Basic Information | |||
Gene ID | 64344 ; Check Expression Profles ; Check TFs & Targets Binding | ||
Gene Name | HIF3A; BHLHE17, MOP7, PASD7 | ||
Full Name | Hypoxia-inducible factor 3-alpha | ||
Organism | Homo sapiens [9606] |
Cross Reference | |||
UniProt | Q9Y2N7 | UniGene | Hs.420830 |
PDB | NULL | OMIM | 609976 |
KEGG | hsa:64344 | UCSC | uc010xxy.2 |
Protein Interactions | |
DIP | NULL |
IntAct | NULL |
MINT | NULL |
STRING | 9606.ENSP00000366898 |
Ensembl/RefSeq | Transcript ID | Protein ID | Gene ID |
ENSEMBL | |||
ENSEMBL | |||
ENSEMBL | |||
ENSEMBL | |||
ENSEMBL | |||
REFSEQ | |||
REFSEQ | |||
REFSEQ | |||
REFSEQ | |||
REFSEQ | |||
REFSEQ |
InterPro Annotation | |||||||
Protein | Program | Term | IPRS | Start | End | Score | Description |
ENSP00000366898 | Pfam | PF00989 | IPR013767 | 92 | 146 | 9.70e-07 | PAS fold |
ENSP00000366898 | Pfam | PF11413 | IPR021537 | 478 | 509 | 5.40e-15 | Hypoxia-inducible factor, alpha subunit |
ENSP00000366898 | ProSiteProfiles | PS50112 | IPR000014 | 246 | 297 | 0.00e-00 | PAS domain |
ENSP00000366898 | ProSiteProfiles | PS50112 | IPR000014 | 90 | 154 | 0.00e-00 | PAS domain |
ENSP00000366898 | ProSiteProfiles | PS50888 | IPR011598 | 14 | 67 | 0.00e-00 | Myc-type, basic helix-loop-helix (bHLH) domain |
ENSP00000366898 | SMART | SM00086 | IPR001610 | 301 | 344 | 2.20e-05 | PAC motif |
ENSP00000366898 | SMART | SM00091 | IPR000014 | 227 | 295 | 2.80e-05 | PAS domain |
ENSP00000366898 | SMART | SM00091 | IPR000014 | 84 | 150 | 1.10e-12 | PAS domain |
ENSP00000366898 | SMART | SM00353 | IPR011598 | 20 | 75 | 5.40e-10 | Myc-type, basic helix-loop-helix (bHLH) domain |
ENSP00000366898 | SUPERFAMILY | SSF47459 | IPR011598 | 14 | 70 | 0.00e-00 | Myc-type, basic helix-loop-helix (bHLH) domain |
ENSP00000366898 | SUPERFAMILY | SSF55785 | IPR000014 | 241 | 342 | 0.00e-00 | PAS domain |
ENSP00000366898 | SUPERFAMILY | SSF55785 | IPR000014 | 93 | 155 | 0.00e-00 | PAS domain |
ENSP00000366898 | TIGRFAM | TIGR00229 | IPR000014 | 248 | 324 | 5.90e-06 | PAS domain |
Pfam Annotation | ||||
Protein | Pfam ID | E.value | Name | Description |
ENSP00000366898 | PF14598 | 2.3e-22 | PAS_11 | PAS domain |
ENSP00000366898 | PF08447 | 7.7e-21 | PAS_3 | PAS fold |
ENSP00000366898 | PF00989 | 1.9e-15 | PAS | PAS fold |
ENSP00000366898 | PF11413 | 2.7e-15 | HIF-1 | Hypoxia-inducible factor-1 |
ENSP00000366898 | PF13426 | 2.8e-09 | PAS_9 | PAS domain |
ENSP00000366898 | PF08448 | 8.4e-08 | PAS_4 | PAS fold |
Gene Ontology Annotation | |||
Protein | Entry | Name Space | Description |
ENSP00000366898 | GO:0001666 | biological_process | response to hypoxia |
ENSP00000366898 | GO:0045893 | biological_process | positive regulation of transcription, DNA-templated |
ENSP00000366898 | GO:0071456 | biological_process | cellular response to hypoxia |
ENSP00000366898 | GO:0005634 | cellular_component | nucleus |
ENSP00000366898 | GO:0005737 | cellular_component | cytoplasm |
ENSP00000366898 | GO:0003700 | molecular_function | sequence-specific DNA binding transcription factor activity |
ENSP00000366898 | GO:0004871 | molecular_function | signal transducer activity |
ENSP00000366898 | GO:0035035 | molecular_function | histone acetyltransferase binding |
ENSP00000366898 | GO:0046983 | molecular_function | protein dimerization activity |
Orthologs | |||||
TAXID | Organism | Gene ID | TAXID | Organism | Gene ID |
61853 | Nomascus leucogenys | 100582446 | 8128 | Oreochromis niloticus | 100708832 |
9597 | Pan paniscus | 100979253 | 9555 | Papio anubis | 101007659 |
39432 | Saimiri boliviensis | 101027930 | 9595 | Gorilla gorilla | 101146641 |
43179 | Ictidomys tridecemlineatus | 101976940 | 9598 | Pan troglodytes | 456149 |
10090 | Mus musculus | 53417 | 28377 | Anolis carolinensis | ENSACAG00000016766 |
9646 | Ailuropoda melanoleuca | ENSAMEG00000008615 | 10141 | Cavia porcellus | ENSCPOG00000024199 |
10020 | Dipodomys ordii | ENSDORG00000004664 | 9796 | Equus caballus | ENSECAG00000020693 |
9365 | Erinaceus europaeus | ENSEEUG00000009703 | 9685 | Felis catus | ENSFCAG00000014181 |
9785 | Loxodonta africana | ENSLAFG00000017230 | 9315 | Macropus eugenii | ENSMEUG00000002474 |
30608 | Microcebus murinus | ENSMICG00000016033 | 59463 | Myotis lucifugus | ENSMLUG00000014423 |
9669 | Mustela putorius furo | ENSMPUG00000005285 | 30611 | Otolemur garnettii | ENSOGAG00000008187 |
9978 | Ochotona princeps | ENSOPRG00000014480 | 8090 | Oryzias latipes | ENSORLG00000002004 |
9813 | Procavia capensis | ENSPCAG00000006067 | 9601 | Pongo abelii | ENSPPYG00000010147 |
132908 | Pteropus vampyrus | ENSPVAG00000003553 | 10116 | Rattus norvegicus | ENSRNOG00000017198 |
9305 | Sarcophilus harrisii | ENSSHAG00000004128 | 9823 | Sus scrofa | ENSSSCG00000003101 |
37347 | Tupaia belangeri | ENSTBEG00000002129 | 99883 | Tetraodon nigroviridis | ENSTNIG00000006798 |
31033 | Takifugu rubripes | ENSTRUG00000008563 | 9478 | Tarsius syrichta | ENSTSYG00000009179 |
9739 | Tursiops truncatus | ENSTTRG00000001609 | 8083 | Xiphophorus maculatus | ENSXMAG00000003186 |