Basic Information
Gene ID ENSGALG00000011870
Gene Name HIF1A
Full Name Hypoxia-inducible factor 1-alpha
Organism Gallus gallus [9031]

Cross Reference
UniProt F1NJK2 UniGene NULL
PDB NULL OMIM NULL
KEGG NULL UCSC NULL

Protein Interactions
DIP NULL
IntAct NULL
MINT NULL
STRING NULL

Ensembl/RefSeq
Transcript ID
Protein ID
Gene ID
ENSEMBL

InterPro Annotation
Protein Program Term IPRS Start End Score Description
ENSGALP00000019338 Pfam PF00989 IPR013767 94 151 3.00e-05 PAS fold
ENSGALP00000019338 Pfam PF08778 IPR014887 772 811 9.90e-23 HIF-1 alpha, transactivation domain, C-terminal
ENSGALP00000019338 Pfam PF11413 IPR021537 548 580 3.00e-16 Hypoxia-inducible factor, alpha subunit
ENSGALP00000019338 PRINTS PR01080 IPR001321 201 224 6.10e-34 Hypoxia-inducible factor-1 alpha
ENSGALP00000019338 PRINTS PR01080 IPR001321 360 378 6.10e-34 Hypoxia-inducible factor-1 alpha
ENSGALP00000019338 PRINTS PR01080 IPR001321 415 433 6.10e-34 Hypoxia-inducible factor-1 alpha
ENSGALP00000019338 PRINTS PR01080 IPR001321 455 475 6.10e-34 Hypoxia-inducible factor-1 alpha
ENSGALP00000019338 ProSiteProfiles PS50112 IPR000014 247 298 0.00e-00 PAS domain
ENSGALP00000019338 ProSiteProfiles PS50112 IPR000014 80 148 0.00e-00 PAS domain
ENSGALP00000019338 ProSiteProfiles PS50888 IPR011598 17 70 0.00e-00 Myc-type, basic helix-loop-helix (bHLH) domain
ENSGALP00000019338 SMART SM00086 IPR001610 302 345 8.50e-11 PAC motif
ENSGALP00000019338 SMART SM00091 IPR000014 230 296 1.80e-10 PAS domain
ENSGALP00000019338 SMART SM00091 IPR000014 87 153 2.40e-10 PAS domain
ENSGALP00000019338 SMART SM00353 IPR011598 23 78 1.30e-11 Myc-type, basic helix-loop-helix (bHLH) domain
ENSGALP00000019338 SUPERFAMILY SSF47459 IPR011598 15 71 0.00e-00 Myc-type, basic helix-loop-helix (bHLH) domain
ENSGALP00000019338 SUPERFAMILY SSF55785 IPR000014 242 343 0.00e-00 PAS domain
ENSGALP00000019338 SUPERFAMILY SSF55785 IPR000014 96 200 0.00e-00 PAS domain
ENSGALP00000019338 TIGRFAM TIGR00229 IPR000014 100 155 4.10e-06 PAS domain
ENSGALP00000019338 TIGRFAM TIGR00229 IPR000014 249 330 1.90e-08 PAS domain

Pfam Annotation
Protein Pfam ID E.value Name Description
ENSGALP00000019338 PF14598 3.2e-27 PAS_11 PAS domain
ENSGALP00000019338 PF08447 3e-25 PAS_3 PAS fold
ENSGALP00000019338 PF08778 4.8e-23 HIF-1a_CTAD HIF-1 alpha C terminal transactivation domain
ENSGALP00000019338 PF11413 1.4e-16 HIF-1 Hypoxia-inducible factor-1
ENSGALP00000019338 PF00989 7.1e-16 PAS PAS fold
ENSGALP00000019338 PF13426 5.8e-12 PAS_9 PAS domain
ENSGALP00000019338 PF08448 3.6e-08 PAS_4 PAS fold

Gene Ontology Annotation
Protein Entry Name Space Description
ENSGALP00000019338 GO:0001666 biological_process response to hypoxia
ENSGALP00000019338 GO:0006351 biological_process transcription, DNA-templated
ENSGALP00000019338 GO:0006355 biological_process regulation of transcription, DNA-templated
ENSGALP00000019338 GO:0007165 biological_process signal transduction
ENSGALP00000019338 GO:0045893 biological_process positive regulation of transcription, DNA-templated
ENSGALP00000019338 GO:0005634 cellular_component nucleus
ENSGALP00000019338 GO:0005737 cellular_component cytoplasm
ENSGALP00000019338 GO:0003677 molecular_function DNA binding
ENSGALP00000019338 GO:0003700 molecular_function sequence-specific DNA binding transcription factor activity
ENSGALP00000019338 GO:0004871 molecular_function signal transducer activity
ENSGALP00000019338 GO:0035035 molecular_function histone acetyltransferase binding
ENSGALP00000019338 GO:0046983 molecular_function protein dimerization activity

Orthologs
TAXID Organism Gene ID TAXID Organism Gene ID
9483 Callithrix jacchus 100411678 61853 Nomascus leucogenys 100582446
8128 Oreochromis niloticus 100703737 9555 Papio anubis 100999094
8083 Xiphophorus maculatus 102217674 7897 Latimeria chalumnae 102348279
7070 Tribolium castaneum 655772 9361 Dasypus novemcinctus ENSDNOG00000017069
9796 Equus caballus ENSECAG00000015597 9365 Erinaceus europaeus ENSEEUG00000005910
7029 Acyrthosiphon pisum 100167974 10224 Saccoglossus kowalevskii 100329032
9597 Pan paniscus 100993223 39432 Saimiri boliviensis 101044689
9685 Felis catus 101083686 9669 Mustela putorius furo 101692645
13735 Pelodiscus sinensis 102457736 7955 Danio rerio 393202
9615 Canis familiaris 480348 10090 Mus musculus 53417
7668 Strongylocentrotus purpuratus 577801 9598 Pan troglodytes 746195
28377 Anolis carolinensis ENSACAG00000016205 9646 Ailuropoda melanoleuca ENSAMEG00000003105
9358 Choloepus hoffmanni ENSCHOG00000008208 10141 Cavia porcellus ENSCPOG00000005317
51511 Ciona savignyi ENSCSAVG00000005768 10020 Dipodomys ordii ENSDORG00000004304
69293 Gasterosteus aculeatus ENSGACG00000008525 9595 Gorilla gorilla ENSGGOG00000003957
9315 Macropus eugenii ENSMEUG00000003867 59463 Myotis lucifugus ENSMLUG00000015244
30611 Otolemur garnettii ENSOGAG00000016112 9978 Ochotona princeps ENSOPRG00000007753
8090 Oryzias latipes ENSORLG00000002004 9601 Pongo abelii ENSPPYG00000005881
132908 Pteropus vampyrus ENSPVAG00000014497 10116 Rattus norvegicus ENSRNOG00000008292
9823 Sus scrofa ENSSSCG00000005096 37347 Tupaia belangeri ENSTBEG00000011941
59729 Taeniopygia guttata ENSTGUG00000012978 99883 Tetraodon nigroviridis ENSTNIG00000017339
9478 Tarsius syrichta ENSTSYG00000001081 8364 Xenopus tropicalis ENSXETG00000014449
8049 Gadus morhua ENSGMOG00000010900 9785 Loxodonta africana ENSLAFG00000013410
9103 Meleagris gallopavo ENSMGAG00000013552 30608 Microcebus murinus ENSMICG00000002224
13616 Monodelphis domestica ENSMODG00000008760 9258 Ornithorhynchus anatinus ENSOANG00000009092
9986 Oryctolagus cuniculus ENSOCUG00000017741 9813 Procavia capensis ENSPCAG00000011584
42254 Sorex araneus ENSSARG00000011198 9305 Sarcophilus harrisii ENSSHAG00000004128
43179 Ictidomys tridecemlineatus ENSSTOG00000004833 31033 Takifugu rubripes ENSTRUG00000012093
9739 Tursiops truncatus ENSTTRG00000012558 30538 Vicugna pacos ENSVPAG00000002395