Basic Information
Gene ID 5241 ; Check Expression Profles ; Check TFs & Targets Binding
Gene Name PGR; NR3C3
Full Name Progesterone receptor
Organism Homo sapiens [9606]

Cross Reference
UniProt P06401 UniGene Hs.742403
PDB 4APU OMIM 607311
KEGG hsa:5241 UCSC uc001pgh.2

Protein Interactions
DIP DIP-5967N
IntAct P06401
MINT MINT-1505587
STRING 9606.ENSP00000325120

Ensembl/RefSeq
Transcript ID
Protein ID
Gene ID
ENSEMBL
ENSEMBL
ENSEMBL
REFSEQ
REFSEQ
REFSEQ
REFSEQ

InterPro Annotation
Protein Program Term IPRS Start End Score Description
ENSP00000325120 Gene3D G3DSA:1.10.565.10 IPR008946 665 916 2.10e-73 Nuclear hormone receptor, ligand-binding
ENSP00000325120 Gene3D G3DSA:3.30.50.10 IPR013088 563 634 1.50e-24 Zinc finger, NHR/GATA-type
ENSP00000325120 Pfam PF00104 IPR000536 702 883 2.50e-27 Nuclear hormone receptor, ligand-binding, core
ENSP00000325120 Pfam PF00105 IPR001628 566 633 3.10e-26 Zinc finger, nuclear hormone receptor-type
ENSP00000325120 Pfam PF02161 IPR000128 1 564 1.80e-272 Progesterone receptor
ENSP00000325120 PRINTS PR00047 IPR001628 567 583 2.10e-13 Zinc finger, nuclear hormone receptor-type
ENSP00000325120 PRINTS PR00047 IPR001628 583 598 2.10e-13 Zinc finger, nuclear hormone receptor-type
ENSP00000325120 PRINTS PR00047 IPR001628 616 624 2.10e-13 Zinc finger, nuclear hormone receptor-type
ENSP00000325120 PRINTS PR00047 IPR001628 624 632 2.10e-13 Zinc finger, nuclear hormone receptor-type
ENSP00000325120 PRINTS PR00398 IPR001723 721 742 2.10e-12 Steroid hormone receptor
ENSP00000325120 PRINTS PR00398 IPR001723 742 758 2.10e-12 Steroid hormone receptor
ENSP00000325120 PRINTS PR00398 IPR001723 811 826 2.10e-12 Steroid hormone receptor
ENSP00000325120 PRINTS PR00544 IPR000128 104 121 2.70e-93 Progesterone receptor
ENSP00000325120 PRINTS PR00544 IPR000128 137 151 2.70e-93 Progesterone receptor
ENSP00000325120 PRINTS PR00544 IPR000128 302 324 2.70e-93 Progesterone receptor
ENSP00000325120 PRINTS PR00544 IPR000128 349 365 2.70e-93 Progesterone receptor
ENSP00000325120 PRINTS PR00544 IPR000128 48 64 2.70e-93 Progesterone receptor
ENSP00000325120 PRINTS PR00544 IPR000128 506 522 2.70e-93 Progesterone receptor
ENSP00000325120 PRINTS PR00544 IPR000128 523 542 2.70e-93 Progesterone receptor
ENSP00000325120 PRINTS PR00544 IPR000128 544 563 2.70e-93 Progesterone receptor
ENSP00000325120 ProSitePatterns PS00031 IPR001628 567 593 - Zinc finger, nuclear hormone receptor-type
ENSP00000325120 ProSiteProfiles PS51030 IPR001628 564 639 0.00e-00 Zinc finger, nuclear hormone receptor-type
ENSP00000325120 SMART SM00399 IPR001628 564 635 4.30e-32 Zinc finger, nuclear hormone receptor-type
ENSP00000325120 SMART SM00430 IPR000536 720 884 8.00e-36 Nuclear hormone receptor, ligand-binding, core
ENSP00000325120 SUPERFAMILY SSF48508 IPR008946 617 643 0.00e-00 Nuclear hormone receptor, ligand-binding
ENSP00000325120 SUPERFAMILY SSF48508 IPR008946 674 913 0.00e-00 Nuclear hormone receptor, ligand-binding

Pfam Annotation
Protein Pfam ID E.value Name Description
ENSP00000325120 PF02161 0 Prog_receptor Progesterone receptor
ENSP00000325120 PF00104 1.8e-27 Hormone_recep Ligand-binding domain of nuclear hormone receptor
ENSP00000325120 PF00105 2e-26 zf-C4 Zinc finger, C4 type (two domains)

Gene Ontology Annotation
Protein Entry Name Space Description
ENSP00000325120 GO:0006351 biological_process transcription, DNA-templated
ENSP00000325120 GO:0006355 biological_process regulation of transcription, DNA-templated
ENSP00000325120 GO:0043401 biological_process steroid hormone mediated signaling pathway
ENSP00000325120 GO:0005634 cellular_component nucleus
ENSP00000325120 GO:0005737 cellular_component cytoplasm
ENSP00000325120 GO:0003677 molecular_function DNA binding
ENSP00000325120 GO:0003700 molecular_function sequence-specific DNA binding transcription factor activity
ENSP00000325120 GO:0003707 molecular_function steroid hormone receptor activity
ENSP00000325120 GO:0005496 molecular_function steroid binding
ENSP00000325120 GO:0008270 molecular_function zinc ion binding
ENSP00000325120 GO:0008289 molecular_function lipid binding
ENSP00000325120 GO:0043565 molecular_function sequence-specific DNA binding
ENSP00000325120 GO:0046872 molecular_function metal ion binding

Orthologs
TAXID Organism Gene ID TAXID Organism Gene ID
7955 Danio rerio 100005148 9986 Oryctolagus cuniculus 100009094
9555 Papio anubis 100303420 9483 Callithrix jacchus 100395871
9601 Pongo abelii 100454831 30611 Otolemur garnettii 100945812
9597 Pan paniscus 100989324 39432 Saimiri boliviensis 101046070
9595 Gorilla gorilla 101152212 9669 Mustela putorius furo 101680284
8083 Xiphophorus maculatus 102233217 10029 Cricetulus griseus 100757656
9796 Equus caballus ENSECAG00000011511 9031 Gallus gallus ENSGALG00000017195
30608 Microcebus murinus ENSMICG00000006331 13735 Pelodiscus sinensis ENSPSIG00000013654
9823 Sus scrofa ENSSSCG00000014977 31033 Takifugu rubripes ENSTRUG00000013128
9544 Macaca mulatta 613024 28377 Anolis carolinensis ENSACAG00000013594
9646 Ailuropoda melanoleuca ENSAMEG00000017449 9913 Bos taurus ENSBTAG00000024648
9615 Canis familiaris ENSCAFG00000003978 9358 Choloepus hoffmanni ENSCHOG00000007092
10141 Cavia porcellus ENSCPOG00000020113 9371 Echinops telfairi ENSETEG00000009960
9685 Felis catus ENSFCAG00000011489 69293 Gasterosteus aculeatus ENSGACG00000012162
8049 Gadus morhua ENSGMOG00000002886 7897 Latimeria chalumnae ENSLACG00000013150
9785 Loxodonta africana ENSLAFG00000006479 9315 Macropus eugenii ENSMEUG00000015727
9103 Meleagris gallopavo ENSMGAG00000015180 59463 Myotis lucifugus ENSMLUG00000022851
13616 Monodelphis domestica ENSMODG00000000509 61853 Nomascus leucogenys ENSNLEG00000007154
9258 Ornithorhynchus anatinus ENSOANG00000010494 9978 Ochotona princeps ENSOPRG00000008534
9813 Procavia capensis ENSPCAG00000013031 7757 Petromyzon marinus ENSPMAG00000005858
9598 Pan troglodytes ENSPTRG00000004206 132908 Pteropus vampyrus ENSPVAG00000006626
10116 Rattus norvegicus ENSRNOG00000006831 9305 Sarcophilus harrisii ENSSHAG00000016670
43179 Ictidomys tridecemlineatus ENSSTOG00000020694 37347 Tupaia belangeri ENSTBEG00000009619
59729 Taeniopygia guttata ENSTGUG00000012778 99883 Tetraodon nigroviridis ENSTNIG00000019045
9739 Tursiops truncatus ENSTTRG00000000030 30538 Vicugna pacos ENSVPAG00000008979
8364 Xenopus tropicalis ENSXETG00000005089