Basic Information
Gene ID 4092 ; Check Expression Profles ; Check TFs & Targets Binding
Gene Name SMAD7; MADH7, MADH8
Full Name Mothers against decapentaplegic homolog 7
Organism Homo sapiens [9606]

Cross Reference
UniProt O15105 UniGene Hs.465087
PDB 2LTZ OMIM 612229
KEGG hsa:4092 UCSC uc002ldg.3

Protein Interactions
DIP DIP-42252N
IntAct O15105
MINT MINT-1179821
STRING 9606.ENSP00000262158

Ensembl/RefSeq
Transcript ID
Protein ID
Gene ID
ENSEMBL
ENSEMBL
ENSEMBL
REFSEQ
REFSEQ
REFSEQ
REFSEQ

InterPro Annotation
Protein Program Term IPRS Start End Score Description
ENSP00000262158 Gene3D G3DSA:2.60.200.10 IPR017855 257 424 6.00e-59 SMAD domain-like
ENSP00000262158 Gene3D G3DSA:3.90.520.10 IPR013019 1 27 9.70e-52 MAD homology, MH1
ENSP00000262158 Gene3D G3DSA:3.90.520.10 IPR013019 91 214 9.70e-52 MAD homology, MH1
ENSP00000262158 PANTHER PTHR13703 IPR013790 1 424 0.00e-00 Dwarfin
ENSP00000262158 Pfam PF03165 IPR003619 93 202 2.30e-30 MAD homology 1, Dwarfin-type
ENSP00000262158 Pfam PF03166 IPR001132 257 425 2.60e-62 SMAD domain, Dwarfin-type
ENSP00000262158 ProSiteProfiles PS51075 IPR013019 64 207 0.00e-00 MAD homology, MH1
ENSP00000262158 ProSiteProfiles PS51076 IPR001132 261 426 0.00e-00 SMAD domain, Dwarfin-type
ENSP00000262158 SMART SM00523 IPR003619 87 205 8.30e-54 MAD homology 1, Dwarfin-type
ENSP00000262158 SMART SM00524 IPR001132 259 424 5.00e-85 SMAD domain, Dwarfin-type
ENSP00000262158 SUPERFAMILY SSF49879 IPR008984 205 424 0.00e-00 SMAD/FHA domain
ENSP00000262158 SUPERFAMILY SSF56366 IPR013019 10 27 0.00e-00 MAD homology, MH1
ENSP00000262158 SUPERFAMILY SSF56366 IPR013019 91 202 0.00e-00 MAD homology, MH1

Pfam Annotation
Protein Pfam ID E.value Name Description
ENSP00000262158 PF03166 0 MH2 MH2 domain
ENSP00000262158 PF03165 1.1e-30 MH1 MH1 domain

Gene Ontology Annotation
Protein Entry Name Space Description
ENSP00000262158 GO:0006351 biological_process transcription, DNA-templated
ENSP00000262158 GO:0007179 biological_process transforming growth factor beta receptor signaling pathway
ENSP00000262158 GO:0005634 cellular_component nucleus
ENSP00000262158 GO:0005667 cellular_component transcription factor complex
ENSP00000262158 GO:0003700 molecular_function sequence-specific DNA binding transcription factor activity

Orthologs
TAXID Organism Gene ID TAXID Organism Gene ID
9601 Pongo abelii 100460706 9823 Sus scrofa 100521305
9597 Pan paniscus 100982938 39432 Saimiri boliviensis 101039142
8090 Oryzias latipes 101165328 9669 Mustela putorius furo 101689895
7897 Latimeria chalumnae 102346848 59463 Myotis lucifugus 102427200
10090 Mus musculus 17131 9555 Papio anubis 101009976
13735 Pelodiscus sinensis 102456346 9785 Loxodonta africana ENSLAFG00000008013
9813 Procavia capensis ENSPCAG00000015115 9598 Pan troglodytes 455411
10116 Rattus norvegicus 81516 28377 Anolis carolinensis ENSACAG00000018004
9646 Ailuropoda melanoleuca ENSAMEG00000006739 9615 Canis familiaris ENSCAFG00000019069
7719 Ciona intestinalis ENSCING00000009022 10141 Cavia porcellus ENSCPOG00000021302
51511 Ciona savignyi ENSCSAVG00000011118 7955 Danio rerio ENSDARG00000016858
10020 Dipodomys ordii ENSDORG00000001837 9796 Equus caballus ENSECAG00000020583
9371 Echinops telfairi ENSETEG00000001041 9685 Felis catus ENSFCAG00000025462
69293 Gasterosteus aculeatus ENSGACG00000016510 9031 Gallus gallus ENSGALG00000027843
9595 Gorilla gorilla ENSGGOG00000010554 8049 Gadus morhua ENSGMOG00000003441
9315 Macropus eugenii ENSMEUG00000011322 30608 Microcebus murinus ENSMICG00000001332
13616 Monodelphis domestica ENSMODG00000003475 61853 Nomascus leucogenys ENSNLEG00000011529
9258 Ornithorhynchus anatinus ENSOANG00000007018 8128 Oreochromis niloticus ENSONIG00000007747
9978 Ochotona princeps ENSOPRG00000003587 132908 Pteropus vampyrus ENSPVAG00000001966
42254 Sorex araneus ENSSARG00000004025 43179 Ictidomys tridecemlineatus ENSSTOG00000020985
59729 Taeniopygia guttata ENSTGUG00000000033 99883 Tetraodon nigroviridis ENSTNIG00000018764
31033 Takifugu rubripes ENSTRUG00000010212 9478 Tarsius syrichta ENSTSYG00000003256
9739 Tursiops truncatus ENSTTRG00000004362 8364 Xenopus tropicalis ENSXETG00000020317
8083 Xiphophorus maculatus ENSXMAG00000004239