Basic Information
Gene ID 5978 ; Check Expression Profles ; Check TFs & Targets Binding
Gene Name REST; NRSF, XBR
Full Name RE1-silencing transcription factor
Organism Homo sapiens [9606]

Cross Reference
UniProt Q13127 UniGene Hs.307836
PDB 2CZY OMIM 600571
KEGG hsa:5978 UCSC uc031sex.1

Protein Interactions
DIP DIP-35264N
IntAct Q13127
MINT NULL
STRING 9606.ENSP00000311816

Ensembl/RefSeq
Transcript ID
Protein ID
Gene ID
ENSEMBL
REFSEQ
REFSEQ

InterPro Annotation
Protein Program Term IPRS Start End Score Description
ENSP00000311816 Gene3D G3DSA:3.30.160.60 IPR013087 274 305 8.70e-10 Zinc finger C2H2-type/integrase DNA-binding domain
ENSP00000311816 Gene3D G3DSA:3.30.160.60 IPR013087 306 333 1.10e-15 Zinc finger C2H2-type/integrase DNA-binding domain
ENSP00000311816 Gene3D G3DSA:3.30.160.60 IPR013087 334 362 1.00e-06 Zinc finger C2H2-type/integrase DNA-binding domain
ENSP00000311816 Gene3D G3DSA:3.30.160.60 IPR013087 363 394 7.80e-05 Zinc finger C2H2-type/integrase DNA-binding domain
ENSP00000311816 PANTHER PTHR10032 IPR027775 1 460 0.00e-00 C2H2- zinc finger protein family
ENSP00000311816 PANTHER PTHR10032:SF71 IPR027757 1 460 0.00e-00 RE1-silencing transcription factor
ENSP00000311816 ProSitePatterns PS00028 IPR007087 1062 1082 - Zinc finger, C2H2
ENSP00000311816 ProSiteProfiles PS50157 IPR007087 1060 1082 0.00e-00 Zinc finger, C2H2
ENSP00000311816 ProSiteProfiles PS50157 IPR007087 159 186 0.00e-00 Zinc finger, C2H2
ENSP00000311816 ProSiteProfiles PS50157 IPR007087 276 303 0.00e-00 Zinc finger, C2H2
ENSP00000311816 ProSiteProfiles PS50157 IPR007087 304 331 0.00e-00 Zinc finger, C2H2
ENSP00000311816 ProSiteProfiles PS50157 IPR007087 332 360 0.00e-00 Zinc finger, C2H2
ENSP00000311816 ProSiteProfiles PS50157 IPR007087 361 388 0.00e-00 Zinc finger, C2H2
ENSP00000311816 SMART SM00355 IPR015880 1060 1082 3.10e-04 Zinc finger, C2H2-like
ENSP00000311816 SMART SM00355 IPR015880 159 181 4.90e-04 Zinc finger, C2H2-like
ENSP00000311816 SMART SM00355 IPR015880 216 238 1.10e-02 Zinc finger, C2H2-like
ENSP00000311816 SMART SM00355 IPR015880 248 270 8.40e-05 Zinc finger, C2H2-like
ENSP00000311816 SMART SM00355 IPR015880 276 298 8.60e-05 Zinc finger, C2H2-like
ENSP00000311816 SMART SM00355 IPR015880 304 326 7.00e-07 Zinc finger, C2H2-like
ENSP00000311816 SMART SM00355 IPR015880 332 355 8.40e-05 Zinc finger, C2H2-like
ENSP00000311816 SMART SM00355 IPR015880 361 383 3.40e-05 Zinc finger, C2H2-like
ENSP00000311816 SMART SM00355 IPR015880 389 412 8.50e-05 Zinc finger, C2H2-like

Pfam Annotation
Protein Pfam ID E.value Name Description
ENSP00000311816 PF13465 6.7e-32 zf-H2C2_2 Zinc-finger double domain
ENSP00000311816 PF13909 1.2e-17 zf-H2C2_5 C2H2-type zinc-finger domain
ENSP00000311816 PF00096 1.6e-10 zf-C2H2 Zinc finger, C2H2 type
ENSP00000311816 PF13894 3.9e-09 zf-C2H2_4 C2H2-type zinc finger

Gene Ontology Annotation
Protein Entry Name Space Description
ENSP00000311816 GO:0006351 biological_process transcription, DNA-templated
ENSP00000311816 GO:0006355 biological_process regulation of transcription, DNA-templated
ENSP00000311816 GO:0005634 cellular_component nucleus
ENSP00000311816 GO:0003700 molecular_function sequence-specific DNA binding transcription factor activity
ENSP00000311816 GO:0046872 molecular_function metal ion binding

Orthologs
TAXID Organism Gene ID TAXID Organism Gene ID
9823 Sus scrofa 100621006 10029 Cricetulus griseus 100756480
13735 Pelodiscus sinensis 102445246 7955 Danio rerio 564772
9305 Sarcophilus harrisii 100921808 9597 Pan paniscus 100968041
9555 Papio anubis 101007427 39432 Saimiri boliviensis 101031593
28377 Anolis carolinensis ENSACAG00000002355 9646 Ailuropoda melanoleuca ENSAMEG00000008541
9483 Callithrix jacchus ENSCJAG00000004081 10020 Dipodomys ordii ENSDORG00000010073
69293 Gasterosteus aculeatus ENSGACG00000016320 9031 Gallus gallus ENSGALG00000011390
8049 Gadus morhua ENSGMOG00000004977 7897 Latimeria chalumnae ENSLACG00000002133
9315 Macropus eugenii ENSMEUG00000010330 13616 Monodelphis domestica ENSMODG00000020702
9669 Mustela putorius furo ENSMPUG00000004729 9258 Ornithorhynchus anatinus ENSOANG00000008887
9986 Oryctolagus cuniculus ENSOCUG00000001776 9978 Ochotona princeps ENSOPRG00000008088
8090 Oryzias latipes ENSORLG00000020493 7757 Petromyzon marinus ENSPMAG00000002008
9601 Pongo abelii ENSPPYG00000014745 132908 Pteropus vampyrus ENSPVAG00000010391
10116 Rattus norvegicus ENSRNOG00000002074 42254 Sorex araneus ENSSARG00000010385
43179 Ictidomys tridecemlineatus ENSSTOG00000007375 59729 Taeniopygia guttata ENSTGUG00000004749
99883 Tetraodon nigroviridis ENSTNIG00000006357 9478 Tarsius syrichta ENSTSYG00000008676
9913 Bos taurus ENSBTAG00000019359 10141 Cavia porcellus ENSCPOG00000014066
9796 Equus caballus ENSECAG00000022536 9365 Erinaceus europaeus ENSEEUG00000001134
9371 Echinops telfairi ENSETEG00000011728 9685 Felis catus ENSFCAG00000003904
9595 Gorilla gorilla ENSGGOG00000002165 9103 Meleagris gallopavo ENSMGAG00000008536
30608 Microcebus murinus ENSMICG00000017078 59463 Myotis lucifugus ENSMLUG00000014530
9544 Macaca mulatta ENSMMUG00000018821 30611 Otolemur garnettii ENSOGAG00000015986
8128 Oreochromis niloticus ENSONIG00000001589 37347 Tupaia belangeri ENSTBEG00000014480
31033 Takifugu rubripes ENSTRUG00000017683 9739 Tursiops truncatus ENSTTRG00000010832
30538 Vicugna pacos ENSVPAG00000000465 8364 Xenopus tropicalis ENSXETG00000005323
8083 Xiphophorus maculatus ENSXMAG00000015136