Basic Information
Gene ID 3661 ; Check Expression Profles ; Check TFs & Targets Binding
Gene Name IRF3
Full Name Interferon regulatory factor 3
Organism Homo sapiens [9606]

Cross Reference
UniProt Q14653 UniGene Hs.75254
PDB 3QU6 OMIM 603734
KEGG hsa:3661 UCSC uc002pow.3

Protein Interactions
DIP DIP-41448N
IntAct Q14653
MINT MINT-253351
STRING 9606.ENSP00000310127

Ensembl/RefSeq
Transcript ID
Protein ID
Gene ID
ENSEMBL
ENSEMBL
ENSEMBL
ENSEMBL
ENSEMBL
ENSEMBL
ENSEMBL
ENSEMBL
ENSEMBL
ENSEMBL
ENSEMBL
ENSEMBL
REFSEQ
REFSEQ
REFSEQ
REFSEQ
REFSEQ
REFSEQ
REFSEQ
REFSEQ

InterPro Annotation
Protein Program Term IPRS Start End Score Description
ENSP00000471896 Gene3D G3DSA:1.10.10.10 IPR011991 7 113 6.80e-38 Winged helix-turn-helix DNA-binding domain
ENSP00000471896 Gene3D G3DSA:2.60.200.10 IPR017855 198 361 2.40e-42 SMAD domain-like
ENSP00000471896 Pfam PF00605 IPR001346 7 111 9.90e-32 Interferon regulatory factor DNA-binding domain
ENSP00000471896 Pfam PF10401 IPR019471 201 326 2.30e-27 Interferon regulatory factor-3
ENSP00000471896 PRINTS PR00267 IPR001346 33 46 1.50e-17 Interferon regulatory factor DNA-binding domain
ENSP00000471896 PRINTS PR00267 IPR001346 50 67 1.50e-17 Interferon regulatory factor DNA-binding domain
ENSP00000471896 PRINTS PR00267 IPR001346 7 26 1.50e-17 Interferon regulatory factor DNA-binding domain
ENSP00000471896 PRINTS PR00267 IPR001346 73 95 1.50e-17 Interferon regulatory factor DNA-binding domain
ENSP00000471896 ProSitePatterns PS00601 IPR019817 26 58 - Interferon regulatory factor, conserved site
ENSP00000471896 ProSiteProfiles PS51507 IPR001346 5 111 0.00e-00 Interferon regulatory factor DNA-binding domain
ENSP00000471896 SMART SM00348 IPR001346 1 112 4.90e-57 Interferon regulatory factor DNA-binding domain
ENSP00000471896 SUPERFAMILY SSF49879 IPR008984 189 328 0.00e-00 SMAD/FHA domain

Pfam Annotation
Protein Pfam ID E.value Name Description
ENSP00000471896 PF00605 6.9e-32 IRF Interferon regulatory factor transcription factor
ENSP00000471896 PF10401 1.3e-27 IRF-3 Interferon-regulatory factor 3

Gene Ontology Annotation
Protein Entry Name Space Description
ENSP00000471896 GO:0006351 biological_process transcription, DNA-templated
ENSP00000471896 GO:0005634 cellular_component nucleus
ENSP00000471896 GO:0005737 cellular_component cytoplasm
ENSP00000471896 GO:0003700 molecular_function sequence-specific DNA binding transcription factor activity

Orthologs
TAXID Organism Gene ID TAXID Organism Gene ID
9646 Ailuropoda melanoleuca 100471184 9555 Papio anubis 101013579
39432 Saimiri boliviensis 101033122 9685 Felis catus 101095934
9669 Mustela putorius furo 101693423 43179 Ictidomys tridecemlineatus 101961861
10116 Rattus norvegicus 292892 9597 Pan paniscus 100977114
59463 Myotis lucifugus 102422872 9823 Sus scrofa 396656
9615 Canis familiaris ENSCAFG00000003594 10020 Dipodomys ordii ENSDORG00000014920
9796 Equus caballus ENSECAG00000018265 69293 Gasterosteus aculeatus ENSGACG00000007945
9315 Macropus eugenii ENSMEUG00000004666 13616 Monodelphis domestica ENSMODG00000013603
61853 Nomascus leucogenys ENSNLEG00000005277 9986 Oryctolagus cuniculus ENSOCUG00000027558
9978 Ochotona princeps ENSOPRG00000001971 42254 Sorex araneus ENSSARG00000006248
99883 Tetraodon nigroviridis ENSTNIG00000011381 9478 Tarsius syrichta ENSTSYG00000001716
7955 Danio rerio 564854 28377 Anolis carolinensis ENSACAG00000014027
10141 Cavia porcellus ENSCPOG00000026146 9595 Gorilla gorilla ENSGGOG00000000499
9785 Loxodonta africana ENSLAFG00000028074 30608 Microcebus murinus ENSMICG00000001752
30611 Otolemur garnettii ENSOGAG00000011935 8090 Oryzias latipes ENSORLG00000006703
9813 Procavia capensis ENSPCAG00000008633 9598 Pan troglodytes ENSPTRG00000011309
132908 Pteropus vampyrus ENSPVAG00000010968 9305 Sarcophilus harrisii ENSSHAG00000003813
37347 Tupaia belangeri ENSTBEG00000003466 9739 Tursiops truncatus ENSTTRG00000005531
8364 Xenopus tropicalis ENSXETG00000033198