Basic Information
Gene ID 2908 ; Check Expression Profles ; Check TFs & Targets Binding
Gene Name NR3C1; GRL
Full Name Glucocorticoid receptor
Organism Homo sapiens [9606]

Cross Reference
UniProt P04150 UniGene Hs.122926
PDB 4LSJ OMIM 138040
KEGG hsa:2908 UCSC uc003lmz.3

Protein Interactions
DIP DIP-576N
IntAct P04150
MINT MINT-150603
STRING 9606.ENSP00000231509

Ensembl/RefSeq
Transcript ID
Protein ID
Gene ID
ENSEMBL
ENSEMBL
ENSEMBL
ENSEMBL
ENSEMBL
ENSEMBL
ENSEMBL
ENSEMBL
ENSEMBL
REFSEQ
REFSEQ
REFSEQ
REFSEQ
REFSEQ
REFSEQ
REFSEQ
REFSEQ
REFSEQ
REFSEQ
REFSEQ
REFSEQ
REFSEQ
REFSEQ
REFSEQ
REFSEQ
REFSEQ
REFSEQ
REFSEQ
REFSEQ
REFSEQ
REFSEQ

InterPro Annotation
Protein Program Term IPRS Start End Score Description
ENSP00000231509 Gene3D G3DSA:1.10.565.10 IPR008946 537 764 6.80e-67 Nuclear hormone receptor, ligand-binding
ENSP00000231509 Gene3D G3DSA:3.30.50.10 IPR013088 418 498 7.90e-27 Zinc finger, NHR/GATA-type
ENSP00000231509 Pfam PF00104 IPR000536 545 736 1.10e-30 Nuclear hormone receptor, ligand-binding, core
ENSP00000231509 Pfam PF00105 IPR001628 420 488 4.80e-27 Zinc finger, nuclear hormone receptor-type
ENSP00000231509 Pfam PF02155 IPR001409 26 401 1.10e-183 Glucocorticoid receptor
ENSP00000231509 PRINTS PR00047 IPR001628 421 437 8.70e-14 Zinc finger, nuclear hormone receptor-type
ENSP00000231509 PRINTS PR00047 IPR001628 437 452 8.70e-14 Zinc finger, nuclear hormone receptor-type
ENSP00000231509 PRINTS PR00047 IPR001628 471 479 8.70e-14 Zinc finger, nuclear hormone receptor-type
ENSP00000231509 PRINTS PR00047 IPR001628 479 487 8.70e-14 Zinc finger, nuclear hormone receptor-type
ENSP00000231509 PRINTS PR00398 IPR001723 483 493 7.90e-13 Steroid hormone receptor
ENSP00000231509 PRINTS PR00398 IPR001723 567 588 7.90e-13 Steroid hormone receptor
ENSP00000231509 PRINTS PR00398 IPR001723 588 604 7.90e-13 Steroid hormone receptor
ENSP00000231509 PRINTS PR00398 IPR001723 657 672 7.90e-13 Steroid hormone receptor
ENSP00000231509 PRINTS PR00528 IPR001409 109 129 3.30e-78 Glucocorticoid receptor
ENSP00000231509 PRINTS PR00528 IPR001409 26 46 3.30e-78 Glucocorticoid receptor
ENSP00000231509 PRINTS PR00528 IPR001409 275 296 3.30e-78 Glucocorticoid receptor
ENSP00000231509 PRINTS PR00528 IPR001409 322 340 3.30e-78 Glucocorticoid receptor
ENSP00000231509 PRINTS PR00528 IPR001409 382 401 3.30e-78 Glucocorticoid receptor
ENSP00000231509 PRINTS PR00528 IPR001409 76 96 3.30e-78 Glucocorticoid receptor
ENSP00000231509 ProSitePatterns PS00031 IPR001628 421 447 - Zinc finger, nuclear hormone receptor-type
ENSP00000231509 ProSiteProfiles PS51030 IPR001628 418 494 0.00e-00 Zinc finger, nuclear hormone receptor-type
ENSP00000231509 SMART SM00399 IPR001628 418 490 2.80e-37 Zinc finger, nuclear hormone receptor-type
ENSP00000231509 SMART SM00430 IPR000536 566 730 4.50e-35 Nuclear hormone receptor, ligand-binding, core
ENSP00000231509 SUPERFAMILY SSF48508 IPR008946 531 777 0.00e-00 Nuclear hormone receptor, ligand-binding

Pfam Annotation
Protein Pfam ID E.value Name Description
ENSP00000231509 PF02155 0 GCR Glucocorticoid receptor
ENSP00000231509 PF00104 7.4e-31 Hormone_recep Ligand-binding domain of nuclear hormone receptor
ENSP00000231509 PF00105 2.6e-27 zf-C4 Zinc finger, C4 type (two domains)

Gene Ontology Annotation
Protein Entry Name Space Description
ENSP00000231509 GO:0006351 biological_process transcription, DNA-templated
ENSP00000231509 GO:0006355 biological_process regulation of transcription, DNA-templated
ENSP00000231509 GO:0016568 biological_process chromatin modification
ENSP00000231509 GO:0042921 biological_process glucocorticoid receptor signaling pathway
ENSP00000231509 GO:0043401 biological_process steroid hormone mediated signaling pathway
ENSP00000231509 GO:0043402 biological_process glucocorticoid mediated signaling pathway
ENSP00000231509 GO:0005634 cellular_component nucleus
ENSP00000231509 GO:0005737 cellular_component cytoplasm
ENSP00000231509 GO:0005739 cellular_component mitochondrion
ENSP00000231509 GO:0003677 molecular_function DNA binding
ENSP00000231509 GO:0003700 molecular_function sequence-specific DNA binding transcription factor activity
ENSP00000231509 GO:0003707 molecular_function steroid hormone receptor activity
ENSP00000231509 GO:0004883 molecular_function glucocorticoid receptor activity
ENSP00000231509 GO:0005496 molecular_function steroid binding
ENSP00000231509 GO:0008270 molecular_function zinc ion binding
ENSP00000231509 GO:0008289 molecular_function lipid binding
ENSP00000231509 GO:0043565 molecular_function sequence-specific DNA binding
ENSP00000231509 GO:0046872 molecular_function metal ion binding

Orthologs
TAXID Organism Gene ID TAXID Organism Gene ID
59729 Taeniopygia guttata 100008583 9601 Pongo abelii 100189725
9483 Callithrix jacchus 100394916 8128 Oreochromis niloticus 100534398
9785 Loxodonta africana 100664515 9597 Pan paniscus 100970978
9555 Papio anubis 101011541 39432 Saimiri boliviensis 101043581
9669 Mustela putorius furo 101688907 43179 Ictidomys tridecemlineatus 101954529
7897 Latimeria chalumnae 102354325 59463 Myotis lucifugus 102429264
13735 Pelodiscus sinensis 102454070 9796 Equus caballus 100061217
61853 Nomascus leucogenys 100605325 10029 Cricetulus griseus 100763961
31033 Takifugu rubripes 101062852 10090 Mus musculus 14815
9358 Choloepus hoffmanni ENSCHOG00000013777 9685 Felis catus ENSFCAG00000026823
9103 Meleagris gallopavo ENSMGAG00000009322 8364 Xenopus tropicalis ENSXETG00000001879
9823 Sus scrofa 396740 9615 Canis familiaris 478047
9646 Ailuropoda melanoleuca ENSAMEG00000010159 9361 Dasypus novemcinctus ENSDNOG00000010685
10020 Dipodomys ordii ENSDORG00000010001 9365 Erinaceus europaeus ENSEEUG00000008977
9371 Echinops telfairi ENSETEG00000014280 69293 Gasterosteus aculeatus ENSGACG00000018209
9031 Gallus gallus ENSGALG00000007394 9595 Gorilla gorilla ENSGGOG00000004334
8049 Gadus morhua ENSGMOG00000005668 9315 Macropus eugenii ENSMEUG00000009869
30608 Microcebus murinus ENSMICG00000009473 9544 Macaca mulatta ENSMMUG00000000421
9258 Ornithorhynchus anatinus ENSOANG00000005745 9986 Oryctolagus cuniculus ENSOCUG00000011676
30611 Otolemur garnettii ENSOGAG00000003356 9978 Ochotona princeps ENSOPRG00000015535
8090 Oryzias latipes ENSORLG00000006022 9598 Pan troglodytes ENSPTRG00000017363
132908 Pteropus vampyrus ENSPVAG00000014255 10116 Rattus norvegicus ENSRNOG00000014096
42254 Sorex araneus ENSSARG00000000617 9305 Sarcophilus harrisii ENSSHAG00000001727
37347 Tupaia belangeri ENSTBEG00000016278 99883 Tetraodon nigroviridis ENSTNIG00000008946
9478 Tarsius syrichta ENSTSYG00000013696 9739 Tursiops truncatus ENSTTRG00000003260
30538 Vicugna pacos ENSVPAG00000006590 8083 Xiphophorus maculatus ENSXMAG00000009167