLRASRLENDFKVAG 749

		

		Query: 484 T-----RGEYNQNALTTSVESGYQWPVYANLVLEPYGKVSYSRIGSADYTLSNGMVAEVA 538

		           +     +G+Y  + +  S+E+G ++       LEP  +++  R G   Y  +NG+     

		Sbjct: 750 SDGYAVKGKYRTHGVGASLEAGRRFTHADGWFLEPQAELAVFRAGGGAYRAANGLRVRDE 809

		

		Query: 539 KADSVQGELGTVLAASYSI-NQMTIKPYIKLAITREFTKSNAVAINNIGFDNDFSGNVGK 597

		              SV G LG  +     +     ++PYIK ++ +EF  +  V  N I    +  G   +

		Sbjct: 810 GGSSVLGRLGLEVGKRIELAGGRQVQPYIKASVLQEFDGAGTVHTNGIAHRTELRGTRAE 869

		

		Query: 598 YGVGINATVANNTAIFAEVDYLNGSKIETPVTANIGFRLRF 638

		            G+G+ A +    +++A  +Y  G K+  P T + G+R  +

		Sbjct: 870 LGLGMAAALGRGHSLYASYEYSKGPKLAMPWTFHAGYRYSW 910

		

		

		>PF03627#PapG

		          Length = 336

		

		 Score = 26.1 bits (57), Expect = 0.024

		 Identities = 10/46 (21%), Positives = 20/46 (43%)

		

		Query: 5   SNNSRAHCSKPFLYRQNQWHFNQAISEYRLPAPLSAQDLTDSVNHI 50

		           + ++   C KP    +    F+  I +  LPA L   D + ++ + 

		Sbjct: 131 AFDAGNLCQKPGETTRLTEKFDDIIFKVALPADLPLGDYSVTIPYT 176

		

		

		>CHANLCOLICIN#Channel forming colicin signature.

		          Length = 522

		

		 Score = 28.9 bits (64), Expect = 0.006

		 Identities = 10/48 (20%), Positives = 20/48 (41%), Gaps = 1/48 (2%)

		

		Query: 2   PMFNTLLAVFIGGGVGSMARWLVSLKLNSASAHLPVGTLIVNLVGAFI 49

		           P+F TL       GV  +   L SL   +      +  ++  ++ ++I

		Sbjct: 462 PLFLTLEKKAADAGVSYVVALLFSLLAGTTLGIWGIA-IVTGILCSYI 508

		

		

		>FLGPRINGFLGI#Flagellar P-ring protein signature.

		          Length = 373

		

		 Score = 28.4 bits (63), Expect = 0.013

		 Identities = 11/24 (45%), Positives = 18/24 (75%)

		

		Query: 134 LKARTLIQVLEPIKARGALETDLL 157

		           LKA  +I +L+ IK+ GAL+ +L+

		Sbjct: 348 LKADGIIAILQGIKSAGALQAELV 371

		

		

		>HTHTETR#TetR bacterial regulatory protein HTH signature.

		          Length = 215

		

		 Score = 28.1 bits (62), Expect = 0.047

		 Identities = 12/106 (11%), Positives = 31/106 (29%), Gaps = 14/106 (13%)

		

		Query: 16  QGMSSRAIARELGISRNTVKRYLQAKSEPPKYTPRPAVASLLDEYRDYIRQRIAD----- 70

		              S   IA+  G++R  +  + + KS+          + + +     I +   +     

		Sbjct: 30  SSTSLGEIAKAAGVTRGAIYWHFKDKSD--------LFSEIWELSESNIGELELEYQAKF 81

		

		Query: 71  -AHPYKIPATVIAREIRDQGYRGGMTILRAFIRSLSVPQEQEPAVR 115

		              P  +   ++   +          +L   I        +   V+

		Sbjct: 82  PGDPLSVLREILIHVLESTVTEERRRLLMEIIFHKCEFVGEMAVVQ 127

		

		

		>UREASE#Urea amidohydrolase (urease) protein signature.

		          Length = 570

		

		 Score =  977 bits (2528), Expect = 0.0

		 Identities = 328/570 (57%), Positives = 417/570 (73%), Gaps = 5/570 (0%)

		

		Query: 3   QISRQEYAGLFGPTTGDKIRLGDTNLFIEIEKDLRGYGEESVYGGGKSLRDGMGANNNLT 62

		           ++SR  YA +FGPT GDK+RL DT LFIE+EKD   +GEE  +GGGK +RDGMG  + +T

		Sbjct: 4   RMSRAAYANMFGPTVGDKVRLADTELFIEVEKDFTTHGEEVKFGGGKVIRDGMG-QSQVT 62

		

		Query: 63  RDNGVLDLVITNVTIVDARLGVIKADVGIRDGKIAGIGKSGNPGVMDGVTQGMVVGVSTD 122

		           R+ G +D VITN  I+D   G++KAD+G++DG+IA IGK+GNP +  GVT  ++VG  T+

		Sbjct: 63  REGGAVDTVITNALILDH-WGIVKADIGLKDGRIAAIGKAGNPDMQPGVT--IIVGPGTE 119

		

		Query: 123 AISGEHLILTAAGIDSHIHLISPQQAYHALSNGVATFFGGGIGPTDGTNGTTVTPGPWNI 182

		            I+GE  I+TA G+DSHIH I PQQ   AL +G+    GGG GP  GT  TT TPGPW+I

		Sbjct: 120 VIAGEGKIVTAGGMDSHIHFICPQQIEEALMSGLTCMLGGGTGPAHGTLATTCTPGPWHI 179

		

		Query: 183 RQMLRSIEGLPVNVGILGKGNSYGRGPLLEQAIAGVVGYKVHEDWGATANALRHALRMAD 242

		            +M+ + +  P+N+   GKGN+   G L+E  + G    K+HEDWG T  A+   L +AD

		Sbjct: 180 ARMIEAADAFPMNLAFAGKGNASLPGALVEMVLGGATSLKLHEDWGTTPAAIDCCLSVAD 239

		

		Query: 243 EVDIQVSVHTDSLNECGYVEDTIDAFEGRTIHTFHTEGAGGGHAPDIIRVASQTNVLPSS 302

		           E D+QV +HTD+LNE G+VEDTI A +GRTIH +HTEGAGGGHAPDIIR+  Q NV+PSS

		Sbjct: 240 EYDVQVMIHTDTLNESGFVEDTIAAIKGRTIHAYHTEGAGGGHAPDIIRICGQPNVIPSS 299

		

		Query: 303 TNPTLPYGVNSQAELFDMIMVCHNLNPNVPADVSFAESRVRPETIAAENVLHDMGVISMF 362

		           TNPT PY VN+ AE  DM+MVCH+L+P +P D++FAESR+R ETIAAE++LHD+G  S+ 

		Sbjct: 300 TNPTRPYTVNTLAEHLDMLMVCHHLSPTIPEDIAFAESRIRKETIAAEDILHDIGAFSII 359

		

		Query: 363 SSDSQAMGRVGENWLRILQTADAMKAARGKLPEDAAGNDNFRVLRYVAKITINPAITQGV 422

		           SSDSQAMGRVGE  +R  QTAD MK  RG+L E+   NDNFRV RY+AK TINPAI  G+

		Sbjct: 360 SSDSQAMGRVGEVAIRTWQTADKMKRQRGRLKEETGDNDNFRVKRYIAKYTINPAIAHGL 419

		

		Query: 423 SHVIGSVEVGKMADLVLWDPRFFGAKPKMVIKGGMINWAAMGDPNASLPTPQPVFYRPMF 482

		           SH IGS+EVGK ADLVLW+P FFG KP MV+ GG I  A MGDPNAS+PTPQPV YRPMF

		Sbjct: 420 SHEIGSLEVGKRADLVLWNPAFFGVKPDMVLLGGTIAAAPMGDPNASIPTPQPVHYRPMF 479

		

		Query: 483 GAMGKTLQDTCVTFVSQAALDDGVKEKAGLDRQVIAVKNCR-TISKRDLVRNDQTPNIEV 541

		           GA G++  ++ VTFVSQA+LD G+  + G+ ++++AV+N R  I K  ++ N  TP+IEV

		Sbjct: 480 GAYGRSRTNSSVTFVSQASLDAGLAGRLGVAKELVAVQNTRGGIGKASMIHNSLTPHIEV 539

		

		Query: 542 DPETFAVKVDGVHATCEPIATASMNQRYFF 571

		           DPET+ V+ DG   TCEP     M QRYF 

		Sbjct: 540 DPETYEVRADGELLTCEPATVLPMAQRYFL 569

		

		

		>HTHFIS#FIS bacterial regulatory protein HTH signature.

		          Length = 484

		

		 Score = 74.1 bits (182), Expect = 9e-18

		 Identities = 27/112 (24%), Positives = 52/112 (46%), Gaps = 1/112 (0%)

		

		Query: 1   MRIALESEGWRVFESETLQRGLIEAGTRKPDLIILDLGLPDGDGLNYIQDLRQWSA-IPI 59

		           +  AL   G+ V  +               DL++ D+ +PD +  + +  +++    +P+

		Sbjct: 19  LNQALSRAGYDVRITSNAATLWRWIAAGDGDLVVTDVVMPDENAFDLLPRIKKARPDLPV 78

		

		Query: 60  IVLSARNNEEDKVAALDAGADDYLSKPFGISELLARVRVALRRHSGASQESP 111

		           +V+SA+N     + A + GA DYL KPF ++EL+  +  AL        +  

		Sbjct: 79  LVMSAQNTFMTAIKASEKGAYDYLPKPFDLTELIGIIGRALAEPKRRPSKLE 130

		

		

		>SHAPEPROTEIN#Bacterial cell shape determinant MreB/Mbl protein

		           signature.

		          Length = 347

		

		 Score =  103 bits (259), Expect = 4e-26

		 Identities = 58/267 (21%), Positives = 108/267 (40%), Gaps = 30/267 (11%)

		

		Query: 150 GLVNPVQVSAEILKTLAQRAQ-AALAGELDGVVITVPAYFDDAQRQGTKDAARLAGLHVL 208

		           G++    V+ ++L+   ++    +       V++ VP      +R+  +++A+ AG   +

		Sbjct: 79  GVIADFFVTEKMLQHFIKQVHSNSFMRPSPRVLVCVPVGATQVERRAIRESAQGAGAREV 138

		

		Query: 209 RLLNEPTAAAIAYGLDSGQEGVIAVYDLGGGTFDISILRLSRGVFEVLATGGDSALGGDD 268

		            L+ EP AAAI  GL   +     V D+GGGT +++++ L+  V           +GGD 

		Sbjct: 139 FLIEEPMAAAIGAGLPVSEATGSMVVDIGGGTTEVAVISLNGVV-----YSSSVRIGGDR 193

		

		Query: 269 FDHLLADWLREQAGVATRDDHGIQRQLLDTAIAAKI----ALSEAETAVVSVAG---WQG 321

		           FD  + +++R   G       G       TA   K     A    E   + V G    +G

		Sbjct: 194 FDEAIINYVRRNYGSLI----GEA-----TAERIKHEIGSAYPGDEVREIEVRGRNLAEG 244

		

		Query: 322 -----EVTREQLESLIAPQVKRTLMACRRALKD-AGVTADEILE--VVMVGGSTRVPLVR 373

		                 +   ++   +   +   + A   AL+      A +I E  +V+ GG   +  + 

		Sbjct: 245 VPRGFTLNSNEILEALQEPLTGIVSAVMVALEQCPPELASDISERGMVLTGGGALLRNLD 304

		

		Query: 374 EQVGQFFGRTPLTSIDPDKVVAIGAAI 400

		             + +  G   + + DP   VA G   

		Sbjct: 305 RLLMEETGIPVVVAEDPLTCVARGGGK 331

		

		

		>PRTACTNFAMLY#Pertactin virulence factor family signature.

		          Length = 910

		

		 Score = 52.4 bits (125), Expect = 2e-11

		 Identities = 27/87 (31%), Positives = 42/87 (48%)

		

		Query: 1   MSAFSSGKSAVKLSNGMVAQSSSTRSMIGTLGVNAGYRFVLKNGVEMKPYVSASVDHEFA 60

		           ++ F +G  A + +NG+  +     S++G LG+  G R  L  G +++PY+ ASV  EF 

		Sbjct: 788 LAVFRAGGGAYRAANGLRVRDEGGSSVLGRLGLEVGKRIELAGGRQVQPYIKASVLQEFD 847

		

		Query: 61  ANNKFRVNQEMFDNNLNGTRVNTGAGL 87

		                  N       L GTR   G G+

		Sbjct: 848 GAGTVHTNGIAHRTELRGTRAELGLGM 874

		

		

		>PRTACTNFAMLY#Pertactin virulence factor family signature.

		          Length = 910

		

		 Score =  105 bits (263), Expect = 4e-25

		 Identities = 78/312 (25%), Positives = 131/312 (41%), Gaps = 44/312 (14%)

		

		Query: 724 LVMDSLAGNGTFKLGSMLQQDASAPVNVTGNADGDFILQIDGSGIDPTNLN----VVSTG 779

		           L +++LAG+G F++        S  + V  +A G   L +  SG +P + N    V +  

		Sbjct: 473 LTVNTLAGSGLFRMNVFADLGLSDKLVVMQDASGQHRLWVRNSGSEPASANTLLLVQTPL 532

		

		Query: 780 GGDARFTLT--DGPIGLGNRVYNLVKDASGKVTLVANESTVTPG---------------- 821

		           G  A FTL   DG + +G   Y L  + +G+ +LV  ++   P                 

		Sbjct: 533 GSAATFTLANKDGKVDIGTYRYRLAANGNGQWSLVGAKAPPAPKPAPQPGPQPPQPPQPQ 592

		

		Query: 822 ----------TASILAVANT---------TPVIFNAELSSVQQRLDKQSTEANESGIWGT 862

		                        + A AN             ++ AE +++ +RL +     +  G WG 

		Sbjct: 593 PEAPAPQPPAGRELSAAANAAVNTGGVGLASTLWYAESNALSKRLGELRLNPDAGGAWGR 652

		

		Query: 863 YLHNNFAVKGRAAN-FDQTLNGITLGGDKATALADGVLSVGGFASASTSSIKTDYQSKGN 921

		                  +  RA   FDQ + G  LG D A A+A G   +GG A  +           G+

		Sbjct: 653 GFAQRQQLDNRAGRRFDQKVAGFELGADHAVAVAGGRWHLGGLAGYTRGDRGFTGDGGGH 712

		

		Query: 922 VDSHSFGAYAQYLANNGGYVNGVVKANKFNQDIHVTSADNSA-SGNTNFSGMGVAVKAGK 980

		            DS   G YA Y+A++G Y++  ++A++   D  V  +D  A  G     G+G +++AG+

		Sbjct: 713 TDSVHVGGYATYIADSGFYLDATLRASRLENDFKVAGSDGYAVKGKYRTHGVGASLEAGR 772

		

		Query: 981 HINH-NHLYVSP 991

		              H +  ++ P

		Sbjct: 773 RFTHADGWFLEP 784

		

		

		>PRTACTNFAMLY#Pertactin virulence factor family signature.

		          Length = 910

		

		 Score =  148 bits (374), Expect = 4e-38

		 Identities = 119/438 (27%), Positives = 183/438 (41%), Gaps = 44/438 (10%)

		

		Query: 1065 LTMASLNGTGNFNLGSVMQSDSVAPLNVSGDANGDFIIAMNSSGQAPTNLN----VVNTN 1120

		            LT+ +L G+G F +           L V  DA+G   + + +SG  P + N    V    

		Sbjct: 473  LTVNTLAGSGLFRMNVFADLGLSDKLVVMQDASGQHRLWVRNSGSEPASANTLLLVQTPL 532

		

		Query: 1121 GGDARFALAN--GPVALGNYMTNLAKDANGNFVLTADKSAMTPGTAGIL----------- 1167

		            G  A F LAN  G V +G Y   LA + NG + L   K+   P  A              

		Sbjct: 533  GSAATFTLANKDGKVDIGTYRYRLAANGNGQWSLVGAKAPPAPKPAPQPGPQPPQPPQPQ 592

		

		Query: 1168 -------------------AVANTTPV-----IFNAELSSIQQRLDKQSTETNQSGMWGS 1203

		                               A  NT  V     ++ AE +++ +RL +     +  G WG 

		Sbjct: 593  PEAPAPQPPAGRELSAAANAAVNTGGVGLASTLWYAESNALSKRLGELRLNPDAGGAWGR 652

		

		Query: 1204 YLNNNFAVKGRAAN-FDQKLNGMTLGGDKATALADGVLSVGGFASYSSSDIKTDYQSKGK 1262

		                   +  RA   FDQK+ G  LG D A A+A G   +GG A Y+  D        G 

		Sbjct: 653  GFAQRQQLDNRAGRRFDQKVAGFELGADHAVAVAGGRWHLGGLAGYTRGDRGFTGDGGGH 712

		

		Query: 1263 VDSHSFGAYAQYLANSGYYMNAVVKNNQFSQDVNITSINGSA-SGVSNFSGMGIALKAGK 1321

		             DS   G YA Y+A+SG+Y++A ++ ++   D  +   +G A  G     G+G +L+AG+

		Sbjct: 713  TDSVHVGGYATYIADSGFYLDATLRASRLENDFKVAGSDGYAVKGKYRTHGVGASLEAGR 772

		

		Query: 1322 HFNFNEA-YVSPYVAMSAFSSGKSNISLSNGMEAQSSSTRSAMGTLGVNAGYRFVMNNGA 1380

		             F   +  ++ P   ++ F +G      +NG+  +     S +G LG+  G R  +  G 

		Sbjct: 773  RFTHADGWFLEPQAELAVFRAGGGAYRAANGLRVRDEGGSSVLGRLGLEVGKRIELAGGR 832

		

		Query: 1381 ELKPYAIFAVDHEFAKNNQVTVNQEVFDNNLSGTRVNTGAGMNVNITPNLSVGSEVKLSS 1440

		            +++PY   +V  EF     V  N       L GTR   G GM   +    S+ +  + S 

		Sbjct: 833  QVQPYIKASVLQEFDGAGTVHTNGIAHRTELRGTRAELGLGMAAALGRGHSLYASYEYSK 892

		

		Query: 1441 GKDIKTPVTINLNVGYSF 1458

		            G  +  P T +    YS+

		Sbjct: 893  GPKLAMPWTFHAGYRYSW 910

		

		

		>SYCDCHAPRONE#Gram-negative bacterial type III secretion SycD

		           chaperone signature.

		          Length = 168

		

		 Score = 29.5 bits (66), Expect = 0.008

		 Identities = 17/89 (19%), Positives = 25/89 (28%)

		

		Query: 39  LGLAYLAQGDLTAARKNLEKAVEADPQDYRTQLGMAFYAQRIGENSAAEQRYQQAMKLAP 98

		           L       G    A K  +     D  D R  LG+    Q +G+   A   Y     +  

		Sbjct: 42  LAFNQYQSGKYEDAHKVFQALCVLDHYDSRFFLGLGACRQAMGQYDLAIHSYSYGAIMDI 101

		

		Query: 99  GNGTVLNNYGAFLCSLGQYVSAQQQFSAA 127

		                  +    L   G+   A+     A

		Sbjct: 102 KEPRFPFHAAECLLQKGELAEAESGLFLA 130