[Proteopedia] New kind of inter-chain bond involved in redox allostery

[Amr ALHOSSARY]

Good idea.
I had searched the PDB for occurrence of cation-pi interaction on both sides of aromatic rings, during my MSc.
I believe I still have that code. I can change and run it to search for NOS bonds.

Amr



Amr Ali Mokhtar ALHOSSARY MBBS, PhD
Nanyang Technological University
11 Mandalay Road #14-03, Clinical Sciences Building, Singapore 308232.
T +65 6904-1355 M +65-9457-2816 
E aalhossary at ntu.edu.sg Web www.rris.ntu.edu.sg











-----Original Message-----
From: Proteopedialist-for-users <proteopedialist-for-users-bounces at bioinformatics.org> On Behalf Of Kevin Karplus
Sent: Wednesday, May 26, 2021 9:40 AM
To: Forum for the Proteopedia User Community <proteopedialist-for-users at bioinformatics.org>
Subject: Re: [Proteopedia] New kind of inter-chain bond involved in redox allostery

Cool!  Is anyone planning to write a program or query to scan all of PDB looking for places where this structure may have been missed?  Or has that already been done?

Kevin Karplus   karplus at soe.ucsc.edu    http://www.soe.ucsc.edu/~karplus
Undergraduate Director for Biomolecular Engineering and Bioinformatics Professor of Biomolecular Engineering, University of California, Santa Cruz Author of *Applied Analog Electronics
<https://leanpub.com/applied_analog_electronics>*

*Affiliations for identification only.*


On Tue, May 25, 2021 at 5:03 PM Eric Martz <emartz at microbio.umass.edu>
wrote:

> Earlier this month, a new kind of covalent linkage between the 
> sidechains of Lys and Cys was reported in Nature, a 
> Nitrogen-Oxygen-Sulfur (NOS) bond. In the initial case of the 
> transaldolases studied, it serves as an allosteric redox switch for 
> enzymatic activity. NOS appears likely to occur in proteins in all 
> domains of life including /Homo sapiens/, apparently overlooked in 
> earlier interpretations of electron density maps.
>
> Have a look at this new page:
>
> https://proteopedia.org/w/Lysine-cysteine_NOS_bonds
>
> -Eric
>
> P.S. Thanks to crystallographer Fadel Samatey for pointing out the 
> original report to me.
>
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